Clinical trials: Musculoskeletal Cancers
Breast Neoplasms
High Dose Vit D Musculoskeletal Symptoms & Bone Density in Anastrozole-Treated Breast Cancer With Marginal Vit D Status
The purpose of this study is to determine whether Vitamin D supplementation reduces the symptoms of muscle stiffness and joint tenderness that some patients may develop after starting therapy with Anastrozole for breast cancer.
- Trial name
- NCT00263185
- Testing
- Vitamin D, Calcium carbonate
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Washington University School of Medicine
Acromegaly
Prediction of Tumor Shrinkage in Acromegaly
In the last two decades, somatostatin analogs have become a cornerstone of medical therapy for acromegaly. One year of treatment with octreotide-LAR (LAR) controls GH and IGF-I excess in 54% and 63% of unselected patients, with…
- Trial name
- NCT00616408
- Testing
- Octreotide-LAR
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Federico II University
Rheumatoid Arthritis
Andecaliximab as Add-On Therapy to a Tumor Necrosis Factor Inhibitor and Methotrexate Regimen in Adults With Moderately to Severely Active Rheumatoid Arthritis
The primary objective of this study is to evaluate the efficacy of andecaliximab (GS-5745) versus placebo as an add-on therapy to a tumor necrosis factor (TNF) inhibitor and methotrexate in adults with moderate to severe…
- Trial name
- NCT02862574
- Testing
- Andecaliximab, Methotrexate, TNF Inhibitor
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Gilead Sciences
Fracture, Lengthening; Leg
Pediatric Orthopaedic Implant Safety & Efficacy
Implant devices are important tools - their use is essential across a number of orthopaedic indications, including hip conditions, trauma and limb deformity.
- Conditions
- Fracture, Lengthening; Leg, Orthopedic Disorder, Deformity of Limb
- Trial name
- Global POISE (NCT05361980)
- Testing
- Pediatric orthopaedic implant
- Where
- Canada
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Breast Cancer, Osteoporosis
Study of Bone Mineral Density in Women With Breast Cancer Treated With Triptorelin and Tamoxifen or Exemestane on Protocol IBCSG 25-02
RATIONALE: Gathering information over time from bone density and laboratory tests of women with breast cancer treated with triptorelin and tamoxifen or exemestane may help the study of breast cancer in the future.
- Trial name
- TEXT-Bone (NCT00963417)
- Testing
- laboratory biomarker analysis, dual x-ray absorptiometry
- Where
- 13 sites in Australia, Belgium and 1 more
- Volunteers
- 119 people
- Sponsor
- ETOP IBCSG Partners Foundation
Musculoskeletal Diseases, Soft Tissue Mass
"The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors"
The objective of this proposed project is to determine which local anesthetic is more efficacious for use in soft tissue tumors: Exparel (liposomal bupivacaine) or a cocktail of Ropivicaine, Epinepherine, Ketolorac and Clonidine.
- Trial name
- NCT05355597
- Testing
- Exparel Injectable Product, Multi-Drug Cocktail (Ropivicaine, Epinephrine, Ketolorac, Clonidine)
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Atlantic Health System
Chronic Fatigue Syndrome
A Complex Intervention for Chronically Fatigued Lymphoma Survivors
The present study is a randomized controlled trial (RCT) with an overall objective to examine the effect of an interdisciplinary complex intervention on the level of fatigue in lymphoma survivors with chronic fatigue.
- Trial name
- NCT05130099
- Testing
- Interdisciplinary complex intervention
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Oslo University Hospital
Dupuytren's Disease
Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture
The purpose of this study is to determine if of manipulation of digits following collagenase injection for treatment of Dupuytren's contracture is effected by the amount of time between injection and manipulation.
- Trial name
- NCT01226121
- Testing
- Clostridial collagenase injectable
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Indiana Hand to Shoulder Center
Breast Cancer, Musculoskeletal Pain
TCM as an Adjuvant Treatment in Breast Cancer Patients
Chinese herbs can alleviates the side effects caused by conventional treatment in breast cancer patients and affects the syndrome element differentiation by altering the specific set of proteomes at specific time point of…
- Trial name
- NCT04843865
- Testing
- Chinese Herbs
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Universiti Tunku Abdul Rahman
Hyperparathyroidism, Primary, Osteoporosis
The Bone-parathyroid Crosstalk in Primary Hyperparathyroidism
The PARABONE study aims to investigate the interaction between bone and parathyroid glands in patients with primary hyperparathyroidism (HPT).
- Conditions
- Hyperparathyroidism, Primary, Osteoporosis, Parathyroid Neoplasms
- Trial name
- PARABONE (NCT05556499)
- Testing
- Biomarker assays
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Prostate Cancer, Metabolic Syndrome
Akkermansia Muciniphilia and Metabolic Side Effects of ADT
The overriding objectives of this study are: 1. Primary outcomes: 1. To confirm that administration of oral acetate increases the proportion of A.
