Clinical trials: Muscular Weakness, open to volunteers
Intensive Care Unit Acquired Weakness, Critical Illness
Locomotor Muscle Oxygenation and Activation During Acute Interval Compared to Constant-load Bed-cycling Exercise
Up to 60% of patients admitted to the Intensive Care Unit (ICU) with a prolonged stay in the ICU develop complications such as intensive care unit acquired weakness (ICUAW) characterized by limb and respiratory muscle weakness.
- Trial name
- NCT05279547
- Testing
- Constant-load bed-cycling exercise, Interval bed-cycling exercise
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Primary Mitochondrial Disease
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
The primary objective of the FALCON study is to evaluate the efficacy of KL1333 on selected disease manifestations of primary mitochondrial disease (PMD) following 48 weeks of treatment.
- Trial name
- FALCON (NCT05650229)
- Testing
- KL1333
- Where
- 55 sites in United States, Australia and 9 more
- Volunteers
- 180 people
- Sponsor
- Pharming Technologies B.V.
Aging, Muscle Atrophy or Weakness
C-Protein in Fatigue and Aging
This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.
- Conditions
- Aging, Muscle Atrophy or Weakness, Sarcopenia in Elderly, Sarcopenia
- Trial name
- NCT05926219
- Testing
- Fatiguing Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Neuromuscular Disorders
Bidirectional Tuning of the AFO Stiffness
The goal of this pilot study with a pre-post design is to investigate the effects of separate individualization of the AFO stiffness towards plantar- and dorsiflexion in a spring-hinged AFO on walking compared to a spring-like…
- Trial name
- NEUROSWING (NCT06412055)
- Testing
- NEURO SWING AFO (Fior& Gentz, Lüneburg, Germany), WalkOn Reaction® (Ottobock, Duderstadt), Matrix Max2® (TruLife, Dublin, Ireland)
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Muscle Atrophy or Weakness
Metformin and Muscle Recovery
A hallmark of aging is an impaired ability to adequately recover following a stressor, such as muscle disuse, resulting in muscle fibrosis and weakness thereby increasing the risk for falls and loss of independence.
- Trial name
- NCT06185179
- Testing
- Metformin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Utah
Muscle Weakness, Pain, Postoperative
Depo-Medrol on Psoas After LLIF
The goal of this study is to determine the effects of a corticosteroid administered to the psoas muscle following a transpsoas lateral lumbar interbody fusion (LLIF) on postoperative hip flexor weakness and thigh pain and…
- Conditions
- Muscle Weakness, Pain, Postoperative, Paresthesia, Pain, Muscle
- Trial name
- NCT05929755
- Testing
- Depo-Medrol, Gel-Flow NT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hardeep Singh
Intensive Care Unit Acquired Weakness, Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)
Functional Assessment in Critically Ill Patients
This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx).
- Trial name
- NCT07191743
- Where
- Brazil
- Volunteers
- 186 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Critical Illness, Sarcopenia
Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors
Older ICU survivors with ICU acquired weakness (ICUAW) are malnourished, sarcopenic, and functionally debilitated as a consequence of the high burden of comorbidities common in the elderly.
- Conditions
- Critical Illness, Sarcopenia, ICU Acquired Weakness
- Trial name
- ProMoTE (NCT05326633)
- Testing
- MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Maryland, Baltimore
Shoulder Pain
PREVALENCE OF SCAPULAR DYSKINESIS
Objective: This study will aim to determine the prevalence of scapular dyskinesis (SD) among Egyptian physical therapy practitioners and will explore associated epidemiological factors, including age, sex, BMI, shoulder and neck…
- Trial name
- NCT07123532
- Where
- Egypt
- Volunteers
- 121 people
- Sponsor
- Cairo University
Muscle Weakness, Problems Moving Their Arms and Legs
Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults
People with cerebral palsy (CP), muscular dystrophy (MD), spina bifida, or spinal cord injury often have muscle weakness, and problems moving their arms and legs.
- Trial name
- NCT06998134
- Testing
- Extension assist knee ankle foot orthosis (EA-KAFO)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Duchenne Muscular Dystrophy With Mutations Amenable to PBGENE-DMD
PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular Dystrophy (FUNCTION-DMD)
The purpose of this Phase 1/2a trial is to evaluate the safety, tolerability, and preliminary efficacy of PBGENE-DMD in patients with DMD harboring mutations amenable to excision of exons 45-55.
