Clinical trials: Musculoskeletal Symptom
Knee Osteoarthritis, Persistent Postsurgical Pain
Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain
Chronic knee pain remains a disabling disease despite current treatment strategies. There is an increase in the prevalence of osteoarthritis (OA) of the knee in the general population, presently affecting approximately 450,000…
- Conditions
- Knee Osteoarthritis, Persistent Postsurgical Pain, Chronic Knee Pain
- Trial name
- COGENIUS (NCT05407610)
- Testing
- Conventional Radiofrequency ablation of the genicular nerves, Cooled Radiofrequency ablation of the genicular nerves
- Where
- 15 sites in Belgium, Netherlands
- Volunteers
- 400 people
- Sponsor
- Ziekenhuis Oost-Limburg
Fibromyalgia
Efficacy of a Gluten-free Diet for the Treatment of Fibromyalgia
Fibromyalgia patients frequently suffer from symptoms similar to those of adult celiac disease, raising the possibility that some fibromyalgia patients experience oligosymptomatic celiac disease or non-celiac gluten intolerance.
- Trial name
- NCT01881360
- Testing
- Gluten-free diet, Hypocaloric diet
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Universidad de Granada
Low Back Pain, Spondylolisthesis
Effects of Exercise Intervention in Patients With Spondylolisthesis Related LBP
The first purpose of this study is to define parameters of the trunk neuromuscular functions that are pathologically altered in patients with low back pain due to spondylolytic spondylolisthesis.
- Trial name
- EXER-SPO-TNC (NCT01985776)
- Testing
- Exercise intervention, Exercise and e-stim
- Where
- 4 sites in Slovenia
- Volunteers
- 48 people
- Sponsor
- University of Primorska
Acute Pain
A Study Of The Effectiveness Of Wafermine Alone And In Combination With Opioids In Subjects Undergoing Bunionectomy
To evaluate the safety and effectiveness of Wafermine administered with and without an opioid medication for acute pain following bunionectomy surgery.
- Trial name
- NCT02541396
- Testing
- Wafermine, Oxycodone
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- iX Biopharma Ltd.
Grip, Muscle Disorder
Investigation of Grip Strength, Pain and Anxiety Levels in Dentists
The aim of the study is to evaluate the relationship between professional experience and grip strength, pain threshold and anxiety level in dentists.
- Conditions
- Grip, Muscle Disorder, Pain, Chronic, Anxiety
- Trial name
- NCT06721117
- Testing
- Grip strength assessment, Forearm muscle strength assessment, Pain threshold assessment
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Myotonic Dystrophy 1, Excessive Daytime Sleepiness
Safety and Efficacy of Pitolisant on Excessive Daytime Sleepiness and Other Non-Muscular Symptoms in Patients With Myotonic Dystrophy Type 1
The primary objective of this study is to evaluate the safety and efficacy of pitolisant compared with placebo in treating excessive daytime sleepiness (EDS) in patients with Myotonic Dystrophy Type 1 ages 18 to 65 years.
- Trial name
- NCT04886518
- Testing
- Pitolisant Oral Tablet
- Where
- 13 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Harmony Biosciences Management, Inc.
Ulnar Wrist Pain
Ulnar Wrist Pain Treatment With Dextrose Prolotherapy
Participants who have failed therapy for chronic wrist pain on the little finger side of the wrist will recieve dextrose prolotherapy.
- Trial name
- NCT03411811
- Testing
- Usual Care, Dextrose
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Universidad Abierta Interamericana
Chronic Periodontitis, Periodontal Bone Loss
Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.
The aim of this study is to compare the effectiveness in periodontal regeneration of cross-linked hyaluronic acid at 1.8% (Hyadent BG®) with enamel matrix derivative (Emdogain®) in periodontal bone defects evaluating their…
- Trial name
- NCT04274244
- Testing
- Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML, Enamel Matrix Proteins (Active comparator group)
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Andres Lopez Roldan
Patellofemoral Osteoarthritis
Proximal and Distal Therapeutic Approach in Pain and Lower Limb Kinematic in People With Patellofemoral Osteoarthritis
This is a crossover study that will investigate the immediate effects of a proximal therapeutic approach (SERF strap) and a distal one (foot orthoses) on knee pain intensity, global change, symptoms, ease of performance and…
- Trial name
- NCT04332900
- Testing
- Elastic hip strap, Insole
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Sao Carlos
Osteoarthritis Hip, Joint Disease
Mobilization With Movement in Patients With Osteoarthritis of the Hip
The concept of mobilization with movement, also referred to as a Mulligan mobilization, has not been studied in patients with hip osteoarthritis, subsisting questions about the possible effects in this population.
