Clinical trials: Muscular Weakness, active
Muscle Weakness, Muscle Loss
Physical Activity as Intervention Against Age-related Loss of Muscle Mass and Function
A minimum of 450 healthy individuals (62-70 years old) will be recruited. Each individual will be randomized into one of three groups stratified according to gender (M/F), BMI (≤28/>28), and 30 sec chair stand (≤11/>11).
- Conditions
- Muscle Weakness, Muscle Loss, Sarcopenia, Physical Activity
- Trial name
- LISA (NCT02123641)
- Testing
- Heavy resistance training, Moderate intensity training, Control
- Where
- Denmark
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Weakness, Muscle
Blood Flow Restriction Training for People With Disabilities
A large portion of the American population live with disabilities. People with disabilities can find it difficult to perform standard exercise routines. Regular exercise is necessary to be healthy, especially as people age.
- Trial name
- NCT06441422
- Testing
- Blood flow restriction training, No blood flow restriction training
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Sepsis, Acute Lung Injury(ALI)
Recovery of Physical Function After Critical Illness In Older Adults
The proposed study is a prospective, observational study assessing the recovery of muscle and physical function in patients surviving critical illness (n =150) at hospital discharge (baseline) and repeated serially.
- Trial name
- RETURN (NCT07225257)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Respiratory Muscle Weakness, Quality of Lifte
Effects of a Pulmonary and Cardiovascular Rehabilitation Program
Non-communicable chronic diseases (NCDs) affect approximately 30% of the adult global population, significantly impacting respiratory function and quality of life.
- Conditions
- Respiratory Muscle Weakness, Quality of Lifte, Dyspnea; Asthmatic, Dyspnea; Cardiac
- Trial name
- NCT06772922
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- University of Campinas, Brazil
Motor Disorders, Gait Disorders, Neurologic
Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult Population
In 2019, approximately 2.4 billion people worldwide required rehabilitation for various health pathologies, a 63% increase since 1990.
- Conditions
- Motor Disorders, Gait Disorders, Neurologic, Neurodegenerative Diseases, Spinal Cord Injuries
- Trial name
- ALERT (NCT06538974)
- Testing
- Hands-free exoskeleton
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Wandercraft
Sarcopenia, Aging
Effects of Functional Task Training on Muscle Health and Function in Older Adults With Sarcopenia
Sarcopenia is a condition associated with aging that causes a loss of muscle mass, strength, and physical function. This decline limits the ability to perform basic daily activities and increases the risk of falls and dependency.
- Conditions
- Sarcopenia, Aging, Physical Functional Performance, Muscle Weakness | Patient
- Trial name
- NCT07494916
- Testing
- Functional Task Training in Power Zones, Standard Functional Task Training, Traditional Resistance Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad de Granada
Critical Illness Myopathy
NLRP3 Inflammasome and Physical Therapy in ICU-Acquired Weakness
The goal of this clinical trial is to study whether physical therapy can reduce NLRP3 inflammasome activation and muscle atrophy in patients with critical illness myopathy (CIM).
- Trial name
- PT-NLRP3-CIM (NCT07017517)
- Testing
- Motomed Letto® servo-assisted cycling + standard physiotherapy, Standard physiotherapy
- Where
- 3 sites in Chile
- Volunteers
- 24 people
- Sponsor
- University of Chile
Pompe Disease
Phrenic Nerve and Diaphragm Electrophysiology in Pompe Disease
Pompe disease is traditionally considered a lysosomal myopathy. However, increasing experimental and clinical evidence suggests involvement of the entire motor unit, including motor neurons, peripheral nerves, neuromuscular…
- Trial name
- NCT07664930
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Ventilator Weaning
Instrumental Respiratory Physiotherapy in Difficult-to-wean ICU Patients
Difficult ventilatory weaning is associated with a 20% mortality rate. 40% of these patients will develop intensive care unit (ICU)-acquired neuromyopathy, associated with reduced cough strength and a 4-fold increase in the risk…
- Trial name
- PHYSIO WEAN (NCT06499389)
- Testing
- Systematic and early intensive instrumental respiratory physiotherapy for patients undergoing difficult ventilatory weaning, Protocolized standard-of-care respiratory physiotherapy
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Muscle Damage, Muscle Strength
HIFEM and Radiofrequency for Muscular System Function Improvement
The goal of this clinical trial is to investigate the effect of the BTL-899M device on muscular system function in adult subjects seeking treatment for improving their muscular system function in the lower extremities.
- Conditions
- Muscle Damage, Muscle Strength, Muscle Weakness
- Trial name
- NCT06703749
- Testing
- Treatment with BTL-899M, Treatment with BTL-899M with intensities below therapeutic threshold
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Neuromuscular Diseases
Measuring Physical Activity With ActivPal
This study measures the level of physical activity in participants with neuromuscular disorders. The patient wears a small button like meter on their leg for a period of 1 week every 6 months over a period of 3 years.
- Trial name
- Activpal (NCT06084026)
- Testing
- ActivPal
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Columbia University
Severe Stroke or Similar Neurological Muscle Weakness
Mobility Training Using Exoskeletons for Functional Recovery After Stroke
The purpose of this study is to assess the safety and effectiveness of the Ekso robotic exoskeleton in persons affected by a severe stroke.
- Trial name
- NCT02128152
- Testing
- Ekso exoskeleton
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shirley Ryan AbilityLab
Cardiac Surgery, Muscle Weakness | Patient
Pulmonary Function, Muscle Strength, and Functional Capacity in Minimally Invasive Cardiac Surgery
The goal of this observational study is to evaluate pulmonary function, respiratory muscle strength, peripheral muscle strength, and functional capacity in adult patients undergoing either minimally invasive cardiac surgery (via…
- Conditions
- Cardiac Surgery, Muscle Weakness | Patient, Pulmonary Function, Functional Capacity
- Trial name
- NCT07172529
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Zehra Can Karahan
Metabolomics, Critical Care
Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness
In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation.
- Conditions
- Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy
- Trial name
- MIRACLE I (NCT03810768)
- Where
- 3 sites in Austria, Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Arthropathy of Hip, Hip Arthropathy
Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach.
- Conditions
- Arthropathy of Hip, Hip Arthropathy, Locoregional Anesthesia, Complication of Anesthesia
- Trial name
- Peng_lfcn/WI (NCT07284615)
- Testing
- PENG plus LFCN block, PENG plus WI
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Ospedale Edoardo Bassini
Myopathy, Muscle Weakness
Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle Disease
Visits to the emergency department (ED) for chest pain are extremely common and require a safe, rapid and efficacious treatment algorithm to exclude a possible AMI.
- Conditions
- Myopathy, Muscle Weakness, Muscle Damage, Muscle Spasticity
- Trial name
- H&M (NCT03660969)
- Where
- 5 sites in Austria, Switzerland
- Volunteers
- 797 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Obstructive Pulmonary Disease (COPD), Respiratory Muscle Dysfunction
Multimodal Assessment of NMES Effects on Respiratory and Peripheral Muscles in COPD
The goal of this clinical trial is to learn if targeted neuromuscular electrical stimulation (NMES) can treat respiratory and peripheral muscle weakness in patients with chronic obstructive pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Respiratory Muscle Dysfunction, Muscle Weakness
- Trial name
- NMES in COPD (NCT07910006)
- Testing
- Neuromuscular Electric Stimulation, Exercise
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Universitas Padjadjaran
Intensive Care Unit Acquired Weakness
Blood Flow Restriction Training for Mechanically Ventilated Patients With ICU-Acquired Weakness
Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop ICU-acquired weakness - a condition marked by widespread muscle loss and weakness caused by prolonged bed rest, severe illness, and…
- Trial name
- BFRT-ICU (NCT07802743)
- Testing
- Blood flow restriction training, Standard ICU Care and Routine Rehabilitation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital of Jining Medical University
Obesity, Insulin Sensitivity
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity.
- Conditions
- Obesity, Insulin Sensitivity, Muscle Weakness, Adiposity
- Trial name
- NCT06129110
- Testing
- Diet Weight Loss
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Muscle Weakness, Critical Illness Myopathy
CPAx: Responsiveness and Minimal Clinically Important Difference
Intensive care unit (ICU) acquired weakness is a common complication associated with long-term physical impairments in survivors of a critical illness.
- Conditions
- Muscle Weakness, Critical Illness Myopathy, Critical Illness Polyneuropathy, Critical Illness Polyneuromyopathy
- Trial name
- NCT06419699
- Where
- 3 sites in Australia, Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern