Clinical trials: Muscle Tumor
Non-small Cell Lung Cancer (NSCLC), Small Cell Lung Cancer (SCLC)
Sarcopenia and Cachexia in Patients With Lung Cancer
The PHILICA study investigates whether muscle mass, muscle strength, and muscle function are associated with treatment tolerance, quality of life and survival in patients with lung cancer.
- Trial name
- PHILUCA (NCT06730685)
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Zealand University Hospital
NMIBC
A Phase I-II Study of Novel Oncolytic Virus VG161 Via Intravesical Instillation for BCG-Unresponsive Non-Muscle-Invasive Bladder Cancer
A Phase I-II Study of Novel Oncolytic Virus VG161 via Intravesical Instillation for BCG-Unresponsive Non-Muscle-Invasive Bladder Cancer (VG-INFUSE Trial) Background: The treatment of recurrent/refractory non-muscle-invasive…
- Trial name
- VG-INFUSE Tria (NCT07505615)
- Testing
- VG161 via Intravesical Instillation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ding-Wei Ye
Bladder Cancer
Radiation Therapy and Durvalumab, With or Without Tremelimumab, in Patients With Bladder Cancer
This is a multi-site, randomized, prospective, open-label phase II study. Patients in this study will have localized (cT3-cT4), or metastatic bladder cancer with a symptomatic, intact primary bladder tumor.
- Trial name
- NCT03150836
- Testing
- Durvalumab, Tremelimumab, Radiation Therapy
- Where
- United States
- Sponsor
- Terence Friedlander, MD
Prostate Cancer, Urinary Incontinence
Relations Between Pelvic Floor, Diaphragm and Trunk Muscles
The present study evaluates the functional relations of pelvic floor, diaphragm, and torso muscles, their variation and correlations with urinary incontinence while separately training physical characteristics of the mentioned…
- Trial name
- NCT03858452
- Testing
- Muscles exercises program
- Volunteers
- 148 people
- Sponsor
- Lithuanian University of Health Sciences
Breast Cancer, Ovarian Cancer
A Mind-body Intervention to Improve Body and/or Self Image
The purpose of this study is to determine if hypnotic relaxation therapy is a more effective intervention for improving self-image in women who have been diagnosed with breast or gynecologic cancer when compared to progressive…
- Conditions
- Breast Cancer, Ovarian Cancer, Uterine Cancer, Cervical Cancer
- Trial name
- NCT02531997
- Testing
- Hypnotic Relaxation Therapy, Progressive Muscle Relaxation
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Michigan
Leiomyoma, Vitamin D Deficiency
Vitamin D Deficit in Women With Uterine Fibroids
Determinate the level of vitamin D in blood, and evaluate the prevalence of deficit and insufficiency among patients with diagnosis of uterine fibroids
- Conditions
- Leiomyoma, Vitamin D Deficiency, Fibroid Uterus
- Trial name
- NCT04030182
- Testing
- Level of Vitamin D
- Where
- 2 sites in Mexico
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Rhabdomyosarcoma
Clinico-biological Study/Characterization of Rhabdomyosarcoma in Adolescents and Young Adults, 15-25-year-old Patients
Rhabdomyosarcoma (RMS) stands for the most frequent soft tissue sarcoma in children and, adolescents and young adults (AYA, 15-25-year-old population), accounting for approximately half of the whole soft tissue sarcomas in these…
- Trial name
- RMS-AJA-1701 (NCT03462888)
- Where
- 20 sites in France
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Centre Oscar Lambret
Tenosynovial Giant Cell Tumor
Accuracy of Indocyanine Green (ICG) Fluorescence Imaging in Tenosynovial Giant Cell Tumor Surgery
This study evaluates the diagnostic accuracy of Indocyanine Green (ICG) fluorescence imaging in visualizing Tenosynovial Giant Cell Tumor (TGCT) lesions during surgery.
- Trial name
- ICG-TGCT (NCT07315841)
- Testing
- Indocyanine Green
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Sarcopenia, Lung Cancer
Assessment System of Sarcopenia in Lung Cancer Patients
1. To explore the diagnostic value of musculoskeletal cross-modal imaging assessment system of ultrasound combined with abdominal CT/MRI for sarcopenia in patients with lung cancer. 2.
- Conditions
- Sarcopenia, Lung Cancer, Ultrasound
- Trial name
- NCT06327594
- Testing
- ultrasound scan, CT/MRI scan
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- West China Hospital
Chronic Inflammatory Demyelinating Polyradiculoneuropathy, NMO Spectrum Disorder
Safety and Efficacy of BAFF-R CART for Refractory Neuroimmune Diseases
This study is a phase Ib/IIa dose-escalation study designed to evaluate the safety, tolerability, and preliminary efficacy of autologous T cells expressing chimeric antigen receptor (CAR)-targeted B-cell activating factor…
- Conditions
- Chronic Inflammatory Demyelinating Polyradiculoneuropathy, NMO Spectrum Disorder, Myasthenia Gravis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT07022197
- Testing
- BAFF-R CART
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Tianjin Medical University General Hospital
Urinary Bladder Neoplasms, Urologic Neoplasms
Pilot Study to Evaluate the Clinical Response to Mitomycin-C in Hydrogel (TC-3) Administered Intravesically in NMIBC Patients
The purpose of this study is to evaluate the clinical response of the tumors within the bladder of recurrent NMIBC patients to Mitomycin-C embedded in UroGen Pharma's (known at that time as TheraCoat Ltd.) TC-3 Sterile Hydrogel…
- Conditions
- Urinary Bladder Neoplasms, Urologic Neoplasms, Neoplasms, Urinary Bladder Diseases
- Trial name
- NCT02891460
- Testing
- 40 mg MMC in 40 mL TC-3., 80 mg MMC in 40 mL TC-3.
- Where
- India
- Volunteers
- 18 people
- Sponsor
- UroGen Pharma Ltd.
Uterine Fibroids
Non-interventional Study to Evaluate Long Term Safety, Prescription Management Patterns of Esmya in a Long Term Setting
This is a multi-centre, multinational, prospective, non-interventional study in females with a diagnosis of moderate to severe uterine fibroids, and for whom a treatment with Esmya in a long term manner is planned, and in…
- Trial name
- Premium (NCT02748460)
- Where
- 115 sites in Belgium, Czechia and 14 more
- Volunteers
- 1,527 people
- Sponsor
- PregLem SA
Alveolar Soft Part Sarcoma (ASPS), Sarcoma
A Study to Determine the Safety and Effectiveness of the Investigational Cellular Therapy GCAR1 in a Patient With Alveolar Soft Part Sarcoma
A single patient study to determine whether GCAR1 is safe and effective for refractory, progressive metastatic alveolar soft part sarcoma (ASPS).
- Trial name
- SPS-C (NCT07104682)
- Testing
- GCAR1
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Bladder Cancer
Research on the Combined-Modality Treatment Model of Bladder Preservation in Muscular Invasive Bladder Cancer
This research aims to explore the therapeutic effect of neoadjuvant chemotherapy in muscular invasive bladder cancer of T2-4aN0M0, and the survival effect of combined-modality treatment model，then to clarify the probability of…
- Trial name
- NCT02861196
- Testing
- Intensity modulated radiation therapy, Radical cystectomy
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Urinary Bladder Cancer
An Epidemiologic Study on PD-L1 Expression Combined With Clinical Observation in the Chinese MIUBC Patients.
The Primary Objective of this observational study is to investigate the prevalence of high PD-L1 expression in Chinese MIUBC patients.
- Trial name
- POLARIS (NCT03433924)
- Where
- 17 sites in China
- Volunteers
- 248 people
- Sponsor
- AstraZeneca
NMIBC
RC48-ADC in Combination With Gemcitabine in High Risk NMIBC Subjects
In this study, participants with high risk non-muscle-invasive bladder cancer (NMIBC) who are BCG Naïve or BCG Unresponsive and are considered ineligible for or have refused to undergo radical cystectomy, will receive RC48-ADC in…
- Trial name
- NCT05943379
- Testing
- RC48-ADC in Combination with gemcitabine
- Where
- China
- Volunteers
- 85 people
- Sponsor
- RemeGen Co., Ltd.
Cervical Cancer, Female Sexual Dysfunction (FSD)
Biofeedback-Assisted Pelvic Floor Rehabilitation for Radiation-Induced Sexual Dysfunction in Cervical Cancer Survivors
This randomized controlled trial aims to evaluate the efficacy of biofeedback-assisted pelvic floor muscle training on radiation-induced sexual dysfunction in cervical cancer survivors following pelvic radiotherapy.
- Conditions
- Cervical Cancer, Female Sexual Dysfunction (FSD), Radiation Induced Pelvic Floor Muscle Dysfunction
- Trial name
- NCT07597083
- Testing
- Biofeedback-Assisted Pelvic Floor Muscle Rehabilitation, Conventional Pelvic Floor Muscle Training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Sarcopenia, Cancer
Leucine-enriched Formulas in Patients With Tumor-induced Sarcopenia
Currently there is a lack of evidence for recommending specific oral supplements (OS) for nutritional support in patients with cancer, including leucine-enriched supplements.
- Trial name
- NCT05837741
- Testing
- Standard hypercaloric hyperproteic oral nutritional supplement, Leucine-enriched hypercaloric hyperproteic oral nutritional supplement
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Uterine Fibroids, Uterine Leiomyomata
Pilot Study of MRI-Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids
Uterine fibroids (leiomyomas) are a common cause of heavy uterine bleeding and pain in reproductive aged women and are the most common cause of hysterectomy in the United States.
- Trial name
- NCT00837161
- Testing
- Philips MR guided HIFU system
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Philips Healthcare
Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall, Stage II Bladder Cancer AJCC v8
Avelumab in Combination With Fluorouracil and Mitomycin or Cisplatin and Radiation Therapy in Treating Participants With Muscle-Invasive Bladder Cancer
This phase II trial studies the side effects of avelumab and how well it works in combination with fluorouracil and mitomycin or cisplatin and radiation therapy in treating participants with muscle-invasive bladder cancer.
- Conditions
- Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall, Stage II Bladder Cancer AJCC v8, Stage II Renal Pelvis Cancer AJCC v8, Stage II Ureter Cancer AJCC v8
- Trial name
- NCT03617913
- Testing
- Avelumab, Cisplatin, Fluorouracil
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
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