Clinical trials: Musculoskeletal Disease
Disc Degenerative Disease, Back Pain
Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration
The goal of this clinical trial is to find out if a new medicine can help people who have long-lasting back pain caused by damaged spinal discs. The study will also check if the medicine is safe to use.
- Trial name
- CBT005 (NCT07668466)
- Testing
- High Dose, Low Dose
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Cartago Biotech Pty Ltd
Osteoporosis
HORIZON-PFT: Pivotal Fracture Trial
HORIZON-PFT (Pivotal Fracture Trial) will study the effect of zoledronic acid, given once per year, on the treatment of osteoporosis in women past menopause.
- Trial name
- NCT00049829
- Testing
- Zoledronic Acid
- Where
- 60 sites in United States, Germany
- Volunteers
- 7,700 people
- Sponsor
- Novartis Pharmaceuticals
Ankylosing Spondylitis
Canadian Humira Post Marketing Observational Epidemiological Study: Assessing Effectiveness in Ankylosing Spondylitis
The current study will assess the real - life effectiveness of adalimumab in the management of Ankylosing Spondylitis (AS) with emphasis on the prevention and management of extra-articular manifestations.
- Trial name
- Complete-AS (NCT01387802)
- Where
- 56 sites in Canada
- Volunteers
- 722 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Degenerative Disc Disease, Chronic Low-back Pain
Discure Technologies Feasibility Study for DDD
The objective of this study is to evaluate the safety and performance of the Discure System therapy in subjects with early to moderate degeneration of the disc (DDD).
- Conditions
- Degenerative Disc Disease, Chronic Low-back Pain, Discogenic Pain
- Trial name
- NCT06127745
- Testing
- Discure System
- Volunteers
- 20 people
- Sponsor
- Discure Technologies Ltd.
Knee Osteoarthritis (Knee OA)
Study in Patients With Knee Osteoarthritis Treated by Embolization Using NBGM200
Study in patients with knee osteoarthritis treated by embolization using NBGM200
- Trial name
- NCT06930677
- Testing
- embolization therapy
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 72 people
- Sponsor
- Next Biomedical Co., Ltd.
Mitochondrial Diseases, Drug Resistant Epilepsy
A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy
This is a parallel-arm, double-blind, placebo-controlled study with a screening phase that includes a 28-day run-in phase to establish baseline seizure frequency, followed by a 24-week, randomized, placebo-controlled phase.
- Conditions
- Mitochondrial Diseases, Drug Resistant Epilepsy, Leigh Disease, Leigh Syndrome
- Trial name
- MIT-E (NCT04378075)
- Testing
- Vatiquinone
- Where
- 27 sites in United States, Canada and 7 more
- Volunteers
- 68 people
- Sponsor
- PTC Therapeutics
Arthritis, Rheumatoid
Phase 1 Dose Escalating Study to Assess Safety, Tolerability, Food Effect and PK of CHR-5154 in Healthy Male Volunteers
Primary Objective: To determine the safety and tolerability of single and multiple ascending oral doses of CHR-5154 in healthy volunteers.
- Trial name
- NCT01934101
- Testing
- CHR-5154
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
A Study of the Effects of Oral Prednisone in Patients With Rheumatoid Arthritis (MK0000-088)
The study will compare the effects of prednisone vs placebo on synovial blood flow and overall DAS (disease activity score) in patients with rheumatoid arthritis.
- Trial name
- NCT00746512
- Testing
- Prednisone 15 mg, Prednisone 7.5 mg
- Volunteers
- 45 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis
Study of SHR0302 Tablets (SHR0302) as Monotherapy in Active Rheumatoid Arthritis (RA) Patients
To evaluate the safety and efficacy of SHR0302 tablets (SHR0302) in subjects with moderate to severe active rheumatoid arthritis.
- Trial name
- NCT03254966
- Testing
- SHR0302
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Psoriatic Arthritis
A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis
The main purpose of this study is to evaluate the effectiveness and safety of ixekizumab versus adalimumab in participants with psoriatic arthritis (PsA) who are biologic disease-modifying anti-rheumatic drugs (DMARD) naive.
- Trial name
- SPIRIT-H2H (NCT03151551)
- Testing
- Ixekizumab, Adalimumab
- Where
- 131 sites in Argentina, Australia and 20 more
- Volunteers
- 566 people
- Sponsor
- Eli Lilly and Company
Knee Osteoarthritis
Clinical Study of Artz in the Treatment of Knee Osteoarthritis
This is a multi-center, randomized, open-label, parallel-arm phase IV clinical study, for which a total of 300 patients with mild to moderate knee osteoarthritis will be enrolled.
