Clinical trials: Myocardial Function
Heart Diseases, Coronary Disease
Effects of Respiratory Muscle Training on Postoperative Pulmonary Complications of Cardiac Surgery
This study will evaluate the profilatic effects of inspiratory muscle training (IMT) on functional capacity, respiratory muscle strength, postoperative pulmonary complications and days of hospitalization (PPC) in patients…
- Conditions
- Heart Diseases, Coronary Disease, Cardiovascular Diseases, Coronary Artery Occlusion
- Trial name
- NCT03094923
- Testing
- Inspiratory Muscle Training
- Volunteers
- 32 people
- Sponsor
- University of the State of Santa Catarina
Chronic Kidney Diseases, Cardio-Renal Syndrome
Left Ventricular Fibrosis in Chronic Kidney Disease
This study aims to understand the onset an functional consequences of left ventricular interstitial fibrosis in patients with chronic kidney disease (stage 2 to 5), as well as assess whether transplantation results in a…
- Conditions
- Chronic Kidney Diseases, Cardio-Renal Syndrome, Myocardial Fibrosis, Uraemic Cardiomyopathy
- Trial name
- FibroCKD (NCT03176862)
- Testing
- cardiac magnetic resonance scan, Cardiopulmonary exercise test with stress echocardiogram, 24-hour ECG holter monitor
- Where
- United Kingdom
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Dr Manvir Kaur Hayer
Psoriasis
Effect of Chronic Inflammation on Myocardial Perfusion and Function
Background: Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF.
- Trial name
- NCT04870827
- Testing
- 13N Amonia
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myocardial Infarction
the Association of Intestinal Microbial Metabolites and Cardiac Function in Acute Myocardial Infarction
Recently, more and more studies have confirmed that intestinal flora is closely related to the occurrence and development of cardiovascular diseases.Bile acids (BAS), short chain fatty acids (SCFA) and trimethylamine oxide…
- Trial name
- NCT04955054
- Testing
- diagnose
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed to relieve this blockage as quickly as possible to minimize damage to the heart muscle.
- Trial name
- NCT00965120
- Testing
- Forearm vascular study, bradykinin receptor antagonist (HOE-140)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cardiovascular Diseases
Effects of Breaking up Sitting Time on Cardiometabolic Risk Markers and Cardiac Function Post Myocardial Infarction
Cardiovascular Disease (CVD) is one of the greatest causes of mortality and morbidity globally, particularly in middle to high income countries. In the UK alone, it was accountable for 124,641 deaths in 2017.
- Trial name
- MOVE-MI (NCT05193175)
- Testing
- Prolonged sitting
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Bedfordshire
Angina (Stable), Ischemic Heart Disease (IHD)
Angina After PCI: a Systems Medicine Study
Angina may persist or recur in patients treated by coronary angioplasty. The angioplasty involves a balloon treatment to open a blocked heart blood vessel and usually a stent (thin metal tube) is placed.
- Trial name
- CorMicA-PCI (NCT06854302)
- Testing
- Cardiovascular magnetic resonance imaging, Coronary physiology
- Where
- 4 sites in United Kingdom
- Volunteers
- 600 people
- Sponsor
- NHS National Waiting Times Centre Board
Coronary Artery Disease, Frail Elderly Syndrome
Biodex Sit2Stand for Individuals With Cardiac Disease
Patients with cardiac disease have been shown to have deficits in activities such as standing up from a chair. The Biodex Sit2Stand Trainer is a new device meant to improve sit to stand performance by providing a lifting force…
- Conditions
- Coronary Artery Disease, Frail Elderly Syndrome, Heart Failure
- Trial name
- NCT03170011
- Testing
- Exercise using the Biodex Sit2Stand Trainer
- Sponsor
- St. Ambrose University
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Diabetes Mellitus Type 2 (T2DM), Left Ventricular Diastolic Dysfunction
Diastolic Dysfunction in Patients With Type 2 Diabetes Mellitus
Examination of the effect of Linagliptin versus placebo on diastolic function in patients with type 2 diabetes mellitus and diastolic dysfunction as assessed by transthoracic echocardiography.
- Trial name
- Diast Dysfkt (NCT01888796)
- Testing
- Linagliptin
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- RWTH Aachen University
Acute Coronary Syndrome
Tailored Antiplatelet Therapy Versus Recommended Dose of Prasugrel
The purpose of this study is to demonstrate the superiority of a strategy of platelet monitoring (Monitoring Arm) with down-adjustment of the dose of prasugrel in high responders and up-adjustment of the dose of prasugrel in low…
- Trial name
- ANTARCTIC (NCT01538446)
- Testing
- Modification of Prasugrel based on a biological assay, prasugrel / clopidogrel, Verify Now
- Where
- 2 sites in France
- Volunteers
- 880 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Atherosclerosis
The CHORAL Flow Study
CHORAL Flow is a randomised, double blinded, placebo-controlled trial of the effects of evolocumab on coronary flow at 12 weeks.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Hyperlipidemias
- Trial name
- CHORAL (NCT04073134)
- Testing
- Evolocumab
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Coronary Disease
The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Prior work (Chris, M. et al, Clinical Science 2005; 109, 55-60) has demonstrated that drinking a cup of coffee (80-100 mg of caffeine) an hour before endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery…
- Trial name
- NCT00564824
- Testing
- Caffeine
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Coronary Artery Disease, Hypercholesterolemia
The Role of Atorvastatin on Monocyte Function in Patients With Coronary Artery Disease and Hypercholesterolemia
The aim of this study is to determine, whether an intensified atorvastatin therapy can improve monocyte function in patients with coronary artery disease and hypercholesterolemia.
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Monocyte Function
- Trial name
- NCT00329069
- Testing
- atorvastatin (drug)
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Coronary Artery Disease, Myocardial Ischemia
Comprehensive Functional Assessments for NOCAD
To validate and investigate the efficacy of comprehensive functional assessments for the diagnostic and prognostic value in NOCAD.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Microvascular Dysfunction
- Trial name
- NCT06175572
- Testing
- coronary physiological indices
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Stenosis, Coronary Artery Disease
Diastolic Hyperemia-Free Ratio in Patients With CAD
The investigators aimed to identify the value of concordance between the diastolic hyperemia-free ratio (DFR) and fractional flow reserve (FFR) during pre-interventional and post-interventional period using a 0.014" COMET II…
- Trial name
- ICE-HEAT (NCT05421169)
- Testing
- diastolic hyperemia-free ratio (DFR)
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Caffeine
Effect of Caffeine on Myocardial Oxygenation
The purpose of this study is to investigate the impact of caffeine on myocardial oxygenation and other cardiovascular magnetic resonance parameters in healthy controls.
- Trial name
- Coffee-O2 (NCT04585854)
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Rheumatoid Arthritis, Coronary Artery Disease
Effects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery Disease
Inhibition of interleukin-1 (IL-1) activity in patients with RA without CAD ameliorates vascular and LV function. Moreover, data from species shows beneficial effect of this treatment on LV function after experimental myocardial…
- Conditions
- Rheumatoid Arthritis, Coronary Artery Disease, Inflammation
- Trial name
- NCT01566201
- Testing
- anakinra
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Athens
Insulin Resistance
Cardiovascular Effects of Metformin on Obesity
It has been shown that asymptomatic obese adolescents can demonstrate abnormal regional myocardial contraction, with preserved global cardiac function.
- Trial name
- NCT01910246
- Testing
- Metformin
- Where
- United States
- Sponsor
- University of California, San Francisco
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital