Clinical trials: Muscle Spasms
Movement Disorders
Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders
This study will use three neurophysiological tests (see below) to determine what areas of the brain are responsible for paroxysmal hyperkinetic movement disorders.
- Trial name
- NCT00056888
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Hyperkinesis
Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range
Expression of hypokinetic and hyperkinetic motor symptoms in Parkinson's disease (PD) is associated with pathological synchronous oscillations of neuronal activity (local field potential/LFP) in the cortico-subcortical network…
- Conditions
- Parkinson Disease, Hyperkinesis, Hypokinesia
- Trial name
- MOVOSCILLCBGT (NCT06438419)
- Testing
- Electrophysiological recordings
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Refractory Infantile Spasms
A Study of Orally Administered JBPOS0101 in Refractory Infantile Spasms Patients
A Phase 2 Study to Assess the Safety, Tolerability, Exploratory Efficacy, and pharmacokinetics of Orally Administered JBPOS0101 for Refractory Infantile Spasms Patients.
- Trial name
- NCT03976076
- Testing
- JBPOS0101
- Where
- 23 sites in United States, South Korea
- Volunteers
- 16 people
- Sponsor
- Bio-Pharm Solutions Co., Ltd.
Spasm
Development and Evaluation of a Portable Wedge Device for Calf Stretching to Alleviate Strain and Spasms
This research aimed to contribute valuable insights into the potential benefits of incorporating the portable wedge device into preventive or therapeutic interventions for calf-related musculoskeletal issues.
- Trial name
- NCT06441253
- Testing
- Deep Friction massage, Therapeutic exercises
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Superior University
Pediatric Urolithiasis, Ureteral Stent-Related Symptoms
Comparison of Ureteral Stent Designs in Children With Kidney Stones
This study will compare two commonly used ureteral stents in children and adolescents undergoing staged treatment for kidney stones.
- Trial name
- NCT07742358
- Testing
- Polaris Ultra Ureteral Stent, Cook Double-J Ureteral Stent
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injury
Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity
Muscle stiffness and muscle spasms are common after spinal cord injury. They can interfere with washing and dressing, moving between the bed and a wheelchair, walking, and sleep, and they can cause pain.
- Conditions
- Spinal Cord Injuries (Complete and Incomplete), Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
- Trial name
- NCT07792616
- Testing
- Transcutaneous spinal stimulation at 30 Hz, Transcutaneous spinal stimulation at 75 Hz, Tizanidine
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Mississippi Medical Center
Acute Low-back Pain, Muscle Spasm; Back Pain
Efficacy and Safety of Etoricoxib/Tizanidine Versus Etoricoxib for Acute Low Back Pain Associated to Muscle Spasm
This is a Phase III, longitudinal, multicenter, randomized, double-blind clinical trial. The aim of the study is to evaluate the efficacy and safety of a fixed-dose combination of etoricoxib and tizanidine compared to etoricoxib…
- Trial name
- NCT06863662
- Testing
- Etoricoxib + Tizanidine fixed dose, Etoricoxib fixed dose
- Where
- Mexico
- Volunteers
- 136 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Attention Deficit Disorder With Hyperactivity Disease, Hyperkinesis
Tipepidine in Children With Attention Deficit/Hyperactivity Disorder (AD/HD): a Double-blind, Placebo-controlled Trial
Tipepidine (3-[di-2-thienylmethylene]-1-methylpiperidine) has been used solely as a nonnarcotic antitussive in Japan since 1959. The safety of tipepidine in children and adults has already been established.
