Clinical trials: Musculoskeletal Cancers
Cholangiocarcinoma
A Study of E7090 in Participants With Unresectable Advanced or Metastatic Cholangiocarcinoma With Fibroblast Growth Factor Receptor (FGFR) 2 Gene Fusion
The primary purpose of the study is to assess the objective response rate (ORR) of E7090 by Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 based on independent imaging review (IIR) in participants with unresectable…
- Trial name
- NCT04238715
- Testing
- E7090
- Where
- 56 sites in China, Japan
- Volunteers
- 63 people
- Sponsor
- Eisai Co., Ltd.
Metastatic Bone Tumor
ERAS Anesthetic Care for Metastatic Spine Cancer Resection
Spinal metastases account for 60% of all malignant bone metastases and represent a medically important treatment goal. For patients with malignant tumors diagnosed at this stage, performing En bloc spondylectomy with wide margin…
- Trial name
- NCT05427825
- Testing
- ERAS anesthetic care, Standard anesthetic care
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Impact Molar, Mandible Cyst
Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF.
This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction.
- Conditions
- Impact Molar, Mandible Cyst, Bone Regeneration, Platelet Rich Fibrin
- Trial name
- Cystregen (NCT07652216)
- Testing
- Impacted third molar extraction, Advanced Platelet-Rich Fibrin (A-PRF), Mandibular dentigerous cyst enucleation
- Where
- Poland
- Volunteers
- 35 people
- Sponsor
- Jagiellonian University
Neurofibromatosis Type 1, Muscle Weakness
Whole-body Vibration in Children With Neurofibromatosis Type 1
It is known that children with NF1 can have weak muscles and suffer from tiredness. It is also known that in similar conditions affecting children's muscles, standing on a vibration device for a few minutes each day can…
- Trial name
- NCT03888248
- Testing
- Whole-body vibration, Muscle strengthening exercises
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Metastatic Leiomyosarcoma, Unresectable Leiomyosarcoma
XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma
This phase II trial tests how well zanzalintinib (XL092) works in treating patients with leiomyosarcoma that has spread from where it first started to other places in the body (metastatic) or that cannot be removed by surgery…
- Conditions
- Metastatic Leiomyosarcoma, Unresectable Leiomyosarcoma, Bone Sarcoma, Translocation-associated Soft Tissue Sarcoma
- Trial name
- NCT06571734
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Northwestern University
Solid Tumor Malignancy
Efficacy and Safety of Pemigatinib in Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)
The purpose of this study is to evaluate the efficacy and safety of pemigatinib in participants with previously treated locally advanced/metastatic or surgically unresectable solid tumor malignancies harboring activating FGFR…
- Trial name
- NCT03822117
- Testing
- Pemigatinib
- Where
- 90 sites in United States, Denmark and 9 more
- Volunteers
- 111 people
- Sponsor
- Incyte Corporation
Neoplasm Metastasis, Bone Neoplasms
The Palliative Radiotherapy And Inflammation Study - PRAIS
Radiation therapy (RT) is one of the primary treatments for bone cancer pain due to metastatic cancer disease. About 6 of 10 patients obtain pain relief from RT.
- Trial name
- PRAIS (NCT02107664)
- Testing
- Palliative RT for bone cancer pain
- Where
- 3 sites in Norway
- Volunteers
- 580 people
- Sponsor
- Norwegian University of Science and Technology
Breast Neoplasms
Upper Limb Function After Breast Cancer Surgery: the Role of Post-operative Physical Therapy Intervention
Surgical treatments can cause late effects influencing activity of daily living, physical activity, and overall health. Late effects include persistent pain reported by 30 - 50% of women that underwent breast operations…
- Trial name
- NCT03389204
- Testing
- PHYSICAL THERAPY
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Assuta Medical Center
Breast Neoplasm, Osteoporosis, Postmenopausal
Optimizing Body Composition & Health After Breast Cancer
The purpose of this study is to conduct a 12-month randomized controlled trial comparing the effects of strength training exercise to stretching and relaxation exercise (control) on body composition (bone, muscle and fat mass)…
- Trial name
- NCT00659906
- Testing
- Resistance Exercise, Flexibility Training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- OHSU Knight Cancer Institute
Chemotherapeutic Agent Toxicity, Infection
Using Whole-Person-Care Guide in Patients Receiving Care for Cancer or Complications From Cancer Treatment
RATIONALE: Gathering information about patients with cancer and cancer-related conditions may help doctors learn more about a patient's needs and help doctors plan the best treatment.
- Conditions
- Chemotherapeutic Agent Toxicity, Infection, Malnutrition, Musculoskeletal Complications
- Trial name
- NCT00608738
- Testing
- informational intervention, medical chart review, questionnaire administration
- Volunteers
- 750 people
- Sponsor
- Northwestern University
Rheumatoid Arthritis
Anti-TNF Agents for the Treatment of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic disease that leads to inflammation and progressive joint damage. RA is a systemic inflammatory autoimmune disorder affecting almost 1% of the United States population.
- Trial name
- NCT00837434
- Testing
- Etanercept, Adalimumab
- Where
- 7 sites in United States
- Volunteers
- 63 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Metastatic Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC
Ficerafusp alfa is directed against two targets, Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor beta (TGF-β).
- Trial name
- FORTIFI-FLEX (NCT07807163)
- Testing
- Ficerafusp alfa, Pembrolizumab (KEYTRUDA®)
- Where
- 7 sites in United States
- Volunteers
- 160 people
- Sponsor
- Bicara Therapeutics
Inclusion Body Myositis, Myotonic Dystrophy
The Risk of Falls Index for Patients With Neuromuscular Disorders
The combination of short quantitatively assessing muscular function and balance in combination with short clinical scores, can be a new valid approach to evaluate the patient risk of fall and help to create a quick checkup test…
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy, Facioscapulohumeral Muscular Dystrophies, Myasthenia Gravis
- Trial name
- NCT05890833
- Testing
- The risk of falls
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- LMU Klinikum
Acromegaly, Neuroendocrine Tumours
Somatuline Predictive Factors in Acromegaly and NET
The aim of the study is to identify predictive factors for the response to Lanreotide treatment in Acromegaly as well as in Neuroendocrine Tumours.
- Trial name
- SOPRANo (NCT01840449)
- Testing
- Somatuline Autogel® 60, 90 or 120 mg
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 156 people
- Sponsor
- Ipsen
Neoplasms, Breast
Lapatinib and Bevacizumab for Metastatic Breast Cancer
This study will examine the efficacy and safety of lapatinib and bevacizumab in patients with ErbB2-overexpressing breast cancer.
- Trial name
- NCT00444535
- Testing
- lapatinib, bevacizumab
- Where
- 9 sites in United States
- Volunteers
- 52 people
- Sponsor
- Novartis Pharmaceuticals
Cancer, Cancer Cachexia
Effects of WB-EMS and Specific Dietary Supplements on Cancer Patients
Patients suffering from cancer often experience a loss of muscle mass and strength during disease and its therapy. Muscle wasting is the main characteristic of the so-called cancer cachexia syndrome and responsible for many…
- Conditions
- Cancer, Cancer Cachexia, Weight Loss, Muscle Loss
- Trial name
- NCT03151291
- Testing
- β-hydroxy-β-methylbutyrate (HMB), L-carnitine (LC), Eicosapentaenoic acid (EPA)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Bone Cancer
Genomic Analysis of Pediatric Bone Tumors
To determine whether gene expression analysis of primary tumor samples before and after chemotherapy are predictive of long-term survival in pediatric patients with bone sarcomas (Ewings sarcoma (ES) and Osteosarcoma(OS)).
- Trial name
- NCT01047878
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Stanford University
Breast Cancer
Study of Arimidex and Radiotherapy Sequencing
The purpose of this study is to compare TGF-β1 change in concomitant with that in sequential Arimidex in postmenopausal women with breast cancer, as measured by the proportion of patients with an elevation of TGF-β1 level at the…
- Trial name
- NCT01402193
- Testing
- Pre-radiotherapy commencement of Arimidex, Post radiotherapy commencement of Arimidex, Radiotherapy
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Fudan University
Exophthalmos, Graves Ophthalmopathy
Exophthalmometry With 3D Face Scanners
This study investigates diagnostic methods to measure eyeball protrusion with a smartphone face scanner compared to the traditional Hertel exophthalmometer.
- Conditions
- Exophthalmos, Graves Ophthalmopathy, Orbital Tumor, Orbital Fractures
- Trial name
- EX3D (NCT04704414)
- Testing
- Exophthalmos measurement
- Where
- Switzerland
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Rheumatoid Arthritis
Stopping TNF Alpha Inhibitors in Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA) is often treated with drugs known as tumor necrosis factor (TNF) inhibitors, that can help decrease joint pain and swelling and can even result in RA remission.
- Trial name
- STARA (NCT01793519)
- Testing
- Etanercept, Infliximab, Adalimumab
- Where
- 2 sites in United States
- Volunteers
- 290 people
- Sponsor
- Georgetown University
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