Clinical trials: Muscle Dysfunction
Respiratory Support
The ACCESSIT Study
The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.
- Trial name
- ACCESSIT (NCT05207046)
- Testing
- Mechanical Ventilation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Pelvic Floor Disorders, Diastasis Recti
Pelvic Floor Muscle Function, Pelvic Floor Dysfunction and Diastasis Recti Abdominis in Postpartum Women
Background: Pregnancy and childbirth are factors that affect a woman's pelvic floor. Pelvic floor disorders (PFD) often occur in the perinatal period.
- Trial name
- NCT05004402
- Where
- Poland
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Żelazna Medical Centre, LLC
Temporomandibular Disorder, Temporomandibular Joint Disorders
Cognitive Exercise Therapy Approach Biopsychosocial Questionnaire (BETY-BQ) in Patient with Temporomandibular Disorders
The aim of this study is to investigate the validity, reliability, and responsiveness of the Cognitive Exercise Therapy Approach-Biopsychosocial Questionnaire (BETY-BQ) in individuals with temporomandibular disorder.
- Conditions
- Temporomandibular Disorder, Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome
- Trial name
- NCT06186830
- Testing
- Validity and reliability analyses
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Hacettepe University
Tendinopathy
Exercise and Shoe Orthoses in Treatment of Posterior Tibial Tendon Dysfunction
Posterior tibial tendon dysfunction (PTTD) is the most common cause of painful and debilitating acquired flatfoot deformity in adults.
- Trial name
- NCT00279630
- Testing
- Orthoses and Exercise
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Southern California
Doxorubicin Induced Cardiomyopathy, Chemotherapeutic Toxicity
Mitochondrial dysfUnction: a Key Player in Doxorubicin-induced Skeletal and Cardiac muscLE Damage
The goal of this observational study is to demonstrate the ability of using non-invasive Phosphorus (31P) Magnetic Resonance Spectroscopy (MRS) to monitor changes of in-vivo markers of mitochondrial function in skeletal and…
- Conditions
- Doxorubicin Induced Cardiomyopathy, Chemotherapeutic Toxicity, Anthracyclines
- Trial name
- MUSCLE (NCT05731375)
- Testing
- 31-MRS at 7 Tesla (T)
- Where
- 4 sites in Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Diaphragm Dysfunction, Mechanical Ventilation
A Biobank for Diaphragm Muscular Fiber
This non-interventional study focuses on mechanical ventilation used in intensive care unit to supplement ventilatory function in patients.
- Trial name
- BOTAN (NCT02900300)
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Head and Neck Neoplasms, Deglutition Disorders
EMST and Swallowing in Long-Term Survivors of HNCA
This study is a randomized trial examining the impact of expiratory muscle strength training (EMST) on oral intake, swallowing function, and swallow-related quality of life in persons treated for cancer of the head and neck…
- Trial name
- NCT03975465
- Testing
- Expiratory Muscle Strength Training, Pharyngeal Muscle Strengthening Exercises
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Wisconsin, Milwaukee
Exercise-induced Myocardial Damage, Right Ventricular Diastolic Dysfunction
Effects of Exogenous Ketones on Acute Changes and Recovery of the Heart Muscle After Intense Exercise.
It is well known that scar tissue on the heart muscle can cause (life-threatening) arrhythmias. However, the exact cause of this scar tissue is not entirely clear.
- Trial name
- NCT06715748
- Testing
- Ketone Monoester (KE)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Temporomandibular Joint Dysfunction Syndrome
Additional Effects of Therapeutic Exercises Under a Behavioral Umbrella for Chronic Temporomandibular Disorders Treatment
Temporomandibular dysfunction (TMD) It's one of the main causes of oro-facial chronic pain. The psychological aspects of patients with TMD have a huge importance, affecting their ability to manage pain and interfering with the…
- Trial name
- NCT03596606
- Testing
- Manual Treatment, Myofunctional Motor control exercises
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Maxilofacial Institute Bara Gaseni
Critical Illness, Sepsis
Measuring Outcomes of Activity in Intensive Care
Millions of older adults are hospitalized for a critical illness each year and although they are more likely than ever to survive this illness, they commonly face significant morbidity in the form of disabilities in basic…
- Conditions
- Critical Illness, Sepsis, Mechanical Ventilation, Physical Activity
- Trial name
- MOSAIC (NCT03115840)
- Where
- 2 sites in United States
- Volunteers
- 312 people
- Sponsor
- Vanderbilt University Medical Center
Innominate Upslip Suprapubic Dysfunction
PIR of Quadratus Lumborum With and Without Gluteus Maximus Activation in Innominate Upslip Suprapubic Dysfunction
The innominate up slip dysfunction is the most common in athletes and non-athletes, who present with low back pain and sacroiliac dysfunction.
