Clinical trials: Muscle Relaxants
Neuromuscular Blockade
Myorelaxation Practice in Paediatric Anesthesia
In retrospective data search the investigators will identified the percentage of patients with muscle relaxants administered during perioperative period.
- Trial name
- PAMPE (NCT03086915)
- Testing
- Neuromuscular Blocking Agent
- Where
- Czechia
- Volunteers
- 1,650 people
- Sponsor
- Brno University Hospital
Laryngeal Mask Airway
Effect of Muscle Relaxants on Postoperative Sore Throat in Video Laryngeal Mask Airway(LMA) Use
Video laryngeal masks (VLMAs) are increasingly used as a minimally invasive alternative in airway management. The use of neuromuscular blocking agents can affect VLMA placement and airway physiology.
- Trial name
- NCT07838051
- Testing
- using rocuronium before vide laryngeal mask airway
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Samsun University
Pain, Postoperative
Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty
This is a prospective, cluster-randomized, two-arm, comparative study aimed at determining whether addition of tizanidine ( an oral muscle relaxant) to a multimodal pain regimen following primary TKA reduces opioid consumption.
- Trial name
- NCT04574791
- Testing
- TiZANidine 2 MG Oral Capsule
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Muscle Relaxation
Interindividual Variability in Duration of Action of Rocuronium in Pediatric Patients
Muscle relaxants represent an important part of general anesthesia in adult and pediatric patients. Their role is to facilitate intubation and enable some surgical interventions.
- Trial name
- DurAct (NCT05529420)
- Testing
- measurement of the depth of neuromuscular blockade
- Where
- Czechia
- Volunteers
- 107 people
- Sponsor
- Brno University Hospital
Surgical Procedures, Operative, Anaesthesia
POPULAR: POst-operative PULmonary Complications After Use of Muscle Relaxants in Europe
International multicenter observational study of a random-sample cohort of patients undergoing any in-hospital surgical procedure under general or regional anaesthesia during a continued 14-day period of recruitment.
- Trial name
- POPULAR (NCT01865513)
- Where
- 2 sites in Germany, Sweden
- Volunteers
- 22,000 people
- Sponsor
- European Society of Anaesthesiology
Anesthesia, Neuromuscular Blockade
Measurement of Blood Loss in Adenotonsillectomy During General Anesthesia According to the Application of Nondepolarizing Muscle Relaxants
Although tonsillectomy is one of the most commonly performed surgeries, a review of literature reveals no articles dealing with the study of intraoperative blood loss in tonsillectomy and adenotonsillectomy according to the use…
- Conditions
- Anesthesia, Neuromuscular Blockade, Intraoperative Bleeding, Intraoperative Blood Loss
- Trial name
- NCT06399445
- Testing
- conventional cold tonsillectomy and curettage adenoidectomy, Rocuronium Bromide
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital of Split
Muscle Relaxants
The Dose-Response Relationship of Rocuronium in Patients Taking Pyridostigmine
Pyridostigmine is a medication that is used in certain heart rate and blood pressure conditions. This medication, as a side effect, is known to also cause changes in the junction between a nerve and muscle.
- Trial name
- NCT02157545
- Where
- United States
- Sponsor
- Shashi Bhatt, MD
Anesthesia Intubation Complication
Fentanyl and Propofol for Tracheal Intubation During Sevoflurane Induction Without Muscle Relaxants in Children
Several methods have been proposed to improve intubating conditions and minimize sevoflurane induction time during sevoflurane induction in children.
- Trial name
- NCT02442128
- Testing
- propofol /Fentanyl, Fentanyl / propofol
- Where
- Saudi Arabia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King Saud University
Surgery, Postoperative Pain
Effect of NMBA on Surgical Conditions in THR
During Total hip replacement arthroplasty (THA), the hip joint first must be luxated in order to have access to the joints. A lot of force and torque must be carried out on the joint to perform this manipulation.
- Trial name
- NCT03369782
- Testing
- Rocuronium, Sugammadex
- Where
- Belgium
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Entropy Device and How Will Muscle Relaxants Affect it
Impact of Entropy Monitoring on Anesthetic Consumption and Recovery After Laparoscopic Cholecystectomy
The goal of this clinical trial is to learn if brainwave-guided anesthesia (entropy monitoring) can reduce anesthetic drug consumption and speed up recovery time in adult patients undergoing elective laparoscopic cholecystectomy…
- Trial name
- NCT07847788
- Testing
- Entropy Monitoring-Guided Anesthesia Titration, Standard Clinical Parameter-Guided Anesthesia Titration
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- KRL Hospital, Islamabad
Inguinal Hernia, Endotracheal Intubation
Pediatric Inguinal Hernia Repair: Are Muscle Relaxants Necessary? Endotracheal Intubation vs Laryngeal Mask Airway
In prospective, safety-control study; children undergoing laparoscopic inguinal hernia repair using PIRS (Percutaneous Internal Ring Suturing) method will be randomly assigned into four groups.
- Conditions
- Inguinal Hernia, Endotracheal Intubation, Laryngeal Mask, Muscle Relaxants
- Trial name
- NCT02696837
- Testing
- ETT, Proseal LMA, Rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Maltepe University
Anesthesia Intubation Complication
Muscle Relaxants on Efficacy of LMA Insertion
The use of laryngeal mask airway (LMA) is increasing in pediatric anesthesia because it provides lesser direct mechanical stimulation of the airway due to being placed above the larynx.
- Trial name
- LMA_MR (NCT03487003)
- Testing
- rocuronium, saline
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Daegu Catholic University Medical Center
Temporomandibular Joint Disorders, Bruxism
Usage of Skeletal Muscle Relaxants Survey Among Egyptian Dental Practitioners
Pharmacists may also logistically serve as ideal health-care destinations to implement and deliver prevention, early intervention, and referral of oral health services to reduce the incidence of potentially preventable oral…
- Trial name
- NCT04747743
- Testing
- a self structured questionnaire
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Future University in Egypt
Complication of Ventilation Therapy, Observation of Neuromuscular Block
Influence of the Neuromuscular Blockade on Mask Ventilation
Mask ventilation during induction of anesthesia can be improved by administration of neuromuscular blocking agents (NMBAs). NMBAs are usually administered after testing mask ventilation; however, muscle relaxants may improve mask…
- Trial name
- NCT02318810
- Testing
- Rocuronium 0.3 mg/kg, Rocuronium 0.6 mg/kg, Rocuronium 0.9 mg/kg
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University of Rostock
Muscle Relaxants
The Association Between Residual Neuromuscular Block Risk Prediction Score and the Train-of-Four Ratio
evaluate the degree of association, and the predictive accuracy of the REPS (as a predictive tool) compared with the TOFr as a quantitative assessment tool for (rNMB) in surgical patients in the early postoperative phase.
- Trial name
- NCT06899048
- Testing
- residual neuromuscular block risk prediction score
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- Assiut University
Urologic Surgery
Preoperative Dexmedetomidine & EC50 of Propofol
Dexmedetomidine is a useful anaesthetic adjuvant for general anaesthesia. In this prospective randomised study, we determined whether preoperative dexmedetomidine administration could reduce the half maximal effective…
- Trial name
- PreopDXM (NCT02097407)
- Testing
- Group C : Saline + propofol group, Group D : Dexmedetomidine + propofol group
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Seoul National University Hospital
Neuromuscular Block
Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block
The magnesium sulfate and lidocaine have been increasingly used alone or in combination during anesthesia procedure to meet various objectives, such as reduction of pain, use of smaller anesthetic doses and stabilization of…
- Trial name
- NCT02483611
- Testing
- Magnesium Sulfate, Lidocaine, Isotonic Solution
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Muscle Relaxant, General Anesthesia
Effect of Neostigmine on the Recovery of Rocuronium: A Comparison Between Partial and TOF Ratio-Based Dose
This study aimed to evaluate the effect of Neostigmine partial dose towards neuromuscular blockade of rocuronium
- Trial name
- NCT03058263
- Testing
- Dose of Neostigmine
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Induction of Anaesthesia, Muscle Relaxants
Developing a Physiology-Pharmacodynamic Model of Rocuronium Dose and Cardiac Output to Investigate the Onset Time of Neuromuscular Relaxation
After a patient is put to sleep, a breathing tube is often placed through the larynx (voice box) into the trachea (windpipe). To place a breathing tube requires the muscles of the jaw, voice box, and diaphragm to be relaxed.
- Conditions
- Induction of Anaesthesia, Muscle Relaxants, Rocuronium
- Trial name
- NCT07168252
- Testing
- Rocuronium dosing
- Volunteers
- 32 people
- Sponsor
- Clare Hayes-Bradley
Sore Throat
Effect of Intraoperative Neuromuscular Blockade on Postoperative Sore Throat and Hoarseness
Investigators assess and compare postoperative sore throat and hoarseness in the group using the muscle relaxant and not using it during the operation.
- Trial name
- NCT03397797
- Testing
- Rocuronium
- Where
- South Korea
- Volunteers
- 117 people
- Sponsor
- SMG-SNU Boramae Medical Center