Clinical trials: Myocardial Function
Coronary Artery Bypass Grafting, Coronary Artery Disease
Cardiac and Endothelial Function Response to Early Exercise Training After Coronary Artery Bypass Surgery
Background: Coronary artery bypass grafting (CABG) due to coronary artery disease (CAD) is one of the main surgical procedures performed in the area of cardiology.
- Conditions
- Coronary Artery Bypass Grafting, Coronary Artery Disease, Cardiac Rehabilitation
- Trial name
- CEFREET (NCT03096158)
- Testing
- Ventilatory Muscle Training (TREMVEN), Aerobic Training (AERO), Isometric Handgrip Training (ISO)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Myocardial Infarction
Functional Assessment in Elderly MI Patients With Multivessel Disease
Elderly patients presenting with myocardial infarction (MI) and multivessel disease are the highest risk population with the worst prognosis. No trial has ever been designed to optimize their outcome.
- Trial name
- FIRE (NCT03772743)
- Testing
- Culprit-only revascularization, Complete functionally-guided revascularization
- Where
- 37 sites in Italy, Poland and 1 more
- Volunteers
- 1,445 people
- Sponsor
- Consorzio Futuro in Ricerca
Ischemic Heart Disease
Effects of Home-based Respiratory Muscle Training Progamme in Individuals With Ischemic Heart Disease
The main objective of the present study is to verify whether respiratory muscle training programme (IMT+EMT; included both inspriratory and expiratory muscles), applied by telerehabilitation, is an effective intervention (versus…
- Trial name
- NCT06856915
- Testing
- Inspiratory muscle training, Combined inspiratory and expiratory muscle training, Conventional cardiac rehabilitation programme
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Universidad Complutense de Madrid
Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction
Sex Related Differences in Cardiac Function
The aim of the study is to investigate sex-specific differences in LV and RV function (systolic and diastolic) with regarding the development and progression of heart failure with preserved ejection fraction based on a…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Diastolic Dysfunction, Systolic Dysfunction
- Trial name
- NCT05796050
- Where
- Germany
- Volunteers
- 6,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Coronary Artery Disease
Evaluation of CTCA in Assessing Plaque Pathology and Physiology
Computed tomographic coronary angiography (CTCA) has been recently introduced to non-invasively evaluate coronary artery pathology.
- Trial name
- NCT03556644
- Testing
- CTCA imaging
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Heart Diseases
Evaluation of Cognitive Status, Kinesiophobia, Physical Activity Level, and Functional Performance in Coronary Intensive Care
The aim of our study is to evaluate cognitive status, kinesiophobia, physical activity level, and functional performance in coronary intensive care.
- Trial name
- NCT05553106
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Hacettepe University
Coronary Artery Disease, Postoperative Care
CABG-AI-Supported Discharge Education
This randomized controlled trial will evaluate the effectiveness of artificial intelligence-supported individualized discharge education for patients undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Postoperative Care, Patient Discharge, Recovery of Function
- Trial name
- AI-D-E-CABG (NCT07503678)
- Testing
- AI-Supported Individualized Discharge Education, Standard Discharge Education
- Volunteers
- 128 people
- Sponsor
- Hasan Kalyoncu University
Coronary Heart Disease, Cognitive Impairment, Mild
Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease
This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic…
- Trial name
- NCT07657624
- Where
- China
- Volunteers
- 2,352 people
- Sponsor
- Beijing Anzhen Hospital
Acute Coronary Syndrome
The ACS Ethnicity Platelet Function Study
This study is being done to assess the effects of the CTP inhibitor on the function of your platelets (cells within your blood that are involved in the formation of blood clots) and to assess whether you have responded to the…
- Trial name
- NCT01829659
- Testing
- Ticagrelor
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medstar Health Research Institute
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Platelet Aggregation, Acute Myocardial Infarction
Effect of Exercise on Platelet Reactivity After Myocardial Infarction
This project aims to evaluate, in recent post-acute myocardial infarction (AMI) patients on dual antiplatelet therapy, the impact of regular exercise training on platelet aggregability and the correlation between the level of…
- Conditions
- Platelet Aggregation, Acute Myocardial Infarction, Exercise Training
- Trial name
- NCT02958657
- Testing
- Exercise Training
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
Obesity, Diabetes
Effect of GLP-1 Receptor (GLP-1R) Agonists on Cardiac Function and on Epicardial Adipose Tissue (EAT) Volume and on Myocardial TG Content in Obese Diabetics
Glucagon-like peptide-1 (GLP-1) receptor agonist are new treatment of type 2 diabetes, they lower blood glucose level (by enhancement of glucose-dependent insulin secretion and suppression of excess glucagon secretion) and reduce…
- Trial name
- NCT02042664
- Testing
- BYETTA treatment, Metformine
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Coronary Syndrome
Reduce Bolus Injection of Bivalirudin
There are fewer studies on the bleeding risk of the currently administered bivalirudin bolus injection dose and the safety of bivalirudin in patients with CKD.
- Trial name
- NCT03588611
- Testing
- Bivalirudin
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Han Yaling, MD
Cardiogenic Shock
Venous Oxygen Saturation During ECMO Support
Extracorporeal veno-arterial membrane oxygenation" (ECMO-VA), are used to manage refractory cardiogenic shocks by replacing the failed "heart-lung" block.
- Trial name
- ECMOxygen (NCT04934566)
- Testing
- ECMO flow
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Heart Failure, Heart Failure, Congestive
ANTHEM-HFrEF Pivotal Study
A multi-center randomized controlled clinical trial to evaluate Autonomic Regulation Therapy with the VITARIA system in patients with symptomatic heart failure and reduced ejection fraction.
- Conditions
- Heart Failure, Heart Failure, Congestive, Heart Failure, Systolic
- Trial name
- NCT03425422
- Testing
- VITARIA System
- Where
- 22 sites in United States
- Volunteers
- 533 people
- Sponsor
- LivaNova
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
STEMI, Elevated IMR (>32)
A Study of Low-dose Intracoronary Thrombolytic Therapy in STEMI (Heart Attack) Patients.
Heart attacks are caused by a blood clot blocking the blood vessels of the heart, preventing blood getting to the heart muscle. Opening up the artery with a balloon (angioplasty) and a small mesh tube (stent) although life saving…
- Trial name
- RESTORE-MI (NCT03998319)
- Testing
- Tenecteplase (1/3 systemic weight based dose), Sterile water for injection (WFI)
- Where
- 22 sites in Australia, New Zealand
- Volunteers
- 445 people
- Sponsor
- University of Sydney
Coronary Heart Disease
Efficacy of Enhanced External Counterpulsation on Ventricular Function
The purpose of this study is to investigate the efficacy of Enhanced External Counterpulsation (EECP) therapy on ventricular function in patients with coronary heart disease
- Trial name
- EECPVF (NCT03106116)
- Testing
- Experimental: Enhanced External Counterpulsation, Standard medical therapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Acute Coronary Syndrome
Pharmacodynamic Study on Efficacy of Clopidogrel With St. John's Wort
The purpose of this study is to evaluate whether patients post PCI receiving clopidogrel who are carriers of at least one CYP 2C19 loss-of-function allele may achieve improved pharmacodynamic efficacy of clopidogrel when treated…
- Trial name
- INDUCE-it (NCT01330589)
- Testing
- St. Johns Wort
- Where
- United States
- Sponsor
- Lancaster General Hospital
Heart Failure, Congestive
Effect of 48 Hours of Treatment With the Natural Peptide-Hormone GLP-1 in Patients With Chronic Heart Failure
The purpose of this study is to determine whether 48 hours of glucagon-like-peptide-1 (GLP-1) infusion can improve heart function and alter substrate metabolism in non-diabetic patients with heart failure.
- Trial name
- NCT00264199
- Testing
- GLP-1
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital Skejby