Clinical trials: Muscle Hypertonia
Spasticity
Effectiveness of an Interprofessional Approach to the Treatment of Spasticity With Botulinum Toxin & Non-pharmacological Therapies
Many people with neurological conditions will experience spasticity, a nonvolitional and uncontrollable tightening and/or spasm of muscles.
- Trial name
- NCT07160699
- Testing
- Botulinum Neurotoxin Type A, Non-pharmacological therapies
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Technical University of Bern
Stroke
Neural Mobilization for Reduction of Spasticity in Stroke
Spasticity after stroke is common that affect upper limb strength and make activities of daily living difficult. There are many techniques but not any standardized technique for long term effect on reduction of spasticity and…
- Trial name
- NCT05314465
- Testing
- Median nerve mobilization
- Where
- 3 sites in India
- Volunteers
- 7 people
- Sponsor
- Asir John Samuel
Transcutaneous Spinal Stimulation, Walking
Spinal Cord Stimulation to Augment Activity Based Therapy
Involuntary muscle activity, often called spasticity, is a common problem following spinal cord injury (SCI) that can make it hard to move.
- Conditions
- Transcutaneous Spinal Stimulation, Walking, Spasticity, Human
- Trial name
- NCT03240601
- Testing
- Transcutaneous spinal stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Shepherd Center, Atlanta GA
Cerebral Palsy, Genetic Disease
Genetic Etiology in Patients With Cerebral Palsy
Cerebral palsy (CP) is a permanent disorder of movement or posture due to non-progressive impairments of the developing brain. Current estimates indicate that as many as 30% of CP cases may be genetic in nature.
- Conditions
- Cerebral Palsy, Genetic Disease, Developmental Delay, Metabolism, Inborn Errors
- Trial name
- GenCP (NCT05123768)
- Testing
- NGS
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Muscle Spasticity, Stroke
Powered Exoskeleton for the Treatment of Elbow Spasticity
This is a phase-II clinical study to assess whether intense passive mobilization of the elbow during the early stage is effective in preventing spasticity from occurring at a later stage.
- Trial name
- NCT02934646
- Testing
- Robotic treatment
- Volunteers
- 20 people
- Sponsor
- Auxilium Vitae Volterra
Cerebral Palsy, Spastic
The Effect of Botulinum Toxin and ESWT Applications on Spasticity and Functionality in Cerebral Palsy Patients
Cerebral Palsy (CP) is a group of movement and posture disorders associated with a non-progressive affect during brain development that can cause limitation of activity and disability.
- Trial name
- NCT05627921
- Testing
- Extracorporeal Shock Wave Therapy, Botilinum Toxin injection
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Encephalopathy, Psychosis
Neuroimmunology Registry and Biobank
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases.
- Conditions
- Encephalopathy, Psychosis, Impaired Consciousness, Epilepsy
- Trial name
- NCT06958341
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Stroke
Comparative Study of LoKomat® Exoskeleton VS C-Mill® Treadmill for Gait Recovery in Rehabilitation.
The use of robotic technology for the treatment of gait in neurological pathologies has provided different results in scientific evidence.
- Trial name
- NCT07230470
- Testing
- Lokomat®, C-Mill
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad Pontificia de Salamanca
Stroke, Hypertonia
Validity and Reliability of the Hypertonia Assessment Tool (HAT) in Stroke Patients
In this study, the validity and reliability of the Hypertonia Assessment Tool (HAT), which has previously been validated in the pediatric cerebral palsy (CP) population, will be evaluated in adult individuals who have experienced…
- Conditions
- Stroke, Hypertonia, Dystonia, Rigidity
- Trial name
- NCT07429383
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Spinal Cord Injury, Spasticity
Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury
Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands.
- Conditions
- Spinal Cord Injury, Spasticity, Shockwave Therapy
- Trial name
- NCT07501429
- Testing
- Focused extracorporeal shockwave therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Muscle Spasticity, Spinal Cord Injury
Effect of Joint Mobilization on Alpha Motoneuron Reflex Excitability
Objective: To determine the effect of ankle joint mobilization on the alpha motoneuron reflex excitability of the soleus muscle in people with spasticity.
- Conditions
- Muscle Spasticity, Spinal Cord Injury, Stroke, Craniocerebral Trauma
- Trial name
- JM-HRreflex (NCT01153022)
- Testing
- joint mobilization techniques
- Where
- Colombia
- Volunteers
- 24 people
- Sponsor
- Universidad Autónoma de Manizales, Colombia
Deep Pressure, Muscle Activity
Effect of Local Pressure on Muscle Activity and General Relaxation in Persons With Hypertonia Following Stroke
The purpose of this study is to examine the effect of - both constant as intermittent - local application of deep pressure on muscle activity and general relaxation in persons with hypertonia following stroke.
