Clinical trials: Muscle Synthesis
Muscle Protein Synthesis, Whole-body Protein Balance
Essential Amino Acids and Protein Kinetics During Caloric Deprivation
The amount of essential amino acids (EAA) necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined.
- Trial name
- NCT03372928
- Testing
- Standard EAA, High EAA
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Type 2 Diabetes Mellitus, Insulin Resistance
Effects of Six Months of Moderate Resistance- Versus Endurance-Training on Muscle ATP Synthesis in First-Degree Relatives of Patients With Type 2 Diabetes
Life style intervention including diet and exercise is the recommended strategy for prevention of type 2 diabetes mellitus (T2DM).
- Trial name
- RECO2 (NCT01145092)
- Testing
- exercise training, endurance training
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Landsteiner Institut
Non Muscle Invasive Bladder Cancer
A Prospective Open Label Comparative Dose Ranging Study Evaluating the Effect of Pre-TURBT Intravesical Instillation of Mitomycin C (MMC) Mixed With TC-3 Gel in Patients With Non Muscle Invasive Bladder Cancer (NMIBC)
This study is a prospective randomized open labeled dose ranging comparative study. Twenty four (24) patients with NMIBC who meet the inclusion/exclusion criteria will be recruited for the study following the initial diagnostic…
- Trial name
- NMIBC TURBT HG (NCT01799499)
- Testing
- TC-3 hydrogel
- Where
- Israel
- Sponsor
- UroGen Pharma Ltd.
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Tendinopathy
Patellar Tendinopathy - Effect of Training and Enhancement of the Collagen Synthesis by Insulin-like Growth Factor-I
The purpose of the study is to test the hypothesis that stimulation of the synthesis of new structural tendon proteins combined with training improve the tendon structure in patients with chronic knee tendon pain.
- Trial name
- IGF-I (NCT01834989)
- Testing
- Insulin-like growth factor I
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Bispebjerg Hospital
Duchenne Muscular Dystrophy
Open Label Extension Study of HT-100 in Patients With DMD
This study is designed to provide 6-months continuous dosing with the study medication, called HT-100, on participants who successfully completed the predecessor study (HALO-DMD-01).
- Trial name
- NCT01978366
- Testing
- HT-100
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- Processa Pharmaceuticals
Sarcopenia, Muscle Atrophy
Concurrent Assessment of Skeletal Muscle Mass and Synthesis/Breakdown in Old Age
This study involves minimally-invasive techniques to measure muscle mass, muscle protein breakdown and synthesis simultaneously in older age.
- Trial name
- NCT04114383
- Testing
- D3-Creatine, Deuterium Oxide, D3-3-methylhistidine
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscle Damage, Healthy
Exploring Muscle Breakdown During Exercise Recovery
This study will allow researchers to explore how muscle responds to heavy exercise. The researchers will characterise rates of muscle protein breakdown and synthesis 24hours after heavy exercise with a post exercise protein…
- Trial name
- EMBER (NCT04841772)
- Testing
- Recover Vegan Protein Supplement
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Physical Inactivity, Vascular Dysfunction
Heat Therapy During Reduced Physical Activity
The purpose of this randomized controlled trial is to determine whether daily Finnish dry sauna therapy attenuates the adverse cardiovascular, muscular, and metabolic effects of seven days of experimentally reduced physical…
- Conditions
- Physical Inactivity, Vascular Dysfunction, Skeletal Muscle Atrophy
- Trial name
- HEAT-RPA (NCT07847424)
- Testing
- Sauna, Reduced Physical Activity
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Healthy Volunteers, Female
Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS)
The goal of this clinical trial is to learn if micronized progesterone (PROMETRIUM®) influences the muscle-building response to resistance exercise in healthy premenopausal women aged 18-30 years.
