Clinical trials: Muscular Weakness
Respiratory Muscle Weakness, Mechanical Ventilation Weaning
Progressive Pressure Support Reduction as Inspiratory Muscle Endurance Training in Mechanically Ventilated Patients
Mechanical ventilation causes rapid diaphragm muscle atrophy, detectable within 18 hours of ventilator support, which is a major contributor to weaning failure and prolonged ICU stay.
- Conditions
- Respiratory Muscle Weakness, Mechanical Ventilation Weaning, Physiotherapy, Endurance Training
- Trial name
- inspira-rct (NCT07689110)
- Testing
- Progressive Pressure Support Reduction (IRT-PS), Standard ICU Care
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
End Stage Liver Disease
Evaluation of Frailty and Functional Capacity in End-Stage Liver Disease
Development of fibrosis plays a main role in the pathophysiology of liver diseases. The rate of progression in fibrogenesis varies according to the type of underlying liver disease and varies with the environment and host-related…
- Trial name
- NCT04220723
- Testing
- Frailty Assessment, Functional Capacity Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Neuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness
Effects of Neuromuscular Electrical Stimulation on Muscle Mass and Strength in Critically Ill Patients After Cardiothoracic Surgery
The purposes of this study are 1) to determine whether neuromuscular electrical stimulation (NMES) is effective in preventing loss of muscle mass and strength and 2) to observe the time variation of MLT and strength from…
- Conditions
- Neuromuscular Electrical Stimulation, Intensive Care Unit Acquired Weakness, Muscle Wasting, Muscle Loss
- Trial name
- Catastim 2 (NCT02391103)
- Testing
- Compex 3 Professional (CefarCompex Medical AB) stimulator
- Volunteers
- 54 people
- Sponsor
- Medical University of Vienna
Cerebrovascular Stroke, Muscle Weakness
Cold Therapy and Cross-Education of Muscle Strength
The aim of this study is to investigate whether a cold application to the contralateral (affected side) extremity in addition to unilateral neuromuscular electrical stimulation (NMES) application has a facilitating effect on…
- Trial name
- NCT04886843
- Testing
- Cold pack, NMES
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Critical Illness Myopathy
Rehabilitation Following Critical Illness
The principal research question to be answered by this study is whether an exercise based rehabilitative intervention following critical illness can generate improvements in exercise capacity and quality of life beyond current…
- Trial name
- NCT00976807
- Testing
- Pulmonary Rehabilitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Respiratory Muscle Weakness
Effects of Respiratory Muscle Training in Mechanically Ventilated Adults
Respiratory muscle training (RMT) is considered a therapeutic strategy to improve respiratory muscle strength in mechanically ventilated (MV) patients and facilitates ventilator weaning.
- Trial name
- RMTMVA (NCT02469064)
- Testing
- Respiratory muscle training, Cardiopulmonary Physical Therapy
- Volunteers
- 126 people
- Sponsor
- Fundacion Clinica Valle del Lili
Type 2 Diabetes Mellitus With Complication
Comparing Effects of HIIT and MICT on Functional Mobility, Muscle Strength, and Quality of Life in Diabetic Patients
To compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) on functional mobility, muscle strength, and quality of life in individuals with type-2-diabetes.
- Trial name
- NCT07484399
- Testing
- High Intensity Interval Training, Moderate Intensity Continuous Training
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Muscle Soreness, Muscle Weakness
Lumbosacral Muscle Sensitivity & Pressure Pain Threshold After Kettlebell Swings
The primary purpose of the study is to assess the muscle contractility and sensitivity of lumbar erector spinae, biceps femoris, and gluteus maximus short-term response to Tabata kettlebell swing protocol.
- Conditions
- Muscle Soreness, Muscle Weakness, Muscle Tenderness
- Trial name
- NCT05607212
- Testing
- Kettlebell Swing, Isometric Hold, Control
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Pelvic Floor Dysfunction, Pelvic Floor Muscle Weakness
Ultrasound and Electromyography Biofeedback for Pelvic Floor Muscle Training
This study aims to investigate the factors influencing adherence to pelvic floor muscle training (PFMT) devices among patients with pelvic floor dysfunction (PFD) through structured questionnaires, while simultaneously comparing…
- Trial name
- NCT07243028
- Testing
- Ultrasound Biofeedback Device, Manometer Biofeedback Device
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Cheng-Kung University Hospital
Patellofemoral Pain Syndrome
Muscle Strength Loss and Its Effect on Knee Cap Motion in Volunteers With Anterior Knee Pain
Background: Researchers are interested in how the muscles affect the movement of the knee cap. These muscles may be related to different kinds of knee pain that are not caused by an injury or a disease.
