Clinical trials: Musculoskeletal Growth and Development
Osteoporosis
Roles of microRNAs in the Development of Osteoporosis in Men - Preliminary Study
This study is aimed to evaluate the roles of specific miRNAs in osteoporosis in men.
- Trial name
- NCT02705040
- Testing
- Normal, Osteopenia, Osteoporosis
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Lumbar Disc Disease, Lumbal Disc Herniation
Development of a Fascial Training Based Mobile Application and Investigation of Its Effectiveness in Patients With Disc Herniation
This study will compare three different groups for lumbar disc herniation. The first group will do fascia exercises via a mobile application, the second group will do fascia exercises via a home leaflet, and the third group will…
- Trial name
- Fascia-M (NCT07060235)
- Testing
- fascial exercise home brochure, Fascial exercise based mobile application, lumbal stabilizasyon home brochure
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Baskent University
Growth Hormone Deficiency
Transition Study: Growth Hormone Therapy In Partial Growth Hormone Deficient Adolescents
To evaluate in boys and girls the improvement in body composition under GH treatment in adolescents with CO-GHD who remain partially GHD after GH discontinuation.
- Trial name
- TAUBER (NCT00156143)
- Testing
- Blood sample, Radiography
- Volunteers
- 90 people
- Sponsor
- Pfizer
Osteoporosis, Osteoporotic Fracture of Vertebra
Development and Evaluation of an Exercise Intervention for Prevention of Vertebral Osteoporosis and Deformity in Postmenopausal Women
Osteoporotic fractures of the vertebrae (bones in the back) cause substantial pain and disability. Exercise could help to prevent these fractures by increasing bone strength and improving posture.
- Conditions
- Osteoporosis, Osteoporotic Fracture of Vertebra, Postural, Thoracic Kyphosis
- Trial name
- NCT04660825
- Testing
- A resistance band exercise programme, Control
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Clubfoot
Novel Dynamic Foot Abduction Bar for Treatment of Clubfoot
The goal of this clinical trial is to evaluate a new Dynamic Bar for foot abduction bracing for clubfoot treatment. The main questions that this study aims to answer are: How easy is it to recruit and retain participants for a…
- Trial name
- NCT05293743
- Testing
- Foot abduction bracing for clubfoot with novel Dynamic Bar, Foot abduction bracing for clubfoot with Standard Bar
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Cleft Lip
TWIST Human Gene and Cleft Lips and Palates
This study uses a sequence analysis for TWIST and other craniofacial development genes, among patients presenting with facial clefting.
- Trial name
- NCT00213889
- Testing
- None: molecular genetics diagnosis procedure only
- Where
- 4 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Strasbourg, France
Fibromyalgia
Prehabilitation for Being Active. A Feasibility Study in Fibromyalgia
Twelve people with FM will be recruited from the FM patient support groups. The investigators will develop and test a 4-week prehabilitation educational programme (i.e., a behavioural change intervention) consisting of meeting…
- Trial name
- NCT03764397
- Testing
- Prehabilitation for behavioural change
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Universidad de Granada
Osteoarthritis, Knee
Development of Spin-lock and FSE Acquisitions Based 3D Quantitative Biochemical Imaging for Osteoarthritis
In Hong Kong, joint diseases are common health problems as identified by the Elderly Health Service under the Department of Health. It accounts for most of the disability of the elderly in Hong Kong.
- Trial name
- NCT04431752
- Testing
- Magnetic Resonance Imaging Scan
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Genu Varum, Genu Valgum
Retrospective Evaluation of Guided Growth Plate System Plus's Safety and Clinical Performance for the Treatment of Lower Limbs Deformities.
Orthofix is conducting this retrospective Post-market clinical follow up (PMCF) study to assess the safety and clinical performance of the Guided Growth Plate System Plus (GGPSP) device, which is a new version of the Guided…
- Conditions
- Genu Varum, Genu Valgum, Joint Diseases, Knee Deformity
- Trial name
- NCT05241691
- Testing
- Guided Growth Plate System Plus
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- Orthofix s.r.l.
Growth Hormone Deficiency
Evalutation of Insulin Sensitivity Through Hyperinsulinemic Clamp in Children With GH Deficiency
Data about the impact of growth hormone treatment on insulin sensitivity in children are quite controversial, due to the different surrogate indexes that have been used, like Homa-IR, QUICKI, ISI-Matsuda or adipokine levels.
- Trial name
- clamp-GHD (NCT03525171)
- Testing
- euglycemic hyperinsulinemic clamp
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- University of Palermo
Growth Hormone Deficiency, Turner Syndrome
Evaluation of Convenience and Compliance of the Easypod™ Electronic Self-injector
This is an international, multicenter study involving children treated with Saizen®, a growth hormone, who will be trained to use easypod, a new electronic injector and will complete a questionnaire after 12 week of use.
- Conditions
- Growth Hormone Deficiency, Turner Syndrome, Chronic Renal Failure, Small for Gestational Age
- Trial name
- NCT00738205
- Volunteers
- 834 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Short Stature, Growth Disorder
Genetic Causes of Growth Disorders
Background: Some growth disorders are caused by a change in genes. Genes are the instructions the body uses to function. Changes in genes often cause them not to work correctly.
- Conditions
- Short Stature, Growth Disorder, Syndromic Growth Disorder, Tall Stature
- Trial name
- NCT02311322
- Where
- United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Chromosome Aberrations, Growth Hormone Deficiency
Chromosome 18 Clinical Research Center
Our vision, that of the researchers at the University of Texas Health Science Center at San Antonio, is that every person with a chromosome 18 abnormality will have an autonomous and healthy life.
- Conditions
- Chromosome Aberrations, Growth Hormone Deficiency, Hypomyelination
- Trial name
- Chromosome18 (NCT00227253)
- Testing
- Determination of growth hormone status, Measurement of growth, thyroid and sex hormone levels, Behavior and neuropsychometric evaluations
- Where
- 2 sites in United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Multiple Myeloma, Disease of the Marrow
Evaluation of PET/MR and PET/CT Imaging for Bone Marrow Lesions
Developing an MRI protocol at 1.5 T allowing quantification of the hematopoietic, fatty and trabecular moieties of marrow. An ideal protocol would differentiate red marrow from neoplastic cellular infiltration, and detect loss of…
- Conditions
- Multiple Myeloma, Disease of the Marrow, Osteoporosis
- Trial name
- NCT01880762
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Psoriatic Arthritis, Psoriasis
HIPPOCRATES Prospective Observational Study
HIPPOCRATES is an Innovative Medicines Initiative (IMI) funded EU Consortium established to address key unmet clinical needs in psoriatic disease.
- Trial name
- HPOS (NCT05858528)
- Testing
- PEST screening questionnaire
- Where
- United Kingdom
- Volunteers
- 25,000 people
- Sponsor
- University of Oxford
Bone Growth Abnormal, Inflammation
Effects of Increased Greek Yogurt Consumption in Youth and Young Adult Athletes
Physical activity and dairy consumption during growth and development are each known to improve peak bone mass in young adults. Peak bone mass, the maximum amount of bone a person will have in their lifetime, is typically reached…
- Trial name
- NCT05922462
- Testing
- Greek yogurt, Whey protein
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brock University
Infant, Small for Gestational Age
Follow-up to Adult Height of a Cohort of Subjects Born Small for the Gestational Age and Treated With Growth Hormone
This non-interventional study for prospective follow up of a cohort of 220 subjects born small for gestational age (SGA) is planned for the purpose of finding out if normalisation of adult height is associated or not with…
- Trial name
- SGA (NCT01196156)
- Where
- 28 sites in Spain
- Volunteers
- 443 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Knee Osteoarthritis, Total Knee Arthroplasty
A PROMs Based Educational Tool (PROM-DA) for Patients Considering Total Knee Arthroplasty
The primary objectives of this study are to: 1) develop an educational tool known as the Patient Reported Outcome Measure informed Decision Aid (PROM-DA) that will describe the options for patients considering total knee…
- Trial name
- NCT03240913
- Testing
- Baseline and Follow-up Surveys, Patient Reported Outcome Measure informed Decision Aid, Pamphlet
- Where
- Canada
- Volunteers
- 163 people
- Sponsor
- University of Calgary
Dwarfism, Growth Disorder
Study of Luteinizing Hormone-Releasing Hormone Analog (LHRHa) in Pubertal Patients With Extreme Short Stature
Children with extreme short stature (height) and their families often experience significant psychological stress related to concerns about adult height.
- Trial name
- NCT00001190
- Testing
- Deslorelin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Dyslipidemia, Diabetes
Meta-analyses of Fructose and Cardiometabolic Risk
Diabetes and heart associations continue to discourage high intakes of dietary fructose, a constituent part of the sucrose molecule that is found in fruits and vegetables as a natural sugar and in some processed foods and…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01363791
- Testing
- Dietary fructose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper