Clinical trials: Myocardial Function
Coronary Artery Disease, Valvular Heart Disease
The ABC Trial Does All-Blood Cardioplegia Prevent Blood Transfusion in Cardiac Surgery? A Single Centre Pilot Study
This study is a single centre pilot for a randomized trial comparing all-blood cardioplegia to more dilute 4:1 blood cardioplegia during cardiac surgery.
- Trial name
- ABC (NCT01623193)
- Testing
- All-blood cardioplegia, Standard cardioplegia
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Pam Trenholm
Coronary Artery Disease
Effect of Eplerenone on Endothelial Function in Patients With Stable Coronary Heart Disease
The aim of the present study is to investigate wether endothelial dysfunction associated with stable coronary artery disease is altered by selective aldosterone antagonism with Eplerenone as potential anti-inflammatory drug…
- Trial name
- NCT00427284
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Zurich
Left Bundle-Branch Block
Effects of Isolated LBBB on Maximal Functional Capacity
Left bundle branch block (LBBB) has been commonly associated with adverse cardiovascular (CV) events, but the effect of an isolated LBBB on maximal functional capacity is not well characterized.
- Trial name
- NCT05643404
- Testing
- Cardiopulmonary exercise testing, Echocardioghaphy
- Where
- Spain
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Pregnancy
Echo-Cardiographic Assessment of Cardiovascular Characteristics During Pregnancy and Postpartum Periods
The purpose of this echocardiographic study is to restudy the longitudinal changes in cardiac size and function during and after pregnancy in healthy women using relatively new parameters of systolic and diastolic function as…
- Trial name
- NCT00522977
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Gender Dysphoria
Effects of Cross-sex Hormone Treatment on Cardiac Function, Myocardial and Hepatic Fat Content
Background: Sex hormones are believed to play an important role in the development and progression of cardiovascular disease. However, the gender gap in onset and mortality is not yet completely understood.
- Trial name
- NCT06245681
- Testing
- gender affirming hormone therapy
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Acute Coronary Syndrome
Protective Effect of Early High Dose stATins On Cardiovascular and Renal Events in Acute Coronary Syndrome
Registration of all ACS patients (STEMI and NSTEMI) admitted to the cardiology ward and scheduled for early invasive strategy. The aim is to evaluate the protective effects of early (on admission) high-dose high-potency statin…
- Trial name
- PRATO-ACS (NCT04087200)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Centro Cardiopatici Toscani
Coronary Artery Disease
Effect of Abrupt Plavix® Discontinuation on Platelet Function
The well established importance of regular administration of antiplatelet drugs stands on firm grounds, as large meta-analyses have shown these therapies to significantly reduce the risk of death.
- Trial name
- NCT00670943
- Testing
- Platelet function testing
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Université de Montréal
Mitral Valve Insufficiency, Mitral Valve Regurgitation
EVEREST II Pivotal Study High Risk Registry (HRR)
Prospective, multi-center, single arm registry. Clinical follow-up at discharge, 30 days, 6, 12, 18 and 24, months, and 3, 4 and 5 years.
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation
- Trial name
- HRR (NCT01940120)
- Testing
- Percutaneous mitral valve repair using MitraClip implant
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Abbott Medical Devices
Coronary Heart Disease, Cognitive Impairment, Mild
Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease
This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic…
- Trial name
- NCT07657624
- Where
- China
- Volunteers
- 2,352 people
- Sponsor
- Beijing Anzhen Hospital
Ischemic Heart Disease, Angina Pectoris
Physiology and Residual Ischemia After Percutaneous Coronary Intervention
Despite optimal angiographic result after stent implantation, a number of patients will undergo repeat angiography within 1 year of index procedure.
- Conditions
- Ischemic Heart Disease, Angina Pectoris, Chest Pain, Coronary Artery Disease
- Trial name
- EASY-PRIPCI (NCT04494750)
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Laval University
Coronary Artery Disease
Effect of Different Dosing Regimens of Clopidogrel Before Elective Percutaneous Coronary Intervention (PCI) on Platelet Function
Adequate platelet inhibition before percutaneous coronary intervention (PCI) reduces peri-procedural and long-term ischemic complications.
- Trial name
- NCT00693069
- Testing
- Clopidogrel
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Percutaneous Coronary Intervention, Myocardial Ischemia
Analysis of Myocardial Layer Specific Systolic and Diastolic Function During and After PCI
Investigators will analyzed systolic and diastolic function during and after ischemia induced by percutaneous coronary intervention.Also will be analyzed a local work index during acute ischemia induced by percutaneous coronary…
- Conditions
- Percutaneous Coronary Intervention, Myocardial Ischemia, Anginal Pain
- Trial name
- PCI-Strain (NCT02004483)
- Testing
- Percutaneous Coronary Intervention
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- RWTH Aachen University
Healthy Participants, Reference Values
Cardiac Normal Values Assessed by Magnetic Resonance Imaging
This study carried out a study enrolled healthy volunteers to comprehensively provide age and sex specific reference values of the normal cardiac structure and function of Chinese adults, using the steady-state free precession…
- Trial name
- NCT05346094
- Testing
- No intervention
- Where
- China
- Volunteers
- 938 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Diabetes Mellitus, Type 2
Effect of the Antidiabetic Drug Dapagliflozin on the Coronary Macrovascular and Microvascular Function in Type 2 Diabetic Patients
Cardiovascular events remain a major driver of morbidity and mortality in patients with type 2 diabetes mellitus. Diffuse coronary atherosclerosis, combined with impairment of the microcirculation are frequent even in…
- Trial name
- DAPAMICRO (NCT05392959)
- Testing
- Dapagliflozin 10 mg Tab
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Hypercortisolism
Hypercortisolism and Epicardial Adipose Tissue
Identifying hypercortisolism patients at risk for cardio-vascular events despite biological cure, and determine which patients should be particularly followed.
- Trial name
- Hyper-Cor (NCT02335996)
- Testing
- Blood samples for measuring adiponectin, leptin and omentin plasma, MRI at 3 Tesla
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Modes of Exercise and Myocardial and Endothelial Function, Microcirculation
Investigation of Cardiac Function and Cardiovascular Risk Factors in Marathon Runners- The Munich Marathon Study
The purpose of this study is to determine the cardiovascular risk involved in the exertional exercise of marathon running. The researchers aim to investigate the beneficial effects of regular well-dosed exercise on health and…
- Conditions
- Modes of Exercise and Myocardial and Endothelial Function, Microcirculation, Subclinical Endorgan Damage, Obesity
- Trial name
- MMS (NCT00500773)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Transthyretin Amyloid Cardiopathy, Mitochondrial Pathology
The Effect of Trimetazidine on Mitochondrial Function, Myocardial Performance, and Invasive Hemodynamics in Patients Diagnosed With Wild-Type Transthyretin Cardiac Amyloidosis
Wild-type transthyretin cardiac amyloidosis (ATTRwt) is a deposition disorder in which one of the proteins of the body misfolds and accumulates at various places in the body, including the heart, leading to both mechanical and…
- Trial name
- CACTuS - TMZ (NCT05633563)
- Testing
- Trimetazidine
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steen Hvitfeldt Poulsen
Pulmonary Hypertension, Valvular Heart Disease
Evaluating Right Ventricular (RV) Size and Function Using the Upper Valley RV Algorithm and Novel Imaging Modalities
The primary purpose of this study is to evaluate the diagnostic performance of three methods for measuring right ventricular size and function including the Philips Novel RV quantification technologies (RV Heart Model volumetric…
- Conditions
- Pulmonary Hypertension, Valvular Heart Disease, Congenital Heart Disease, Congestive Heart Failure
- Trial name
- UVRV (NCT03935178)
- Testing
- Measuring Right Ventricular Size and Function
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease
Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease
The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with…
- Conditions
- Coronary Artery Disease (CAD), Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction (CMD), Vasospasm, Coronary
- Trial name
- NCT07449052
- Testing
- Coronary function testing, Percutaneous coronary intervention
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Post MI Left Ventricular Dysfunction
IdeNtifying High riSk Patients Post Myocardial Infarction With REduced Left Ventricular Function Using External Loop Recorders (INSPIRE-ELR Study)
The purpose of the INSPIRE-ELR study is to characterize arrhythmias in post MI low EF (≤35%) patients in the acute phase (at discharge from hospital after index MI) and chronic phase (at 8-10 weeks after index MI) and to…
- Trial name
- INSPIRE-ELR (NCT01995552)
- Testing
- External Loop Recorder
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Medtronic BRC