Clinical trials: Muscle Tumor
Bladder Transitional Cell Carcinoma, Bladder Cancer
Phase I BLASST-3 Trial
The aim of this research is to see whether using a drug that blocks a protein called FGFR (fibroblast growth factor receptor) prior to surgery is safe and effective in patients with bladder cancer that have mutations in FGFR3 or…
- Conditions
- Bladder Transitional Cell Carcinoma, Bladder Cancer, Fibroblast Growth Factor Receptor
- Trial name
- (BLASST)-3 (NCT04972253)
- Testing
- Infigratinib
- Sponsor
- Guru P. Sonpavde
Oral Cancer
Morphological Changes of Upper Trapezius Muscle After Physotherapy in Oral Cancer
The study aims to evaluate the morphological changes of upper trapezius muscle, using B-mode ultrasonography, in patients with oral cancer undergone neck dissection and physiotherapy.
- Trial name
- NCT07166575
- Testing
- B-mode ultrasonography
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Osteoporosis, Sarcopenia
Bone Microstructure by Using HR-pQCT in Long Courses After Gastrectomy
Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy.
- Conditions
- Osteoporosis, Sarcopenia, Gastric Cancer
- Trial name
- NCT03251430
- Testing
- gastrectomy
- Where
- Japan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Kobayashi Shinichiro
Leiomyosarcoma
Activity of Trabectedin or Gemcitabine + Docetaxel in Uterine Leiomyosarcoma
The management of patients with uterine leiomyosarcomas poses many difficulties. Despite 60% of women present with disease limited to the uterus, cure rates range from 20 to 60%.
- Trial name
- TAUL (NCT02249702)
- Testing
- gemcitabine + docetaxel, trabectedin
- Where
- 34 sites in Italy
- Volunteers
- 168 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Colorectal Cancer, Nutrition Aspect of Cancer
Immunonutrition for Prehabilitation of Patients With Colorectal Cancer Before Surgery
Perioperative immunonutrition has been proposed as a strategy to modulate the inflammatory response and improve outcomes after colorectal surgery.
- Trial name
- IMNUTPREH-CRC (NCT07653737)
- Testing
- Oral nutritional supplement with inmmunonutrition, Standard oral nutritional supplement
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Muscle Invasive Bladder Cancer
Pegylated Liposomal Doxorubicin, PD-1 in Treating Muscle Invasive Bladder Cancer
Despite primary surgical management of muscle invasive bladder cancer (MIBC) with radical cystectomy and pelvic lymphnode dissection, up to 50% of patients will eventually develop tumours at distant sites, owing to pre-existing…
- Trial name
- NCT04101812
- Testing
- pegylated liposomal doxorubicin (PLD), PD-1
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Medical University Second Hospital
Bladder Cancer, Muscle-Invasive Bladder Carcinoma
ctDNA in Subjects With Muscle-invasive Bladder Cancer Treated With Trimodality Therapy
The purpose of this prospective biospecimen collection study is to evaluate the feasibility of measuring circulating tumor DNA (ctDNA) in subjects with muscle-invasive bladder cancer (MIBC) treated with trimodality therapy…
- Trial name
- NCT05630131
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Dupuytren's Disease, Surgical Incision
Tolerance and Efficacy Study of Second-line Surgery After Percutaneous Needle Aponeurotomy for Dupuytren's Disease.
As part of a graduated medical-surgical strategy, and in our practice, surgery for Dupuytren's disease appears as a second-line treatment indicated in a situation of failure after treatment with percutaneous needle…
- Trial name
- URAM3 (NCT04164953)
- Testing
- Surgical treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Colorectal Cancer
Qigong Exercise for Muscles Strength and Quality of Life in Colorectal Cancer Patients Undergoing Chemotherapy
The purpose of this study is to evaluate therapeutic effect of Qigong for muscle strength and quality of life in colorectal cancer patients undergoing chemotherapy.
- Trial name
- NCT07709429
- Testing
- Qigong Exercise, Conventional Exercise Program
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Cairo University
Low Anterior Resection Syndrome
Paula Method of Exercises in Patients With LARS Syndrome:Randomized Controlled Trial
Sphincter sparing rectal resection surgery, either total mesorectal excision (TME) with a temporary loop ileostomy or partial mesorectal excision (PME), is the mainstay of rectal cancer treatment , however, these treatments are…
- Trial name
- NCT05682157
- Testing
- Paula Method of muscle exercises
- Where
- 2 sites in Israel
- Volunteers
- 62 people
- Sponsor
- Hadassah Medical Organization
Leiomyoma, Leiomyosarcoma
Concordance Between Sonography Amd MRI for Presurgical Diagnosis of Uterine Mesenchymal Malignant Tumors
Determine the concordance between gynaecological sonography and pelvic MRI for the pre-surgical diagnosis of uterine malignant tumors.
- Trial name
- CERTUM (NCT02940041)
- Testing
- Pre-surgical diagnosis of uterine malignant tumors
- Volunteers
- 15 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
NMIBC, High Risk NMIBC
A Phase 1/1b Study of ZH9 Treatment in Patients With Non-Muscle Invasive Bladder Cancer
This is a first-in-human, multicenter, Phase 1/1b, 3-part, double-blind study of ZH9 in patients with recurrent NMIBC who are eligible for intravesical therapy.
- Conditions
- NMIBC, High Risk NMIBC, Non Muscle Invasive Bladder Cancer
- Trial name
- PARADIGM-1 (NCT06181266)
- Testing
- ZH9
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- Prokarium Ltd
Non-muscle-invasive Bladder Cancer
Safety and Efficacy of BCG Combined With Tislelizumab for BCG-untreated Patients With High-risk Non-muscle Invasive Bladder Cancer
For patients with high-risk non-muscle-invasive bladder cancer (NMIBC), intravesical therapy of BCG is the standard treatment proved to reduce the risk of recurrence and progression.
- Trial name
- NCT05580354
- Testing
- BCG combined with Tislelizumab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Ruijin Hospital
Uterine Fibroid
Efficacy of Paracervical Block in Laparoscopic Myomectomy: a Randomized Controlled Trial (PALM)
It remains controversial whether paracervical block should be performed as a powerful strategy for pain relief in laparoscopic myomectomy (LM), because convincing conclusions are difficult to draw because of the heterogeneous and…
- Trial name
- PALM (NCT04068766)
- Testing
- Paracervical block, 5% bupivacaine, Normal saline
- Where
- 2 sites in South Korea
- Volunteers
- 62 people
- Sponsor
- Kangbuk Samsung Hospital
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Use of Nitrous Oxide During Office Hysteroscopy
The goal of this clinical trial is to assess the use of inhaled nitrous oxide during office hysteroscopy. The main questions it aims to answer are: Does it reduce pain during the procedure? Does it increase the success rate? Does…
- Conditions
- Abnormal Uterine Bleeding, Postmenopausal Bleeding, Endometrial Polyps, Retained Products of Conception
- Trial name
- NCT07074795
- Testing
- Inhalation of Nitrous Oxide (N₂O) during Office Operative Hysteroscopy, inhalation of ambient air during office hysteroscopy
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Maaynei Hayesha Medical Center
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma
Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well vemurafenib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with BRAF V600 mutations that have spread to other places in the body…
- Conditions
- Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma, Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma, Ependymoma
- Trial name
- NCT03220035
- Testing
- Laboratory Biomarker Analysis, Vemurafenib
- Where
- 116 sites in United States, Puerto Rico
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
Bladder Cancer
Efficacy and Safety of Multi-Instillations of Apaziquone in Patients With Non-Muscle Invasive Bladder Cancer
This is an international, multicenter, double-blind, placebo-controlled, randomized study. All eligible patients entering the open label phase of the study will receive a single immediate instillation of apaziquone (4 mg in 40 mL…
- Trial name
- NCT01410565
- Testing
- Apaziquone
- Where
- 47 sites in United States, Canada
- Volunteers
- 66 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Chemotherapy-Induced Amenorrhea
Metabolism, Circadian Rhythms and Ovarian Function
Chemotherapy for cancer, due to its gonadotoxicity, can lead to impaired female fertility, resulting in the occurrence of transient or prolonged chemo-induced amenorrhea (CIA).
- Trial name
- METAB-OV (NCT05007834)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Dupuytren Contracture, Dupuytren Disease of Palm and Finger
Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB® Resorbable Implant Device
Dupuytren's disease is a progressive fibroproliferative condition of the hand which progresses in 20% of patients into a serious condition.
- Trial name
- Vivosorb (NCT03741764)
- Testing
- Vivosorb
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- prof. dr. Ilse Degreef
Esophageal Cancer, Sarcopenia
Influence of Nutrition and Sarcopenia on Esophageal Cancer Outcomes
Prospective multicenter longitudinal (observational) study recruiting from tertiary centers for the surgical management of esophageal cancer; Virginia Mason Medical Center (Seattle, USA) and St Mary's Hospital (Imperial College…
- Trial name
- INSPECT (NCT06314516)
- Where
- United States
- Volunteers
- 1,717 people
- Sponsor
- Benaroya Research Institute
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