Clinical trials: Muscle Weakness | Patient
Neurophysiology, Physiology
Functional Implication of Corpus Callosum in Voluntary Strength in COPD Patients
Patients with COPD have lower capability of activating their muscles. At the cortical level, force production is not only controlled by contralateral primary motor cortex but also by ipsilateral motor cortex.
- Trial name
- NCT03807258
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- 2 sites in France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- 5 Santé
Stroke, Hemiplegia
Impact of Hip Flexors Isokinetic Strengthening on Gait Capacities in Subacute Stroke Patients
Post-stroke patients often present with gait disorders due to several physical impairments. Hip flexor deficit is one of the more prevalent trouble and is associated with gait capacities.
- Conditions
- Stroke, Hemiplegia, Gait
- Trial name
- ISOKINETIC (NCT02917850)
- Testing
- Isokinetic hip flexors strengthening, Conventional rehabilitation
- Sponsor
- University Hospital, Lille
Cerebral Palsy (CP), Diaplegia
Effect of Treatment on Cerebral Palsy Patient With Crouch Gait Associated With Anterior Pelvic Tilt and Soleus Muscle Weakness"Marouf Syndrome", and Muscle Assesment by Using EMG
Children with cerebral palsy (CP) often develop gait abnormalities, with crouch gait being a common and challenging issue that affects their posture and daily function.
- Conditions
- Cerebral Palsy (CP), Diaplegia, Muscle Weakness | Patient, Anterior Pelvic Tilt
- Trial name
- NCT07147933
- Testing
- phusical therapy program, physical therapy program
- Where
- Jordan
- Volunteers
- 40 people
- Sponsor
- Philadelphia University, Jordan
Polyneuropathies, Septic Shock
Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock
The aim of this study is to compare the effect of EMS and conventional physical therapy on strength and muscle mass and development in adult patients with severe sepsis and septic shock.
- Conditions
- Polyneuropathies, Septic Shock, Muscle Weakness
- Trial name
- NCT03765489
- Testing
- electrical muscle stimulation, conventional physical therapy
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Chile
Stroke
Treatment of Chronic Stroke With IpsiHand
The ultimate goal of this project is to develop a functioning and clinically feasible method for restoring function to motor-impaired stroke survivors. This ultimate goal will be approached through two different means.
- Trial name
- NCT02552368
- Testing
- IpsiHand Device
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Alzheimer Disease (AD), Sarcopenia
A Study of Silkworm Pupa Powder Intervention in the Nutritional Status of Patients with Alzheimer's Disease.
The goal of this clinical trial is to learn if silkworm pupa powder works to improve the nutritional status of Alzheimer's disease patients.
- Conditions
- Alzheimer Disease (AD), Sarcopenia, Asthenia
- Trial name
- AD (NCT06770309)
- Testing
- Silkworm pupa powder
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yanbu Ke
Dysphagia, Stroke
Investigation of the Effect of Neuromuscular Electrical Stimulation Techniques on Suprahyoid Muscles and Swallowing Function in Acute Hemiparetic Stroke Patients
This randomized controlled trial aims to investigate the effects of sensory, motor, and modified combined neuromuscular electrical stimulation (NMES) protocols on swallowing function in patients with acute stroke-related…
- Conditions
- Dysphagia, Stroke, Hemiparesis
- Trial name
- NMESWAL (NCT07445204)
- Testing
- Conventional Swallowing Therapy, Vitalstim-Sensory NMES, Vitalstim-Motor NMES
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Arel University
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Severe Sepsis, Acute Respiratory Failure
Effect of Different Electric Muscle Stimulation in Patients With Severe Sepsis and Respiratory Failure
Rationale : Electric muscle stimulation reduced critical-illness related weakness in patients with severe sepsis and septic shock. But optimal protocol of the stimulation in unknown.
- Conditions
- Severe Sepsis, Acute Respiratory Failure, Muscle Hypotonia, Inflammation
- Trial name
- NCT01895647
- Testing
- EMS
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Mackay Memorial Hospital
Paralysis
Feasibility Study of the Instrumented Evaluation of Eccentric Strengthening in Paresis Patients
he aim of the "RE PAR EX" research is to evaluate the feasibility of the instrumented examination of the effects of eccentric muscle strengthening in paralytic patients.
- Trial name
- RE PAR EX (NCT05415514)
- Testing
- Instrumented assessment of muscle function
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Nantes University Hospital
ICU Acquired Weakness
Evaluation of FDY-5301 in Major Trauma Patients in ICU
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of FDY-5301 compared to placebo in major trauma ICU patients at risk of intensive care unit acquired weakness (ICUAW)
- Trial name
- NCT04430283
- Testing
- FDY-5301
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Faraday Pharmaceuticals, Inc.