- Conditions
- Deep Pressure, Muscle Activity, General Relaxation, Stroke
- Trial name
- NCT04188769
- Testing
- constant deep pressure applied by an air splint, intermittent deep pressure applied by an air splint, uninflated air splint
- Where
- Belgium
- Sponsor
- University Ghent
Paraparesis, Gait Disorders, Neurologic
Effect of Electromagnetic Field Therapy on Balance and Gait in Paraparetic Patients
This study will investigate whether adding electromagnetic field therapy (EMT) to a standard physical therapy program is more effective than physical therapy alone for improving balance and walking ability in paraparetic…
- Conditions
- Paraparesis, Gait Disorders, Neurologic, Postural Balance Disorders
- Trial name
- EMT-BG (NCT07196956)
- Testing
- Low-Frequency Electromagnetic Field Therapy (0.5 Hz)
- Where
- Saudi Arabia
- Volunteers
- 30 people
- Sponsor
- MTI University
Spasticity as Sequela of Stroke, Stroke
Prevalence of Postural Patterns of Upper Extremity.
A high number of patient with stroke develops spasticity of the upper extremity, this clinical sign of damage of 1 motoneuro (MN), causes postures and patterns of abnormal movement, due to the hyperexcitability of the MN and the…
- Conditions
- Spasticity as Sequela of Stroke, Stroke, Upper Extremity Paresis
- Trial name
- Patterns (NCT03588832)
- Testing
- Evaluation Upper Extremity patterns.
- Where
- Chile
- Volunteers
- 600 people
- Sponsor
- Universidad de La Frontera
Spasticity, Muscle
Efficiency of the Super Inductive System in Spasticity Treatment
The aim of the study is to see whether a physical therapy program can relieve pain, decrease spasticity and increase muscle contraction force by using the super inductive system (high frequency electromagnetic field).
- Trial name
- NCT04190238
- Testing
- Super inductive system (high frequency electromagnetic field), Physical therapy
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Upper Limb Spasticity Unilaterally in Adults With History of Stroke, Increased Muscle Tone in Elbow, Wrist, Finger, and Thumb Flexors.
ASIS for Botox in Upper Limb Spasticity
Botox act on nerve endings, yet there are no nerve endings inside the muscle, where they are typically injected. All nerves terminate on the fascia, where ASIS device can precisely deliver Botox by creating that subdermal…
- Trial name
- ASISinULS (NCT02074150)
- Testing
- Gadolinium, Efficacy of Botox intramuscularly at Week 6, Efficacy of Botox intramuscularly at Week 12,
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- li nguyen
Stroke Patients With Hemiplegia or Hemiparesis in the Subacute Stage
The Effect of Combined Transcranial Pulse Current Stimulation (tPCS) and Transcutaneous Electrical Nerve Stimulation (TENS) on Lower Limb Motor Function in Subacute to Chronic Stroke Patients With Hemiplegia (COMPENSATOR-Stroke)
The goal of this study is to evaluate the effects of high frequency tPCS + TENS compared to Sham device stimulation + TENS (Control) in lower limb motor function recovery in stroke patients with hemiplegia or hemiparesis in the…
- Trial name
- COMPENSATOR (NCT06999876)
- Testing
- The AscenZ-VIII Stimulator (Investigational Medical Device)
- Where
- 2 sites in Singapore
- Volunteers
- 90 people
- Sponsor
- National University Health System, Singapore
Spasticity
Safety Study of SPARC1104
Open-label, safety study of SPARC1104 in subjects with spasticity due to multiple sclerosis
- Trial name
- NCT01797185
- Testing
- SPARC1104 modified dose regimen I, SPARC1104 modified dose regimen II, SPARC1104 modified dose regimen III
- Where
- 51 sites in United States
- Volunteers
- 375 people
- Sponsor
- Sun Pharma Advanced Research Company Limited
Stroke, Spasticity, Muscle
Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients
This study evaluates the effects of an isokinetic fatigue protocol of the quadriceps on the amount of co-contractions of this last with the hamstrings during a maximal isometric flexion movement in hemiparetic stroke patients.
- Conditions
- Stroke, Spasticity, Muscle, Muscle Fatigue, Gait, Hemiplegic
- Trial name
- COCON (NCT03342820)
- Testing
- Muscle fatigue
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Stroke
The Effects of Early and Late Injection of Botulinum Toxin Type A on Upper Limb Function in Patients With Stroke
The aim of this study is to determine whether early use of OnabotulinumtoxinA is more effective to improve functional outcomes of upper limb in patients with stroke.
- Trial name
- NCT02580838
- Testing
- OnabotulinumtoxinA
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Cheng-Kung University Hospital