Clinical trials: Myocardial Deformation
Myocardial Deformation, Coronary Artery Anomaly
Correlation Between Myocardial Deformation and Coronary Artery Tortuosity in Patients With Hypertrophic Cardiomyopathy
Correlation between Myocardial Deformation and Coronary Tortuosity and Analysis of Genetic Factors Among Hypertrophic Cardiomyopathy Patients
- Conditions
- Myocardial Deformation, Coronary Artery Anomaly, Hypertrophic Cardiomyopathy, Genetic Mutation
- Trial name
- NCT04830787
- Testing
- no intervention
- Where
- China
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Coronary Artery Disease
Integrated RF and B-mode Deformation Analysis for 4D Stress Echocardiography
The specific aim of this clinical trial is to translate the investigators new 4DE (three sptial dimensions pluse time) stress echocardiographic method to patients with coronary artery disease referred for clinically indicated…
- Trial name
- NCT02327455
- Testing
- Stress Dobutamine Echocardiographic using 4DE System
- Sponsor
- Yale University
Disorder of Cardiac Function
Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection
BACKGROUND Myocarditis and pericarditis are inflammatory conditions of the heart commonly due to viral or autoimmune etiologies. Human CMV represents one of the leading causes of congenital infections worldwide.
- Trial name
- NCT02787382
- Testing
- echocardiographic examination
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Neurofibromatosis Type 1
Subtle Myocardial Deformation Abnormalities in Asymptomatic Nf-1 Patients
Subtle myocardial deformation abnormalities in asymptomatic nf-1 patients: is cardiac screening needed?
- Trial name
- NCT02505412
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Cardiac and Non Cardiac Thoracal Disorder
Acute Coronary Disease (ACS)- Strain
Examination of probable distinction between cardiac or non- cardiac thoracal disorder via echocardiographic myocardial strain analysis
- Trial name
- ACS-Strain (NCT02357641)
- Testing
- retrospective echographic myocardial strain analysis refering to acute coronary syndrome
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- RWTH Aachen University
Coronary Artery Disease
Effect of Olivomed (Olive Extract) on Endothelial, Cardiac and Vascular Function
Olive extracts are considered to have antioxidant properties. The investigators will study the effect of olive extracts containing hydroxytyrosol (HT)-olivomed and combination of Oleuropein (OL), Hydroxytyrosol (HT), Oleocanthal…
- Trial name
- NCT04520126
- Testing
- Olivomed (capsules containing hydroxytyrosol), OlivomedSmart - Capsules containing - combination of Oleuropein (OL), Hydroxytyrosol (HT), Oleocanthal (OC) - (OL:HT:OC 2:1:3), (5 mg HT bid).
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Athens
STEMI, Covid19
Evaluation of the Effect of Long-term Lipid-lowering Therapy in STEMI Patients With Coronavirus Infection COVID-19
It is planned to include 200 patients hospitalized with primary myocardial infarction with and without ST segment elevation (STEMI or NSTEMI) in combination with COVID-19 within the first 15 days from the disease onset.
- Conditions
- STEMI, Covid19, NSTEMI
- Trial name
- CONTRAST-3 (NCT04900155)
- Testing
- Atorvastatin 80mg, Atorvastatin-Ezetimibe
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Penza State University
Heart Failure
Left Ventricular Lead Position in Cardiac Resynchronization Therapy
Left ventricular (LV) lead position has crucial impact on cardiac resynchronization therapy (CRT) success. This study will compare fluoroscopy and myocardial deformation imaging for optimal definition of LV lead position.
- Trial name
- NCT00748735
- Testing
- Implantation of a cardiac resynchronization therapy device, Echocardiography (myocardial deformation imaging)
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- RWTH Aachen University
Athlete Heart
Myocardial Mechanics in Athlete's Heart
Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling.
- Trial name
- NCT05543525
- Testing
- Echocardiography, Cardiopulmonary exercise testing
- Where
- France
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Myocardial Infarction, Acute, Myocardial Strain
Assessment of the Effects of Long-term Lipid-lowering Therapy in Patients With Primary STEMI or NSTEMI
In a single-center, open-label, prospective, controlled, clinical study, it is planned to include 300 patients hospitalized in the cardiology department of SBHI Penza regional clinical hospital n.a. N.N. Burdenko.
- Conditions
- Myocardial Infarction, Acute, Myocardial Strain, Arterial Stiffness, Quality of Life
- Trial name
- CONTRAST-2 (NCT04347434)
- Testing
- Atorvastatin 80mg
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Penza State University
COVID-19, Endothelial Dysfunction
The Effect of Dietary Intervation on Endothelial Glycocalyx in COVID-19 Patients.
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis.
- Trial name
- NCT05185934
- Testing
- Food supplement Endocalyx
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
Myocardial Dysfunction
Myocardial Deformation Imaging After Acute Alcohol Excess
Background: Chronic excessive alcohol consumption leads to progressive and chronic cardiac dysfunction. In general, patients consuming alcohol more than five years are at risk for the development of dilated cardiomyopathy.
- Trial name
- C2 (NCT02759445)
- Testing
- routine treatment
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Heart Disease
Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery
The SHAPE study is a prospective, randomized study evaluating changes in cardiac function in adult patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- SHAPE (NCT07770269)
- Testing
- BIS-guided anesthesia: BIS 45-55, BIS-guided anesthesia: BIS 30-35
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- AHEPA University Hospital
Psoriasis
Effects of Treatment With Biological Agents on Vascular and Cardiac Function in Psoriasis
Psoriasis has been associated with an increasing risk for atherosclerosis. The investigators investigated whether surrogate markers of subclinical atherosclerosis, vascular dysfunction and myocardial dysfunction are impaired in…
- Trial name
- NCT02144857
- Testing
- etanercept, ustekinumab, cyclosporine
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Athens
HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction
Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction
Patients with HOCM and severe LVOT obstruction can remain asymptomatic while significant cellular and structural changes of the heart (adverse remodeling) may occur preceding heart failure and rhythm disorders.
- Conditions
- HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction, Remodeling, Ventricular
- Trial name
- RASTA (NCT04230551)
- Testing
- PTSMA
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- St. Antonius Hospital
Smoking Cessation, Arterial Stiffness
The Effect of Cytisine Treatment for Smoking Cessation on Cardiovascular Function in Adult Smokers
Introduction: Pharmacological interventions can enhance smoking cessation success and long-term abstinence. Cytisine, a plant derived alkaloid, is a selective partial agonist at alpha-4 beta-2 nicotinic acetylcholine receptors…
- Conditions
- Smoking Cessation, Arterial Stiffness, Endothelial Dysfunction
- Trial name
- Cytisin-angio (NCT06885970)
- Testing
- Cytisinicline administration
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Athens
Psoriasis
The Effect of Dietary Intervention on Endothelial Glycocalyx in Psoriasis
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis.
- Trial name
- NCT05184699
- Testing
- Food supplement Endocalyx
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
Heart Diseases
Inhaled Anesthetics and Myocardial Strain
Speckle tracking imaging measuring software will be used for offline analysis of transesophageal echocardiogram (TEE) -acquired images of the left ventricle(LV) in four chambers(4C), two chambers (2C) and long axis (LAX) views to…
- Trial name
- NCT03569085
- Testing
- Sevoflurane, Isoflurane
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Kathirvel Subramaniam