- Conditions
- Osteoarthritis Hip, Joint Disease, Musculoskeletal Diseases, Pathologic Processes
- Trial name
- MWM (NCT02390336)
- Testing
- Real mobilization-with-movement (MWM)
- Volunteers
- 40 people
- Sponsor
- Natália Maria Oliveira Campelo
Acromegaly Cardiomyopathy
Endocrine Cardiomyopathy: Response to Cyclic GMP PDE5 Inhibitors in Acromegaly Cardiomyopathy
Pathophysiology of acromegaly cardiomyopathy is yet unclear and a specific treatment have not been indicated. It was already demonstrated the positive impact of phosphodiesterase type 5A (PDE5A) inhibition in several models of…
- Trial name
- SUM (NCT02611336)
- Testing
- Tadalafil
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Andrea M. Isidori
Temporomandibular Disorders (TMDs)
Investigation of the Effects of Different Treatment Approaches in Jaw (Temporomandibular) Joint Disorders
Temporomandibular joint disorders (TMD) are common conditions that may cause jaw pain, limited jaw movement, and reduced quality of life.
- Trial name
- NCT07392671
- Testing
- Conventional Physiotherapy and Rehabilitation Program, Limbic-Oriented Manual Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Long COVID, Long Covid19
Stellate Ganglion Block to Treat Long COVID 19 Case Series
An assessment of the effectiveness of Stellate Ganglion Block in alleviating symptoms of Long COVID-19.
- Conditions
- Long COVID, Long Covid19, Post-COVID-19 Syndrome, Post Acute COVID-19 Syndrome
- Trial name
- NCT05812209
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Metamorphosis LTD
Chronic Pain
2B Active: Outpatient Rehabilitation for Adolescents With Chronic Pain
The purpose of this study is to evaluate whether a multimodal rehabilitation program effectively reduces functional disability in adolescents with chronic musculoskeletal pain, compared to care as usual.
- Trial name
- NCT02181725
- Testing
- Multimodal Rehabilitation Program, Care as Usual
- Where
- 4 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Degeneration of Lumbar Intervertebral Disc
Qualitative Pain Measurement at Patients With Degenerative Low Back Pain
The purpose of the study is: to measure sensitization of the nociceptive system at patients with low back pain in order to carry out a necessary surgical procedure to examine a possible association between low back pain and…
- Trial name
- NCT01980576
- Where
- Denmark
- Volunteers
- 1 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Breast Cancer
Musculoskeletal Pain in Postmenopausal, Early Breast Cancer Patients Receiving Aromatase Inhibitor Therapy - A Pilot Study
In 2005, the EBCIG demonstrated the efficacy of tamoxifen in improving overall survival in hormone receptor positive breast cancers.
- Trial name
- AIMS (NCT00653718)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Fibromyalgia
Living With Fibromyalgia: Triggers,Subgroups, and a Cognitive-Behavioral and Interactive Technology-Based Intervention
The purpose of this study is to conduct semi-structured qualitative interviews to examine the personal experiences of women living with fibromyalgia.
- Trial name
- NCT00222690
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Obesity, Morbid, Back Pain
THE EFFECT OF FAST WEIGHT EFFICIENCY AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY ON THE COBB ANGLE IN MORBID OBESE PATIENTS
Obesity has become an increasingly common health problem today. In this context, although many anatomical, physiological and metabolic problems arising from obesity in morbid obese patients are tried to be solved in daily…
- Conditions
- Obesity, Morbid, Back Pain, Scoliosis
- Trial name
- NCT04844320
- Testing
- Cobb angle measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Lumbar Disc Herniation
Effect of Pulsed Mode Radiofrequency as a Treatment of Lumbar Disc Related Radicular Pain on Tumor Necrotic Factor α Level
Lumbar radiculopathy is a term that describes symptoms of pain, numbness, and/or weakness that radiate along the sciatic nerve from the lower back to the buttocks and leg (1).
- Trial name
- NCT05288920
- Testing
- Radiofrequency pulsed mode on dorsal root ganglion combined with transforaminal steroids injection, Transforaminal injection of Steroids alone
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Beni-Suef University
Root Canal Infection, Bisphosphonate-Associated Osteonecrosis
Root Canal Treatment Outcome in Patients Under Bisphosphonate Therapy
The aim of this study was to evaluate the survival rate and healing time of compromised teeth and seriously compromised teeth that were endodontically treated in patients which received bisphosphonate therapy .
- Conditions
- Root Canal Infection, Bisphosphonate-Associated Osteonecrosis, Periapical Abscess, Endodontically Treated Teeth
- Trial name
- NCT04399720
- Testing
- Root canal treatment
- Volunteers
- 111 people
- Sponsor
- University of Bologna
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