Clinical trials: Musculoskeletal Cancers
Rheumatoid Arthritis
Efficacy and Safety of Olokizumab With Rheumatoid Arthritis With Previously Failed to Anti-tumor Necrosis Factor (Anti-TNF) Therapy
The primary objective of this study is to evaluate the efficacy and safety of CDP6038 administered subcutaneous (sc) at various doses compared to placebo.
- Trial name
- NCT01463059
- Testing
- Olokizumab 60 mg, Olokizumab 120 mg, Olokizumab 240 mg
- Where
- 39 sites in Japan, South Korea and 1 more
- Volunteers
- 119 people
- Sponsor
- UCB Japan Co. Ltd.
Breast Cancer, Bone Diseases
Ph I/II of Vitamin D on Bone Mineral Density & Markers of Bone Resorption
Aromatase inhibitors are potent suppressors of breast cancer growth, but side effects include bone loss, fractures, arthralgias and myalgias.
- Trial name
- NCT00904423
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mark Pegram
Multiple Myeloma, Disease of the Marrow
Evaluation of PET/MR and PET/CT Imaging for Bone Marrow Lesions
Developing an MRI protocol at 1.5 T allowing quantification of the hematopoietic, fatty and trabecular moieties of marrow. An ideal protocol would differentiate red marrow from neoplastic cellular infiltration, and detect loss of…
- Conditions
- Multiple Myeloma, Disease of the Marrow, Osteoporosis
- Trial name
- NCT01880762
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Osteosarcoma Metastatic, Ewing's Sarcoma Metastatic
BIO-11006 for Osteosarcoma and Ewing's Sarcoma Lung Metastases
This is a Phase 2 study of an investigational drug, BIO-11006, for the treatment of lung metastases in pediatric patients with advanced osteosarcoma or Ewing's sarcoma.
- Trial name
- NCT04183062
- Testing
- Chemotherapy (gemcitabine & docetaxel) plus BIO-11006
- Where
- United States
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Skull Base Neoplasms
ICG Use in Angiography for Nasoseptal Flap Harvest
This is a feasibility study in which indocyanine green (ICG) will be administered during routine expanded endonasal approach (EEA) for cranial base pathologies in which a nasoseptal flap harvest will be necessary.
- Trial name
- ICG (NCT02117310)
- Testing
- indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Ohio State University
Orbital Tumor
MRI Perfusion Curves Typology and Orbital Tumors (PERFORM)
Orbital masses develop at the expense of the orbital structures lacrimal glands, oculomotor muscles, optic nerve, meningeal spaces, peripheral nerves, bone wall, orbital fat, lymphoid structures or vascular structures.
- Trial name
- PERFORM (NCT02434120)
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Malignant Bone Neoplasm
Supervised Exercise in Improving Physical Fitness Before Surgery in Patients With Resectable Bone Cancer
This clinical trial studies how well supervised exercise works in improving physical fitness before surgery in patients with bone cancer that can be removed by surgery.
- Trial name
- NCT02893397
- Testing
- Activity Monitor, Exercise Intervention
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- M.D. Anderson Cancer Center
Mandible Tumor, Mandibular Injuries
Evaluation of EpiBone-CMF for Mandibular Ramus Reconstruction
EpiBone-Craniomaxillofacial (EB-CMF) is an autologous, anatomically shaped bone graft created specifically for the patient's defect, using the patients own adipose-derived mesenchymal stem cells.
- Conditions
- Mandible Tumor, Mandibular Injuries, Mandible; Deformity
- Trial name
- EB-CMF (NCT03678467)
- Testing
- EB-CMF
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Epibone, Inc.
Liver Cancer (Primary and Metastatic), Lung Cancer (Diagnosis)
Registry of Minimally Invasive Cancer Treatment Using Spectral Angio-CT Image Guidance
This study collects data from patients undergoing minimally invasive, image-guided cancer treatments at participating hospitals in the Netherlands and France.
- Conditions
- Liver Cancer (Primary and Metastatic), Lung Cancer (Diagnosis), Bone Cancer Metastatic, Bone Cancer Tumor
- Trial name
- PreciseOnco (NCT07636148)
- Where
- 3 sites in France, Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Mark C Burgmans, MD PhD
Sarcoma
An Adequate Cost Effective Follow Up Protocol For Bone & Soft Tissue Sarcomas - A Prospective Randomized Trial
The purpose of this study is to evaluate the impact on overall survival of an intensive follow-up protocol (as practiced today at TMH) against a more cost effective follow-up protocol in patients operated for extremity sarcoma.
- Trial name
- TOSS (NCT00384735)
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Terry Fox Foundation
Quality of Life, Ichthyosis
Qualitative Study in Patients With Genodermatoses and Healthcare Professionals on Reproductive Counselling
The goal of this observational study is to understand the perspectives and needs of patients with genodermatoses and their partners who wish to have children, regarding their decision-making process and their consideration of…
- Conditions
- Quality of Life, Ichthyosis, Palmoplantar Keratoses, Epidermolysis Bullosa
- Trial name
- NCT06330350
- Testing
- Qualitative interview
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht University Medical Center
Breast Neoplasm Female, Arthralgia
Pilot Observational Study Examining the Effect of Endocrine Therapy on Aging
The goal of this pilot observational study is to learn about the feasibility of collecting patient-reported data and stool and blood samples from patients age 65 and older treated with aromatase inhibitor therapy for breast…
- Conditions
- Breast Neoplasm Female, Arthralgia, Aging
- Trial name
- BETA (NCT05700006)
- Testing
- Aromatase inhibitor
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Michigan
Pigmented Villonodular Synovitis
Screening of Specific Genes for Pigmented Villous Nodular Synovitis
This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions.
- Trial name
- NCT04955535
- Testing
- Arthroscopic synovectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Brain Tumor, Spinal Stenosis
Heparin Solution and INTEM/HEPTEM Analysis
Heparinized solution has been used for maintenance of arterial catheter during perioperative period. Although the infused dose of heparin is very low, the investigators examine whether the heparin effect is remained or not in…
- Conditions
- Brain Tumor, Spinal Stenosis, Cerebral Artery Anuerysm
- Trial name
- NCT01522846
- Testing
- Heparin
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Seoul National University Bundang Hospital
Subchondral Cyst
Knee Related Subchondral Bone Lesions Treated With IOBP
The study will be a prospective, multicenter clinical study evaluating clinical and patient reported outcome measures of subjects receiving IOBP® surgical technique using Angel cPRP and BMA processing system to treat subchondral…
- Trial name
- IOBP (NCT05314608)
- Testing
- IntraOsseous BioPlasty® (IOBP®) Surgical Technique into the knee
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Arthrex, Inc.
Rheumatoid Arthritis
Safety Study of Remsima® (Infliximab) in Rheumatoid Arthritis Patients in Jordan
The purpose of this observational study is to assess the safety and effectiveness of biosimilar Infliximab in patients with rheumatoid arthritis(RA) in Jordan where no visits or intervention(s) additional to the daily practice…
- Trial name
- PASSRRA (NCT03348046)
- Testing
- Biosimilar Infliximab
- Where
- 2 sites in Jordan
- Volunteers
- 22 people
- Sponsor
- Hikma Pharmaceuticals LLC
Basal Cell Nevus Syndrome
Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas in Gorlin Syndrome Patients
Multicenter, double-blind, randomized, vehicle-controlled study that evaluates the efficacy and safety of patidegib gel 2% and 4% in comparison with vehicle in participants at least 18 years of age that meet the diagnostic…
- Trial name
- NCT02762084
- Testing
- Patidegib, Vehicle gel
- Where
- 2 sites in United Kingdom
- Volunteers
- 17 people
- Sponsor
- PellePharm, Inc.
Bone Cancer
Sodium Fluoride PET/CT for the Evaluation of Skeletal Cancer
This clinical trial studies fluorine F-18 sodium fluoride positron emission tomography (PET)/computed tomography (CT) in diagnosing bone tumors in patients with cancer.
- Trial name
- NCT01541358
- Testing
- fluorine F 18 sodium fluoride, positron emission tomography/computed tomography
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Stanford University
Bone Cancer, Bone Diseases
Massive Implants the Next Generation
The study will review the use of massive segmental replacements in the femur, which have a porous collar with and without HA, and autologous stem cell augment. This is a randomised controlled trial.
- Trial name
- MING (NCT03905174)
- Testing
- custom made device
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Iva Hauptmannova
Basal Cell Carcinoma
Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)
This 22 week study will assess the efficacy, safety, and tolerability of LDE225 versus vehicle when applied topically to basal cell carcinoma (BCC) in patients with NBCCS. Patients will treat multiple BCCs for up to 12 weeks.
- Trial name
- NCT03070691
- Testing
- LDE225B, Vehicle
- Where
- 35 sites in Belgium, Canada and 8 more
- Sponsor
- Novartis Pharmaceuticals
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