Clinical trials: Myocardial Failure
Cerebral Hemorrhage, Head Injury
Biomarkers Correlation With Volemia
The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7…
- Conditions
- Cerebral Hemorrhage, Head Injury, Non Traumatic Post Surgery, Poly Trauma Patients Without Heart Failure
- Trial name
- ENVOL (NCT01858675)
- Testing
- Biomarkers, red blood cells and plasma assessment
- Where
- France
- Volunteers
- 66 people
- Sponsor
- ThermoFisher Scientific Brahms Biomarkers France
Heart Failure, Congestive
Catheterization Laboratory Study: Acute Responses in Diastolic Heart Failure
1. Research question: What is the response of the heart's pumping function to changes in heart chamber pressures? 2. Experimental design: Patients undergoing routine cardiac catheterization will be studied.
- Trial name
- NCT00204945
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Wisconsin, Madison
Heart Failure, Hyperkalemia
Cardiovascular and Renal Treatment in Heart Failure Patients With Hyperkalaemia or at High Risk of Hyperkalaemia
The CARE-HK in HF is a registry study based on the hypothesis that adherence to guidelines is associated with improved real-world outcomes for heart failure (HF) patients.
- Trial name
- CARE-HK (NCT04864795)
- Where
- 116 sites in United States, Austria and 5 more
- Volunteers
- 2,636 people
- Sponsor
- Vifor (International) Inc.
Chronic Heart Failure
Iron Stores and Skeletal Muscle Metabolism in Chronic Heart Failure
Iron deficiency may contribute to exercise intolerance by altering mitochondrial oxidative capacity in skeletal muscle. Functional iron deficiency is common in heart failure patients, but the relationship to exercise intolerance…
- Trial name
- NCT02737995
- Testing
- Ferric carboxymaltose infusion
- Volunteers
- 8 people
- Sponsor
- NYU Langone Health
Heart Failure, Cardiac Failure
Blood Pressure Reduction in Heart Failure
Previous studies have demonstrated a direct association between blood pressure level and cardiovascular risk. However in patients with heart failure this association is considered controversial.
- Conditions
- Heart Failure, Cardiac Failure, Congestive Heart Failure
- Trial name
- REPIC (NCT01255475)
- Testing
- Hydralazine/amlodipine
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- University of Sao Paulo
Conduction System Pacing, Biventricular Pacing
CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy
The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in…
- Conditions
- Conduction System Pacing, Biventricular Pacing, Cardiac Resynchronization Therapy, Right Ventricular Pacing
- Trial name
- CSP-UPGRADE (NCT06241651)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- China
- Volunteers
- 66 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Heart Failure
CHANges iN skEletal muscLe in Heart Failure
The mechanisms behind heart failure are largely unknown. Despite an increasing arsenal of pharmacological therapies, cardiovascular disease is still the most common cause of death in the western world, which demonstrates a…
- Trial name
- Channel-HF (NCT03401151)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Heart Failure, Cognitive Impairment
Reducing Cognitive Impairment by Management of Heart Failure as a Modifiable Risk Factor
This study will test the feasibility and effectiveness of an innovative model of care for cognitively impaired patients with heart failure.
- Conditions
- Heart Failure, Cognitive Impairment, Dementia, Left Ventricular Dysfunction
- Trial name
- Cog-HF (NCT06088212)
- Testing
- Disease management program
- Where
- Australia
- Volunteers
- 168 people
- Sponsor
- Baker Heart and Diabetes Institute
Left Ventricular Dysfunction, Right Ventricular Dysfunction
Levosimendan In Patients Undergoing LVAD Implantation
According to the results from the literature, it has been shown that levosimendan usage 24-48 hours before LVAD implementation can improve short and long-term outcome in these patients regarding to the patients without…
- Conditions
- Left Ventricular Dysfunction, Right Ventricular Dysfunction, Biventricular Failure
- Trial name
- NCT03659851
- Testing
- Levosimendan 2.5 MG/ML Injectable Solution
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Dubrava
Ischemic Heart Disease, Stenotic Coronary Lesion
RESOLUTE ONYX China RCT Study
It is a randomized controlled trial to evaluate the safety and efficacy of the Medtronic Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System in comparison with the Medtronic Resolute Integrity™ Zotarolimus-Eluting coronary…
- Conditions
- Ischemic Heart Disease, Stenotic Coronary Lesion, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT03466151
- Testing
- Resolute Onyx™ Zotarolimus-Eluting Coronary Stent System, Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System
- Where
- 2 sites in China
- Volunteers
- 550 people
- Sponsor
- Medtronic Vascular
Aortic Valve Stenosis, Heart Failure
The Effectiveness and Safety of Levosimendan in Patients With Severe Aortic Stenosis and Heart Failure Undergoing Transcatheter Aortic Valve Replacement
A study to evaluate the effectiveness and safety of levosimendan compared with placebo in subjects with severe aortic stenosis and heart failure undergoing transcatheter aortic valve replacement
- Conditions
- Aortic Valve Stenosis, Heart Failure, Inotropic Agents, Safety Issues
- Trial name
- NCT04573049
- Testing
- Levosimendan
- Where
- China
- Volunteers
- 124 people
- Sponsor
- China National Center for Cardiovascular Diseases
Congestive Heart Failure
Testosterone Improves Exercise Oxygen Uptake, Insulin Resistance and Muscle Strength in Elderly Patients With Chronic Heart Failure
Background: Patients with congestive heart failure (CHF) show muscle mass wasting and decreased testosterone levels. Long-term testosterone supplementation improves walking distance and glucose metabolism of patients CHF.
- Trial name
- NCT00512408
- Testing
- testosterone
- Where
- Italy
- Sponsor
- IRCCS San Raffaele
Heart Failure, Transplant; Failure, Heart
Assessing the Effects of Mechanical Unloading on Repair Version-1
The mechanism by which heart failure initiates and progresses and the mechanisms of heart repair remain unclear. The left ventricular assist device (LVAD) is a therapy to stabilise patients while they await their transplant.
- Trial name
- NCT06026215
- Volunteers
- 23 people
- Sponsor
- Manchester University NHS Foundation Trust
Heart Failure; With Decompensation
Evaluation Of A Virtual Cardiology Program To Improve Outcomes After Acute Decompensated Heart Failure
The purpose of this study is to evaluate how safe and effective a remote, virtual, cardiology program is that provides heart failure education to patients, monitors for worsening heart failure, and quickly adjusts heart failure…
- Trial name
- ELEVATE-HF (NCT06592508)
- Testing
- Remote Virtual Cardiology Program
- Where
- 5 sites in United States
- Volunteers
- 73 people
- Sponsor
- Duke University
Heart Failure With Normal Ejection Fraction
ImCardia for DHF to Treat Diastolic Heart Failure (DHF) Patient a Pilot Study
This study is designed to evaluate the ImCardia safety and to demonstrate system functionality in patients undergoing AV replacement with respect to 36 months follow up.
- Trial name
- ImCardia (NCT01347125)
- Testing
- ImCardia Device
- Volunteers
- 19 people
- Sponsor
- CorAssist Cadiovascular Ltd.
Heart Failure
Exercise Oscillatory Breathing and Sildenafil in Heart Failure
Exercise oscillatory breathing (EOB) is a ventilatory abnormality that occurs in approximately 20% of heart failure (HF) patients and carries a very unfavourable prognosis.
- Trial name
- NCT01185925
- Testing
- Sildenafil
- Volunteers
- 32 people
- Sponsor
- University of Milan
Heart Failure
Effect of His-Ventricular (HV) Interval Optimisation in Cardiac Resynchronisation Therapy
Cardiac resynchronisation therapy (CRT) is a specialised type of pacemaker used in patients with severe heart failure to improve symptoms and survival.
- Trial name
- NCT02748876
- Testing
- His-Ventricular (HV) optimisation
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Neuroendocrine Tumors, Heart Failure
Phase I Study of the Safety, Distribution, and Radiation Dosimetry of Ultratrace Iobenguane 123I-mIBG
The goal of this proposal is to produce and test high specific activity Ultratrace iobenguane I 123 in normal human volunteers.
- Trial name
- mIBG (NCT01730417)
- Testing
- no carrier added metaiodobenzylguanidine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bennett Chin
Lymphoma
Revlimid® Capsules Drug Use-results Surveillance (Relapsed or Refractory ATLL)
To understand the safety and efficacy of Revlimid® Capsules 2.5 mg and 5 mg (hereinafter referred to as Revlimid) under actual conditions of use in patients with relapsed or refractory adult T-cell leukemia lymphoma (hereinafter…
- Trial name
- NCT03098589
- Testing
- Revlimid
- Where
- Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Systemic Sclerosis, Cardiac Diseases
Development and Prevention of Severe Heart Disease in Systemic Sclerosis
Systemic sclerosis is an orphan, multiorgan disease affecting the connective tissue of the skin and all internal organs. Cardiac involvement, mainly characterised by small intramyocardial coronary artery involvement and…
- Conditions
- Systemic Sclerosis, Cardiac Diseases, Heart Block, Cardiac Arrhythmia
- Trial name
- NCT01829126
- Where
- 11 sites in France, Germany and 4 more
- Volunteers
- 765 people
- Sponsor
- Gabriele Valentini