- Conditions
- Healthy Volunteers, Female, Progesterone, Premenopausal
- Trial name
- MP4 MPS (NCT07173361)
- Testing
- Micronized progesterone (oral capsules)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Supplement, Resistance Training Adaptation
Skeletal Muscle Adaptations to Peptide-Supplemented Resistance Exercise Training
Skeletal muscle size, an important metabolic tissue, is governed by the balance between two opposing processes, muscle protein synthesis and muscle protein breakdown.
- Trial name
- NCT07773142
- Testing
- Resistance Exercise Training with or without daily supplementation, Dual Energy X-Ray Absorptiometry (DEXA) Scan, Muscle Sampling
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Metabolism, Exercise
The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise
Plant-based proteins contain several amino acids that are essential to signal growth, reconditioning, maintenance and preservation of skeletal muscle mass.
- Conditions
- Metabolism, Exercise, Dietary Supplements
- Trial name
- NCT05020808
- Testing
- NEAA, PPI
- Where
- Ireland
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Cancer
Effects of Nutritional Supplementation (Product 4808) on Acute Skeletal Muscle Protein Synthesis in Cancer Patients
The purpose of the study is to compare two different nutritional supplements with respect to their effect on building muscle, and to determine the factors that control the rate at which muscle tissue can be produced in subjects…
- Trial name
- NCT00446888
- Testing
- Standardized Meals for Diet Stabilization, Forticare, Product 4808
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Arkansas
Muscle Loss, Muscle Anabolism
Skeletal Muscle Response to Amino Acids and Load Carriage Exercise
Warfighters often experience physical overload, as the uniform and associated gear that they carry burdens them with substantial loads.
- Conditions
- Muscle Loss, Muscle Anabolism, Muscle Performance
- Trial name
- NCT01714479
- Testing
- Leucine-enriched nutritional supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Sedentary Lifestyle
Influence of Sedentary Time on Skeletal Muscle Protein Metabolism
This study will investigate the influence of increased sedentary time on long-term measures of muscle protein synthesis and metabolic health.
- Trial name
- NCT02624011
- Testing
- 7 days of habitual physical activity followed by 7 days of reduced physical activity
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Muscle Synthesis
Protein Supply in Elderly
Stimulating overnight muscle protein synthesis, might augment muscle hypertrophy, increase mitochondrial mass, and/or improve muscle tissue repair.
- Trial name
- NCT01317511
- Testing
- Protein
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Old Age; Debility, Muscle Weakness
Probiotic-Muscle Study
This study will examine the effect of probiotic supplementation (Bacillus coagulans) on muscle protein synthesis in older adults in response to a plant-based diet.
- Conditions
- Old Age; Debility, Muscle Weakness, Protein Deregulation, Protein Deposition
- Trial name
- NCT04297111
- Testing
- Probiotic
- Where
- Ireland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Cardiac Disease, Mitochondrial Biogenesis
CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle
This study will test if inhalation of Carbon Monoxide (CO) will increase the numbers of mitochondria in heart muscle. Mitochondria are the small components of muscle and other cells that convert fuel and oxygen to the easily…
- Conditions
- Cardiac Disease, Mitochondrial Biogenesis, Carbon Monoxide
- Trial name
- NCT01727167
- Testing
- 200ppm CO for one hour, Control
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- John J Freiberger
Aging
Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women
Using stable isotope methodology, investigators will determine the postabsorptive and postprandial muscle protein synthetic response in 60 female adults (Age 50-79, BMI: <30 kg/m2) immediately after an acute bout of resistance…
- Trial name
- NCT02918981
- Testing
- Resistance Exercise, 14 g Whey protein, 6.6 g Whey protein + 1.25 g leucine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Diet, Healthy, Protein Deficiency
Protein and Performance (PROPER) in Endurance Athletes
The present study is a parallel group design with randomised allocation to either a 1) reduced protein diet (RP) or a 2) normal protein diet (NP).
- Trial name
- PROPER (NCT05426447)
- Testing
- Dietary intervention of reduced protein intake, Dietary intervention of normal protein intake
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen