Clinical trials: Muscle Synthesis
Aging, Muscle Loss
Protein Intake and Step Reduction in Older Adults
Sarcopenia, the loss in muscle mass with age, is associated with several negative health outcomes including cancer, stroke, cardiovascular disease and diabetes.
- Trial name
- DRI (NCT03285737)
- Testing
- Whey, Collagen
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity
Resistance Exercise and Muscle Protein Synthesis in Obese Adults
Obesity has numerous comorbidities that are associated with exceedingly high healthcare costs. In addition to well- characterized impairments in lipid and glucose metabolism, obesity is associated with altered protein metabolism.
- Trial name
- NCT03411681
- Testing
- Resistance Exercise
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Healthy
Amino Acid Profile and Muscle Protein Synthetic Response to Consuming Meat or Plant-based Alternatives
The purpose of the study is to quantify and compare the serum amino acid profile, and muscle protein synthesis rates, in response to consuming isonitrogenous amounts of ground meat (beef and pork) or plant-based alternatives…
- Trial name
- NCT04784806
- Testing
- Ground beef, Ground pork, Tofu
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Parkinson Disease
Essential Amino Acids and Parkinsons Disease
Parkinson's disease is a neuromuscular disease that is relatively common in elderly that has many potentials symptoms, including a variety of physical features that together reduce quality of life.
- Trial name
- EAAPD (NCT06604065)
- Testing
- AMS2434 (amino acids)
- Sponsor
- University of Arkansas
Aging, Sarcopenia
Mycoprotein as the Basis of a Sustainable Diet to Support Muscle Mass Maintenance and Reconditioning in Older Adults.
A hallmark of ageing is loss of skeletal muscle mass and strength (sarcopenia). Sarcopenia is explained, partially, by reduced responsiveness of muscle to dietary protein.
- Trial name
- MASS (NCT04325178)
- Testing
- Protein, calorie and macronutrient controlled diet, derived from either omnivorous or non-animal sources, alongside unilateral resistance exercise, over a three-day period.
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Protein Synthesis
Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response
Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response…
- Trial name
- BPM (NCT04894747)
- Testing
- Bolus ingestion of protein
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Muscle Protein Synthesis
Effects of Whey and Collagen Protein Blend on Protein Synthesis Rates
Rationale: Protein ingestion stimulates muscle protein synthesis and augments the muscle protein synthetic response to a single exercise session.
- Trial name
- Blend (NCT05386771)
- Testing
- Whey/collagen protein blend, Resistance exercise
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Phenylketonuria, PKU
Moderate Intensity Exercise and Phenylketonuria
Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consistently maintained throughout…
- Trial name
- NCT01904708
- Testing
- Acute Moderate Intensity Exercise
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Oregon Health and Science University
Myoma
Safety and Efficacy Study of a Hydrogel, Applied Following Removal of Myomas During Gynecologic Surgery, Administered for the Prevention/Reduction of Postoperative Adhesion Formation
The purpose of this study was to determine whether the adhesion prevention gel was safe to use, and was effective for the prevention/reduction of adhesion formation that typically occurs following gynecological surgery to remove…
- Trial name
- NCT00562471
- Testing
- Adhibit Adhesion Prevention Gel, Standard of Care Comparator
- Where
- 6 sites in Canada, Germany and 1 more
- Volunteers
- 76 people
- Sponsor
- Angiotech Pharmaceuticals
Sarcopenia, Skeletal Muscle Atrophy
Plant Protein Blend and Milk Protein Supplements in Older Individuals
Background Protein intake is important for skeletal muscle mass maintenance with aging and the ingestion of specifically-timed protein supplements could increase overall protein intake and thereby contribute to skeletal muscle…
- Conditions
- Sarcopenia, Skeletal Muscle Atrophy, Protein Malnutrition
- Trial name
- Blend-D2O (NCT06403137)
- Testing
- Resistance exercise, Standardized diet, Plant protein supplement
- Where
- Netherlands
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Muscle Protein Synthesis
Effect of Protein-nutrition Beverages on Muscle Protein Synthesis in Women
This study investigates whether a protein-nutrition beverage can increase muscle protein synthesis to a similar magnitude as a control beverage.
- Trial name
- NCT02282566
- Testing
- Protein-nutrition beverage
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Chronic Obstructive Pulmonary Disease (COPD)
Electrostimulation, Skeletal Muscle Function, and Exercise Capacity in Chronic Obstructive Pulmonary Disease (COPD)
This study was designed to test the following hypothesis: The benefit of electrostimulation training will be greater than sham stimulation training in term of muscle strength and mass (muscle hypertrophy), exercise tolerance…
- Trial name
- ESTIM (NCT00874965)
- Testing
- Electrostimulation
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Laval University
Muscle Protein Synthesis
Effect of Protein Quality During Overreaching in Trained Cyclists
Athletes frequently undertake periods of intensified training commonly referred to as "overreaching." These training periods acutely decrease performance, with the expectation that performance will rebound and improve after a…
- Trial name
- NCT03994198
- Testing
- Alpha-lactalbumin, Collagen peptides
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- McMaster University
Protein Metabolism
Skeletal Muscle Protein Synthetic Response to Amino Acid and Peptides
Skeletal muscle quality is an important determinant of exercise performance and overall health. It is vital for not just movement, but also metabolizing nutrients.
- Trial name
- NCT03952884
- Testing
- Resistance Exercise, No Resistance Exercise, Leucine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Muscle Anabolism
A Study to Evaluate the Effect of Testosterone on Muscle Fractional Synthetic Rate (MK-0000-064)
This is a study to evaluate the use of fractional synthetic rate as an early biomarker of muscle anabolism (muscle build-up).
- Trial name
- NCT00816712
- Testing
- Comparator: Testosterone 300 mg, intramuscular injection, Comparator: Testosterone 100 mg, Intramuscular injection
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
Omega-3 Fatty Acids and Muscle Protein Synthesis
The purpose of this study is to determine whether omega-3 fatty acid supplementation influences muscle protein synthesis rates in young and older adults.
- Trial name
- NCT00794079
- Testing
- omega-3 fatty acids, corn oil
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Muscle, Skeletal, High-Intensity Interval Training
Whey Protein Support to Metabolic and Performance Adaptations in Response HIIT
High intensity interval training (HIIT) has recently emerged as a time efficient alternative to conventional endurance exercise, conferring similar or superior benefits in terms of metabolic and performance adaptations in both…
- Conditions
- Muscle, Skeletal, High-Intensity Interval Training, Exercise
- Trial name
- NCT03570424
- Testing
- Nutrient support to HIIT
- Where
- Ireland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Healthy
Effect of Amino Acid on Muscle Damage
The primary objective is to determine the impact of essential amino acids on integrated muscle protein synthesis over 4 days after resistance exercise.
- Trial name
- NCT03319147
- Testing
- Active
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
25-hydroxyvitamin D Concentration (Vitamin D Status)
D-Light Intervention
Vitamin D insufficiency has become a global concern, with low vitamin D status associated with bone disorders, cardiovascular disease and certain cancers.
- Trial name
- D-Light (NCT02495584)
- Testing
- Fortified milk (10µg vitamin D3), 10µg vitamin D3 supplement
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Muscle Disuse, Muscle Disuse Atrophy
Muscle Response to Different Amounts of Dietary Protein During Leg Immobilization
Individuals who sustain musculoskeletal injuries (MSKI) can experience a rapid loss of muscle mass due to declines in muscle loading and activation that occur post-injury (i.e., disuse atrophy).
- Trial name
- NCT07069426
- Testing
- 20 grams protein, 40 grams protein
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine