Clinical trials: Muscle Physiology
Chronic Kidney Disease, Frailty
Effect of Synchronized Transcutaneous Electrical Diaphragm Stimulation Using Surged Faradic Current Combined With Inspiratory Muscle Training on Diaphragm Function and Clinical Outcomes in Patients With COPD
Chronic kidney disease (CKD) is a progressive condition that can be associated with reduced physical capacity, muscle weakness, fatigue, respiratory impairment and frailty.
- Trial name
- COPD TEDS (NCT07803900)
- Testing
- Transcutaneous electrical diaphragm stimulation (TEDS), Inspiratory muscle training (IMT)
- Where
- India
- Volunteers
- 42 people
- Sponsor
- Maharashtra University of Health Sciences
Cerebral Palsy
Ischemic Conditioning to Enhance Function (I-C-FUN) in Children With Cerebral Palsy
The purpose of this research study is to determine if remote limb ischemic conditioning (RLIC) can increase skeletal muscle power, enhance learning of motor (dynamic balance) task, and improve walking performance in children with…
- Trial name
- I-C-FUN (NCT04598711)
- Testing
- RLIC, Muscle Power training, Balance training
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- East Carolina University
Head & Neck Cancer
Muscle Composition and Function for Swallowing in Head/Neck Cancer Patients
Swallowing dysfunction after chemo-radiation is common, but there is no reliable evidence for how it should be managed. This pilot randomized controlled trial evaluated the relative benefit of a battery of isometric / isotonic…
- Trial name
- Pharyngocise (NCT00796952)
- Testing
- focused attention sessions, Valchuff, Pharyngocise
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Florida
Muscle Weakness, Quadriceps Muscle Atrophy
NM Balance Regulation With ULLS and Loss of Sleep
The goal of this trial is to learn about how restricted sleep and not bearing weight on the leg affects muscle strength and posture control.
- Conditions
- Muscle Weakness, Quadriceps Muscle Atrophy, Sleep Disturbance
- Trial name
- NCT05956964
- Testing
- Sleep Restriction, Sleep Adequate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lance Bollinger
Genetic Disorder
Skeletal Muscle Biomarkers in People With Fragile Sarcolemmal Muscular Dystrophy
Background: Some kinds of muscular dystrophy affect the skeletal muscle membrane. In these conditions, the muscle membrane is more fragile. This affects how the muscles contract and relax, which causes movement problems.
- Trial name
- NCT01851447
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Neurofibromatosis Type 1, Muscle Weakness
Whole-body Vibration in Children With Neurofibromatosis Type 1
It is known that children with NF1 can have weak muscles and suffer from tiredness. It is also known that in similar conditions affecting children's muscles, standing on a vibration device for a few minutes each day can…
- Trial name
- NCT03888248
- Testing
- Whole-body vibration, Muscle strengthening exercises
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Bed Rest
Preserving Muscle Mass and Function in Bedridden Older Adults
The investigators propose that low-intensity exercise and supplementing daily meals with leucine or whey will independently and synergistically reduce the deleterious effects of inactivity on skeletal muscle and facilitate…
- Trial name
- EBR (NCT01846130)
- Testing
- Leucine, Exercise, Whey protein
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Parkinson Disease, Pilates
Effect of Pilates Application on Abdominal Muscle Function, Core Stability, Musculoskeletal Pain, Quality of Life, Anxiety and Depression in Parkinson's Patients
In this study, it is aimed to investigate the effect of Pilates application on abdominal muscle function, core stability, musculoskeletal pain, quality of life, anxiety and depression in Parkinson's Patients.
- Conditions
- Parkinson Disease, Pilates, Muscle Function
- Trial name
- NCT04619784
- Testing
- Pilates Exercises, control
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Dokuz Eylul University
Ischemic Stroke
Ischemic Stroke Nutrition Intervention Study
The primary goal of this clinical trial is to assess whether vitamin K2 supplementation can effectively improve skeletal muscle and neurological function in patients with ischemic stroke.
- Trial name
- ISNIS (NCT06817512)
- Testing
- Vitamin K2
- Where
- 3 sites in China
- Volunteers
- 190 people
- Sponsor
- Harbin Medical University
Sarcopenia
Understanding Acute Sarcopenia
This study aims to characterise acute changes in muscle mass, strength, physical performance in hospitalised older adults. We will assess the impact of these changes upon physical function at three month follow-up, and assess for…
- Trial name
- NCT03858192
- Testing
- Colorectal surgery procedure, Emergency abdominal surgery, Antibiotics
- Where
- United Kingdom
- Volunteers
- 168 people
- Sponsor
- University of Birmingham
Subacute Stroke, Balance Deficits
Effects of Inspiratory Muscle Training and Abdominal Drawing-In Maneuver on Balance, Gait and Pulmonary Function in Stroke Patients
This study examines how Inspiratory Muscle Training (IMT) combined with the Abdominal Drawing-In Maneuver (ADIM) affects balance, gait, and breathing in stroke patients.
