Clinical trials: Musculoskeletal Injury Trauma
Overuse Injury, Lower Extremity Problem
Step Rate Retraining to Reduce Injury and Disability (STRIDe)
This study will be the first project to evaluate the effectiveness of wearable technology (Garmin Forerunner35) while performing gait retraining in field on military members.
- Conditions
- Overuse Injury, Lower Extremity Problem, Stress Injury, Repetitive, Patellofemoral Pain Syndrome
- Trial name
- STRIDe (NCT04747223)
- Testing
- Run Gait Retraining
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Army-Baylor University Doctoral Program in Physical Therapy
Fractures or Dislocations
INternational ORthopaedic MUlticenter Study in Fracture Care (INORMUS)
Background: Worldwide, injuries from trauma represent a major public health problem. The World Health Organization (WHO) has deemed this problem as one of the most important global priorities, calling 2011-2020 the 'Decade of…
- Trial name
- INORMUS (NCT02150980)
- Where
- 69 sites in Argentina, Botswana and 24 more
- Volunteers
- 39,797 people
- Sponsor
- McMaster University
Acute Kidney Injury
Acute Kidney Injury in Severe Trauma
Acute kidney injury (AKI) represents a serious complication following severe injury associated with adverse outcome. Main goals of the presented study were to define the incidence of AKI and to evaluate the validity of AKI…
- Trial name
- NCT03433079
- Testing
- Neutrophil gelatinase-associated lipocalin (NGAL), Arterial lactate, Interleukin-6 (IL-6)
- Where
- Czechia
- Volunteers
- 81 people
- Sponsor
- University Hospital Ostrava
Osteoarthritis
Autologous Bone Marrow Mesenchymal Stem Cells Transplantation for Articular Cartilage Defects Repair
This is a non-randomized study aimed to determine the safety and efficacy of intra-articular injection of autologous bone marrow-derived mesenchymal stem cells in patients with knee articular cartilage defects.
- Trial name
- NCT01895413
- Testing
- Bone marrow aspiration
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Alexandra Cristina Senegaglia
Work-related Illness, Work Injury
Investigation of Musculoskeletal System Disorders Seen in Automotive Industry Workers
The aim of this study is to examine the musculoskeletal disorders seen in automotive industry workers.
- Trial name
- NCT06484582
- Testing
- workers
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Rheumatoid Arthritis, Osteoarthritis
Low Dose Dexamethasone in Supraclavicular Blocks
Brachial plexus nerve blocks provide superior analgesia over opioids while avoiding unwanted side effects. Single shot blocks with local anesthetic alone usually do not last the duration of the acute post-surgical pain period.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Nerve Entrapment, Ligament Injury
- Trial name
- NCT02666443
- Testing
- Control intervention (no dexamethasone), Peri-neural Dexamethasone 1 mg, Intravenous Dexamethasone 1 mg
- Where
- Canada
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Spinal Cord Injury, Muscle Spasticity
Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the arms and legs.
- Trial name
- NCT00041717
- Testing
- Fampridine-SR
- Where
- 45 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- Acorda Therapeutics
Spinal Cord Injury, Spasticity
Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury
Spasticity is a common consequence of spinal cord injury and can have a profound impact on quality of life. The goal of this study is to learn if an intervention called focused extracorporeal shockwave therapy can enhance the…
- Trial name
- NCT07894991
- Testing
- Focused extracorporeal shockwave therapy, Botulinum toxin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Hip Osteoarthritis, Hip Arthropathy
Comparative Study of Minimally Invasive Surgical Approaches for Total Hip Arthroplasty
Total hip arthroplasty is a method of choice for treating advanced osteoarthritis of the hip and one of the most frequent orthopedic procedures.
- Conditions
- Hip Osteoarthritis, Hip Arthropathy, Minimal Invasive, Anterior Approach
- Trial name
- NCT04311125
- Testing
- Mini posterior approach Total Hip Replacement, Anterior approach total hip replacement without a traction table, Anterior approach total hip replacement with a traction table
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- National and Kapodistrian University of Athens
Musculoskeletal Injury
Effects of Kinesio-Taping and Muscle Energy Technique on Chronic Sacroiliac Joint Dysfunction
Pregnancy is the main occasion of every woman's life in which numerous episodes of physiological and anatomical adjustments takes place within woman's body to become a mother.
