Clinical trials: Muscle Morphology
Focus on Healthy Infants
Development of Muscle Function in Prepubertal Children As a Response to Growth and Resistance Training
Healthy skeletal muscle development is crucial for a life-long quality of life. Childhood and puberty may be key periods for developing muscle growth and neuromuscular capacities, which are essential for bone-muscle interaction…
- Trial name
- decade-fit (NCT06594900)
- Testing
- resistance training intervention
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ralf Roth
Spastic Cerebral Palsy, Acquired Brain Injury
Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy
A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP).
- Trial name
- 3D-MMAP (NCT05197764)
- Where
- Belgium
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy, Spastic
Influence of Immobilisation, Stretching and Activity on Morphological and Mechanical Properties of Spastic Muscle
Neurologic changes caused by cerebral palsy (CP) result in adaptation of muscle architecture and function (e.g. shortened muscles and contractures).
- Trial name
- NCT05269745
- Testing
- Stretching through immobilisation (IG), Stretching through immobilisation and activity (IAG), Control Phase
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Graz
Duchenne Dystrophy Muscular
Biomechanical and Morphological Changes in Dystrophic Muscle
The loss of ability to walk in many children with DMD (Duchenne muscular Dystrophy) is a pejorative event. Biomechanical and morphological unknowledge about the loss of the walk ability in children with DMD is an obstacle in…
- Trial name
- MARCHE-DMD (NCT02472990)
- Where
- 10 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Healthy, Temporomandibular Joint Disorders
ChAracterization of Normal and Pathological moRphological Variations of the TEMporomandibular Joint by Real-time magnetIc reSonance Imaging
The Real Time MRI Rapid Flash sequence is particularly interesting for the study of moving organs and joints. This sequence will make it possible to characterize normal and pathological temporomandibular joint movements by MRI.
- Trial name
- ARTEMIS (NCT06070558)
- Testing
- MRI with Real Time MRI Rapid Flash sequence
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Low Back Pain, Mechanical, Low Back Pain
The Effect of Core Stability Training on Deep Stabilizing Muscles.
Non-specific low back pain is the most cause of adult disability throughout life. Its prevalence widens in young adults. Background of this pathology can be multifactorial.
- Conditions
- Low Back Pain, Mechanical, Low Back Pain, Low Back Pain, Postural
- Trial name
- NCT04554563
- Testing
- Core stability training
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Stroke, Spasticity
Pilot Study on Muscle, Tendon, and Neural Changes Post-Botulinum Toxin Injections in Post-stroke Spastic Equinovarus
Poststroke spasticity significantly impairs function, particularly through the development of pes equinovarus. Botulinum toxin A (BoNT) injections into the medial gastrocnemius (MG) are a first-line treatment.
- Conditions
- Stroke, Spasticity, Equinovarus Foot
- Trial name
- NCT06767631
- Testing
- threedimensional freehand ultrasound and instrumented spasticity assessment
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sarcopenia
Morphological and Functional Biomarkers of Skeletal Muscle Adaptations in Sarcopenia
Sarcopenia is an age-related condition characterized by progressive loss of skeletal muscle mass, muscle strength, and physical performance.
- Trial name
- EXEDOS (NCT07692308)
- Testing
- Digitally delivered home-based exercise intervention, General physical activity recommendations
- Where
- Italy
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Frailty, Aging
Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition
This randomized clinical trial investigates the effects of a home-based multicomponent exercise program (Vivifrail) on physical function, muscle morphology, and cognition in community-dwelling adults aged 90 years and older.
- Conditions
- Frailty, Aging, Cognitive Decline
- Trial name
- Vivifrail (NCT07731529)
- Testing
- Vivifrail multicomponent exercise program
- Where
- 2 sites in Brazil
- Volunteers
- 54 people
- Sponsor
- Federal University of Rio Grande do Sul
Athletic Performance Enhancement
Effects of Blood Flow Restriction Training on Physical Function, Muscle Adaptations, and Performance in Roller Skaters
This randomized controlled trial evaluates the effects of adding blood flow restriction training to regular roller skating training on neuromuscular function under non-fatigued and fatigued conditions, muscle morphology, body…
- Trial name
- NCT07736157
- Testing
- Blood Flow Restriction Roller Skating Training, Standardized Roller Skating Training
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Sport
Fibromyalgia, Interstitial Cystitis
HBOT for Patients With IC/FM (Interstitial Cystitis/Fibromyalgia)
The investigators observed 12 fibromyalgia and interstitial cystitis patients undergoing hyperbaric oxygen oxygen treatment in a multiplace pressure chamber for 90 minutes, 40 treatment each, using an oro-nasal mask.
- Trial name
- IC/FMHBOT (NCT03693001)
- Testing
- Intermittent Exposure to Oxygen via Oro-Nasal Mask
- Volunteers
- 12 people
- Sponsor
- University of South Florida
Blood Flow Restriction
Effects of Blood Flow Restriction During Eccentric Resistance Exercise
The purpose of this study is to compare the muscle strength and muscle soreness effects experienced following short term (acute) eccentric exercise with and without blood flow restriction (BFR) performed at low - moderate…
- Trial name
- NCT05606744
- Testing
- Eccentric exercise / Eccentric exercise with blood flow restriction
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Utah State University
Spastic Cerebral Palsy
Homebased (6-week) Stretching Intervention in Children With Spastic Cerebral Palsy
This study will investigate the effect of a 6-week stretching intervention, consisting of a combination of a 2-week casting period and a home-based stretching program of the plantar flexors and hamstrings, on muscle and tendon…
- Trial name
- NCT04904094
- Testing
- Casting of the lower limb and homebased stretching exercise program.
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Muscle Spasticity, Gait Disorders, Neurologic
Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy
This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities.
- Conditions
- Muscle Spasticity, Gait Disorders, Neurologic, Cerebral Palsy, Spastic
- Trial name
- US-sCP (NCT07118228)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Kocaeli University
Healthy
Tendon Mechanical Properties and Morphological Characteristics of Human Bicep and Tricep Muscles: An In Vivo Ultrasonographical Study
This current study tests whether the load-displacement and stress-strain characteristics of human bicep and tricep muscles and tendons change during graded maximal voluntary elbow extension and flexion exercises.
- Trial name
- NCT00173979
- Where
- Taiwan
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Total Hip Arthroplasty (THA)
Effects of Foot Core Exercises in Patients With Total Hip Arthroplasty
The goal of this clinical trial is to investigate the effects of foot core exercises on lower extremity muscle strength, viscoelastic properties, functional parameters, foot and ankle posture, balance, and the morphological…
- Trial name
- NCT07665801
- Testing
- Hip Rehabilitation Exercise Program, Foot-Core Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Premature Birth, Cerebral Palsy
Neuro-biomechanical Determinants for Motor Behavior in High-risk Infants
This project focuses on motor development, muscle growth and muscle activity. Using advanced, instrumented tests such as , the link between muscles and the movement characteristics will be studied.
- Conditions
- Premature Birth, Cerebral Palsy, Neurodevelopmental Disorders, Brain Injuries
- Trial name
- BAMBI (NCT06111898)
- Testing
- No Intervention
- Where
- Switzerland
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Cerebral Palsy (CP)
Effect of rESWT Session Frequency on Spasticity and Function Assessed by Sonoelastography in Children With Cerebral Palsy
Spasticity is a major contributor to functional limitations in children with cerebral palsy. Radial extracorporeal shock wave therapy (rESWT) has emerged as a non-invasive method for reducing spasticity; however, the optimal…
- Trial name
- CP-rESWT-FREQ (NCT07476690)
- Testing
- Real radial extracorporeal shock wave therapy (rESWT), Conventional physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Tennis Elbow, Lateral Epicondylitis
Leukocyte-Poor Platelet-Rich Plasma Reduces Pain Symptoms in the Treatment of the Lateral Epicondylitis
Lateral epicondylar tendinopathy (LET), or tennis elbow, is a degenerative condition affecting the forearm's extensor tendons. It commonly leads to pain, reduced grip strength, and impaired function, particularly in individuals…
- Conditions
- Tennis Elbow, Lateral Epicondylitis, Lateral Epicondylitis (tennis Elbow), PRP Injection
- Trial name
- LET (NCT06854666)
- Testing
- effectiveness of platelet-rich plasma (PRP) in treating lateral epicondylar tendinopathy (LET)
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Rehasport Clinic
Chronic Non-specific Low Back Pain
Morphological Changes in Back Muscles With Low Back Pain Patients
The purpose of this study is to assess the morphological changes in the lumbar multifidus, Erector spinae and Quadratus lumborum muscles and to investigate whether they are correlated with trunk extensor muscle strength in CNSLBP…
- Trial name
- NCT06071364
- Testing
- Ultrasonography imaging and Hand-held dynamometer (HHD)
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- omnia Yasser Mohamed Talat Harb