- Trial name
- NCT06838871
- Testing
- Inspiratory Muscle Training (IMT) with Abdominal Drawing-In Maneuver (ADIM) training
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Sahmyook University
Diplegic Spastic Cerebral Palsy
Comparing the Instrument-Assisted Soft Tissue Mobilization and Neurodevelopmental Therapy for Gross Motor Functions, Muscle Tone and Spasticity in Children with Spastic Diplegic Cerebral Palsy (GMFCS Levels I and II)
Cerebral palsy is a neurological condition that affects individuals worldwide, with a global burden of 0.9%. However, prevalence rates show regional variation, with high-income countries reporting rates of 0.2% and low-income…
- Trial name
- IASTM;NDT;CP (NCT06702709)
- Testing
- Instrument Assisted Soft Tissue Mobilization, Neurodevelopmental Therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Ziauddin University
Healthy Volunteers
Comparison of the Effect of Different Inspiratory Loads on Diaphragmatic Function in Healthy Individuals
This pilot study aims to evaluate how the diaphragm responds to different inspiratory muscle training loads using ultrasound in healthy individuals.
- Trial name
- NCT07143721
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Fibromyalgia, Pain
A New Rehabilitation Tool in Fibromyalgia
The aim of the investigators study was to measure reductions in chronic pain in female patients with Fibromylgia comparing individual proprioceptive rehabilitation treatments with perceptual surfaces to a group exercises…
- Trial name
- NCT02472093
- Testing
- Physical exercises treatment, Perceptive Rehabilitation Treatment, Control group
- Volunteers
- 88 people
- Sponsor
- University of Roma La Sapienza
Tennis Elbow
Eccentric Exercise or Radiofrequent Microtenotomy as Treatment of Lateral Epicondylalgia
The aim is to study the effects related to function and pain during eccentric exercise and surgery with radiofrequency microtenotomy as post-surgical rehabilitation, compared with only eccentric exercise, in patients with lateral…
- Trial name
- NCT02304952
- Testing
- Radiofrequency microtenotomy, Eccentric exercise, Arthrocare Topaz MicroDebrider
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- St Goran's Hospital
Sporadic Inclusion Body Myositis
Efficacy and Safety of Bimagrumab/BYM338 at 52 Weeks on Physical Function, Muscle Strength, Mobility in sIBM Patients
This study evaluated the efficacy, safety and tolerability of multiple doses of bimagrumab/BYM338 vs placebo, when administered intravenously (i.v.), on physical function, muscle strength, and mobility in patients with sporadic…
- Trial name
- RESILIENT (NCT01925209)
- Testing
- BYM338/bimagrumab
- Where
- 38 sites in United States, Australia and 8 more
- Volunteers
- 251 people
- Sponsor
- Novartis Pharmaceuticals
Sarcopenia
Effect of Essential Aminoacid Supplementation and Exercise on Skeletal Muscle Function in Hemodialysis Patients
Sarcopenia can be easily observed in patients with hemodialysis. However, there were few studies on the precise concept and diagnostic criteria for sarcopenia in patients with hemodialysis.
- Trial name
- NCT05884138
- Testing
- exercise and nutritional support
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Chungnam National University Hospital
Hysterectomy, Ovariectomy
TDSM- Testosterone Dose Response in Surgically Menopausal Women
TDSM will study the physiology of testosterone in women ages 21-60 who have had surgical menopause (uterus and both ovaries removed).
- Conditions
- Hysterectomy, Ovariectomy, Menopause, Testosterone Deficiency
- Trial name
- NCT00494208
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Heart Failure With Reduced Ejection Fraction
Neuromuscular Fatigability in Individuals With Heart Failure
Brief summary The aims of this project are to 1) characterise muscle fatigue in individuals with chronic heart failure during exercise involving a smaller and larger muscle mass (Part I), 2) to determine the effect of nitrate…
- Trial name
- NCT06551012
- Testing
- Nitrate-rich beetroot juice, Beetroot juice with nitrate extracted
- Volunteers
- 28 people
- Sponsor
- Newcastle University
Chronic Shoulder Pain
The Effectiveness of Isometric Exercise on the Management of Chronic Shoulder Pain
The aim of this study was to evaluate the influence of the intensity of Isometric Contraction of shoulder external rotators, comparing the effect of a high-level IC (80% maximal voluntary isometric contraction) versus a low-level…
- Trial name
- NCT04475965
- Testing
- Isometric exercise for shoulder external rotators
- Where
- Chile
- Volunteers
- 82 people
- Sponsor
- Jorge Fuentes