Clinical trials: Muscle Tumor
Bladder Cancer
VPM1002BC in Recurrent Non-muscle Invasive Bladder Cancer
This phase I/II trial will assess the safety and efficacy of intravesical instillation of VPM1002BC in patients with recurrent non-muscle invasive bladder cancer after TURB (transurethral resection of the bladder) and standard…
- Trial name
- NCT02371447
- Testing
- VPM1002BC
- Where
- 16 sites in Germany, Switzerland
- Volunteers
- 39 people
- Sponsor
- Swiss Cancer Institute
Symptomatic Uterine Leiomyomas, Fibroids
The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids.
The primary goal of this study is to compare the safety and effectiveness of two standard fibroid treatments: MRI guided ultrasound surgery (MRgFUS) and uterine artery embolization (UAE).
- Conditions
- Symptomatic Uterine Leiomyomas, Fibroids, Uterine Fibroids, Myomas
- Trial name
- NCT00995878
- Testing
- Focused ultrasound (MRgFUS), Uterine artery embolization (UAE)
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Mayo Clinic
Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy
Impact of an Orthotic Intervention in Children With Peripheral Neuropathy
This research study will investigate the effect of two orthotic (brace) devices for the ankle and foot on walking and ankle flexibility in children with cancer not involving the brain or spinal cord.
- Conditions
- Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy, Acute Lymphocytic Leukemia, Pediatric, Rhabdomyosarcoma
- Trial name
- IOPN (NCT03655587)
- Testing
- Solid ankle foot orthotic, Resting night splint
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Ledderhose Disease
Ledderhose Disease - Long Term Effects of Radiotherapy Treatment. LedRad LTE - Study
The aim of the LedRad LTE study is to determine the current complaints, late side effects and satisfaction of patients who were treated with radiotherapy for Ledderhose disease at least two years ago.
- Trial name
- NCT04229147
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 68 people
- Sponsor
- University Medical Center Groningen
Dupuytren's Contracture
Health-Related Quality of Life in Patients With Dupuytren's Disease
Main Research Questions: We want to measure the change in quality of life in Dupuytren's disease patients who do and do not undergo surgery.
- Trial name
- NCT00468949
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Non-muscle Invasive Bladder Cancer (NMIBC)
Using Urine Tumor DNA to De-Intensify Surveillance in Non-Muscle Invasive Bladder Cancer
The goal of this clinical trial is to use urine tumor DNA (utDNA) as an indicator for non-muscle invasive bladder cancer to identify patients suitable for less frequent cystoscopy surveillance.
- Trial name
- NCT07187063
- Testing
- UroAmp Test (Convergent Genomics, Inc.)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Lahey Clinic
Sarcopenia, Cancer of Head and Neck
Assessment of the Prevalence of Sarcopenia by CT Scan in Patients Diagnosed With Head & Neck Cancer
Sarcopenia is defined by the reduction in skeletal muscle mass and physical performance. It results in a decrease in muscle strength, overall physical activity, walking and the development of balance disorders and falls.
- Conditions
- Sarcopenia, Cancer of Head and Neck, CT Scan
- Trial name
- SARVADS 1 (NCT04804852)
- Testing
- sarcopenia assessment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Weprom
Metrorrhagia, Menorrhagia
Surgical Success After Laparoscopic vs Abdominal Hysterectomy
The purpose of the proposed pilot study is to investigate the effectiveness, cost, safety, and long-term impact on quality of life of laparoscopic hysterectomy (LH) in relation to abdominal hysterectomy (AH) for the treatment of…
- Conditions
- Metrorrhagia, Menorrhagia, Leiomyoma, Adenomyosis
- Trial name
- NCT01793584
- Testing
- Laparoscopic hysterectomy, Abdominal hysterectomy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Lung; Disease, Fibroid (Chronic)
Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx)
The main aim of this project is to establish whether ambulatory oxygen in patients with fibrotic ILD whose oxygen saturation falls ≤ 88% on a 6MWT, leads to a significant improvement in health status.
- Trial name
- AmbOx (NCT02286063)
- Testing
- Ambulatory Oxygen
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Bladder Cancer, Metastatic Bladder Cancer
A Phase II Study of Atezolizumab in Combination With Cisplatin + Gemcitabine Before Surgery to Remove the Bladder Cancer
The purpose of this study is to test the safety of the study drug, atezolizumab, when combined with the standard chemotherapy drugs, gemcitabine and cisplatin (or GC).
- Conditions
- Bladder Cancer, Metastatic Bladder Cancer, Urothelial Carcinoma
- Trial name
- NCT02989584
- Testing
- Atezolizumab, Gemcitabine, Cisplatin
- Where
- 9 sites in United States
- Volunteers
- 54 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Superficial Bladder Cancer
ADSTILADRIN (=INSTILADRIN) in Patients With High-Grade, Bacillus Calmette-Guerin (BCG) Unresponsive Non-Muscle Invasive Bladder Cancer (NMIBC)
Previous multi-dose Phase I and Phase II clinical studies have demonstrated that ADSTILADRIN is a safe and effective treatment for BCG-refractory and recurrent NMIBC.
