Clinical trials: Musculoskeletal Cancers
Non-small Cell Lung Cancer, Breast Cancer
Explore the Individual Treatment of Docetaxel and Paclitaxel in NSCLC, NPC and BRC by PK-guided Dosing Strategy
As cytotoxic agents, DTX and PTX have a narrow therapeutic window. BSA dosing leads to great inter-individual PK variability, which is a major contributor for severe toxicity, especially in East-Asian populations.
- Conditions
- Non-small Cell Lung Cancer, Breast Cancer, Nasal Cancer
- Trial name
- NCT01891123
- Testing
- PK guided arm, PTX 175mg/m2, DOC 75mg/m2
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Thoracotomy, Erector Spinae Plane Block
Efficacy of Ipsilateral High Thoracic Ultrasound-guided Erector Spinae Plane Block in Thoracic Cancer Surgeries
To evaluate the effectiveness of ultrasound guided Erector Spinae Plane Block (ESPB) in controlling post thoracotomy ipsilateral shoulder pain.
- Conditions
- Thoracotomy, Erector Spinae Plane Block, Thoracic Cancer, Shoulder Pain
- Trial name
- NCT05238688
- Testing
- Thoracic Epidural Analgesia (TEA) group, Thoracic Epidural Analgesia and Erector Spinae Plane Block (ESPB) group
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Cairo University
Arthritis, Rheumatoid
Effect of Subcutaneous Polyvidone Collagen Treatment on Hand Recovery in Adult Rheumatoid Arthritis.
A study in geriatric rheumatology on the treatment of rheumatoid arthritis (RA) in older adults is described. Its objective is to compare the effects of subcutaneous polyvidone collagen versus placebo, analyzing clinical…
- Trial name
- NCT06656169
- Testing
- Subcutaneous polyvidone collagen, saline solution
- Where
- 2 sites in Mexico
- Volunteers
- 25 people
- Sponsor
- Instituto Mexicano del Seguro Social
Transitional Cell Carcinoma of Bladder
PF-03446962 in Relapsed or Refractory Urothelial Cancer
Salvage chemotherapy for advanced urothelial cancer (UC) yields suboptimal response rates of 15-40%, a median progression-free survival of 2-4 months and a median overall survival of 6 months.
- Trial name
- NCT01620970
- Testing
- PF03446962
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Alpha-Thalassemia, Beta-Thalassemia
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
FLOWER is a completely virtual, nationwide, real-world observational study to collect, annotate, standardize, and report clinical data for rare diseases.
- Conditions
- Alpha-Thalassemia, Beta-Thalassemia, Amyloidosis, Amyotrophic Lateral Sclerosis
- Trial name
- NCT06539169
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- xCures
Bone Cysts
Safety and Tolerability of I-040302 in Children and Young Adults With Solitary Bone Cysts
This is a randomised, controlled, open-label study of a single intralesional administration of I-040302 or a single bone marrow aspirate or a single steroid injection (methylprednisolone).
- Trial name
- NCT00459641
- Testing
- I-040302, Standard of Care
- Sponsor
- Kuros Biosurgery AG
Embolization, Vascular Tumor
Evaluation of a Simple-Prep Controlled Embolic
The objective of this study is to evaluate the safety and effectiveness of the GPX® Embolic Device when used as indicated for embolization requiring distal vessel penetration in 114 subjects in up to 25 investigational sites in…
- Conditions
- Embolization, Vascular Tumor, Renal Angiomyolipoma, Renal Cell Carcinoma
- Trial name
- GPX (NCT06453642)
- Testing
- GPX® Embolic Device
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 114 people
- Sponsor
- Fluidx Medical Technology, Inc.
Breast Neoplasms, Musculoskeletal Pain
Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms
Breast cancer patients who receive endocrine therapy particularly aromatase inhibitors often experience aromatase inhibitors associated symptoms (AIMSS) such as joint and muscle pain along with stiffness and fatigue that can…
- Conditions
- Breast Neoplasms, Musculoskeletal Pain, Arthralgia, Musculoskeletal Diseases
- Trial name
- AIMSS-CARE (NCT07409948)
- Testing
- Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms (AIMSS-CARE)
- Volunteers
- 88 people
- Sponsor
- Addis Ababa University
Rheumatoid Arthritis
Study, Evaluating Pharmacokinetics, Pharmacodynamics, Immunogenicity and Safety Profiles of Rituximab Compared to MabThera® in Patients With Rheumatoid Arthritis
A randomised, double blind, parallel group, multicentre study to compare the pharmacokinetics, pharmacodynamics, immunogenicity and safety of Rituximab (Mabscale LLC, Russia) versus MabThera® in patients with rheumatoid arthritis.
- Trial name
- NCT06175338
- Testing
- Rituximab, MabThera®
- Where
- 12 sites in Russia
- Volunteers
- 208 people
- Sponsor
- Mabscale, LLC
Dupuytren Contracture, Dupuytren Disease of Finger
Safety and Efficacy Study of Collagenase CNT201 Injection for Treatment of Dupuytren's Contracture
This trial is a multicenter, Phase 1/2, study to assess the safety, tolerability, efficacy, PK, and immunogenicity of CNT201 in adult participants with DC (Dupuytren's Contracture).
- Trial name
- NCT07640425
- Testing
- [Step1] CNT201 First-dose, [Step1] CNT201 Low-dose, [Step1] CNT201 Intermediate-dose
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- CONNEXT
Urinary Bladder Neoplasms, Receptors, Fibroblast Growth Factor
A Study of Erdafitinib Intravesical Delivery System in Japanese Participants With Bladder Cancer
The purpose of the study is to determine the tolerability of erdafitinib intravesical delivery system (TAR-210) in Japanese participants.
- Trial name
- TAR-210 (NCT05567185)
- Testing
- Erdafitinib Intravesical Delivery System
- Where
- 4 sites in Japan
- Volunteers
- 5 people
- Sponsor
- Janssen Pharmaceutical K.K.
Bone Neoplasms, Soft Tissue Neoplasms
Investigation Into the Safety and Efficacy of ICG-Labeled Fluorescence Imaging Technology in Guiding the Resection of Bone and Soft Tissue Tumors
Investigate the application protocol, feasibility, and efficacy of indocyanine green (ICG)-assisted near-infrared (NIR) fluorescence-guided resection in bone and soft tissue tumors.
- Trial name
- ICG-BST (NCT06979115)
- Testing
- Indocyanine green (ICG)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Guangdong Provincial People's Hospital
Sarcoma
Translation and Validation of the German Version of the Toronto Extremity Salvage Score (TESS) and Musculoskeletal Tumor Society (MSTS)
The MSTS is an evaluation tool used worldwide to assess physical function in patients with musculoskeletal tumors. The questionnaire has already been successfully translated and validated in Portuguese and Japanese.
- Trial name
- NCT04327908
- Testing
- Questionaire TESS and MSTS
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Spondylolisthesis, Grade 1
A Prospective Analysis of the Efficacy of Allosync Expand and Autograft Bone Graft in Open Lumbar Spinal Fusion
The purpose of this study is to assess the radiographic and clinical outcomes of spinal fusion following use of Allosync Expand and autograft bone graft.
- Trial name
- NCT06415110
- Testing
- Allosync Expand
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Research Source
Exostoses, Multiple Hereditary
Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC
The purpose of this study is to establish the genetic profile of families in British Columbia with HME.
- Trial name
- NCT00473850
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University of British Columbia
Bone Diseases, Breast Neoplasms
Women's Health Initiative (WHI)
To address cardiovascular disease, cancer, and osteoporosis, the most common causes of death, disability, and impaired quality of life in postmenopausal women.
- Conditions
- Bone Diseases, Breast Neoplasms, Cardiovascular Diseases, Colonic Neoplasms
- Trial name
- NCT00000611
- Testing
- hormone replacement therapy, estrogens, progestins
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Breast Cancer, Arthralgia
A Prospective Assessment of Loss of Grip Strength by Baseline BMI in Breast Cancer Patients Receiving Adjuvant Aromatase Inhibitors and Tamoxifen
The Logribmet study is a prospective study that evaluate grip strength changes in both hands of postmenopausal women with breast cancer receiving treatment with tamoxifen or an aromatase inhibitor.
- Trial name
- LOGRIBMET (NCT01223833)
- Where
- Belgium
- Volunteers
- 296 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer
Vitamin D3 for Aromatase Inhibitor Induced Arthralgias
The primary purpose is to determine if high dose vitamin D3 reduces the incidence of musculoskeletal symptoms associated with the aromatase inhibitor letrozole in women with early stage breast cancer and low serum vitamin D…
- Trial name
- VITAL (NCT00867217)
- Testing
- High Dose Vitamin D, Standard Dose Vitamin D3, Letrozole 2.5mg
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Qamar Khan
Arthritis, Rheumatoid
Effectiveness and Safety of Yisaipu Combined With Tripterygium Wilfordii for Active RA
In this 24-week, multi-center, randomized, double-blind study, the investigators will evaluate the efficacy and safety profile of subcutaneously injected Yisaipu, a Tumor Necrosis Factor Receptor Fusion Protein, combined with…
- Trial name
- YISTAR (NCT03589833)
- Testing
- Tripterygium Wilfordii, Methotrexate, Yisaipu
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Peking Union Medical College Hospital
Degenerative Disc Disease, Spondylolisthesis
The European Robotic Spinal Instrumentation (EUROSPIN) Study
In a multinational prospective study, preoperative, intraoperative, perioperative and follow-up data on patients receiving thoracolumbar pedicle screw placement for degenerative disease or infections or tumors will be collected.
- Conditions
- Degenerative Disc Disease, Spondylolisthesis, Spinal Stenosis, Recurrent Disc Herniation
- Trial name
- EUROSPIN (NCT03398915)
- Testing
- Transpedicular Instrumentation
- Where
- 12 sites in Austria, France and 5 more
- Volunteers
- 932 people
- Sponsor
- Marc Schröder