Clinical trials: Musculoskeletal Disease
Ergocalciferol
Pilot Study: The Effect of Ergocalciferol on Plasma Mucin-1 Levels
To determine if a one-time oral administration of ergocalciferol results in a decline in plasma mucin-1 levels in healthy individuals and individuals with ADTKD-MUC1.
- Trial name
- NCT03747523
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypermobility, Joint
The Influence of Whole-body Vibration Training on Postural Stability in People With Generalized Joint Hypermobility
The aim of this study was the assessment of muscle flexibility after 2-weeks of whole-body vibration (WBV) training in people with generalized joint hypermobility (GJH). The study included 33 participants aged 22-25 years.
- Trial name
- NCT05573880
- Testing
- Galileo Med35
- Where
- Poland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Chronic Pain, Hallux Valgus
The Effect of tDCS in the Preoperative Period of Hallux Valgus Surgical Treatment
This is a clinical trial that intend to determine if transcranial direct current stimulation (tDCS) is effective in the treatment of postoperative pain and in the anxiety level in the preoperative period of hallux valgus surgical…
- Trial name
- NCT02360462
- Testing
- Active tDCS
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acetabular Dysplasia
Targeted Exercise and Changes in Femoroacetabular Impingement in Symptomatic Patients With Acetabular Retroversion
The objective of this study is to investigate the effectiveness of an 8-week home-based targeted training intervention aiming at reducing FAI related pain, anterior pelvic tilt and improve hip joint function in a cohort of 40…
- Trial name
- TILT-FAI (NCT03578562)
- Testing
- Targeted training intervention
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- University of Southern Denmark
Osteoporosis
36-month Special Drug Use Surveillance on Frequency of Bone Fractures With Sodium Risedronate 75 mg Tablets
The purpose of this survey is to evaluate the effectiveness (endpoints: frequency of bone fractures, percent change in bone density, etc.) and safety of administration of sodium risedronate tablets 75 mg for 36 months in…
- Trial name
- NCT02106442
- Testing
- Sodium risedronate
- Where
- 2 sites in Japan
- Volunteers
- 579 people
- Sponsor
- Takeda
Pain, Postoperative, Regional Anesthesia
Quadratus Lumborum vs Erector Spinae Supplementary Blocks With Lumbar Plexus Blocks for Hip PAO
This study proposes to evaluate the efficacy of single shot erector spinae block (ESB) versus single shot quadratus lumborum block (QLB) when used in conjunction with continuous lumbar plexus block (LPB) for postoperative…
- Conditions
- Pain, Postoperative, Regional Anesthesia, Hip Dysplasia
- Trial name
- NCT04481451
- Testing
- Erector spinae block with ropivacaine 0.2%, Quadratus lumborum block with ropivacaine 0.2%, Ropivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Skeletal Class II Malocclusion, Mandibular Retrognathia
Fixed Versus Conventional Twin Block Appliances for Skeletal Class II Malocclusion
This study compares two types of dental appliances a fixed Twin Block appliance and a conventional (removable) Twin Block appliance used to treat a bite problem called skeletal Class II malocclusion in growing children and…
- Trial name
- NCT07687927
- Testing
- Conventional Twin Block Appliance
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Degenerative Changes, Stenosis
OsteoStrux™ Collagen Ceramic Scaffold in Instrumented Lumbar Spine Fusion
The objective of this study is to prospectively evaluate the performance of Integra's OsteoStrux Collagen Ceramic Scaffold combined with bone marrow aspirate as an adjunct for instrumented posterolateral spine fusion, as compared…
- Conditions
- Degenerative Changes, Stenosis, Spondylosis
- Trial name
- NCT01873586
- Testing
- Posterolateral Fusion
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- SeaSpine, Inc.
Arthritis, Rheumatoid
A Phase 2 Study to Evaluate the Safety, Tolerability, and Activity of Fontolizumab in Subjects With Active Rheumatoid Arthritis
To evaluate the efficacy of fontolizumab in subjects with active rheumatoid arthritis as determined by a 50% improvement of an American College of Rheumatology criteria (ACR50) response at Week 14 (Stage A of study).
- Trial name
- NCT00281294
- Testing
- Fontolizumab
- Where
- 9 sites in United States
- Volunteers
- 40 people
- Sponsor
- PDL BioPharma, Inc.
Knee Osteoarthritis, Pain
Effects of Voodoo Flossing Technique in Knee Osteoarthritis Patients
Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by pain, stiffness, and reduced physical function, significantly impacting quality of life especially in elderly population.
- Conditions
- Knee Osteoarthritis, Pain, Range of Motion, Physiotherapy
- Trial name
- NCT06986694
- Testing
- Group A will receive Voodoo Flossing Technique along with aerobic and strengthening exercises & conventional physiotherapy protocol for Knee OA., Group B will receive aerobic and strength training and conventional physiotherapy protocol for knee OA only.