Chronic Obstructive Pulmonary Disease
Identification of Explanatory Factors for the Lack of Muscle Strength Gain Following a Pulmonary Rehabilitation Program in COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease associated with various comorbidities, including muscle weakness (MW), which is very worrying due to its negative impact on patients' quality of life…
- Trial name
- NCT06271122
- Testing
- Voluntary activation assessed by magnetic stimulation
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Korian
Stroke, Cerebrovascular, Hemiplegia and Hemiparesis
BCI Driving FES and Hand Orthosis for Upper Limb Rehabilitation in Chronic Stroke
Multi-center, randomized, sham-controlled, double-blind, longitudinal, experimental clinical study to investigate functional recovery effects on the upper limb in chronic stroke patients and the accompanying neural plasticity…
- Conditions
- Stroke, Cerebrovascular, Hemiplegia and Hemiparesis, Stroke/Brain Attack
- Trial name
- NCT06179745
- Testing
- EEG-based brain-computer interface, Functional Electrical Stimulation, Active hand orthosis
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Essex
Stroke, Cerebrovascular Accident
Combining Armodafinil With Neuro-rehabilitation to Improve Neurological Recovery and Reduce Disability Post-Stroke
Armodafinil is an FDA approved medication with wakefulness-promoting properties. It is a relatively safe agent with interesting neurochemical effects on the catecholamine system, producing an improvement in cognitive function…
- Conditions
- Stroke, Cerebrovascular Accident, Hemiparesis
- Trial name
- NCT01896128
- Testing
- Armodafinil
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Burke Rehabilitation Hospital
Stroke, Motor Disorders
Functional Proprioceptive Stimulation of the Upper Limbs in Stroke Patients
Parallel-group, single-blinded controlled clinical trial. The study involved stroke patients (no more than 3 points on a scale Rankin) dived of the control group and experimental group.
- Conditions
- Stroke, Motor Disorders, Upper Extremity Paresis, Muscle Weakness
- Trial name
- NCT06143475
- Testing
- FPS group, Conventional therapy group
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health
Shoulder Pain, Muscle Weakness
Effect of Kinesio Taping on Muscle Strength in Lower Trapezius
The purpose of this project is to investigate the effect of Kinesio tape on muscle strength of the lower trapezius in people with shoulder symptoms and decreased muscle strength in the lower trapezius - a randomized controlled…
- Trial name
- NCT02290730
- Testing
- Kinesio tape
- Where
- Norway
- Volunteers
- 49 people
- Sponsor
- Norwegian School of Sport Sciences
Stroke, Hemiparesis
Robotic Exoskeleton Gait Training With and Without Brain-Computer Interface Control After Stroke
After a stroke, many people have trouble walking. One way to practice walking again is with a wearable robot, called an exoskeleton, that supports the legs and guides them through a walking pattern.
- Conditions
- Stroke, Hemiparesis, Gait Disorders, Neurologic
- Trial name
- NCT07760116
- Testing
- Conventional exoskeleton gait training, BCI-controlled exoskeleton gait training
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Taichung Veterans General Hospital
Stroke Rehabilitation
Effectiveness of Transcranial Magnetic Stimulation in Subacute Stroke Patients With Severe Upper Limb Paresis
There has been A-level evidence for the effectiveness of inhibitory rTMS of the contralesional M1 hand region in stroke patients in the acute stage. However, it has been reported to be ineffective in the chronic stage.
- Trial name
- NCT05505201
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Izmir Katip Celebi University
Brain Diseases, Central Nervous System Diseases
Investigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Improve Upper Limb Recovery in Patients With Stroke
Following a stroke, the function of the distal upper limb, especially hand and finger movements, is often severely compromised, significantly restricting the ability to carry out daily activities.
- Conditions
- Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Stroke
- Trial name
- bi-tDCS+VR (NCT07288385)
- Testing
- Transcranial Direct Current Stimulation combined with virtual reality
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Saud University
Stroke, Hemiparesis
"Comparison of Therapist-Led and Robot-Assisted Arm Therapy in Subacute Stroke Rehabilitation"
This study aims to compare the outcomes of upper limb motor therapy conducted by a physiotherapist with robot-assisted therapy using the Luna EMG device in patients in the subacute phase after stroke.
- Conditions
- Stroke, Hemiparesis, Muscle Spasticity, Upper Extremity Dysfunction
- Trial name
- NCT07002463
- Testing
- Luna EMG, Therapist-assisted upper limb training
- Where
- Poland
- Volunteers
- 58 people
- Sponsor
- Wroclaw University of Health and Sport Sciences