Clinical trials: Musculoskeletal Diseases
Rheumatoid Arthritis
Open Label Long-Term Safety Study of Certolizumab Pegol (CZP) for Patients With Rheumatoid Arthritis
The primary purpose of this study is to obtain long-term safety data with CZP in patients with Rheumatoid Arthritis (RA). Additional objectives are to assess the dose and type of Arthritis medication(s) utilized by patients, and…
- Trial name
- NCT00160693
- Testing
- Certolizumab Pegol
- Where
- 61 sites in United States, Austria and 5 more
- Volunteers
- 402 people
- Sponsor
- UCB Pharma
Adhesive Capsulitis
Comparison of Low-intensity Extracorporeal Shockwave Therapy and Low-intensity Laser Effects in Adhesive Capsulitis
The aim of this study is to compare the effects of extracorporeal shock wave therapy(eswt) applied in addition to conventional physical therapy on pain, mobility, functional ability, sleep quality and activities of daily living…
- Trial name
- NCT05689593
- Testing
- Low-intensity ESWT Group, Low-intensity laser Group, Conventional Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Ahi Evran University Education and Research Hospital
Cerebral Palsy, Spastic
The Effect of Botulinum Toxin and ESWT Applications on Spasticity and Functionality in Cerebral Palsy Patients
Cerebral Palsy (CP) is a group of movement and posture disorders associated with a non-progressive affect during brain development that can cause limitation of activity and disability.
- Trial name
- NCT05627921
- Testing
- Extracorporeal Shock Wave Therapy, Botilinum Toxin injection
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Osteoporosis, Postmenopausal
A Study to Compare the Efficacy of Alendronate With and Without Calcium or Calcium Alone In the Treatment of Osteoporosis in Postmenopausal Women (0217-088)(COMPLETED)
The purpose of this study is to see how well alendronate and calcium as compared to calcium alone increase bone density in postmenopausal women with osteoporosis
- Trial name
- NCT00398606
- Testing
- MK0217, alendronate sodium / Duration of Treatment : 2 Years, Comparator : calcium carbonate /Duration of Treatment : 2 Years
- Volunteers
- 650 people
- Sponsor
- Organon and Co
Primary Sjögren Syndrome
Neurotrophins Implications in Primary Sjögren Syndrome
Neurotrophins (NTs) constitute a family of growth factors, which regulated differentiation, proliferation, and survival of both neuronal cells and astrocytes.
- Trial name
- Neuro-SGSp (NCT01081184)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Cervical Spine Fusion
Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery
The goal of this randomized, double-blinded, clinical trial is to assess the benefit of administering a Multifidus Cervicis Plane (MCP) block compared to a sham block as a method of postoperative pain control in patients…
- Trial name
- MCP (NCT05996133)
- Testing
- Bupivacaine Hcl 0.25% Inj, Normal saline
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Hartford Hospital
Rheumatoid Arthritis (RA)
Clinical Study on the Treatment of Refractory Rheumatoid Arthritis With UTAA91 Injection
This clinical trial is designed as a single - arm, open - label, single - center, investigator - initiated early - phase clinical study.
- Trial name
- NCT06982547
- Testing
- UTAA91 injection
- Where
- China
- Volunteers
- 24 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Pain, Osteoarthritis
Brain Morphometry in OA Patients Treated With Duloxetine
This is a two week,single-blind study evaluating pain response and changes in brain imaging upon treatment with placebo in people with knee OA.
- Trial name
- NCT02903238
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Northwestern University
Knee Osteoarthritis
Comparison of Postoperative Pain Score Between Perioperative Intravenous Ketamine and Placebo in Patients Undergoing Unilateral Total Knee Arthroplasty Under General Anesthesia
The goal of this clinical trial is to compare postoperative pain score between perioperative intravenous ketamine and placebo in patients undergoing unilateral total knee arthroplasty under general anesthesia.
- Trial name
- NCT06267638
- Testing
- Ketamine group
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Thailand
Patellofemoral Pain Syndrome
Investigation of Muscle Activity Pattern of Gluteus Medius and Tensor Fascia Lata in Patients With PFPS
The purpose of this study is to investigate the muscle activity of gluteus medius and tensor fascia lata in health control group and patients with PFPS during submaximal isometric muscle contraction.The research question :Is…
- Trial name
- NCT00451438
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Rehabilitation, Pain, Shoulder
Precision Medicine for Nociception, Sngception and Proprioception.
