Clinical trials: Muscle Weakness | Patient
Stroke, Cerebrovascular Accident (CVA)
The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke
The purpose of this study is to evaluate if 5 consecutive sessions of PathMaker anodal DoubleStim treatment, which combines non-invasive stimulation of the spinal cord (tsDCS- trans-spinal direct current stimulation) and of the…
- Conditions
- Stroke, Cerebrovascular Accident (CVA), Hemiparesis, Spasticity as Sequela of Stroke
- Trial name
- NCT03080454
- Testing
- anodal Doublestim
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Northwell Health
Muscle Weakness, Fatigue
Assessing Fatiguability of Tongue Muscles in MS
Multiple Sclerosis (MS) patients with subjective dysphagia will be tested for tongue strength fatigue using a strictly defined fatigue paradigm.
- Conditions
- Muscle Weakness, Fatigue, Multiple Sclerosis, Deglutition Disorders
- Trial name
- NCT03817073
- Testing
- Iowa Oral Performance Instrument (IOPI)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Thomas More Kempen
Frail Elderly Syndrome, Muscle Weakness
Investigation of Relation With Preoperative Fragility and ASA Score in Elderly Patients
Frailty is a term specific to the geriatric period. It is used to describe weak, unstable, frail patients and partially expresses the frailty of the elderly patient.
- Trial name
- NCT05078983
- Testing
- CGA-FI (COMPREHENSIVE GERIATRIC ASSESMENT - FRAILITY INDEX)
- Where
- Turkey (Türkiye)
- Volunteers
- 320 people
- Sponsor
- Gulhane Training and Research Hospital
Asthenia, COVID-19
Efficacy of the Therapy With BRAINMAX® Using fMRI for the Treatment of Patients With Asthenia After COVID-19
to assess executive network using resting-state fMRI and patterns of brain activation using task fMRI with a cognitive paradigm, against the background of taking the drug in comparison with placebo in patients with post-COVID…
- Conditions
- Asthenia, COVID-19, Functional MRI, Cognitive Impairment
- Trial name
- NCT05939622
- Testing
- Structural and functional MRI, Ethyl methyl hydroxypyridine succinate + Meldonium
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Promomed, LLC
ICU Acquired Weakness, Quadriceps Muscle Atrophy
Ultrasound Measurement of Quadriceps Shortening During Neuromuscular Electrical Stimulation in Critically Ill Patients
ICU-Aw is highly prevalent (50%) among critically ill patients. Its diagnosis is usually delayed as it requires patients' awakening and collaboration to provide accurate measurement.
- Trial name
- DETECT (NCT04722445)
- Testing
- Early ultrasound measurement of quadriceps shortening during neuromuscular electrical stimulation (NMES)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Groupe Hospitalier du Havre
Amyotrophic Lateral Sclerosis & Other Neuromuscular Disorders
Using Gaze to Enable Head-neck Movements in Patients With Head Drop
The investigators will develop and evaluate controllers for a powered neck exoskeleton in patients with amyotrophic lateral sclerosis (ALS) to understand how to allow adequate personalization and function and achieves…
- Trial name
- NCT07836751
- Testing
- neck exoskeleton controller
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Severe Chronic Obstructive Pulmonary Disease, Dyspnea
The Effectiveness Pulmonary Telerehabilitation and Cognitive Telerehabilitation in COPD Patients
The aim of our study is to compare the effectiveness of the supervized pulmonary telerehabilitation program and the cognitive telerehabilitation method, which includes pulmonary telerehabilitation methods, in patients with severe…
- Conditions
- Severe Chronic Obstructive Pulmonary Disease, Dyspnea, Muscle Weakness, Fatigue
- Trial name
- NCT05222295
- Testing
- Supervised Pulmonary Telerehabilitation, Cognitive Telerehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Saglik Bilimleri Universitesi
Cancer, Cancer Cachexia
Effects of WB-EMS and Dietetic Treatment on Cancer Patients
This study evaluates the effects of a 12-week whole-body electromyostimulation (WB-EMS) training combined with individualized nutritional support on body composition, muscle strength and function and quality of life of patients…
- Conditions
- Cancer, Cancer Cachexia, Weight Loss, Muscle Loss
- Trial name
- NCT02293239
- Testing
- Whole-Body Electromyostimulation (WB-EMS)
- Where
- Germany
- Volunteers
- 278 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Stroke Ischemic
Paired Associative Stimulation (PAS) for Stroke Rehabilitation
Paired associative stimulation (PAS) delivered with multi-channel deep transcranial magnetic stimulation (dTMS) may enhance motor recovery in patients with first-ever ischemic stroke.
- Trial name
- PAS-Stroke (NCT07691099)
- Testing
- A multi-channel device with deep TMS coil (Brainsway Ltd., Jerusalem, Israel)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Soroka University Medical Center
Virtual Reality, Intensive Care Unit Acquired Weakness
The Effects of Virtual Reality in Intensive Care Patients
Weakness of respiratory muscles delays weaning from the ventilator, prolongs hospital stay and increases treatment costs. Conventional treatments for respiratory muscles reverse these negative effects.
