Clinical trials: Muscle Relaxation
Neuromuscular Blockade
Efficacy, Safety, and Pharmacokinetics of Sugammadex for Reversal of Neuromuscular Blockade (NMB) in Pediatric Participants (MK-8616-089)
This trial will evaluate the efficacy, safety, and pharmacokinetics of sugammadex for the reversal of both moderate and deep neuromuscular blockade (NMB) induced by either rocuronium or vecuronium in pediatric participants.
- Trial name
- NCT03351608
- Testing
- Sugammadex 2 mg/kg, Sugammadex 4 mg/kg, Neostigmine + Glycopyrrolate
- Where
- 30 sites in United States, Austria and 6 more
- Volunteers
- 288 people
- Sponsor
- Merck Sharp & Dohme LLC
Bowel Dysfunction, Postoperative Complications
Sugammadex To IMprove Bowel Function
Colon and rectal surgery is associated with high cost, long length of stay, high postoperative surgical site infection rate, high incidence of postoperative nausea and vomiting, and a high rate of hospital readmission.
- Conditions
- Bowel Dysfunction, Postoperative Complications, Neuromuscular Blockade
- Trial name
- STIM_Bowel (NCT04546672)
- Testing
- Sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Oregon Health and Science University
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Study to Determine if Administration of Sugammadex Impacts Hospital Efficiency
The purpose of this study is to evaluate the efficacy of Sugammadex in rapidly reversing deep neuromuscular blockaded (induced by rocuronium)
- Trial name
- NCT02860507
- Testing
- sugammadex, Neostigmine, Glycopyrrolate
- Volunteers
- 50 people
- Sponsor
- University of South Florida
Neuromuscular Blockade
Evaluation of the Tof Cuff for Perioperative Neuromuscular Transmission
Acceleromyography (AMG) is the most wide spread used method to assess neuromuscular block during anesthesia. However AMG is known to be inaccurate when compared to the gold standard in neuromuscular transmission monitoring…
- Trial name
- NCT03117387
- Testing
- Measurements of the level of neuromuscular blockade
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Leiden University Medical Center
Neuromuscular Blockade
Sugammadex vs. Neostigmine for Neuromuscular Blockade Reversal in Thoracic Surgical Patients
This prospective, randomized, double blinded study is intended to enroll a total of 92 patients undergoing thoracic surgery with general endotracheal anesthesia at Parkland Hospital.
- Trial name
- NCT03168308
- Testing
- Sugammadex, Neostigmine w/ Glycopyrrolate
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Texas Southwestern Medical Center
Prostate Cancer
The Effect of Deep Versus Moderate Muscle Relaxants in Men During and After Robotic Surgery for Prostate Cancer
The purpose of this study is to determine if there is a difference in intra-abdominal pressure which surgeons use during surgery and post-surgery pain in men who undergo robotic prostate surgery with deep neuromuscular blockade…
- Trial name
- NCT03808077
- Testing
- Rocuronium 0.3mg/kg/hr, Rocuronium 1.5mg/kg/hr
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Robot-Assisted Laparoscopic Radical Prostatectomy
The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy
Intraocular pressure is significantly increase during robot-assisted laparoscopic radical prostatectomy which is performed in a steep trendelenburg position at prolonged times of pneumoperitoneum.
- Trial name
- NCT02109133
- Testing
- deep neuromuscular blockade, moderate neuromuscular blockade, Rocuronium
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Neuromuscular Blockade, Surgery
Effect of Neuromuscular Blockade on Operating Conditions and Overall Satisfaction During Spinal Surgery
The investigators aim to investigate operating conditions, postoperative recovery and overall satisfaction of surgeons between deep neuromuscular blockade (NMB) group and restricted NMB group during spinal surgery under general…
- Conditions
- Neuromuscular Blockade, Surgery, Anesthesia, Spinal Diseases
- Trial name
- NCT02724111
- Testing
- sufficient dose of rocuronium, sugammadex 10 min after position change
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Korea University Guro Hospital
Neuromuscular Block
Effects of Intravenous Lidocaine Associated With Magnesium Sulfate on the Cisatracurium-Induced Neuromuscular Block
The magnesium sulfate and lidocaine have been increasingly used alone or in combination during anesthesia procedure to meet various objectives, such as reduction of pain, use of smaller anesthetic doses and stabilization of…
- Trial name
- NCT02483611
- Testing
- Magnesium Sulfate, Lidocaine, Isotonic Solution
- Volunteers
- 48 people
- Sponsor
- University of Sao Paulo
Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs
Neuromuscular Blockade on Shoulder Pain of Elderly
Insufflation pressure (IP) is the creation of a pressure barrier of air/gas within the abdomen to allow the surgeon more space to work during abdominal surgery.
