Clinical trials: Musculoskeletal Cancers
Osteoporosis, Poor Bone Quality
OsseoScrew Versus Fenestrated Pedicle Screws Augmented With Polymethylmethacrylate
The purpose of this clinical investigation was to collect clinical evidence of the safety and efficacy of the OsseoScrew System.
- Trial name
- EVOLVE (NCT01613144)
- Testing
- OsseoScrew Spinal Fixation System
- Where
- 10 sites in Belgium, Germany and 3 more
- Volunteers
- 94 people
- Sponsor
- Alphatec Spine, Inc.
Oncology, Musculoskeletal Diseases
Evaluation of Telerehabilitation Following Inpatient or Outpatient Rehabilitation Phase II
Telerehabilitation is implemented in the Pensionsversicherungsanstalt (PVA) as an independent rehabilitation offer following a rehabilitation phase II.
- Trial name
- NCT05493306
- Where
- Austria
- Volunteers
- 126 people
- Sponsor
- Pensionsversicherungsanstalt
Breast Cancer, Joint Pain
Trial of Blue Citrus Compared to Placebo in Patients Receiving Aromatase Inhibitor Therapy for Estrogen Receptor Positive Post-Menopausal Breast Cancer
This purpose of this study is to determine if the herbal compound, Blue Citrus, decreases joint and bone pain associated with Aromotase Inhibitor therapy (AIT).
- Trial name
- NCT00702858
- Testing
- Blue Citrus
- Volunteers
- 30 people
- Sponsor
- Legacy Health System
TGCT
Study of Emactuzumab for Tenosynovial Giant Cell Tumor (TGCT)
This is a multicenter, Phase 3, randomised, double-blind, placebo-controlled study, which aims to evaluate the efficacy and safety of the investigational drug emactuzumab for the treatment of patients with localized or diffuse…
- Trial name
- TANGENT (NCT05417789)
- Testing
- Emactuzumab
- Where
- 33 sites in United States, Belgium and 10 more
- Volunteers
- 128 people
- Sponsor
- SynOx Therapeutics Limited
Osteosarcoma, Sarcoma
A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Bone and Soft Tissue Tumors
20 participants are expected to be enrolled for this open，Single-armed clinical trial to evaluate the safety and efficacy of the recombinant herpes simplex virus Ⅰ, R130 in patients with relapsed/refractory bone and soft tissue…
- Conditions
- Osteosarcoma, Sarcoma, Sarcoma,Soft Tissue, Bone Tumor
- Trial name
- NCT05851456
- Testing
- Recombinant oncolytic herpes simplex virus type Ⅰ (R130)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Yunying Medical Technology
Cancer of Muscle
Functional Outcomes and HRQoL in Upper-extremity Sarcoma Patients After Limb Salvage
This study aims to assess the functional ability and health-related quality of life (HRQoL) of upper extremity sarcoma patients who have undergone limb salvage surgery.
- Trial name
- NCT02380651
- Testing
- Limb salvage
- Where
- 2 sites in Finland
- Volunteers
- 55 people
- Sponsor
- Helsinki University Central Hospital
Head and Neck Cancer, Spinal Accessory Nerve Injury
Investigation of Effects of Physiotherapy Interventions on Mechanical Properties of Muscle in Head and Neck Cancer
As the head and neck cancer (HNC) survival rate has increased and therefore, the focus of post-treatments is to improve the quality of patients' life by decreasing the side effects.
- Conditions
- Head and Neck Cancer, Spinal Accessory Nerve Injury, Thyroid Cancer, Scapular Dyskinesis
- Trial name
- NCT05399953
- Testing
- Myofascial Release Technique, Exercise, Scar Tissue Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people
- Sponsor
- Yeditepe University
Inflammatory Bowel Disease (IBD), Spondylarthropathies
Prevelance of Axial Spondylosis Arthritis in Inflammatory Bowel Disease and Its RESPONSE to Tumour Necrosis Factor (TNF) Inhibitors Treatment in Assiut University Hospital
Prevelance of axial spondylosis arthritis in inflammatory bowel disease and its RESPONSE to tumour necrosis factor (TNF) inhibitors TREATMENT
- Conditions
- Inflammatory Bowel Disease (IBD), Spondylarthropathies, TNF-alpha Inhibitors
- Trial name
- NCT06601595
- Testing
- TNF inhibitors, conventional ibd medical treatment
- Volunteers
- 100 people
- Sponsor
- Mohamed Nasr
Acromegaly, Nonfunctioning Pituitary Adenoma
Direct Versus Video Laryngoscopy in Patients With Acromegaly
Acromegaly is associated with craniofacial skeletal changes and upper airway soft tissue hypertrophy, which may increase the risk of difficult laryngoscopy and tracheal intubation.
- Trial name
- ACRO-VL (NCT07659912)
- Volunteers
- 40 people
- Sponsor
- Muzaffer GENCER
Osteoporosis, Hypercalcemia of Malignancy
One Week Comparison Study of PTH and PTHrP Infusions
This is a dose escalation study to determine the maximum tolerable dose of Parathyroid Hormone-related Protein, PTHrP, or Parathyroid Hormone, PTH, that can be given safely over one week in healthy African-American volunteers.
