Clinical trials: Myocardial Function
Cardiovascular Diseases
Effect of a PPAR-Alpha Agonist on the Age Related Changes in Myocardial Metabolism and Mechanical Function
The purpose of this study is to determine if treatment with a drug called fenofibrate, which is a PPAR-alpha agonist and controls how the heart metabolizes fats, will reverse the age-related decline in cardiac fat metabolism and…
- Trial name
- PPAR (NCT00627653)
- Testing
- fenofibrate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Acute Coronary Syndrome (ACS)
OPTImal Management of Antithrombotic Agents: OPTIMA-5
This is a prospective, randomized, open-label clinical trial which will enroll 80 acute coronary syndrome (ACS) patients after Percutaneous Transluminal Coronary Intervention (PCI) in China.
- Trial name
- NCT04116931
- Testing
- Switch ticagrelor to clopidogrel
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
ST Elevation Myocardial Infarction (STEMI)
Effects of Early Vagus Nerve Stimulation on Infarct Damage and Functioning After Acute STEMI
The goal of this clinical trial is to investigate whether early non-invasive vagus nerve stimulation (nVNS) can reduce infarct damage and improve functioning after acute ST-elevation myocardial infarction (STEMI).
- Trial name
- NCT06865716
- Testing
- Active noninvasive vagus nerve stimulation, Chum electrode attached to patient's lower ear lobe
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Bnai Zion Medical Center
Coronary Artery Disease
Assessing Vein Graft Properties Between Conventional & No-Touch Harvesting Technique - (PATENT SVG)
The purpose of this study is to compare saphenous veins harvested using the atraumatic pedicled ("no-touch") technique to saphenous veins harvested using the conventional open technique in patients undergoing isolated coronary…
- Trial name
- NCT01488084
- Testing
- Coronary Artery Bypass Graft Surgery, Conventional open SVG harvesting
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Sunnybrook Health Sciences Centre
Peripheral Artery Disease
Evaluation of Concomitant Administration of Cilostazol and Probucol on Biomarkers, Endothelial Function and Safety
Based upon evidence of efficacy and safety of both cilostazol and probucol administration in independent randomized controlled trials in PAD and CAD, the present trial seeks to investigate the effect of concomitant administration…
- Trial name
- NCT01142284
- Testing
- Cilostazol, Probucol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Hypoxic Encephalopathy, Birth Asphyxia
Passive Cooling Versus Blanket-Roll III on The Myocardial Function of Asphyxiated Neonates
Studying the effect of passive versus Blanket roll III modality of therapeutic hypothermia (TH)on myocardial function of asphyxiated neonates through using tissue Doppler (TD).
- Conditions
- Hypoxic Encephalopathy, Birth Asphyxia, Neonatal Encephalopathy, Hypothermia, Newborn
- Trial name
- NCT05652738
- Testing
- Passive cooling application, cooling using Blanket roll III
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
AMI
Baduanjin Sequential Therapy and Cardiac Function of AMI With Reduced EF After PCI
Acute myocardial infarction (AMI) is one of the leading causes of death around the world, with the potential for substantial morbidity and mortality.
- Trial name
- BST-AMI (NCT05201274)
- Testing
- Baduanjin sequential therapy, Aerobic exercise
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shenyang Northern Hospital
Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram
Endothelin Role In COronary Microcirculation
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries.
- Conditions
- Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram, Microvascular Angina
- Trial name
- ERICOM (NCT07670091)
- Testing
- Cardiac MRI, Invasive Coronary Angiogram, Endothelin Receptor Antagonist
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Coronary Artery Disease
Combined Pressure and Flow Measurements to Guide Treatment of Coronary Stenoses
This study evaluates the prognostic value and therapeutic potential of combined pressure and flow measurements when evaluating a coronary artery stenosis.
- Trial name
- DEFINE-FLOW (NCT02328820)
- Testing
- Percutaneous coronary intervention (PCI), Optimal medical therapy (OMT)
- Where
- 12 sites in Denmark, Italy and 4 more
- Volunteers
- 455 people
- Sponsor
- The University of Texas Health Science Center, Houston
Coronary Artery Disease, Aortic Valve Disease
Effect of Early Mobilization on Length of Stay, Recovery and Readmission Rate of Patients After CABG or AVR/MVR Surgery
The present study will investigate the volume and extent of the expected physiological effects of "early mobilization" on the prevention of the clinical illness' detrimental sequelae and on the functional recovery promotion of…
- Conditions
- Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- NCT04401397
- Testing
- Intensive early mobilization techniques
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Dimitris Chatzitheodorou
Coronary Artery Disease, Cardiac Surgical Procedures
Does Modified Ultrafiltration Improves Inflammatory Response and Cardiopulmonary Function After CABG Procedures?