- Trial name
- NCT06442254
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istinye University
Muscle Atrophy or Weakness, Ventilator-associated Lung Injury
Serial Daily Diaphragm Ultrasounds in Ventilated Patients
When a person is put on a breathing machine the investigators think that the breathing muscles can get weaker. The investigators are not sure how quickly this happens but in some people this leads to problems when they try to…
- Trial name
- NCT02174029
- Testing
- Ventilation- mandatory, Ventilation- voluntary mode only, Voluntary with preceding mandatory
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- Steve Reynolds
Stroke, Upper Extremity Paresis
Comparative Effects of Action Observation and Motor Imagery on Upper Limb in Chronic Stroke Patients
To Compare effects of action observation and motor imagery training on upper limb function in chronic stroke patients.
- Conditions
- Stroke, Upper Extremity Paresis, Motor Activity
- Trial name
- NCT06108440
- Testing
- action observation training, motor imagery training
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Copd, Inspiratory Muscle Weakness
Effects of Inspiratory Muscle Training on Shortness of Breath (Dyspnea) and Postural Control in Patients With COPD
Shortness of breath (dyspnea) is an important symptom during physical exertion in patients with chronic obstructive pulmonary disease (COPD) and is related to respiratory muscle weakness. Dyspnea is a multidimensional sensation.
- Trial name
- NCT03240640
- Testing
- Inspiratory Muscle Strength Training, Inspiratory Muscle Endurance Training
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- KU Leuven
Anterior Cruciate Ligament Injuries, Atrophy
Effect of Blood Flow Restriction Training on Patient With Anterior Cruciate Ligament Reconstruction
This study investigates the effects of plyometric training with blood flow restriction on muscular strength, quadriceps thickness and knee joint function in patients with muscle weakness and atrophy (quadriceps muscle and…
- Conditions
- Anterior Cruciate Ligament Injuries, Atrophy, Muscle Weakness
- Trial name
- NCT04284748
- Testing
- Plyometric exercise with blood flow restriction, Plyometric exercise, Routine physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Stroke, Hemiparesis
Late LTP-like Plasticity Effects of tDCS in Chronic Stroke Patients
Rationale: About 80% of stroke patients suffer motor impairments, but current therapies have limited effects on motor recovery. Therefore, investigating new potential therapeutic approaches is crucial.
- Trial name
- NCT02399540
- Testing
- Conventional Paired tDCS, Conventional Unpaired tDCS, Late LTP-like Plasticity tDCS
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- Erasmus Medical Center
Myasthenia Gravis, Generalized
Study of Telitacicept in Generalized Myasthenia Gravis
The purpose of this study is to evaluate the efficacy and safety of Telitacicept in the treatment of patients with generalized myasthenia gravis.
- Trial name
- NCT05737160
- Testing
- Telitacicept
- Where
- 51 sites in China
- Volunteers
- 114 people
- Sponsor
- RemeGen Co., Ltd.
Low Back Pain, Rehabilitation Program
Oxygenation of Paravertebral Muscles During Exercise in Chronic Low Back Pain Patients
The study evaluate paraspinal aerobic metabolism of chronic low back pain patients and healthy people during an original and standardized isokinetic protocol.
- Conditions
- Low Back Pain, Rehabilitation Program, Muscular Weakness
- Trial name
- OXYLOM (NCT03055182)
- Testing
- Physical rehabilitation program
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Chronic Stroke, Weakness, Muscle
Use of Hand-held Dynamometry to Obtain Objective Measures of Lower Extremity Force Production With Chronic Stroke
This study wants to know if using handheld dynamometry (HHD) to test leg strength in persons who have had a stroke, will reduce mistakes and give therapists better information to use for therapy.
- Trial name
- NCT05941962
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Septic Shock
Muscle Ultrasound Study in Shock Patients
Intensive Care Unit (ICU) patients are known to lose muscle mass and function for many reasons, ranging from prolonged immobilization, to the effects of ICU treatments such as mechanical ventilation (MV), to the critical illness…
- Trial name
- MUSiShock (NCT04550143)
- Testing
- Diaphragm ultrasound (DUS), Peripheral Muscle Ultrasound (PMUS), Airway occlusion pressure (P0.1)
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Covid19, Muscle Atrophy
Electrical Stimulation for Critically Ill Covid-19 Patients
Unfortunately, hospital-acquired weakness is highly prevalent among COVID-19 hospitalized patients, who often require prolonged bed-rest or paralytics for an extended period of time in order to maintain oxygenation.
- Conditions
- Covid19, Muscle Atrophy, Muscle Weakness
- Trial name
- Phase I (NCT04685213)
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine