Clinical trials: Musculoskeletal Disease
Non-radiographic Axial Spondyloarthritis, Ankylosing Spondylitis
Evaluation of Spine Posture, Trunk Position Sense and Gait in Axial Spondyloarthritis Patients
Axial Spondyloarthritis (Ax-SpA) are chronic systemic inflammatory rheumatological diseases characterized by axial skeletal involvement and enthesitis. Sacroiliitis is the most prominent sign of the disease.
- Trial name
- NCT05038189
- Testing
- Gait parameters, Spine posture, Trunk position sense
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Arthritis, Rheumatoid
Study Evaluating the Efficacy and Safety of Etanercept in Chinese Subjects With Rheumatoid Arthritis
The objective of this study is to compare in Chinese subjects with rheumatoid arthritis (RA) the efficacy and safety in this subject population of 50 mg once-weekly injections of etanercept versus placebo in subjects receiving…
- Trial name
- NCT00443950
- Testing
- Etanercept
- Where
- 6 sites in China
- Volunteers
- 150 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Arthritis, Rheumatoid
Efficacy and Safety of TAK-783 in Subjects With Rheumatoid Arthritis
The purpose of this study is to determine the efficacy and safety of TAK-783, once daily (QD), taken in combination with methotrexate in subjects with rheumatoid arthritis.
- Trial name
- NCT00760968
- Testing
- TAK-783 and methotrexate, Methotrexate
- Where
- 25 sites in Czechia, Latvia and 4 more
- Volunteers
- 224 people
- Sponsor
- Takeda
Spinal Cord Injuries, Neurological Injury
Physiological Changes Induced Through MEP Conditioning in People With SCI
The study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place in the nervous system as a…
- Conditions
- Spinal Cord Injuries, Neurological Injury, Paralysis, Spasticity, Muscle
- Trial name
- NCT04286191
- Testing
- Operant Conditioning, Control Group
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medical University of South Carolina
Osteoarthritis, Hip
An Evaluation of Health Outcomes for Mako Hip Replacement
To assess clinical outcomes and surgery related resource use in the year post surgery for patients undergoing hip replacement using the Mako Robo
- Trial name
- HELLO (NCT03846791)
- Testing
- Observational Study Post MAKO Robotic Surgery
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- Bournemouth University
Healthy
Novel Positron Emission Tomography (PET) Radiotracer to Image Phosphodiesterase-4B (PDE4B)
Background: The new drug 18F-PF-06445974 has a little radioactivity. This can be seen by a positron emission tomography (PET) scan. The drug helps researchers see a protein, PDE4B, in the brain.
- Trial name
- NCT03030391
- Testing
- PET, MRI
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Osteoarthritis, Knee, Nociceptive Pain
The Post-operative Analgesia of the Virtual Reality Using a Mirror Therapy After Total Knee Arthroplasty
It was well known that the mirror therapy could decrease pain of upper-limb amputated patients. The mirror therapy is known to make a plastic change some parts of the brain perceiving the painful body part and modulating its…
- Conditions
- Osteoarthritis, Knee, Nociceptive Pain, Virtual Reality
- Trial name
- NCT01979718
- Testing
- Mirrored Virtual reality
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Ulsan University Hospital
Funnel Chest
Cardiorespiratory Assessment and Quality of Life After Surgical Correction of Congenital Wall Malformations
The main objective of this study is to characterize the cardiorespiratory functional gain in patients with pectus excavatum following corrective surgery.
- Trial name
- HeartSoar (NCT03770390)
- Testing
- Surgical correction of pectus excavatum
- Where
- France
- Volunteers
- 43 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
Rebamipide (Regular & Nanoparticulated) vs. Clobetasol in Management of Methotrexate-Induced Oral Ulceration in Rheumatoid Arthritis Patients
The aim of this intervention study is to compare the effect of topical Rebamipide (regular and nanoparticulated) to topical Clobetasol propionate in management of Methotrexate induced oral mucositis in patients with rheumatoid…
- Trial name
- NCT04649697
- Testing
- Rebamipide, Nanoparticulated Rebamipide, Clobetasol Propionate
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Cairo University
Rheumatoid Arthritis
Fibres Supplementation in Rheumatoid Arthritis
Design: Randomized, double-blind, placebo-controlled study with 4 weeks of treatment with either fiber supplements or placebo. Primary outcome: variation in SCFA between baseline and week 4.
- Trial name
- SUPER-FIBRES (NCT04421313)
- Testing
- Dietary Fiber Supplementation
- Where
- France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Montpellier
Systemic Lupus Erythematosus (SLE), Idiopathic Inflammatory Myopathy (IIM)
Safety Study of CC312 in Autoimmune Disease Patients
This study is an open-label, multiple-dose escalation, Investigator-Initiated Trial (IIT) clinical trial designed to evaluate the safety and tolerability of CC312 in adult patients with relapsed and refractory autoimmune…
- Conditions
- Systemic Lupus Erythematosus (SLE), Idiopathic Inflammatory Myopathy (IIM), Systemic Sclerosis (SSc), Rheumatoid Arthritis (RA)
- Trial name
- NCT06888960
- Testing
- CC312
- Where
- China
- Volunteers
- 18 people
- Sponsor
- CytoCares Inc
Chondral Defect, Articular Cartilage Defect
A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle
The objective of this study is to demonstrate the superiority of MACI (autologous cultured chondrocytes on porcine collagen membrane) versus Bone Marrow Stimulation in the treatment of patients aged 17 to 65 years with…
- Trial name
- MASCOT (NCT06915233)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Bone Marrow Stimulation
- Where
- 9 sites in United States
- Volunteers
- 309 people
- Sponsor
- Vericel Corporation
Mental Fatigue, Fatigue
Effect of Ginko and Cistanche Against Fatigue Symptoms
To evaluate the efficacy of Nutrilite® ginkgo biloba cistanche tablets in relieving the symptoms of chronic fatigue syndrome(CFS), the investigators randomly recruit189 subjects with CFS, aged 35-60 yrs.
- Conditions
- Mental Fatigue, Fatigue, Chronic Fatigue Syndrome
- Trial name
- GkoCist (NCT02807649)
- Testing
- Experimental: Nutrilite® Low dose, Experimental: Nutrilite® High dose
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Access Business Group
Epicondylitis, Lateral
Injection in the Treatment of Lateral Epicondylitis. Randomized Controlled Trial
The aim of the study is to compare the effectiveness of injection techniques in the treatment of elbow lateral epicondylitis. The functional and pain levels of the patients will be evaluated with scores such as DASH, VAS, PRTEE.
- Trial name
- NCT04875338
- Testing
- plate-rich plasma, saline (0.9 NACI), betametazon
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University
Acute Respiratory Distress Syndrome ARDS
Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is associated with high mortality, some of which can be attributed to ventilator-induced lung injury (VILI) when artificial ventilation is not customized to the severity of lung injury.
- Trial name
- DRIVENT (NCT06322758)
- Testing
- Tidal volume customization in the acute respiratory distress syndrome
- Volunteers
- 750 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Knee Osteoarthritis
Assessment of the Efficacy of Stromal Vascular Fraction Treatment for Knee Osteoarthritis
One-year follow-up prospective observational study involving male and female patients (over 18-years-old) with unilateral or bilateral knee osteoarthritis treated with intraarticular injection of stromal vascular fraction (SVF)…
- Trial name
- NCT04749758
- Testing
- SVF treatment
- Where
- Andorra
- Volunteers
- 66 people
- Sponsor
- University of Andorra
Alveolar Cleft
Evaluation of Bilateral Alveolar Cleft Grafting With Micro Plate Stabilization Versus Conventional Grafting Technique
The aim of the study is to enhance the maxillary segments stability during graft healing using microplate fixation to be compared with conventional grafting technique regarding gained bone quality and quantity.
- Trial name
- NCT06523855
- Testing
- bilateral alveolar cleft grafting using iliac crest particulate and microplate fixation
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University
Rheumatoid Arthritis
A Pilot Study of Potassium Supplementation for Adult Patients With Rheumatoid Arthritis
Rheumatoid arthritis is the paradigmatic immune-mediated inflammatory arthropathy. With respect to rheumatoid arthritis (RA), patients have been described as having inappropriately low spontaneous and stimulated cortisol…
- Trial name
- NCT00461448
- Testing
- Potassium supplement
- Where
- 2 sites in Iran
- Volunteers
- 36 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Adhesive Capsulitis, Stretch
Efficacy of Static Progressive Stretch Versus Traditional Stretch in Adhesive Capsulitis
This study will be conducted to compare the effectiveness of static progressive stretching using the joint active system (JAS) shoulder device with cyclic manual stretching and controls on shoulder range of motion (ROM), time to…
- Conditions
- Adhesive Capsulitis, Stretch, Physical Neglect
- Trial name
- NCT05988255
- Testing
- Static progressive stretching, Cyclic manual stretching
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Sjogren's Syndrome, Mesenchymal Stem Cells
Allogeneic Mesenchymal Stem Cells Transplantation for Primary Sjögren's Syndrome (pSS)
This study will explore safety and efficacy of allogeneic mesenchymal stem cells transplantation (MSCT) to treat patients with diagnosis of primary Sjögren's Syndrome (pSS) who have been resistant to multiple standard treatments.
- Trial name
- NCT00953485
- Testing
- Allogeneic Mesenchymal Stem Cells (AlloMSC)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School