- Trial name
- NCT07429240
- Testing
- PBGENE-DMD (IV)
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Precision BioSciences, Inc.
Intensive Care Unit Acquired Weakness
Blood Flow Restriction Training for Mechanically Ventilated Patients With ICU-Acquired Weakness
Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop ICU-acquired weakness - a condition marked by widespread muscle loss and weakness caused by prolonged bed rest, severe illness, and…
- Trial name
- BFRT-ICU (NCT07802743)
- Testing
- Blood flow restriction training, Standard ICU Care and Routine Rehabilitation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital of Jining Medical University
Resistance Exercise, Muscle Weakness
Effects of Elastic Band Resistance Exercise on Muscle Strength and Depression in Hospitalized Elderly.
With improved a five-day intensive, low-resistance elastic band exercise program to evaluate its effectiveness in improving total muscle mass, upper and lower extremity muscle strength, self-perceived fear of falling, and…
- Conditions
- Resistance Exercise, Muscle Weakness, Functional Decline
- Trial name
- NCT06205147
- Testing
- Elastic Band
- Where
- Taiwan
- Volunteers
- 62 people
- Sponsor
- National Taiwan University
MULTIPL SCLEROSİS
Comparison of Frailty, Physical Fitness Parameters, and Irisin Levels Between Patients With Multiple Sclerosis and Healthy Volunteers
Multiple Sclerosis (MS) is a chronic immune-mediated and neurodegenerative disease of the central nervous system that often affects young adults and is more common in women.
- Trial name
- NCT07521982
- Where
- Turkey (Türkiye)
- Volunteers
- 782 people, healthy volunteers welcome
- Sponsor
- Baskent University
Childhood Cancer, Muscle Weakness
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors
The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and…
- Trial name
- NCT06819475
- Testing
- Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Physical function assessment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Alzheimer Disease (AD), Sarcopenia
A Study of Silkworm Pupa Powder Intervention in the Nutritional Status of Patients with Alzheimer's Disease.
The goal of this clinical trial is to learn if silkworm pupa powder works to improve the nutritional status of Alzheimer's disease patients.
- Conditions
- Alzheimer Disease (AD), Sarcopenia, Asthenia
- Trial name
- AD (NCT06770309)
- Testing
- Silkworm pupa powder
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yanbu Ke
Sarcopenia, Aging
STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging
The calf muscles (plantarflexors) are the most important muscles for walking, running and daily activities. Weakness of these muscles through aging and disease significantly impact a person's ability to walk and complete daily…
- Conditions
- Sarcopenia, Aging, Muscle Weakness or Atrophy, Frailty
- Trial name
- STRIDE (NCT07726498)
- Testing
- No intervention (observational study)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Motor Deficits, Lumbar Discectomy
Investigation of Preoperative Factors Influencing the Outcome of Motor Deficits in Patients Undergoing Lumbar Microdiskectomy
Lumbar disc herniations may result in lower limb weakness. In such cases, there is a strong indication for surgical intervention through microdiscectomy.
- Conditions
- Motor Deficits, Lumbar Discectomy, Muscle Weakness, Paresis
- Trial name
- NCT07413302
- Where
- 3 sites in Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Sepsis, Critical Illness
MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients
The goal of this clinical trial is to learn if a new medical device that sends electrical signals to the thigh muscles is safe and easy to use for people in the ICU (Intensive Care Unit) who are at risk of losing muscle strength.
- Conditions
- Sepsis, Critical Illness, ICU-acquired Muscle Weakness, ICU-acquired Weakness
- Trial name
- ICUAW (NCT07362862)
- Testing
- Electrical Muscle Stimulation System
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Health Discovery Labs
Cerebral Palsy (CP), Diaplegia
Effect of Treatment on Cerebral Palsy Patient With Crouch Gait Associated With Anterior Pelvic Tilt and Soleus Muscle Weakness"Marouf Syndrome", and Muscle Assesment by Using EMG
Children with cerebral palsy (CP) often develop gait abnormalities, with crouch gait being a common and challenging issue that affects their posture and daily function.
- Conditions
- Cerebral Palsy (CP), Diaplegia, Muscle Weakness | Patient, Anterior Pelvic Tilt
- Trial name
- NCT07147933
- Testing
- phusical therapy program, physical therapy program
- Where
- Jordan
- Volunteers
- 40 people
- Sponsor
- Philadelphia University, Jordan