Clinical trials: Myocardial Function
Noninvasive Myocardial Work, Coronary Artery Disease
Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work
Noninvasive pressure-strain loop (PSL) derived myocardial work (MW) are more sensitive than conventional echocardiographic parameters in quantitative assessment of early myocardial dysfunction.
- Trial name
- NCT05874752
- Testing
- Transthoracic echocardiography
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ischemic Heart Disease, Microvascular Coronary Artery Disease
Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function
The DIAST-CMD registry (Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function) is prospective registry which enrolled patients who underwent echocardiography, cnically-indicated invasive coronary…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DIAST-CMD (NCT05058833)
- Testing
- Echocardiography, Coronary flow reserve and index of microcirculatory dysfunction
- Where
- 4 sites in United States, South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Myocardial Function After LVAD Implant, Ischemic Cardiomyopathy
Recovery of Hibernating Myocardium in End Stage Heart Failure
This study will collect clinical, echocardiographic, nuclear imaging and hemodynamic data in a group of patients with end stage ischemic cardiomyopathy undergoing left ventricular assist device (LVAD) implantation to investigate…
- Trial name
- RHIMES-HF (NCT02573207)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Intermountain Health Care, Inc.
Myocardial Dysfunction
Myocardial Deformation Imaging After Acute Alcohol Excess
Background: Chronic excessive alcohol consumption leads to progressive and chronic cardiac dysfunction. In general, patients consuming alcohol more than five years are at risk for the development of dilated cardiomyopathy.
- Trial name
- C2 (NCT02759445)
- Testing
- routine treatment
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Coronary Artery Disease, Myocardial Ischemia
Comprehensive Functional Assessments for NOCAD
To validate and investigate the efficacy of comprehensive functional assessments for the diagnostic and prognostic value in NOCAD.
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Microvascular Dysfunction
- Trial name
- NCT06175572
- Testing
- coronary physiological indices
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease
Heart Rate Variability-guided Training in Cardiac Rehabilitation
Background: Previous studies have reported that heart rate variability (HRV)-guided training is a better option for improving autonomic function and aerobic capacity (i.e., oxygen uptake and power output at second ventilatory…
- Trial name
- NCT04930939
- Testing
- Aerobic training cardiac rehabilitation program
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Universidad Miguel Hernandez de Elche
Anterior MI
Impact of DApagliflozin on Cardiac Function Following Anterior Myocardial Infarction in Non-Diabetic Patients
Sodium glucose co-transporter 2 inhibitors (SGLT2i) proved their favorable outcomes in heart failure. However, it is still unknown if their role extent into preventing heart failure, especially after acute myocardial infarction.
- Trial name
- DACAMI (NCT05424315)
- Testing
- Dapagliflozin 10mg, Glucose Tab
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Omar Younis
Heart Failure, Congestive
A Multi-center, Placebo-controlled Study to Evaluate the Safety of GSK716155 and Its Effects on Myocardial Metabolism, Myocardial Function, and Exercise Capacity in Patients With NYHA Class II/III Congestive Heart Failure
This exploratory proof of concept study will be conducted in patients with stable New York Heart Association (NYHA) Class II-III heart failure.
- Trial name
- NCT01357850
- Testing
- GSK716155
- Where
- 15 sites in United States, United Kingdom
- Volunteers
- 82 people
- Sponsor
- GlaxoSmithKline
Coronary Artery Disease
The Wire-free Invasive Functional Imaging (WIFI) Study
Quantitative Flow Ratio (QFR) is a new method for evaluating the functional significance of coronary stenosis by calculation of the pressure in the vessel based on two angiographic projections.
- Trial name
- WIFI (NCT02795585)
- Testing
- QFR (observational)
- Where
- Denmark
- Volunteers
- 99 people
- Sponsor
- Niels Ramsing Holm
Coronary Artery Disease
Intravenous Fish Oil in Critically Ill Cardiac Patients
A large body of evidence has accumulated showing that n-3 PUFAs exert extensive cardiac effects. The development of commercial solutions of FO opens perspectives for therapeutic applications in patients with acute cardiac…
- Trial name
- FO-cardiac (NCT00516178)
- Testing
- Fish oil emulsion, Saline
- Where
- 2 sites in Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Coronary Artery Disease, Atherosclerosis
Assessment of Stent Strut Coverage and Endothelial Function After Drug-Eluting Stents
The purpose of this study is to compare coronary endothelium function in patients with a zotarolimus-eluting versus a sirolimus-eluting or a everolimus-eluting stents with optical coherence tomography, vasoconstriction in…
- Trial name
- ASSESS (NCT01073111)
- Testing
- zotarolimus-eluting stent (ENDEAVOR®), sirolimus-eluting stents (CYPHER SELECT® PLUS), everolimus-eluting stents (PROMUS®)
- Where
- Japan
- Sponsor
- Hyogo Medical University
Aging, Mild Cognitive Impairment
A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence.
- Conditions
- Aging, Mild Cognitive Impairment, Angina Pectoris
- Trial name
- NCT01590706
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Oriental Medicine
Coronary Artery Disease
Adenosine Dual Source Computed Tomography (CT) Versus Adenosine Single Photon Emission Computed Tomography (SPECT)
Researchers hope that this new non-invasive multi-detector scanner (DSCT) will provide diagnostic information comparable to the combination of traditional SPECT (for function and blood flow) and CT imaging (for a precise…
- Trial name
- NCT00892307
- Testing
- Dual Source Multidetector CT (DSCT) w/ Adenosine enhancement
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Cedars-Sinai Medical Center
Coronary Artery Disease
The Effect of Colchicine on Platelet Function Profiles in Patients With Stable Coronary Artery Disease
The effects of colchicine on cardiovascular health in patients with stable coronary artery disease have been shown to be beneficial due to its anti-inflammatory properties.
- Trial name
- ECLIPSE (NCT06567678)
- Testing
- Colchicine 0.5 MG oral tablet twice daily
- Where
- Trinidad and Tobago
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Angina, Coronary Artery Disease
Exercise-training Before Coronary Artery Bypass Graft (CABG)
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small…
- Trial name
- NCT00218985
- Testing
- Exercise training
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Acute Coronary Syndrome
Study on Prediction of Left Ventricular Remodeling Using ST2
Patients who underwent percutaneous coronary intervention after diagnosis of acute coronary syndrome should be enrolled in the study and follow - up.
- Trial name
- TRUSTED (NCT03841214)
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Keimyung University Dongsan Medical Center
Cardiac Disease
Effects of Cardiac Telerehabilitation During COVID-19 on Cardiorespiratory Capacities in Coronary Artery Disease Patients.
After an acute coronary syndrome, an adapted cardiac rehabilitation program is necessary to restore or increase physical capacities and decrease cardiovascular risk.
- Trial name
- NCT05749744
- Testing
- cardiac telerehabilitation program by videoconference
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ischemic Heart Disease, Valvular Heart Disease
Milrinone on Right Ventricular Strain in Cardiac Surgery
The purpose of this study is to analyze the changes in right ventricular strain before and after milrinone administration in order to find out whether milrinone improves RV systolic performance in patients undergoing cardiac…
- Trial name
- NCT06077721
- Testing
- Milrinone
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Konkuk University Medical Center
Ischemic Preconditioning, Coronary Disease
Remote Ischaemic Conditioning and Coronary Endothelial Function (RIC-COR)
Intermittent arm cuff inflation reduces the extent of heart muscle injury at the time of cardiovascular injury. The intervention is known as remote ischaemic conditioning (RIC) however the mechanisms by which RIC acts are…
- Trial name
- RIC-COR (NCT02666235)
- Testing
- Remote ischaemic conditioning, Arm cuff placement, no inflation;
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS National Waiting Times Centre Board
Platelet Reactivity
Ticagrelor and Clopidogrel on Platelet Effects in Chinese Patients With Stable Coronary Artery Disease
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor reduces thrombotic events in patients with coronary artery disease, but these benefits come at the expense of increased risk of bleeding when compared with…
- Trial name
- NCT04001894
- Testing
- Ticagrelor 90mg, Clopidogrel 75mg
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University