The inflammatory response after cardiac surgery increases mortality and morbidity. Modified ultrafiltration (MUF) has been shown to decrease the post-cardiac surgery inflammatory response, to improve respiratory function, and…
- Trial name
- NCT01140113
- Testing
- Modified Ultrafiltration
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Campinas, Brazil
Cardiovascular Diseases, Smoking
Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease
The purpose of this study is to demonstrate improvement in flow mediated dilation (FMD), a functional endpoint associated with the progression of atherosclerosis, when switching from cigarettes to the Tobacco Heating System (THS)…
- Conditions
- Cardiovascular Diseases, Smoking, Tobacco Use, Peripheral Arterial Disease
- Trial name
- NCT05566678
- Testing
- Cigarette, THS, Smoking Abstinence
- Sponsor
- Philip Morris Products S.A.
Coronary Artery Disease, Coronary Stenosis
An Evaluation of a Physiology-guided PCI Optimisation Strategy
There has recently been renewed interest in the measurement of post percutaneous coronary intervention (PCI) Fractional Flow Reserve (FFR).
- Trial name
- Target-FFR (NCT03259815)
- Testing
- P.I.O.S., Pre and post-PCI coronary physiology measurements
- Where
- United Kingdom
- Volunteers
- 260 people
- Sponsor
- NHS National Waiting Times Centre Board
Vascular Function, Atherothrombosis
Comparison of Vascular Function in Emergency Service Professionals
Emergency Service Professionals have an increased risk of death from heart attacks when compared to the general public. All the emergency professions share similar responsibilities such as emergency call-outs and shift work.
- Trial name
- FIRECOP (NCT01813032)
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endothelial Dysfunction, FMD
Role of Oxygen for Vascular Dysfunction
Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function.
- Conditions
- Endothelial Dysfunction, FMD, IMT, Microcirculation
- Trial name
- NCT02127333
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Coronary Artery Disease, Percutaneous Coronary Intervention
Physiology Optimized Versus Angio-guided PCI
Angiography-derived Fractional Flow Reserve (FFR) Virtual Percutaneous Coronary Intervention (PCI) plan is superior to conventional angiography-guided PCI in obtaining a good final physiology result, which is, in turn, associated…
- Trial name
- AQVA-II (NCT05658952)
- Testing
- Microcatheter-derived FFR, Angiography-derived FFR, Angiography-guided PCI
- Where
- 2 sites in Italy
- Volunteers
- 305 people
- Sponsor
- University Hospital of Ferrara
Transthyretin Amyloid Cardiopathy, Mitochondrial Pathology
The Effect of Trimetazidine on Mitochondrial Function, Myocardial Performance, and Invasive Hemodynamics in Patients Diagnosed With Wild-Type Transthyretin Cardiac Amyloidosis
Wild-type transthyretin cardiac amyloidosis (ATTRwt) is a deposition disorder in which one of the proteins of the body misfolds and accumulates at various places in the body, including the heart, leading to both mechanical and…
- Trial name
- CACTuS - TMZ (NCT05633563)
- Testing
- Trimetazidine
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steen Hvitfeldt Poulsen
Myocardial Infarction, Echocardiography 2D
Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle Echocardiography
Recovery of the left ventricular function is variable from one patient to another, thus assessment of cardiac function by measuring left ventricular ejection fraction using echocardiography is the most common in the daily…
- Conditions
- Myocardial Infarction, Echocardiography 2D, Left Ventricular Dysfunction
- Trial name
- NCT04103008
- Testing
- Speckle tracking echocardiography
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Coronary Artery Disease
Fast Assessment of STenosis Severity- FASTII Study
The Multicenter FAST (Fast Assessment of STenosis severity) study is a prospective observational multicenter study designed to evaluate the diagnostic accuracy of offline 3D-QCA based FFR, using CAAS Workstation (Pie Medical…
- Trial name
- FASTII (NCT03791320)
- Testing
- Vessel Fractional Flow Reserve
- Where
- 6 sites in United States, France and 4 more
- Volunteers
- 330 people
- Sponsor
- Erasmus Medical Center
Acute Myocardial Infarction
Platelet Function Monitoring in Patients With Acute Myocardial Infarction
This study is being done to learn more about platelet reactivity (how well the small cells in the bloodstream work) in people who undergo Percutaneous coronary intervention (PCI) for stable and unstable (acute myocardial…
- Trial name
- NCT01353261
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Medstar Health Research Institute