- Trial name
- NCT02773849
- Testing
- ADSTILADRIN
- Where
- 34 sites in United States
- Volunteers
- 157 people
- Sponsor
- Ferring Pharmaceuticals
Pulmonary Rehabilitation, Sarcopenia
Pulmonary Rehabilitation in Advanced Non-small Cell Lung Cancer Patients
Lung cancer (LC) is usually diagnosed in advanced stages and continues to be the leading cause of cancer related deaths worldwide.
- Conditions
- Pulmonary Rehabilitation, Sarcopenia, Quality of Life
- Trial name
- NCT02978521
- Testing
- Pulmonary rehabilitation
- Where
- Mexico
- Volunteers
- 94 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Bladder Cancer
Validation of VI-RADS for the Detection of Detrusor Muscle Invasion
To evaluate the accuracy of Multiparametric MRI in differentiation between invasive and non-invasive bladder cancer using vesical imaging reporting and data system (VI-RADS) score.
- Trial name
- NCT05123404
- Testing
- multi parametric MRI, transurethral resection of bladder tumor
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Egyptian Biomedical Research Network
HER2-expressing High-risk or Very High-risk NMIBC Without Visible Foci of Disease After TURBT
RC48 in Combination With Radiotherapy for HER2-Expressing NMIBC Patients
This study is an open, single-arm, single-center exploratory clinical study to explore the efficacy and safety of Disitamab Vedotin (RC-48) in combination with radiotherapy for the treatment of patients with HER2-expressing…
- Trial name
- NCT07100184
- Testing
- Disitamab Vedotin combined with Radiotherapy
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Uterine Fibroids (Leiomyoma), Uterine Myoma
Terlipressin vs Placebo to Reduce Bleeding in Fibroid Surgery
A myomectomy is a surgery to remove noncancerous growths (fibroids) from the uterus while keeping the uterus in place. This surgery can cause significant blood loss.
- Conditions
- Uterine Fibroids (Leiomyoma), Uterine Myoma, Leiomyoma
- Trial name
- NCT07746349
- Testing
- terlipressin (vasoconstrictor)
- Volunteers
- 80 people
- Sponsor
- Sevil Cankaya
Carcinoma, Transitional Cell, Urinary Bladder Neoplasms
A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer
This study will test an experimental drug (enfortumab vedotin) alone and with different combinations of anticancer therapies. Pembrolizumab is an immune checkpoint inhibitor (CPI) that is used to treat patients with cancer of the…
- Conditions
- Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Urologic Neoplasms, Renal Pelvis Neoplasms
- Trial name
- EV-103 (NCT03288545)
- Testing
- enfortumab vedotin (EV), pembrolizumab, cisplatin
- Where
- 106 sites in United States, Canada and 4 more
- Volunteers
- 348 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Fibroid Uterus, Urethral Diseases
Impact of Hysterectomy on Quality of Life and Urethral Length
To establish the impact of hysterectomy on sexual function, urethral length and quality of life
- Conditions
- Fibroid Uterus, Urethral Diseases, Sex Disorder
- Trial name
- NCT03757975
- Testing
- urethral length measure
- Where
- Poland
- Volunteers
- 500 people
- Sponsor
- Medical University of Lublin
Bladder Cancer
Comprehensive Multiparametric Magnetic Resonance Imaging After Transurethral Resection of Non Muscle-invasive Bladder Tumor; Can it Replace Second Look Biopsy? A Prospective Study
The aim of the study is to prospectively assess the role of mpMRI as a non invasive method for assessment of possible residual tumor after initial resection of non muscle invasive bladder tumor.
- Trial name
- NCT03914001
- Testing
- mpMRI, Second look TURBT
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
High-Risk Non-Muscle Invasive Bladder Cancer
A Phase III Randomised Control Clinical Trial of Radiotherapy With Radiosensitisation Versus Intravesical Bacillus Calmette-Guerin Therapy for High-risk Non-muscle Invasive Bladder Cancer.
In the UK 20,000 people develop urothelial bladder cancer each year with 75-80% having Non-Muscle Invasive Bladder Cancer (NMIBC).
- Trial name
- TRAIN (NCT07268339)
- Testing
- radiotherapy, BCG
- Where
- United Kingdom
- Volunteers
- 328 people
- Sponsor
- The Christie NHS Foundation Trust
Non-muscle Invasive Bladder Cancer
Safety and Toxicity Study of Intravesical Instillation of TARA-002 in Adults with High-grade Non-muscle Invasive Bladder Cancer (Phase 1a)
This study is an open-label dose escalation study (Phase 1a) to investigate the safety and toxicity of intravesical treatment of high-grade NMIBC (HGTa or CIS, including CIS with concomitant Ta) after transurethral resection of…
- Trial name
- ADVANCED-1 (NCT05085977)
- Testing
- TARA-002
- Where
- 14 sites in United States, Moldova and 2 more
- Volunteers
- 12 people
- Sponsor
- Protara Therapeutics
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