Clinical trials: Muscle Dysfunction
Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy
DMD Gene Variants and Cardiac Dysfunction in Young Males With Dystrophinopathies
The goal of this observational study is to investigate whether the type, location, and extent of pathogenic variants in the DMD gene are associated with cardiac dysfunction in male children, adolescents, and young adults with…
- Conditions
- Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy, Cardiomyopathy
- Trial name
- NCT07515235
- Where
- Greece
- Volunteers
- 65 people
- Sponsor
- Aristotle University Of Thessaloniki
Duchenne Muscular Dystrophy, Cardiomyopathy
Nebivolol for the Prevention of Left Ventricular Systolic Dysfunction in Patients With Duchenne Muscular Dystrophy
The objective is to determine whether nebivolol, a beta-blockade drug, can prevent the development of heart disease in patients with Duchenne muscular dystrophy aged 10 to 15 year-old.
- Conditions
- Duchenne Muscular Dystrophy, Cardiomyopathy, Heart Failure
- Trial name
- NEBIDYS (NCT01648634)
- Testing
- Nebivolol
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Myofascial Pain, Temporomandibular Disorder
Telerehabilitation in Individuals Temporomandibular Dysfunction With Bruxism
The aim of the study is to compare the effects of Home Exercise Therapy (HET) and Telerehabilitation in patients with myofascial temporomandibular disorders (TMD)with bruxism.
- Conditions
- Myofascial Pain, Temporomandibular Disorder, Bruxism
- Trial name
- NCT04884152
- Testing
- Home Exercise Group, Telerehabilitation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hasan Kalyoncu University
Tracheostomy Complication, Diaphragm Disease
Assessment of the Effect of an Inspiratory Muscle Training Regimen on Decannulation Time in Tracheostomized Subjects
The objective of this project is to evaluate the effect of applying an individualized inspiratory muscle training regimen, combining strength and endurance exercises over a two-week period, on improving maximum inspiratory…
- Trial name
- NCT06684392
- Testing
- Inspiratory muscle training
- Where
- Chile
- Volunteers
- 56 people
- Sponsor
- Hospital Dr. Franco Ravera Zunino
Temporomandibular Disorders, Headache
The BETY-Biopsychosocial Questionnaire (BETY-BQ) in Individuals With Temporomandibular Dysfunction-Related Headache
This study investigates the validity and reliability of the BETY- Biopsychosocial Questionnaire (BETY-BQ) as a biopsychosocial assessment tool in individuals with temporomandibular dysfunction-related headaches.
- Trial name
- NCT05902026
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Hasan Kalyoncu University
Temporomandibular Joint Dysfunction Syndrome
Respiratory Functions and Respiratory Muscle Strength in Patients With Temporomandibular Joint Dysfunction
In our study, it was aimed to evaluate respiratory functions and respiratory muscle strength in patients diagnosed with temporomandibular dysfunction (TMD) and to compare them with healthy individuals.
- Trial name
- NCT05271396
- Testing
- Clinical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Halic University
Pulmonary Disease, Chronic Obstructive
Effect and Feasibility of Non-linear Periodized Resistance Training in People With COPD
This study aims at improving the knowledge about resistance training for people with COPD. Resistance training is an important part of pulmonary rehabilitation when the goal is to improve muscular endurance and strength.
- Trial name
- NCT03518723
- Testing
- Non-linear Periodized Resistance Training, Resistance training
- Where
- 3 sites in Canada, Netherlands and 1 more
- Volunteers
- 57 people
- Sponsor
- Umeå University
Facial Pain
Proprioceptive Treatment for Temporomandibular Dysfunction
The project aims to assess the effects of proprioceptive treatment through the use of hyperbolid mastication apparatus on pain intensity, muscle activity and joint mobility in subjects with TMD.
- Trial name
- NCT02021357
- Testing
- hyperbolid combined with tongue exercises on the palate, hyperbolid
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- University of Nove de Julho
Childhood Cancer, Cancer Survivors
Diaphragm Structure and Function in Childhood Cancer Survivors
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer…
- Trial name
- NCT06205251
- Testing
- POWERbreathe Plus IMT
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Maryland, Baltimore
Temporomandibular Disorder
Photobiomodulation In the Masseter and Temporal In Patients With Temporomandibular Joint Dysfunction
Background: According to the International Association for the Study of Pain (IASP), the term temporomandibular disorder (TMD) regards a subgroup of orofacial pain, the symptoms of which include pain or discomfort in the…
- Trial name
- NCT03005730
- Testing
- phototherapy
- Volunteers
- 15 people
- Sponsor
- University of Nove de Julho
Myofascial Pain Dysfunction Syndrome, Myofascial Pelvic Pain Syndrome
Precise AI-Controlled Radiofrequency Versus Biofeedback-Electrical Stimulation in Women With Myofascial Pelvic Pain Syndrome: A Comparative Study
Study Summary: Comparison of Two Treatments for Female Myofascial Pelvic Pain Syndrome The goal of this study is to compare two treatment methods-precise AI-controlled radiofrequency therapy versus biofeedback combined with…
- Trial name
- NCT07791277
- Testing
- Intervention 1：Precision AI Temperature-Controlled Radiofrequency, Intervention 2:Biofeedback Combined with Electrical Stimulation
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jiangxi Women and Children's Medical Center
Healthy
Analysis of Heart Muscle Function Following Exercise in Patients With Heart Disease
This study is designed to examine the blood flow, the nutrition, and the beating function of the heart under different conditions. Patients with narrowed coronary arteries my have restricted blood flow to the heart.
- Trial name
- NCT00001528
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pericarditis, Tako-TSUBO Cardiomyopathy
Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular Research
INFLAME-BANK is a French multicenter prospective observational ancillary study of the international EACVI-INFLAME project. It aims to establish a biobank and perform immunophenotyping and proteomic analyses in patients with…
- Conditions
- Pericarditis, Tako-TSUBO Cardiomyopathy, Myocarditis, Inflammatory Cardiomyopathies
- Trial name
- INFLAME-BANK (NCT07737470)
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes, Obesity
PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes
The goal of this study is to understand how and why insulin resistant individuals respond differently to exercise as compared with insulin sensitive individuals at the skeletal muscle and gene expression level.
- Trial name
- PGC-1 (NCT02282423)
- Testing
- Pre-study dietary and exercise instruction., Screening examination and oral glucose tolerance test, Euglycemic clamp
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Chronic Obstructive Pulmonary Disease
Impact of Muscle Afferent Feedback During Exercise in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Recently, direct evidences point to the contributing role of peripheral muscle fatigue in exercise tolerance among patients with COPD.
- Trial name
- NCT01522729
- Testing
- Fentanyl
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Laval University
Chronic Fatigue Syndrome, Long COVID
Endothelial Dysfunction in Post-infection Fatigue Syndromes
Post-infection chronic fatigue syndromes, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and post-COVID-19 condition (Long Covid), are conditions primarily characterized by debilitating fatigue.
- Trial name
- NCT06463106
- Where
- Austria
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Liver Dysfunction
Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis
Observed the muscle relaxation of mivacurium in patients with liver cirrhosis.Clear of mivacurium in patients with liver cirrhosis without muscle relaxant accumulation and delayed recovery phenomenon
- Trial name
- NCT02473601
- Testing
- Mivacurium Chloride
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tang-Du Hospital
Low Back Pain
Low Back Pain and Breathing Pattern Dysfunction
The goal of this study is to identify if there is a significant prevalence of abnormal respiratory patterns in a sample of patients with low back pain (LBP), and if the presence of abnormal respiratory patterns are predictive of…
- Trial name
- LBP&BPD (NCT02429752)
- Testing
- Inspiratory muscle training
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Miami
Restrictive Lung Diseases
Effects of Inspiratory Muscle Training and Positive Expiratory Pressure on Mechanically Ventilated Restrictive Lung Disease Patients
Restrictive lung diseases (RLD) represent a significant cause of morbidity, often necessitating intensive interventions such as mechanical ventilation due to diminished lung compliance (LC) and reduced total lung capacity (TLC).
- Trial name
- NCT07867730
- Testing
- Inspiratory muscle training, Conventional Chest Physical Therapy
- Where
- 3 sites in Pakistan
- Volunteers
- 30 people
- Sponsor
- Foundation University Islamabad