- Trial name
- NCT05442476
- Testing
- Kinesiotaping, Muscle Energy Technique, conventional physiotherapy
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Ziauddin University
Acute Kidney Injury, Rhabdomyolysis
Myoglobin Removal With CytoSorb in Rhabdomyolysis
The aim of this observational study is to assess whether myoglobin removal with CytoSorb® ameliorates endothelial damage in severe rhabdomyolysis patients who are admitted to the intensive care unit.
- Conditions
- Acute Kidney Injury, Rhabdomyolysis, Endothelial Dysfunction
- Trial name
- NCT06503289
- Testing
- Cytosorb therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Spasticity
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of lower limb spasticity, in adults followed by an open-label extension…
- Trial name
- NCT04099667
- Testing
- Phase 2; Low Dose MYOBLOC (15,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 40 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Spinal Cord Injury at C5-C7 Level With Incomplete Lesion
Use of Implanted Microstimulators for Decreasing Spasticity and Improving Motion Following Spinal Cord Injury
The primary aims of this study are to determine the safety of the RFM System (Alfred Mann Foundation, Santa Clarita, CA) in a patient with incomplete SCI and the effect of the RFM system on lower limb strength and spasticity.
- Trial name
- NCT00781833
- Testing
- Radio Frequency Microstimulator
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The Alfred E. Mann Foundation for Scientific Research
Spinal Cord Injuries
Spasticity After Spinal Cord Injury
Very often, people who have a SCI have difficulty doing things with their arms or hands as a result of muscle stiffness , or spasticity. Spastacity can cause problems performing even the simplest of everyday tasks.
- Trial name
- NCT04393922
- Testing
- Acoustic stimuli (Startle)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Osteoporosis
Osteoporosis Prevention: Changes to Exercise and Diet in Children
The purpose of this study is to determine whether educating parents about health and behavior management techniques will increase physical activity, calcium intake, fitness, and bone density in their children.
- Trial name
- NCT00063050
- Testing
- Physical activity and nutrition intervention
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Muscle Injury, Muscle Soreness
Effects of Wobenzym® Plus in Healthy, Sportive People After Eccentric Exercise
The aim of the current study is to investigate the therapeutic effect and especially the mode of action of Wobenzym® plus, an anti-inflammatory drug containing proteolytic enzymes, on exercise induced muscle damage (eiMD) and…
- Conditions
- Muscle Injury, Muscle Soreness, Exercise Induced Muscle Damage
- Trial name
- 2012-005003-40 (NCT01845558)
- Testing
- Wobenzym® plus
- Where
- Germany
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Mucos Pharma GmbH & Co. KG
Spinal Cord Injury, Osteoporosis
Early Intervention to Reduce Bone Loss After Spinal Cord Injury
After a complete spinal cord injury (SCI), the patient becomes wheelchair-dependent, and the associated lack of weight-bearing and inactivity of paralysed muscles can lead to extensive bone loss in the long bones of the legs.
- Trial name
- NCT02334410
- Testing
- Whole body vibration (WBV)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Strathclyde
Spastic Tetraplegia, Pain
ESWT for UE Pain in Patients With Cervical Spinal Cord Injury
This study aimed to investigate the efficacy and safety of extracorporeal shockwave therapy (ESWT) for upper extremity pain related to spasticity in patients with spinal cord injury.
- Conditions
- Spastic Tetraplegia, Pain, Myelopathy Cervical
- Trial name
- NCT04319679
- Testing
- Extracorporeal shockwave therapy
- Where
- South Korea
- Volunteers
- 4 people
- Sponsor
- Bundang CHA Hospital
Humerus Fracture, Humerus
RSA vs. Nonop for 3 & 4-Part Proximal Humerus Fractures
There is currently no consensus amongst orthopedic specialists on the best way to treat 3- and 4-part proximal humerus fractures.
- Conditions
- Humerus Fracture, Humerus, Shoulder Fractures, Shoulder Arthropathy Associated With Other Conditions
- Trial name
- NCT03599336
- Testing
- Reverse Total Shoulder Arthroplasty (rTSA), Nonoperative Treatment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Spinal Cord Injuries, Neuropathic Pain
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
The goal of this clinical trial is to evaluate safety and tolerability of multiple oral doses of EC5026 in male and female patients with neuropathic pain due to traumatic or non-traumatic (degenerative) spinal cord injury.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Degenerative Disc Disease, Spinal Stenosis
- Trial name
- NCT06438471
- Testing
- EC5026 oral tablet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- EicOsis Human Health Inc.