- Conditions
- Prostate Cancer, Metabolic Syndrome, Obesity, Cardiovascular Morbidity
- Trial name
- NCT05802121
- Testing
- Apple Cider Vinegar
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Western University
Non-Small Cell Lung Cancer (NSCLC)
Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR Alteration
This is an open-label, single arm study to study the safety, efficacy and tolerability of Pemigatinib when used on participants with squamous or nonsquamous NSCLC with a documented FGFR1-3 mutations or fusions/rearrangement who…
- Trial name
- FIGHT-210 (NCT05253807)
- Testing
- Pemigatinib
- Where
- 36 sites in United States, France and 3 more
- Volunteers
- 8 people
- Sponsor
- Incyte Corporation
Oncology, Musculoskeletal Diseases
Evaluation of Telerehabilitation Following Inpatient or Outpatient Rehabilitation Phase II
Telerehabilitation is implemented in the Pensionsversicherungsanstalt (PVA) as an independent rehabilitation offer following a rehabilitation phase II.
- Trial name
- NCT05493306
- Where
- Austria
- Volunteers
- 126 people
- Sponsor
- Pensionsversicherungsanstalt
Breast Neoplasms, Osteoporosis
Zoledronic Acid - Letrozole Adjuvant Synergy Trial (ZFAST) - Cancer Treatment Related Bone Loss in Postmenopausal Women With Estrogen Receptor Positive and/or Progesterone Receptor Positive Breast Cancer Receiving Adjuvant Hormonal Therapy
This protocol is designed to compare the effect on bone of Zoledronic Acid 4 mg every 6 months when given upfront versus delayed start (based on a post-baseline BMD T- Score below -2.0 SD at either the lumbar spine or total hip…
- Trial name
- NCT00050011
- Testing
- Zoledronic Acid, Letrozole
- Where
- 44 sites in United States, Puerto Rico
- Volunteers
- 602 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer
Nonlinear Elasticity Mapping of Breast Masses
This proposed technique, called "Nonlinear Elasticity Mapping (NEM)", is an innovative approach to estimate (i.e., linear and nonlinear) elasticity to provide complementary and relevant information for identification and…
- Trial name
- NCT04863443
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Odontogenic Cyst, Jaw Cysts
Bone Regeneration Using PRF After Cyst Enucleation
This randomized controlled clinical trial aims to evaluate the clinical efficacy of autologous platelet-rich fibrin (PRF) in promoting osseous regeneration following cystic enucleation in the jaws.
- Conditions
- Odontogenic Cyst, Jaw Cysts, Osseous Defect After Cyst Enucleation
- Trial name
- PRF-Bone (NCT07424716)
- Testing
- Autologous Platelet-Rich Fibrin (PRF), Conventional Surgical Management
- Where
- Yemen
- Volunteers
- 20 people
- Sponsor
- Sana'a University
Degenerative Disc Disease, Kyphosis
Post-Market Clinical Follow-up Study of A-SPINE's Products
This is a post-market clinical follow-up study that use questionnaires such as Visual Analog Scale (VAS), the Neck Disability Index (NDI), or the Oswestry Disability Index (ODI) to compare the clinical improvement effects before…
- Conditions
- Degenerative Disc Disease, Kyphosis, Scoliosis, Trauma
- Trial name
- NCT04848376
- Testing
- (1) SmartLoc (2) SmartLoc Evo (3) Winloc(4) Vigor PEEK Cervical Disc Spacer (5) Combo C (6) Polymer Lumbar Disc Spacer (7) X'Plo (8) Rainboo (9) Combo L
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- A-Spine Asia Co., Ltd.
Osteosarcoma, Metastatic Bone Disease
Musculoskeletal Cancers Remote Monitoring and Care
This study aims to evaluate how walking stability and the ability to perform daily activities change during cancer treatment, and whether a smartwatch can detect these changes.
- Trial name
- NCT07129226
- Testing
- Smart Watch
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer
A Randomized Controlled Trial (RCT) to Determine the Efficacy of a Multidisciplinary CBT Based Pain Management Program for the Treatment of Aromatase Inhibitor Associated Musculoskeletal Symptoms (AIMSS) in Breast Cancer Survivors
The purpose of this research is to evaluate the effectiveness of a multidisciplinary pain management program for AIMSS in reducing pain, subjective cognitive complaints, psychological distress, and impaired functional status…
- Trial name
- NCT06831838
- Testing
- Cognitive Behavioral Therapy based Pain Management Program
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Mayo Clinic
Arthroplasty
Total Temporomandibular Joint Replacement System Post Approval Study
Post-Approval Study (PMA CoA) in Order to Obtain Additional Long Term Safety and Effectiveness Data [PMA P020016]
- Trial name
- NCT00762944
- Testing
- Biomet TMJ Replacement System
- Where
- 4 sites in United States
- Volunteers
- 93 people
- Sponsor
- Zimmer Biomet
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