Precision medicine is defined as "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person" by the Precision Medicine…
- Conditions
- Rehabilitation, Pain, Shoulder, Pain, Chronic, Idiopathic Scoliosis
- Trial name
- NCT06161038
- Testing
- LASER, Ultrasound, Prolotherapy
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Cleft Palate
Optic Nerve Sheath Diameter Measurement in Cleft Palate Repair
The aim of this study is to evaluate the effect of the Boyle-Davis mouth opener, which is routinely used in cleft palate surgery, on intracranial pressure by USG-guided optic nerve sheath diameter measurement, which is a…
- Trial name
- NCT04718558
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Karadeniz Technical University
Spine Deformity, Kyphosis
The Effect of Three-Dimensional Exercises ( Schroth Method ) on Trunk Muscle Endurance, Sleep Quality, and Quality of Life in Adolescents With Hyperkyphosis
Adolescence is a critical period for spinal growth, and progression of thoracic hyperkyphosis may lead to pain, weak trunk muscles, sleep disturbances, and reduced quality of life.
- Conditions
- Spine Deformity, Kyphosis, Adolescent, Sleep Quality
- Trial name
- NCT07261358
- Testing
- Kyphosis Study Form, Scoliosis X-ray (Orthoroentgenogram), Inclinometer Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Malocclusion, Maxillar Hypoplasia
Comparison of 2 Techniques of Surgically Assisted Rapid Maxillary Expansion
This study evaluates 2 Techniques of Surgically Assisted Rapid Maxillary Expansion (SARME) in the treatment of maxillary transverse deficiency.
- Conditions
- Malocclusion, Maxillar Hypoplasia, Transverse Maxillary Deficiency
- Trial name
- SARME (NCT03503448)
- Testing
- Osteotomy between the maxillary central incisors, Osteotomy between the maxillary lateral incisors and canines
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Pedro Ernesto
Rheumatoid Arthritis
Nerve Block of the Proximal Interphalangeal Joints PIPs in Rheumatoid Arthritis (RA) Patients: a Prospective Pilot Study
Researchers will include 83 rheumatoid arthritis patients (either early or established) diagnosed after 2010 ACR/EULAR criteria with bilateral hand arthritis aged 18 or above.
- Trial name
- NCT04130178
- Testing
- Nerve block, Saline injection
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Sohag University
Duchenne Muscular Dystrophy
Phase IIb Study of PRO045 in Subjects With Duchenne Muscular Dystrophy
The purpose of the study is to see whether PRO045 is safe and effective to use as medication for Duchenne Muscular Dystrophy (DMD) patients with a mutation around location 45 in the DNA for the dystrophin protein.
- Trial name
- NCT01826474
- Testing
- PRO045, 0.15 mg/kg/week, PRO045, 1.0 mg/kg/week, PRO045, 3.0 mg/kg/week
- Where
- 6 sites in Belgium, France and 3 more
- Volunteers
- 15 people
- Sponsor
- BioMarin Pharmaceutical
Knee Osteoarthritis
Does Addition of a Functional Knee Brace Improve Rehabilitation Outcome in Subjects With Osteoarthritis of the Knee?
The purpose of this study is to investigate the effect of functional knee brace in the subjects with medial compartment knee OA.
- Trial name
- NCT02712710
- Testing
- functional knee brace
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Menopause, Nutritional Intervention
Short-term Supplementation, Bone Turnover and Antioxidant Status in Menopause
This is a 8-week, double-blinded, placebo-controlled, randomized intervention trial to investigate the effects of Mg and Zn supplementation on antioxidant status and bone hormonal parameters.
- Conditions
- Menopause, Nutritional Intervention, Bone Diseases
- Trial name
- NCT03672513
- Testing
- Zinc Supplement, Magnesium supplement
- Where
- Spain
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Maxillary Sinus Disease, Alveolar Bone Loss
Crestal Sinus Lifting in Periodontally-Compromised Patients Utilizing Autologous Dentin Graft
The integration of artificial intelligence and computer-guided technology offers the potential for improving surgical accuracy, reducing complications, and enhancing outcomes.
- Trial name
- NCT06887582
- Testing
- Free-hand sinus lift augmanted by particulate autologous dentin graft + free-hand implant placement, AI-assisted/computer-guided sinus lift augmanted by particulate autologous dentin graft + computer-guided implant placement, Free-hand sinus lift with autologous dentin block graft +free-hand immediate implant placement
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Hallux Valgus and Bunion
Epidemiology of Bunion and Risk Factors
Analysis of the collected data to determine: Prevalence. Risk factors. Radiological and clinical patterns and their association with specific risk factors Of Hallux Valgus
- Trial name
- NCT06335459
- Testing
- epidemiology
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Assiut University