Clinical trials: Muscle Disuse Atrophy, open to volunteers
Mitochondrial Energetics, Dietary Nitrate
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men
Diminished use of skeletal muscle, such as occurs with many chronic diseases (e.g., heart failure or cancer cachexia), denervation, bedrest, immobilization (e.g., limb casting or bracing), etc., is a common clinical condition…
- Conditions
- Mitochondrial Energetics, Dietary Nitrate, Disuse Atrophy (Muscle) of Lower Leg
- Trial name
- NCT07161973
- Testing
- Beetroot Juice - Active
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Muscular Atrophy, Insulin Resistance
Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults
The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest.
- Conditions
- Muscular Atrophy, Insulin Resistance, Muscle Protein Synthesis
- Trial name
- FABRIC (NCT07178353)
- Testing
- Bedrest
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Queen's University
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Muscle Atrophy, Disuse Atrophy
Effect of Knee Position on Muscle Loss During Leg Immobilization
This study looks at what happens to leg muscles when the knee is kept straight or bent during five days of wearing a brace. We want to find out if keeping the knee bent (so the thigh muscle is stretched) helps prevent muscle loss…
- Conditions
- Muscle Atrophy, Disuse Atrophy, Immobilization
- Trial name
- NCT07690150
- Testing
- Knee immobilization brace (0°) for 5 days, Knee immobilization brace (60°) for 5 days
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Muscle Wasting
The Effect of Repeated Whole-body NMES Sessions With or Without Protein Intake on Muscle Protein Synthesis During 3 Days of Bed Rest in Healthy Young Volunteers
The goal of this clinical trial is to examine the effect of whole-body electrostimulation with protein intake on muscle protein synthesis, muscle mass and function during bed rest in healthy young adults (18-35 years).
- Trial name
- SPRINT (NCT07062562)
- Testing
- NMES, Protein bolus (20g), Standard nutrition
- Where
- Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Disuse Atrophy, Immobilization
Cross-education of Skill and Strength in Healthy People Subjected to an Upper-limb Disuse Model
This randomized controlled trial aims to compare manual dexterity and strength between a group undergoing a contralateral manual dexterity training program and a no-intervention control group in healthy, physically inactive…
- Trial name
- IMMO-CROSS (NCT07615062)
- Testing
- Contralateral Manual Dexterity Training
- Where
- Chile
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidad Catolica de Temuco
Muscle Disuse, Muscle Disuse Atrophy
Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization
Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy).
- Trial name
- NCT07069426
- Testing
- 20 grams protein, 40 grams protein
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Muscle Atrophy, Muscle Weakness
FIT Exercise in 30d of ULLS-induced Muscle Disuse
This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical…
- Trial name
- NCT06631053
- Testing
- velocity-based FIT (VBFIT), No Exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lance Bollinger
Chronic Kidney Disease (CKD)
Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness.
- Trial name
- EMPHASIS (NCT06607913)
- Testing
- Exercise
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- VA Office of Research and Development