Clinical trials: Muscle Tone Increased
Stroke
Dry Needling for Spasticity in Stroke
Stroke is the leading cause of physical disability due to the presence of spasticity. Different needling techniques, including Botulinum Toxin A are proposed for management of spasticity; however results are conflicting.
- Trial name
- NCT02377804
- Testing
- Dry needling, Physical Therapy, stainless steel needles (0.3mm x 50mm)
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Universidad Rey Juan Carlos
Stroke
Comparative Hybrid Effects of Combining BoNT-A With Robot-assisted or Mirror Therapy for U/E Spasticity Stroke Patients
The aim of this study will be to determine and compare the immediate and longer-term effects of combination of BoNT-A injection and mirror therapy vs combination of BoNT-A injection and robot-assisted therapy.
- Trial name
- NCT02749591
- Testing
- Botulinum Toxin Type A, Robot-assisted therapy, Mirror therapy
- Where
- Taiwan
- Volunteers
- 37 people
- Sponsor
- Chang Gung Memorial Hospital
Stroke, Spasticity, Muscle
Multiphasic Neuroplasticity Based Training Protocol With Shock Wave Therapy For Post Stroke Spasticity
this study will be conducted to f find the effects of multiphasic neuroplasticity based training protocol with Shock Wave Therapy on Neurophysiological, Morphological and Functional Parameters of Post Stroke Spasticity.
- Trial name
- NCT05405140
- Testing
- Shock wave therapy with multiphasic neuroplasticity based training protocol, Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Spastic Hemiplegia
Evaluation of Spasticity, Neuropathic Pain, and Gait Analysis in Stroke Patients Receiving Tolperison Therapy After Botulinum Toxin Injection
Tolperison is an antispastic agent used in the treatment of spasticity. Studies on tolperison are limited, and the literature on its effectiveness against spasticity and neuropathic pain is also limited.
- Trial name
- NCT07482618
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ayse Guc
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Severe Spasticity
SISTERS: Spasticity In Stroke Study - Randomized Study
To demonstrate that Intrathecal Baclofen (ITB) Therapy, compared to Best Medical Treatment (BMT), has superior efficacy in the treatment of severe spasticity in adult post-stroke patients with generalized spastic hypertonia who…
- Trial name
- SISTERS (NCT01032239)
- Testing
- intrathecal baclofen
- Where
- 25 sites in United States, Austria and 7 more
- Volunteers
- 61 people
- Sponsor
- MedtronicNeuro
Spasticity/Paresis, Cerebral Palsy
Efficacy of Extracorporeal Shock Wave Therapy in Children With Cerebral Palsy
Spastic plantar and palmar flexion deformities are very common in children with cerebral palsy (CP). These deformities usually involve spasticity of the plantar or palmar muscle complexes, weakness of the antagonist dorsiflexor…
- Trial name
- NCT06128616
- Testing
- ESWT, Botulinum Toxin Type A, Serial Casting
- Volunteers
- 40 people
- Sponsor
- Kocaeli University
Stroke, Hypertonia
Validity and Reliability of the Hypertonia Assessment Tool (HAT) in Stroke Patients
In this study, the validity and reliability of the Hypertonia Assessment Tool (HAT), which has previously been validated in the pediatric cerebral palsy (CP) population, will be evaluated in adult individuals who have experienced…
- Conditions
- Stroke, Hypertonia, Dystonia, Rigidity
- Trial name
- NCT07429383
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hypertonia
Grand Autohemo-Therapy With Oxygen-ozone on Patients With Hypertonia
The objective of this clinical study is to evaluate the influence of the Great autohemotherapy with oxygen-ozone (hyperbaric ozone therapy ) to describe the cardiovascular system in patients with resistant hypertension.
- Trial name
- HAB (NCT01902602)
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Herrmann Apparatebau GmbH
Hyperhidrosis, Muscle Spasticity
Safety and Efficacy of BOTOX® (Botulinum Toxin Type A) in Korea
This post marketing surveillance study in Korea will evaluate the safety and efficacy of BOTOX (botulinum toxin Type A) in patients who receive treatment according to standard of care for primary axillary hyperhidrosis, focal…
- Conditions
- Hyperhidrosis, Muscle Spasticity, Glabellar Lines
- Trial name
- NCT02043145
- Testing
- botulinum toxin Type A
- Where
- South Korea
- Volunteers
- 727 people
- Sponsor
- Allergan
Muscle Spasticity
H-reflex in Spastic Lower Limb Cryoneurotomy
Spasticity is a common complication after many upper motor neurone disorders. Many surgical techniques have been introduced for patients with refractory spasticity though they are not without peri-operative risks.
- Trial name
- NCT04907201
- Testing
- Cryoneurotomy
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vancouver Island Health Authority
Contracture, Spasticity, Muscle
Effect of Cryoneurolysis on Pain in Patients With Hand Contracture.
Contracture which is defined as a limitation of the maximum passive range of motion due to changes in periarticular soft tissue can contributes to severe pain and increased disabilities.
- Trial name
- NCT06051656
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Vancouver Island Health Authority
Stroke
Investigation of the Use of Acupuncture for the Treatment of Spasticity in Chronic Stroke Participants
The purpose of this study is to investigate if acupuncture is more effective than sham treatment in reducing lower extremity spasticity, and improving gait speed in the chronic phase of stroke recovery.
- Trial name
- HHSCSTROKEAC (NCT02085642)
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Age-related Macular Degeneration
Association Between Laser Interferometric Measurement of Fundus Pulsation and Pneumotonometric Measurement of Pulsatile Ocular Blood Flow in Patients With Age-related Macular Degeneration
Several methods have been proposed for the measurement of pulsatile ocular blood flow (POBF). The pneumatic tonometer, which is commercially available, assesses POBF by measurement of intraocular pressure (IOP) changes during the…
- Trial name
- NCT00991666
- Testing
- blood flow measurement
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Spinal Cord Injury
Dose-Response Effects of Whole Body Vibration on Spasticity and Walking in SCI
This study will enroll people with SCI who have spasticity and some ability to walk. The goal is to understand if standing on a platform and receiving WBV results in decreased spasticity and improved walking ability.
- Trial name
- WBV (NCT02340910)
- Testing
- Short Duration, Long Duration
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Shepherd Center, Atlanta GA
Hemiparesis, Paraparesis
Immediate Effects On Gait and Spasticity After The Use Of Passive Kinesiotherapy Equipment In The Lower Limbs Of Neurological Patients
Undergo assessment of muscle tone (Ashworth Scale), gait (BAIOBIT) and risk of falling (Timed Up and Go) before using the device; Use the device on the spastic lower limb(s) for 30 minutes; Go through the same assessment carried…
- Conditions
- Hemiparesis, Paraparesis, Tetraparesis, Cerebral Palsy
- Trial name
- NCT06696040
- Testing
- Passive mobilization using a device
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Fernanda Trubian
Chronic Stroke
Repetitive Transcranial Magnetic Stimulation Associated With Physical Therapy to Reduce Upper Limb Spasticity in Post Stroke Patients
In this study, it is being investigated if the association between high frequency repetitive transcranial magnetic stimulation associated with motor physical therapy reduces spasticity, increases upper limb motor function, and…
- Trial name
- NCT03481179
- Testing
- TMS, Physical therapy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Multiple Sclerosis
Use of Cannabinoids in Patients With Multiple Sclerosis
This is a 10-week, randomised, double blind, placebo-controlled, crossover trial to investigate the effect of Cannabis Based Medicine Extract (Sativex) on patterns of brain activation associated with movement in 20 MS patients…
- Trial name
- NCT00202423
- Testing
- Sativex
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- S. Andrea Hospital
Safety and Pharmacokinetics of Intravenous Baclofen
Dose Escalation Study of Intravenous Baclofen in Healthy Adult Volunteers
The objective of this study is to determine safety and characterize pharmacokinetics of higher doses of intravenous baclofen in healthy subjects.
- Trial name
- NCT01931319
- Testing
- Intravenous baclofen
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Transcutaneous Spinal Stimulation, Walking
Spinal Cord Stimulation to Augment Activity Based Therapy
Involuntary muscle activity, often called spasticity, is a common problem following spinal cord injury (SCI) that can make it hard to move.
- Conditions
- Transcutaneous Spinal Stimulation, Walking, Spasticity, Human
- Trial name
- NCT03240601
- Testing
- Transcutaneous spinal stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Shepherd Center, Atlanta GA