- Conditions
- Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Male Genital Organs, Malignant Neoplasms of Urinary Tract
- Trial name
- NCT03210376
- Testing
- Deep Neuromuscular Blockade (NMB), Moderate Neuromuscular Blockade (NMB), Sugammadex
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Advanced Lung Carcinoma, Extensive Stage Lung Small Cell Carcinoma
Resiliency Among Older Adults Receiving Lung Cancer Treatment
This trial studies how well physical therapy and progressive muscle relaxation works in improving physical performance and mood in older patients with stage IIIA-B or IV lung cancer who are undergoing treatment.
- Conditions
- Advanced Lung Carcinoma, Extensive Stage Lung Small Cell Carcinoma, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
- Trial name
- ROAR-LCT (NCT04229381)
- Testing
- Physical Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Surgical Procedures, Elective
Study of Sugammadex Versus Usual Care on Incidence of Residual Blockade at Post Anesthesia Care Unit Admission (P07981)
This study will compare the incidence of residual neuromuscular blockade in participants who undergo reversal of neuromuscular blockade with sugammadex compared to those who undergo reversal of neuromuscular blockade with usual…
- Trial name
- NCT01479764
- Testing
- Sugammadex, Neostigmine, Glycopyrrolate
- Volunteers
- 154 people
- Sponsor
- Merck Sharp & Dohme LLC
Gastrointestinal Cancer
The Laparotomy Study
The depth of neuromuscular blockade (NMB) during surgery may cause a clinical dilemma between optimal surgical conditions and the risk of postoperative residual blockade.
- Trial name
- NCT02140593
- Where
- Denmark
- Volunteers
- 128 people
- Sponsor
- Herlev Hospital
Laparoscopic Renal Surgery, Laparoscopy
Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics
The primary objective of the current study is to compare intraoperative respiratory mechanics in patients receiving laparoscopic renal surgery under deep neuromuscular blockade (dNMB) and under moderate neuromuscular blockade…
- Conditions
- Laparoscopic Renal Surgery, Laparoscopy, Muscle Relaxation
- Trial name
- NCT02185339
- Testing
- Rocuronium
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Seoul St. Mary's Hospital
Neuromuscular Blockade, Pain
Recovery After Laparoscopic Hysterectomy With Deep Neuromuscular Blockade and Low Intra-abdominal Pressure
The purpose of this study on laparoscopic hysterectomy is to investigate postoperative pain. Patients are allocated to either deep neuromuscular blockade and low intra-abdominal pressure (8 mmHg) or moderate neuromuscular…
- Conditions
- Neuromuscular Blockade, Pain, Laparoscopy
- Trial name
- NCT01722097
- Testing
- Rocuronium
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Herlev Hospital
Hypersensitivity, Anaphylaxis
A Study to Evaluate the Incidence of Hypersensitivity After Administration of Sugammadex in Healthy Participants (MK-8616-101)
The purpose of this study is to assess the potential for hypersensitivity symptoms upon repeat exposure to sugammadex. Healthy participants will be randomized to one of three treatment arms: sugammadex 4 mg/kg, sugammadex 16…
- Trial name
- NCT02028065
- Testing
- Sugammadex
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Neuromuscular Blockade
Neuromuscular Blockade During Transurethral Resection of Bladder Cancer
Transurethral resection of the bladder tumor (TURB) for bladder tumor excision is the mainstream treatment. However, the beneficial effects of sugammadex after general anesthesia for TURB have not been thoroughly evaluated.
- Trial name
- NCT03039543
- Testing
- Rocuronium, Sugammadex
- Where
- South Korea
- Volunteers
- 108 people
- Sponsor
- Seoul National University Bundang Hospital
Residual Neuromuscular Blockade
Thumb vs Great Toe Recovery
Researches are comparing the accuracy of measuring muscle relaxation in the thumb versus the great toe.
- Trial name
- NCT04312256
- Testing
- TetraGraph
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Mayo Clinic
Neuromuscular Blockade
Dialysis of Sugammadex in Participants With Severe Renal Impairment (Study 19.4.333) (P05773)
The clinical trial objectives were to evaluate the dialysability of the sugammadex-rocuronium complex; it's safety and efficacy in participants with severe renal impairment.
- Trial name
- NCT00656799
- Testing
- sugammadex, Rocuronium
- Volunteers
- 6 people
- Sponsor
- Merck Sharp & Dohme LLC