- Conditions
- Osteoporosis, Hypercalcemia of Malignancy, Hyperparathyroidism, Bone Diseases, Endocrine
- Trial name
- NCT01333267
- Testing
- Parathyroid Hormone-related Protein (1-36), parathyroid hormone (1-34), PTH (1-34) and PTHrP (1-36)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Breast Neoplasms, Prostatic Neoplasms
Study to Investigate Adherence of Patients to Clodronate (Bonefos) Treatment
Adherence (or compliance with) a medication regimen is generally defined as the extent to which patients take medication as prescribed by their health care providers.
- Conditions
- Breast Neoplasms, Prostatic Neoplasms, Multiple Myeloma, Osteolysis
- Trial name
- BONA (NCT01198457)
- Testing
- Clodronate (Bonefos, BAY94-8393)
- Where
- Czechia
- Volunteers
- 147 people
- Sponsor
- Bayer
Sarcoma, Ewing, Osteosarcoma
Quality of Life of Patients With Bone Tumor of the Lower Limbs Treated With Salvage Surgery
The aim of the study is to describe, through a minimum follow-up of 18 months, the quality of life of patients undergoing salvage surgery of lower limb for musculoskeletal tumors and to identify possible prognostic factor…
- Conditions
- Sarcoma, Ewing, Osteosarcoma, Bone Tumor
- Trial name
- Onco-QoL (NCT05772312)
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- Istituto Ortopedico Rizzoli
Childhood Soft Tissue Sarcoma, Childhood Liver Cancer
Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of liposomal doxorubicin in treating children who have…
- Conditions
- Childhood Soft Tissue Sarcoma, Childhood Liver Cancer, Bone Cancer, Brain Tumor
- Trial name
- NCT00019630
- Testing
- doxorubicin HCl liposome
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Chronic Fatigue Syndrome
Valganciclovir (Valcyte) for Chronic Fatigue Syndrome Patients Who Have Elevated Antibody Titers Against Human Herpes Virus 6 (HHV-6)and Epstein-Barr Virus (EBV)
The purpose of this study determine whether the drug valganciclovir has a significant and real benefit on the central core of symptoms experienced by patients who have high titers to EBV and HHV-6 and are experiencing…
- Trial name
- NCT00478465
- Testing
- valganciclovir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Arthritis, Rheumatoid
Safety Study Of Tofacitinib Versus Tumor Necrosis Factor (TNF) Inhibitor In Subjects With Rheumatoid Arthritis
This post-marketing study is designed to compare the safety of tofacitinib versus TNF inhibitor with respect to major cardiovascular adverse events and malignancies, excluding non-melanoma skin cancers when given to subjects with…
- Trial name
- NCT02092467
- Testing
- tofacitinib, adalimumab, etanercept
- Where
- 345 sites in United States, Argentina and 28 more
- Volunteers
- 4,372 people
- Sponsor
- Pfizer
Osteoporosis, Prostate Cancer
Zoledronate in Preventing Osteoporosis and Bone Fractures in Patients With Locally Advanced Nonmetastatic Prostate Cancer Undergoing Radiation Therapy and Hormone Therapy
RATIONALE: Zoledronate may prevent bone loss in patients with prostate cancer undergoing radiation therapy and hormone therapy. It is not yet known whether zoledronate is more effective than calcium and vitamin D alone in…
- Trial name
- NCT00329797
- Testing
- Calcium, Zoledronic acid, radiation therapy
- Where
- 88 sites in United States, Canada
- Volunteers
- 109 people
- Sponsor
- Radiation Therapy Oncology Group
Growth Hormone Deficiency, Neoplasms
A Study to Follow Paediatric Participants With Growth Hormone Deficiency Treated With Somapacitan for Long Term Safety Information and Clinical Parameters
The aim of this study is to look at the long-term safety and clinical parameters of somapacitan in paediatric participants with growth hormone deficiency under routine clinical practice conditions.
- Conditions
- Growth Hormone Deficiency, Neoplasms, Diabetes Mellitus Type 2
- Trial name
- NCT06709040
- Testing
- Somapacitan
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Novo Nordisk A/S
Neoplasms of Bone and Articular Cartilage With Unspecified Anatomical Site
EVERolimus and LenvAtinib Versus Everolimus for Bone Sarcoma
Those studies demonstrate strong rationale to combine a multikinase inhibitor targeting VEGFR, PDGFR with mTOR inhibitor. Moreover, another multi-targeted TKI, lenvatinib monotherapy showed promising activity in osteosarcoma.
- Trial name
- NCT07619950
- Testing
- Everolimus and Lenvatinib, Everolimus
- Volunteers
- 94 people
- Sponsor
- Yonsei University
Osteoarthritis, Osteosarcoma
Clinical Orthopaedic Data Bank (Acute and Chronic)
Data involving orthopaedic conditions and rehabilitation aspects of musculoskeletal and neuromuscular disorders will be collected and stored as part of the normal clinical care of patients seen in the University of Florida (UF)…
- Conditions
- Osteoarthritis, Osteosarcoma, Scoliosis, Cerebral Palsy
- Trial name
- NCT00411060
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Florida
Biliary Tract Cancer
Futibatinib (TAS-120) in Patients With Advanced Biliary Tract Cancer
To compare overall survival (OS) of patients in Futibatinib and Zimberelimab in Combination with Gemcitabine plus Cisplatin versus Durvalumab or Pembrolizumab in Combination with Gemcitabine plus Cisplatin for patients with…
- Trial name
- FOENIX-BTC (NCT07710885)
- Testing
- Futibatinib, Zimberelimab, Durvalumab
- Where
- 21 sites in Australia, Japan and 2 more
- Volunteers
- 784 people
- Sponsor
- Taiho Pharmaceutical Co., Ltd.
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