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Neck Pain, Cervical Lordosis
Correlation of Cervical Lordosis Degree Detected on Cervical X-Ray Image With Clinical, Demographic and MRI Findings
In this study we are investigating whether there is a relationship between the lordosis angle measured on cervical X-RAY images on the severity and level of cervical disc herniation detected by cervical MRI, demographic…
- Conditions
- Neck Pain, Cervical Lordosis, Disk, Herniated
- Trial name
- NCT04886661
- Testing
- CHRONIC NECK PAIN
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Gonarthrosis
Prospective Cohort Study Evaluating a Thermal Spa Programme in Symptomatic Knee Osteoarthritis
Knee osteoarthritis is a common cause of pain, functional limitation, and reduced quality of life in older adults. Thermal spa treatment is widely used as a non-pharmacological intervention for the management of osteoarthritis…
- Trial name
- THERMOG (NCT07534189)
- Testing
- X-sens sensor, Transcriptomic, Self-questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Recurrent or Refractory Systemic Lupus Erythematosus, Recurrent or Refractory IgG4 Related Diseases
the Safety and Efficacy of Targeted BCMA In Vivo LV Injection for Recurrent or Refractory Autoimmune Diseases
This study is designed as a single arm, open label, single center clinical trial to evaluate the safety, tolerability, efficacy, pharmacokinetic or pharmacodynamic characteristics of the investigational drug V001-BCMA in…
- Conditions
- Recurrent or Refractory Systemic Lupus Erythematosus, Recurrent or Refractory IgG4 Related Diseases, Recurrent or Refractory Systemic Sclerosis, Recurrent or Refractory Idiopathic Inflammatory Myopathy
- Trial name
- NCT07339540
- Testing
- V001-BCMA
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Tongji Hospital
Osteoarthritis of Knee
Whole-body Vibration Training on Functional Performance of the Elderly With Knee Osteoarthritis
The present study evaluated the effects of adding whole body vibration to squat training on the isometric quadriceps muscle strength, the plasma concentration of brain-derived neurotrophic factor at rest in elderly woman with…
- Trial name
- NCT03918291
- Testing
- Addition of whole-body vibration to squat training, Squat training
- Volunteers
- 15 people
- Sponsor
- Federal University of the Valleys of Jequitinhonha and Mucuri
Knee Osteoarthritis, Hip Osteoarthritis
Mepivacaine Versus Low-Dose Bupivacaine For Primary Total Hip and Knee Arthroplasty
This research is being done to see if there is a difference between two different spinal anesthetics (Mepivacaine vs. Bupivacaine) as it relates to reducing post-operative complications and the time it takes for subjects to…
- Trial name
- NCT03838874
- Testing
- Low-Dose Bupivacaine, Mepivacaine
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Mayo Clinic
Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome
Universal CAR-T Cells (BRL-301) in Relapse or Refractory Autoimmune Diseases
This is an investigator initiated trial to assess the efficacy and safety of BRL-301 in the relapse or refractory autoimmune diseases of China.
- Conditions
- Systemic Lupus Erythematosus (SLE), Sjogren's Syndrome, Systemic Sclerosis, Inflammatory Myopathy
- Trial name
- NCT05859997
- Testing
- BRL-301
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Bioray Laboratories
Spondyloarthritis (SpA), Ankylosing Spondylitis (AS)
Bidirectional Cohort Study of Nanfang Spondyloarthritis
Spondyloarthritis（SpA） patients attending Nanfang Hospital of Southern Medical University will generate a large number of clinical condition scales, laboratory indicators, imaging data such as X-rays or MRIs in the course of…
- Trial name
- BCNS (NCT06988813)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Psoriatic Arthritis
A 24 Week Open Label Study of the Utility of Adalimumab in Active Axial Forms of Psoriatic Arthritis
Based on published data and according to the approved product label for ankylosing spondylitis and psoriatic arthritis, it can be expected that adalimumab 40 mg every 14 days should be effective in psoriatic arthritic patients…
- Trial name
- NCT00963313
- Testing
- Adalimumab (HUMIRA®)
- Where
- 22 sites in Spain
- Volunteers
- 29 people
- Sponsor
- Dr. FRANCISCO J. BLANCO-GARCIA
Staphylococcus Aureus, Surgical Wound Infection
Risk Factors for Staphylococcus Aureus Surgical Site Infections in Orthopedic and Trauma Surgery
The most commonly identified organism for Surgical Site Infection (SSI) in orthopedic surgery is Staphylococcus aureus but risk factors for mono microbial S.aureus SSI are not well-known.
- Conditions
- Staphylococcus Aureus, Surgical Wound Infection, Orthopedic Disorder, Traumatology
- Trial name
- ISO (NCT03040960)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Baker Cyst, Fenestration
"The Importance of Adding Fenestration to Ultrasound-Guided Baker's Cyst Aspiration"
This study aims to evaluate whether adding a fenestration procedure to standard ultrasound-guided aspiration and corticosteroid-lidocaine injection provides additional clinical benefits for patients with symptomatic Baker's cyst…
- Conditions
- Baker Cyst, Fenestration, Musculoskeletal Ultrasound, Steroid Injection
- Trial name
- NCT07385560
- Testing
- Baker's Cyst Aspiration, Steroid-Lidocaine Injection, Ultrasound-Guided Fenestration
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Istanbul University - Cerrahpasa