Clinical trials: Musculoskeletal Cancers
Kidney Transplantation, Anemia
Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients
The purpose of this study is to evaluate the effect of anemia correction and vitamin D supplementation in kidney transplant recipients.
- Conditions
- Kidney Transplantation, Anemia, Vitamin D Deficiency, Renal Insufficiency, Chronic
- Trial name
- CANDLE-KIT (NCT01817699)
- Testing
- High Hb target, cholecalciferol
- Where
- Japan
- Volunteers
- 161 people
- Sponsor
- CANDLE-KIT Trial Study Group
Arthralgia
Effect of a Specific Hand Intervention in Women With Arthralgia Secondary to Hormone Therapy Following Breast Cancer.
This study aims to evaluate the impact of a 12-week hand exercise program on pain, manual dexterity, and hand function in women experiencing hand joint pain (arthralgia) due to hormone therapy after breast cancer.
- Trial name
- NCT06746376
- Testing
- Occupational Therapy
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Chronic Inflammatory Demyelinating Polyradiculoneuropathy, NMO Spectrum Disorder
Safety and Efficacy of BAFF-R CART for Refractory Neuroimmune Diseases
This study is a phase Ib/IIa dose-escalation study designed to evaluate the safety, tolerability, and preliminary efficacy of autologous T cells expressing chimeric antigen receptor (CAR)-targeted B-cell activating factor…
- Conditions
- Chronic Inflammatory Demyelinating Polyradiculoneuropathy, NMO Spectrum Disorder, Myasthenia Gravis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT07022197
- Testing
- BAFF-R CART
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Tianjin Medical University General Hospital
Osteoid Osteoma
Treatment Outcome After Surgical Treatment of Osteoid Osteoma
Purpose of the study: To retrospectively determine the clinical results in an unselected group of consecutive patients with osteoid osteoma treated by surgery.
- Trial name
- NCT01466010
- Testing
- surgical removal of osteoid osteoma
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytrens Contracture
Injectable Collagenase and Percutaneous Needle Fasciotomy for Dupuytren's Contracture
Comparing injectable collagenase and percutaneous needle fasciotomy for Dupuytren's contracture affecting proximal interphalangeal joints. An open label, medico-independent randomized controlled trial.
- Trial name
- NCT01538017
- Testing
- Xiapex, Percutaneous needle fasciotomy
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Jeppe Lange, MD
Spondylitis, Ankylosing
Blocking Tumor Necrosis Factor in Ankylosing Spondylitis
The Division of Rheumatology at University of California San Francisco is conducting a research study on the treatment of ankylosing spondylitis (AS) with a new therapy currently used for people with other forms of arthritis.
- Trial name
- NCT00000433
- Testing
- Anti-Tumor Necrosis Factor
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Breast Cancer
Musculoskeletal Pain in Postmenopausal, Early Breast Cancer Patients Receiving Aromatase Inhibitor Therapy - A Pilot Study
In 2005, the EBCIG demonstrated the efficacy of tamoxifen in improving overall survival in hormone receptor positive breast cancers.
- Trial name
- AIMS (NCT00653718)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Breast Cancer
Nonlinear Elasticity Mapping of Breast Masses
This proposed technique, called "Nonlinear Elasticity Mapping (NEM)", is an innovative approach to estimate (i.e., linear and nonlinear) elasticity to provide complementary and relevant information for identification and…
- Trial name
- NCT04863443
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Apical Periodontitis, Apical Granuloma
Factors Affecting the Endodontic Treatment Outcome
The aim of this prospective cohort observational study is: (i) to assess the endodontic treatment outcome in a private specialist endodontic office in Slovenia; (ii) to estimate the effect of various pre-, intra- and…
- Conditions
- Apical Periodontitis, Apical Granuloma, Apical Cyst
- Trial name
- NCT05221450
- Testing
- primary endodontic treatment
- Where
- Slovenia
- Volunteers
- 700 people
- Sponsor
- Odontos, Specialisticna Zobna Ambulanta, d.o.o.
Metastatic Cancer to the Hip
Fully Constrained Acetabular Liner vs. Dual Mobility Hip Joint in the Surgical Treatment of Metastatic Bone Disease of the Hip
The purpose of the current study is to investigate whether dual mobility liners are non-inferior til constrained liners regarding the post-operative hip joint dislocation risk following total hip replacement in patients with…
- Trial name
- NCT05461313
- Testing
- Constrained Liner, Dual Mobility
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Rheumatoid Arthritis
People-Powered Medicine (PPM): Rheumatoid Arthritis Non-responders to Biologic Therapies (RANT)
The investigators are interested in enrolling patients with rheumatoid arthritis (RA) who had a difficult time getting their disease under control even after trying multiple RA therapies.
- Trial name
- PPM:RANT (NCT05447182)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Brigham and Women's Hospital
Prostate Cancer, Androgen Deprivation Therapy
Osteoporosis Among Men Treated With Androgen Deprivation for Prostate Cancer
The purpose of this study is to determine the rate of osteoporosis among patients with advanced prostate cancer. to propose an algorithm for early detection of patients with advanced prostate cancer who are at risk of developing…
- Conditions
- Prostate Cancer, Androgen Deprivation Therapy, Osteoporosis
- Trial name
- Osteoporosis (NCT00957606)
- Testing
- blood sampling, DXA-scan, bone scintigraphy
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Joint Pain, Breast Cancer
Physical Activity to Reduce Joint Pain During Aromatase Inhibitor Therapy
For post-menopausal women diagnosed with hormone-receptor positive breast cancer tumors, aromatase inhibitors (AIs) are the standard adjuvant hormone treatment to prolong disease-free survival and time-to-recurrence.
- Trial name
- NCT01900418
- Testing
- Walk with Ease
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of North Carolina, Chapel Hill
Haemophilia A (Moderate or Severe), Hemophilia, Classic
A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis
The rationale for conducting this open-label phase 4 study is to assess whether once-weekly prophylaxis with efanesoctocog alfa (50 IU/kg) improves the disease course of existing synovial hypertrophy and prevents the risk of…
- Conditions
- Haemophilia A (Moderate or Severe), Hemophilia, Classic, Haemophilia, Hemophilia
- Trial name
- NCT06752850
- Testing
- Efanesoctocog alfa
- Where
- 10 sites in Italy, Norway and 2 more
- Volunteers
- 37 people
- Sponsor
- Swedish Orphan Biovitrum
Carpal Tunnel Syndrome, Trigger Finger
Alternatives to Hand Therapy for Hand Surgery Patients
Patients will be asked to use a mobile phone app to conduct their hand therapy after having hand surgery.
- Conditions
- Carpal Tunnel Syndrome, Trigger Finger, Ganglion Cysts, Distal Radius Fracture
- Trial name
- NCT03779958
- Testing
- Mobile App
- Where
- United States
- Sponsor
- Stanford University
Adult ALL, Healthy
Iterative Design of Custom Dynamic Orthoses
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. It is expected that carbon fiber braces can be designed to reduce forces in the ankle.
- Trial name
- PRMRP-Norms (NCT04800510)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Iowa
Bone Neoplasm
Multicentric Bone Tumor Imaging Report and Data System
In this study a previously described structured multimodality image report system for the characterization of focal bone lesions is evaluated in a larger patient population.
- Trial name
- BTI-RADS M (NCT04884048)
- Testing
- Radiographs
- Where
- 9 sites in France
- Volunteers
- 1,100 people
- Sponsor
- Central Hospital, Nancy, France
Bone Cyst
Complete Twelve Month Bone Remodeling With a Bi-phasic Injectable Bone Substitute in Benign Bone Tumors
The purpose of this study is to assess the ability a injectable bi-phasic ceramic bone substitute to provide bone generation and bone remodeling in patients with benign bone tumors.
- Trial name
- BRBBT (NCT02567084)
- Testing
- CERAMENT™ |BONE VOID FILLER
- Volunteers
- 14 people
- Sponsor
- Poznan University of Medical Sciences
Breast Cancer, Joint Pain
Glucosamine and Chondroitin for Aromatase Inhibitor Induced Joint Symptoms in Women With Breast Cancer
Investigators are hoping to learn if glucosamine with chondroitin can help relieve joint pain/stiffness associated with aromatase inhibitors.
- Trial name
- NCT00691678
- Testing
- Chondroitin, Glucosamine
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Dawn L. Hershman
Osteopenia
Study of Adults With Low Growth Hormone Who Survived Childhood Cancer Where Treatment Caused Low Bone Density
The purpose of this project is to evaluate the hypothesis that bisphosphonate treatment given to growth hormone deficient patients (regardless of current growth hormone replacement therapy status and without changing that status)…
- Trial name
- NCT00145704
- Testing
- bisphosphonate therapy (risedronate), Vitamin D supplement, Calcium
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- State University of New York - Upstate Medical University
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