- Conditions
- Attention Deficit Disorder With Hyperactivity Disease, Hyperkinesis, Attention Deficit and Disruptive Behavior Disorders
- Trial name
- NCT02305134
- Testing
- Tipepidine Hibenzate
- Where
- Japan
- Volunteers
- 21 people
- Sponsor
- Chiba University
Acute Low Back Pain, Musculoskeletal Pain
Physiotherapy in Emergency Department for Acute Lumbar Spasm
This retrospective observational study aims to evaluate the effectiveness of physiotherapy interventions-such as manual therapy, electrotherapy (TENS), and individualized exercise programs-in managing acute lumbar spasm in…
- Conditions
- Acute Low Back Pain, Musculoskeletal Pain, Emergency Care
- Trial name
- PT-ED (NCT06987656)
- Testing
- Standard Pharmacologic Treatment, Physiotherapy Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Duzce University
Infantile Spasms
Evaluation of Neuroinflammation in Children With Infantile Spasms
The purpose of this study was to investigate the presence of neuroinflammation in children with infantile spasms using 11C-PK11195 positron emission tomography (PK PET) scan, and its response to ACTH treatment by repeating the PK…
- Trial name
- NCT02092883
- Testing
- ACTH
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Wayne State University
Developmental and Epileptic Encephalopathies, Epileptic Spasms
Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies
Epileptic spasms (ES) are a predominantly infantile seizure type observed frequently in certain genetic disorders. Ketogenic diet (high ratio of fat to carbohydrate/protein) is an established non-medication treatment for…
- Conditions
- Developmental and Epileptic Encephalopathies, Epileptic Spasms, Genetic Epilepsy, Neonatal and Infant Epilepsy
- Trial name
- NCT06700811
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Heather Olson
Liver Cirrhosis, Muscle Cramps
Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis
Muscle cramps are common in patients with liver disease and associated with significantly diminished quality of life. Patients with cirrhosis often experience muscle cramps with varied frequency and severity.
- Trial name
- NCT02423395
- Testing
- orphenadrine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sherief Abd-Elsalam
Neuromuscular Disease
Diagnostic Evaluation of Patients With Neuromuscular Disease
The objectives of this protocol are to: 1) screen patients with various neuromuscular disorders and facilitate their entry into appropriate research protocols; 2) help resolve puzzling diagnostic neuromuscular problems and train…
- Trial name
- NCT00015470
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Localization-related Epilepsy
Epilepsy Phenome/Genome Project
The purpose of this study is to collect detailed information about the characteristics and genetics of a large number of individuals with epilepsy.
- Conditions
- Epilepsy, Localization-related Epilepsy, Infantile Spasms, Lennox-Gastaut Syndrome
- Trial name
- EPGP (NCT00552045)
- Where
- 25 sites in United States, Argentina and 1 more
- Volunteers
- 4,150 people
- Sponsor
- University of California, San Francisco
Attention Deficit Disorder With Hyperactivity
Effectiveness of Lobeline in Treating Symptoms of ADHD in Adult Patients
The study will evaluate the effectiveness of the nonstimulant medication lobeline in improving symptoms of attention deficit hyperactivity disorder in adults.
- Trial name
- NCT00664703
- Testing
- Lobeline sulfate, Methylphenidate HCl
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yaupon Therapeutics
Smartphone Addiction, Masseter Muscle Hypertrophy
Investigating the Effects of Smartphone Use on the Masseter Muscle
The aim of this study was to determine the short- and long-term effects of smartphone use on the masseter muscle. In the short term, to investigate whether repetitive thumb movements during phone use will cause a spontaneous…
- Conditions
- Smartphone Addiction, Masseter Muscle Hypertrophy, Masseter Muscle Spasm
- Trial name
- NCT06408766
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Nocturnal Leg Cramps
The Effects of the Myofascial Trigger Point Injections on Pain and Sleep Disturbance in Patients With Nocturnal Leg Cramps With Trigger Points on Gastrocnemius Muscle
Nocturnal leg cramps is involuntary strong contraction of leg muscle, mostly in calves. It occurs suddenly and induces pain. Patients with frequent nocturnal leg cramps suffer from sleep disturbance in company with pain.
- Trial name
- NCT01804556
- Testing
- Myofascial trigger point injections on gastrocnemius muscle
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Yonsei University
Arthritis, Tendonitis
Prospective Analgesic Compound Efficacy (PACE) Study
A 24-week observational prospective study on the efficacy of topical non-steroidal anti-inflammatory drugs for the relief of pain.
- Conditions
- Arthritis, Tendonitis, Gout, Radiculopathy
- Trial name
- PACE (NCT02403687)
- Testing
- baclofen 2%, Bupivacaine hydrochloride 1%, Cyclobenzaprine hydrochloride 2%
- Volunteers
- 300 people
- Sponsor
- Express Specialty Pharmacy
Microcephaly, Hyperkinesis With Developmental Delay
Intensive Therapy for Children With Microcephaly, Hyperkinetic Movements, or Global Developmental Delay
This trial will consist of a clinical series of up to 50 children with Global Developmental Delay and concomitant microcephaly or hyperkinetic movements.
- Conditions
- Microcephaly, Hyperkinesis With Developmental Delay, Global Developmental Delay
- Trial name
- NCT04816175
- Testing
- Acquire Therapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Virginia Polytechnic Institute and State University