- Trial name
- Artz (NCT02826031)
- Testing
- Sodium Hyaluronate Injection, DICL-SR
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- Kunming Baker Norton Pharmaceutical Sales Co., Ltd.
Lumbar Disc Degenerative Disease
Drug Use Survey (DUS) of Triple Therapy (Methycobal (MBL)+ Myonal (MYO)+ Non-steroidal Anti-inflammatory Drags (NSAID)) on the Symptom Relief of Lumbar DDD in China
The purpose of this study is to observe the overall satisfaction of patients with degenerative disc disease after receiving triple therapy.
- Trial name
- NCT01299077
- Where
- 10 sites in China
- Volunteers
- 478 people
- Sponsor
- Eisai China Inc.
Axial Spondyloarthritis (axSpA), Anterior Uveitis (AU)
A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU
The purpose of the study is to demonstrate the effect of Certolizumab Pegol (CZP) treatment on the reduction of Anterior Uveitis (AU) flares in subjects with active axial Spondyloarthritis (axSpA) and a documented history of AU.
- Trial name
- C-VIEW (NCT03020992)
- Testing
- Certolizumab Pegol
- Where
- 23 sites in Czechia, Germany and 3 more
- Volunteers
- 89 people
- Sponsor
- UCB Biopharma SRL
Juvenile Idiopathic Arthritis
Active Juvenile Idiopathic Arthritis (JIA) Compassionate Use
The main objective of this study is to evaluate the safety of adalimumab in patients 2 to < 4 years of age or ≥ 4 years of age weighing < 15 kg, with moderately to severely active polyarticular juvenile idiopathic arthritis (JIA)…
- Trial name
- NCT00775437
- Testing
- Adalimumab
- Volunteers
- 32 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Achondroplasia
A Clinical Trial to Evaluate Efficacy and Safety of Navepegritide in Adolescents (12 - 18 Years of Age) With Achondroplasia.
The purpose of this clinical trial is to evaluate efficacy and safety of once weekly subcutaneous (SC) doses of navepegritide 100 μg/kg compared to placebo (inactive drug) in adolescents aged 12 to 18 years with Achondroplasia.
- Trial name
- teACH (NCT06732895)
- Testing
- Navepegritide
- Where
- 5 sites in Canada, Denmark and 3 more
- Volunteers
- 25 people
- Sponsor
- Ascendis Pharma A/S
Rheumatoid Arthritis
First in Human Study of a Monoclonal Antibody (SOL-116) Targeting BSSL (Bile Salt-Stimulated Lipase), Single and Multiple Dose Parts
This is a randomized, double-blind, placebo-controlled, first-in-human phase I study. It consists of a single ascending dose part in healthy subjects (Part 1) and in patients with rheumatoid arthritis (Part 2) as well as a…
- Trial name
- NCT05576012
- Testing
- SOL-116
- Where
- 2 sites in Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Lipum AB
Knee Arthritis, Osteoarthritis
A Single-Center Phase 1 Study of ceAF for Knee Osteoarthritis (KOA)
Approximately 25 participants aged 18-70 years, with knee pain rated 4-7 on a 10-point visual analogue scale (VAS) and a disease duration of 6 months to 10 years, will be enrolled. The study has two parts.
- Trial name
- KOA (NCT07902128)
- Testing
- Animal early embryo extract
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Anhui HygeianCells BioMedical Co., Ltd.
Rheumatoid Arthritis
A Study in Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and tolerability of multiple doses of LY2439821 in Japanese patients with rheumatoid arthritis.
- Trial name
- NCT01253265
- Testing
- LY2439821
- Where
- 8 sites in Japan
- Volunteers
- 32 people
- Sponsor
- Eli Lilly and Company
Acromegaly
Korean Regulatory Post Marketing Surveillance for Somavert
Non-interventional observational study, to identify safety and effectiveness of Somavert during the post-marketing period based on the Korean RMP as required by the regulations of Ministry of Food and Drug Safety (MFDS)
- Trial name
- NCT05131100
- Testing
- Somavert
- Where
- South Korea
- Volunteers
- 11 people
- Sponsor
- Pfizer
Osteoarthritis, Knee, Diabetic Neuropathic Pain
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs).
- Conditions
- Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
- Trial name
- CPMP (NCT05986292)
- Testing
- LY3016859 ISA, LY3556050 ISA, LY3526318 ISA
- Where
- 64 sites in United States, Puerto Rico
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
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