Clinical trials: Muscle Weakness | Patient
Stroke Rehabilitation
Self-modulated Functional Electrical Stimulation in Chronic Stroke Patients With Severe and Moderate Upper Limb Paresis
The study aims at demonstrating the efficacy of self-modulated functional electrical stimulation (SM-FES) in promoting upper-limb (UL) motor recovery in chronic stroke patients with severe and severe-moderate paralysis.
- Trial name
- SM-FES (NCT04014270)
- Testing
- Self-modulated functional electrical stimulation (SM-FES), Standard Care
- Where
- 4 sites in Switzerland
- Volunteers
- 29 people
- Sponsor
- Intento SA
Weaning Failure
Inspiratory Muscle Training in Difficult to Wean Patients
Prolonged mechanical ventilation secondary to weaning failure demands a significant amount of intensive care unit (ICU) resources, thus increasing the economic burden of public healthcare costs.
- Trial name
- NCT03240263
- Testing
- Inspiratory Muscle Training, Endurance training
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- KU Leuven
Knee Arthroscopic Surgery, Arthrogenic Muscle Inhibition
Blood Flow Restriction Training in Knee Arthropathy
Arthrogenic muscle inhibition (AMI) is the key neurophysiological cause of impeding quadriceps activation following anterior cruciate ligament reconstruction (ACLR).
- Conditions
- Knee Arthroscopic Surgery, Arthrogenic Muscle Inhibition, Quadriceps Muscle Weakness
- Trial name
- NCT07837154
- Testing
- Blood flow restriction training with 60%-80% occlusion
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Yuxiu Ji
Anterior Cruciate Ligament Injuries, Atrophy
Effect of Blood Flow Restriction Training on Patient With Anterior Cruciate Ligament Reconstruction
This study investigates the effects of plyometric training with blood flow restriction on muscular strength, quadriceps thickness and knee joint function in patients with muscle weakness and atrophy (quadriceps muscle and…
- Conditions
- Anterior Cruciate Ligament Injuries, Atrophy, Muscle Weakness
- Trial name
- NCT04284748
- Testing
- Plyometric exercise with blood flow restriction, Plyometric exercise, Routine physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Muscular Dystrophies
Study of Albuterol and Oxandrolone in Patients With Facioscapulohumeral Dystrophy (FSHD)
This is a study to determine whether albuterol or oxandrolone, alone or in combination, are able to increase strength and muscle mass in patients with FSHD.
- Trial name
- NCT00027391
- Testing
- Albuterol, Oxandrolone
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- FDA Office of Orphan Products Development
Muscle Weakness
A Study in Older Participants Who Have Fallen and Have Muscle Weakness
LY2495655 is an investigational drug being tested for muscle wasting.
- Trial name
- NCT01604408
- Testing
- LY2495655
- Where
- 22 sites in United States, Argentina and 4 more
- Volunteers
- 201 people
- Sponsor
- Eli Lilly and Company
Critical Illness, Muscle Weakness
Can Beta-Hydroxy-beta-Methylbutyrate Supplementation Counteract Muscle Catabolism in Critically Ill Patients?
The rapid decline of muscle mass and function in mechanically ventilated critically ill patients is associated with prolonged length of mechanical ventilation, prolonged intensive care (ICU) and hospital stay, increased ICU and…
- Trial name
- HMB-ICU-CH (NCT03628365)
- Testing
- HMB (beta-hydroxy beta-methylbutyrate)
- Where
- Switzerland
- Volunteers
- 37 people
- Sponsor
- Mette M Berger
Pelvic Floor Muscle Weakness
Effect of Verbal Instruction on Pelvic Floor Muscle Contraction in Post Stroke Patients
The aim of this study is to investigate which verbal instruction will lead to the most efficient contraction of pelvic floor muscles in post stroke patients.
- Trial name
- NCT03903627
- Testing
- verbal instruction
- Where
- Israel
- Volunteers
- 77 people
- Sponsor
- University of Haifa
Hemiparesis
Stability of Hemiparetic Patients During a Daily Complex Task
Among the repercussions of hemiparesis following stroke, disturbed stability is responsible for a high risk of falls. Picking up objects from the ground, frequently trained in rehabilitation due to its risk of falling and its…
- Trial name
- HemiSym (NCT07082036)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcopenia, Gait Disorders in Old Age
An OBServational Clinical Trial (SARA-OBS) in Sarcopenia and Sarcopenic Obesity in Patients Aged 65 Years and Over
The SARA-OBS is a single arm phase 2 clinical trial, with no investigational product and no therapeutic intervention that will be conducted in three European countries, (Belgium, France and Italy), and in the US.
- Conditions
- Sarcopenia, Gait Disorders in Old Age, Muscle Weakness
- Trial name
- SARA-OBS (NCT03021798)
- Testing
- No Drug and no aspecific intervention
- Where
- 7 sites in United States, Belgium and 2 more
- Volunteers
- 218 people
- Sponsor
- Biophytis
Sepsis, Primary Myopathies
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular…
- Trial name
- NCT00735384
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Stroke, Upper Limb Paresis
Effects of High-Frequency rTMS on Cortical Motor Mapping in Stroke Patients With Severe Upper Limb Impairment (MAP2024SJD)
The goal of this clinical trial is to learn if a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) can increase cortical motor activity in stroke patients with severe upper limb impairment.
- Trial name
- MAP2024SJD (NCT07787793)
- Testing
- High-frequency repetitive transcranial magnetic stimulation
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Ancor Rebassa Cabrera
ICU-acquired Muscle Weakness
Electrical Muscle Stimulation and Bicycling Combined to Early Standard Rehabilitation in the ICU
Early mobilization (from the first day if possible), first passive and then passive and active, is recommended for critically ill patients in whom it reduces the duration of mechanical ventilation, the length of hospital stay…
- Trial name
- PROMOREA1 (NCT02185989)
- Testing
- Early electrical stimulation and early leg bicycling added to early standard rehabilitation
- Where
- France
- Volunteers
- 314 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Stroke, Hemiparesis
The Comparison of Virtual and Real Boxing Training in Hemiparetic Stroke Patients
The aim of this study is to compare the effects of virtual and real boxing training in addition to neurodevelopmental training on cognitive status, upper extremity functions, balance and activities of daily living in hemiparetic…
- Trial name
- NCT03651479
- Testing
- real boxing training, virtual boxing training
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Eastern Mediterranean University
Weakness of the Lower Limbs
VERARE : Effectiveness of Virtual Motor Actions for Improving Walking in Patients With Post-resuscitation Muscle Weakness
After a hospitalization in Intensive Care Unit (ICU), approximately 50% of patients usually have a ICU-Weakness, i.e. nerves and muscles injury secondary to immobilization and to treatments which had to be used.
- Trial name
- VERARE (NCT04441164)
- Testing
- Observation of Virtual Actions, Relaxation, Acceptability questionnaire
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Intensive Care Unit, Respiratory Insufficiency
Low Creatinine Level and Respiratory Failure
Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients.
- Conditions
- Intensive Care Unit, Respiratory Insufficiency, Muscle Weakness
- Trial name
- NCT04368325
- Testing
- Serum creatinine levels
- Where
- Croatia
- Volunteers
- 107 people
- Sponsor
- Osijek University Hospital
Esophageal Cancer, Nutrition Aspect of Cancer
Assessing Timing of Enteral Feeding Support in Esophageal Cancer Patients on Muscle functTion and Survival
The surgical stress of an esophagectomy causes a detrimental impact on the physiological response of the body. In this perspective, one could question whether the current feeding regimens of starting early nutritional support at…
- Conditions
- Esophageal Cancer, Nutrition Aspect of Cancer, Postoperative Complications, Muscle Weakness
- Trial name
- EFECTS (NCT03676478)
- Testing
- delayed start enteral support @ POD5
- Where
- Belgium
- Volunteers
- 239 people
- Sponsor
- University Hospital, Gasthuisberg
Stroke, Cerebrovascular Disorders
Dose Optimization for Stroke Evaluation
This study is about rehabilitation of arm function after a stroke. The investigators are testing the dosage of therapy that is needed for meaningful recovery of arm and hand function.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Ischemia, Infarction
- Trial name
- DOSE (NCT01749358)
- Testing
- Accelerated Skill Acquisition Program (ASAP), Active Monitoring
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Southern California
Stroke, Hemiplegia and Hemiparesis
The Efficacy of Additional Motor Training Dosage During the Early Stages Post Stroke on the Upper Extremity Recovery
Intervention abstract Background: Stroke is the leading cause of long-term disability, and the second leading cause of death in the western world.
- Trial name
- EFODIN (NCT07056049)
- Testing
- High dosage, high intensity motor rehabilitation
- Where
- 2 sites in Israel
- Volunteers
- 50 people
- Sponsor
- Adi Negev-Nahalat Eran
General Anaesthesia, Muscle Weakness
Electromagnetic Stimulation of the Phrenic Nerve of Intubated Patients
Ventilator-induced diaphragmatic dysfunction is a common issue in critically ill patients. Muscle stimulation has shown to have beneficial effects in muscle groups on the extremities.
- Trial name
- STIMIT-I (NCT04946110)
- Testing
- Electromagnetic stimulation
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- Charite University, Berlin, Germany