- Trial name
- NCT01862731
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Polyneuropathy
Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences.
Even 20-50% of patients under sedation and mechanical ventilation develops myopathy and / or neuropathy which difficulties both the process of extubation and the functional recovery.
- Trial name
- NCT02033057
- Testing
- Muscular electrostimulation and percutaneus muscular biopsy.
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital Universitario La Fe
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Chronic Obstructive Pulmonary Disease
Involvement of Nervous System in Muscle Weakness in COPD Patients
The purpose of this study is to determine whether nervous system alterations and motor drive failure can contribute to muscle weakness in COPD during voluntary movement.
- Trial name
- DesCoM-1 (NCT01679782)
- Where
- France
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- 5 Santé
Muscle Weakness, Angiogenesis
Interactive Hand Exercise Game on Grip Strength and Vascular Maturation
Hemodialysis is currently the most commonly used renal replacement therapy. Compared with arteriovenous graft, central venous catheter, and autologous arteriovenous fistula, the possibility of postoperative re-dredging is low and…
- Trial name
- NCT05493046
- Testing
- Interactive Hand Exercise Game, Soft ball exercise ( routine care)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University
ACL Reconstruction, ACL Surgery
Post Operative Use of Neuromuscular Electrical Stimulation (NMES) Device for ACLR Patients
This study is being conducted to learn about how neuromuscular electrical stimulation (NMES) in addition to standard of care aids in the recovery of muscle strength in patients undergoing ACLR procedure.
- Conditions
- ACL Reconstruction, ACL Surgery, ACL Injury, Electrotherapy
- Trial name
- NCT07171346
- Testing
- Zynex NexWave Electrotherapy Device
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Kansas Medical Center
Muscle Weakness | Patient, Pain
A Prospective Analysis of Preoperative Fascia Iliaca Block for Hip Arthroscopy
Patients undergoing arthroscopic hip surgery have been shown to have significant post-operative pain that may delay discharge, recovery, and early mobilisation.
- Trial name
- NCT02623361
- Testing
- Peripheral Nerve Block
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Francisco
Ankle Disease, Muscle Weakness
Gluteal Musculature Activation to Improve Ankle Stability
The goal of this observational study is to to evaluate and correlate muscle activation in the gluteal musculature and ankle stability in a healthy population.
- Trial name
- TOBEMG (NCT06114654)
- Testing
- Physical Therapy
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Pediatric Burns, Burn Injury
Plyometrics for Strength and Function After Pediatric Burns
Pediatric burn survivors may experience persistent deficits in lower-limb strength, explosive power, and functional performance after hospital discharge.
- Conditions
- Pediatric Burns, Burn Injury, Post-Burn Rehabilitation, Rehabilitation
- Trial name
- NCT07590557
- Testing
- Plyometric Training, Standard Exercise Program
- Where
- Saudi Arabia
- Volunteers
- 62 people
- Sponsor
- Qassim University
Increased Lordosis/Scoliosis, Hyporeflexia
Biomarker for Duchenne Muscular Dystrophy
International, multicenter, observational, longitudinal study to identify biomarker/s for Duchenne Muscular Dystropy (DMD) and to explore the clinical robustness, specificity, and long-term variability of these biomarker/s.
- Conditions
- Increased Lordosis/Scoliosis, Hyporeflexia, Duchenne Muscular Dystrophy, Red-Green Color Blindness
- Trial name
- BioDuchenne (NCT02994030)
- Where
- 12 sites in Albania, Egypt and 6 more
- Volunteers
- 103 people
- Sponsor
- CENTOGENE GmbH Rostock
General Anaesthesia, Muscle Weakness
Electromagnetic Stimulation of the Phrenic Nerve of Intubated Patients
Ventilator-induced diaphragmatic dysfunction is a common issue in critically ill patients. Muscle stimulation has shown to have beneficial effects in muscle groups on the extremities.
- Trial name
- STIMIT-I (NCT04946110)
- Testing
- Electromagnetic stimulation
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- Charite University, Berlin, Germany