Clinical trials: Muscle Wasting
COPD, Quadriceps Muscle Atrophy
Clinimetric Properties of Muscle Mass and Stiffness Measurements of the Quadriceps in Patients With COPD
A large amount of patients with COPD suffer from muscle dysfunction characterized by losses of muscle mass and strength. Studies have shown an association between a loss of quadriceps muscle mass and premature death.
- Trial name
- Metriquad (NCT06994689)
- Testing
- Perimetry and ShearWave measurement of the quadriceps muscle before and after a pulmonary rehabilitation (PR) programme
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Groupe Hospitalier du Havre
Chronic Obstructive Pulmonary Disease (COPD) With Cachexia
BYM338 in Chronic Obstructive Pulmonary Disease (COPD) Patients With Cachexia
This study will assess the pharmacodynamics, pharmacokinetics, safety and tolerability of BYM338 in patients with COPD and cachexia. The primary outcome will be a change in thigh muscle volume compared to placebo.
- Trial name
- NCT01669174
- Testing
- BYM338
- Where
- 9 sites in United States, Netherlands and 1 more
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Sarcopenia, Possible Sarcopenia
HB05P on Muscle Health
The purpose of this pilot study is to evaluate whether HB05P, a health functional food ingredient containing pasteurized Akkermansia muciniphila HB05, improves muscle strength, and to evaluate its safety.
- Trial name
- NCT07749118
- Testing
- HB05P
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Sarcopenia, Metabolic Diseases
Sarcopenia, Metabolic Diseases, and Integrated Aging Longitudinal Evaluation (SMILE)
This study aims to establish an ambispective cohort platform centered on the pathological axis of "sarcopenia-metabolic disorders-aging progression", integrating multimodal data including demographic characteristics, lifestyle…
- Conditions
- Sarcopenia, Metabolic Diseases, All-cause Mortality, Aging
- Trial name
- NCT07205510
- Testing
- nothing
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Spinal Muscular Atrophy (SMA)
A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Participants With Spinal Muscular Atrophy
Risdiplam works by helping the body produce more survival motor neuron (SMN) protein throughout the body. This means fewer motor neurons - nerve cells that pass impulses from nerves to muscles to cause movement - are lost, which…
- Trial name
- MANATEE (NCT05115110)
- Testing
- RO7204239, Risdiplam
- Where
- 30 sites in United States, Australia and 10 more
- Volunteers
- 97 people
- Sponsor
- Hoffmann-La Roche
Spinal Cord Injuries, Skeletal Muscle Atrophy
Metabolic Health in Individuals With Spinal Cord Injury (SCI)
Individuals with spinal cord injury (SCI) live longer than before and live to an age where metabolic disorders become highly prevalent.
- Conditions
- Spinal Cord Injuries, Skeletal Muscle Atrophy, Metabolic Disease
- Trial name
- SCI (NCT03204240)
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Sarcopenia
Prevalence of Sarcopenia and Its Geriatric Features
The goal of this study is to determine the prevalence of sarcopenia in a geriatric hospital ward. Sarcopenia is defined by a loss of muscle mass, loss of muscle strength and loss of muscle quality.
- Trial name
- NCT02664376
- Testing
- Sarcopenia detection
- Where
- Belgium
- Volunteers
- 834 people
- Sponsor
- Brugmann University Hospital
Infantile Spinal Muscular Atrophy of Type 2 or 3
Pilot Study of an Innovative Physiotherapy in Patients With Infantile Spinal Muscular Atrophy (SMA)
This clinical trial aims to test a new physio-therapeutic approach tailored to type 2 and 3 Spinal Muscular Atrophy patients, based on physical training in swimming-pool.
- Trial name
- ExerASI (NCT02061189)
- Testing
- Physical exercise in a swimming pool during 6 months
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Muscular Atrophy, Sprains
Study to Assess the Efficacy and Safety of Ibuprofen 50 mg/g Gel Compared to Profenid 25mg/g Gel
The aim of this study is to determine that ibuprofen 50mg/g gel is effective and safety treating patients with muscle aches, joint pains or due to sprains, bruises, tendinitis or myofascial compared to Profenid 25mg/g gel.
- Conditions
- Muscular Atrophy, Sprains, Tendonitis
- Trial name
- NCT01373697
- Testing
- Ibuprofen, Profenid
- Where
- Brazil
- Volunteers
- 144 people
- Sponsor
- Laboratório Teuto Brasileiro S/A
Sarcopenia, Cirrhosis
Muscle Mass Via UltraSound in Cirrhosis (MMUSCLE)
The goal of this observational cohort study is to learn about loss of muscle mass and muscle strength (sarcopenia) in patients with cirrhosis.