- Trial name
- NCT05347589
- Testing
- Post isometric relaxation of quadratus lumborum and gluteus Gluteus maximus activation exercises, post isometric relaxation of the Quadratus lumborum
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Stress Urinary Incontinence (SUI)
Differences in Pelvic Floor Motion Level Among Chinese Women and Construction of an Assessment System
The purpose of this study is to integrate millimeter-wave radar technology to investigate the dynamic movement characteristics of the pelvic floor muscles in patients with different Body Mass Index (BMI) and stress urinary…
- Trial name
- NCT07608146
- Where
- 20 sites in China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Sleep Bruxism, Hypertension
Selected Disorders and Sleep Bruxism
Sleep apnea is a common and serious health problem in the Polish population. According to epidemiological data problem concerns about 7% of the adult population. The most common sleep disorder is obstructive sleep apnea (OSA).
- Conditions
- Sleep Bruxism, Hypertension, Thyroid Dysfunction, Mental Status Change
- Trial name
- NCT03083405
- Testing
- Opipramol
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Healthy, CVA
Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbaric Medicine and Research Center at the Years 2017-2019.
DELPhI software developed for the analysis of EEG recordings in response to magnetic stimulation in relation to clinical data.
- Conditions
- Healthy, CVA, Hemorrhage, TBI (Traumatic Brain Injury)
- Trial name
- NCT04095377
- Testing
- No intervention, this is a retrospective study.
- Where
- Israel
- Volunteers
- 875 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Temporomandibular Disorders, Headache
Efficacy of Manuel Therapy and BETY in Patients With Temporomandibular Dysfunction Related Headache
The aim of the study is to investigate the effects of Manual Therapy and the Cognitive Exercise Therapy Approach treatment in patients with TMD-related headaches.
- Trial name
- NCT05927545
- Testing
- Patient education and preventive exercise, Patient education, preventive exercise combined with Manual Therapy protocol, Patient education, preventive exercise combined with BETY approach
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hasan Kalyoncu University
Pelvic Floor Dysfunction
The Evaluation of Pelvic Floor Muscle Function: A Reliability and Correlation Study
1. To explore the correlations among measures of PFM strength between using vaginal palpation quantified by modified Oxford Grading Scale and Levator ani testing and manometry in PHENIX instrument; 2.
- Trial name
- NCT03511911
- Testing
- evaluation of pelvic floor muscle function through the PHENIX instrument, vaginal palpation
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Mild Cognitive Impairment
Resistance Exercise Training in Individuals Aged 60 and Older With Mild Cognitive Impairment
The aging population in Chile and worldwide is increasing, with older people expected to represent 32.1% of the population by 2050.
- Trial name
- RET-MCI (NCT06470568)
- Testing
- Progressive Resistance exercise training
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Universidad de La Frontera
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis
Melatonin and Zinc Administration on Cardinal Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
The aim of the study is to investigate the effects of oral melatonin and zinc supplementation on core features in individuals with ME/CFS
- Trial name
- MelatoZincME (NCT05454683)
- Testing
- melatonin plus zinc, isomaltose and magnesium stearate
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Laboratorios Viñas, S.A.
Heart Failure
The Effects of the Inspiratory Muscle Plus Aerobic Training Compare to Aerobic Training Alone in Heart Failure Patients.
This study aims to compare effects of inspiratory muscle training added by aerobic training to aerobic training alone in heart failure patients with inspiratory muscle weakness.
- Trial name
- NCT00634296
- Testing
- Inspiratory muscle added by aerobic to aerobic alone
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hypertension, Atherosclerosis
Age-Related Changes in Body Composition
Background: Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age.
- Trial name
- NCT01517113
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)