- Conditions
- Sarcopenia, Cirrhosis, Malnutrition
- Trial name
- MMUSCLE (NCT06345547)
- Testing
- ultrasound
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Antwerp
Spinal Muscular Atrophy
SMN Circular RNAs as Potential New Targets and Biomarkers for SMA
Spinal Muscular Atrophy (SMA) is a life-threatening disease in infancy that is caused by inactivating mutations in the Survival Motor Neuron 1 (SMN1) gene1,2.
- Trial name
- CircSMA (NCT05760209)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Critical Illness, Physical Disability
Neuromuscular Electrical Stimulation (NMES) Preserves Muscle Mass in Intensive Care Unit (ICU)
Background: Low-frequency neuromuscular electrical stimulation (NMES) attenuates the loss of muscle mass of Intensive Care Unit (ICU) patients.
- Conditions
- Critical Illness, Physical Disability, Muscle Atrophy
- Trial name
- NCT05287919
- Testing
- Patients received the standard physical therapy (SPT) programme (passive mobilization) twice a day., Patients received the low-frequency neuromuscular electrical stimulation (NMES), Patients received the medium-frequency neuromuscular electrical stimulation (NMES)
- Where
- Chile
- Volunteers
- 54 people
- Sponsor
- Gabriel Nasri Marzuca-Nassr
Sarcopenia
Pilates and PNF Methods Induces Similar Strength Gains
To compare the influence of a training program with Pilates and PNF methods to elderly women on the strength gains and motor control during voluntary contractions
- Trial name
- NCT02274909
- Testing
- TRAINING PROGRAM
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do PiauÍ
Sarcopenia
Multidisciplinary Combined Exercise and Nutrition Intervention for Sarcopenia
This study aims to demonstrate the effect of combined exercise-nutrition intervention in old adults with sarcopenia. This study will be conducted with prospectively randomized controlled trial comparing outcome of combined…
- Trial name
- MENTORS (NCT04948736)
- Testing
- Combined exercise and nutrition intervention, Conventional medial care
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Seoul National University Bundang Hospital
Sarcopenia, Frailty
Prevalence of Two Major Geriatric Syndromes: Sarcopenia and Frailty
Sarcopenia and frailty are two major syndromes in older adults. They are shown to be associated with low levels of functioning and higher rates of morbidity and mortality.
- Conditions
- Sarcopenia, Frailty, Frailty Syndrome
- Trial name
- NCT04146844
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Goztepe Training and Research Hospital
Sarcopenia, Coronary Artery Disease
Strength-building Lifestyle-integrated Intervention
This study aims to 1) develop a strength-building lifestyle-integrated intervention for sarcopenic CAD patients and to 2) examine the feasibility and 3) preliminary effects of this intervention on skeletal muscle mass, muscle…
- Trial name
- NCT05497687
- Testing
- Resistance exercise
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Stroke, Ischemic
Effect of Supplementation With Creatine on the Recovery of Ischemic Stroke
Stroke is a leading cause of disability and the second leading cause of death worldwide. Most strokes are ischemic, caused by acute arterial occlusion.
- Trial name
- SUCRE (NCT06576466)
- Testing
- Creatine monohydrate
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Health Behavior, Sarcopenia
Earlier Elderly People in Rural Areas
Social innovation in aging needs to bring new ideas and services to meet new social and welfare needs identified in recent years.
- Conditions
- Health Behavior, Sarcopenia, Nutrition, Sleep
- Trial name
- NCT05273502
- Testing
- Citizen Science intervention
- Where
- Spain
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Colon Cancer, Oxaliplatin-induced Peripheral Neuropathy
Study to Evaluate the Use of Surgical Gloves for the Prevention of Oxaliplatin-Induced Peripheral Neuropathy
The primary objective of this randomized clinical trial is to assess whether the use of surgical gloves during treatment can prevent the occurrence of oxaliplatin-induced peripheral neuropathy.
- Trial name
- GLOX-PEN (NCT07285356)
- Testing
- Surgical Gloves
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- AC Camargo Cancer Center
Sarcopenia, Sarcopenia in Elderly
Effects of Nutritional Supplementation of Leucine and Polyunsaturated Fatty Acids on Muscle Health in the Elderly
Population aging has become a significant global concern, and Taiwan is set to officially enter the "super-aged society" in 2025.
- Trial name
- NCT06991855
- Testing
- Animal-Based Oil Group, Plant-Based Oil Group
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital