Clinical trials: Myocardial Function
Thoracic Neoplasms, Late Effect of Radiation
Monitoring Radiobiological Effects in Thoracic Malignancy by Using Myocardial Perfusion Scan
Background: Chemoradiation is an important treatment strategy of locally advanced inoperable or unresectable disease. Radiation dose is an independent predictor of a pathological response.
- Trial name
- NCT01913769
- Testing
- Thallium-201 Myocardial Perfusion Study
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Far Eastern Memorial Hospital
ST-segment Elevation Myocardial Infarction (STEMI)
Angio-IMR and Cardiac MR-derived MVO in STEMI Patients
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of ST-segment elevation myocardial infarction (STEMI) patients.
- Trial name
- NCT04828681
- Testing
- Cardiac magnetic resonance imaging
- Where
- 2 sites in United States, China
- Volunteers
- 324 people
- Sponsor
- Samsung Medical Center
Angina
The Syndrome X-ercise Study SYNDEX
This pilot study evaluates the effect of exercise training on CFR, functional capacity, heart rate variability, endothelial function and quality of life in patients with no obstructive coronary artery disease and angina.
- Trial name
- SYNDEX (NCT02905630)
- Testing
- Exercise training
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Helse Stavanger HF
Systemic Scleroderma
Cardiac Repercussion of Systemic Sclerodermias
Systemic sclerodermia is a connectivity characterized by multiple visceral impairments, in particular pulmonary, which can lead to the development of a Pulmonary Arterial Hypertension (PAHT).
- Trial name
- HTAP-SCLERO (NCT00697736)
- Testing
- Echocardiography with myocardial tissular Doppler mode
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Female
The Role of Myocardial SPECT in Evaluation of Irradiation-induced Changes.
Helical tomotherapy nowadays provides the most precise data on radiotherapy (RT) dose delivered to each region of the heart in left-sided breast cancer therapy, which allows greater sparing of the heart from doses associated with…
- Trial name
- NCT01758419
- Testing
- Thallium-201 Myocardial Perfusion Study
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Coronary Artery Disease
The Effects of Tirofiban in Diabetic Patients Undergoing Elective Percutaneous Coronary Intervention
The purpose of this study is to examine the effects of tirofiban on platelet function the Ultegra RPFA in diabetic patients undergoing elective coronary angioplasty and stenting already treated with high loading dose (600mg)…
- Trial name
- NCT00407771
- Testing
- Tirofiban
- Where
- Jordan
- Volunteers
- 44 people
- Sponsor
- Jordan Hospital
Hypertension, Coronary Artery Disease
Effects of Different Exercise Training Programs on Short-term Blood Pressure Variability and Atrial Function in Hypertension
The study aim is to compare the effects produced by two different exercise training modalities on short-term blood pressure variability and atrial function evaluated by speckle-tracking echocardiography in hypertensive patients…
- Trial name
- TACITO (NCT04763629)
- Testing
- Physical exercise
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele Roma
Shock, Cardiogenic, Heart Failure
Effects of Pyruvate in Patients With Cardiogenic Shock and Intra-aortic Balloon Counterpulsation
Pyruvate is an intermediate of energy metabolism and was shown to possess pronounced positive inotropic effects in vitro and in vivo without altering myocardial oxygen consumption.
- Conditions
- Shock, Cardiogenic, Heart Failure, Acute Myocardial Infarction
- Trial name
- NCT00604331
- Testing
- Pyruvate
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Herzzentrum Goettingen
Coronary Artery Disease
Use of a Point-of-Care Platelet Function Assay for the Prediction of Atherothrombotic Events
1. To evaluate the role of VerifyNow test as prognostic marker in routine clinical practice using drug-eluting stents. 2. To determine the add-on-effect of VerifyNow test beyond on conventional risk factors (clinical, lesions, or…
- Trial name
- ASAN-VERIFY (NCT01183754)
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- CardioVascular Research Foundation, Korea
Coronary Heart Disease
Clopidogrel Response Evaluation and AnTi-Platelet InterVEntion in High Thrombotic Risk PCI Patients
To identify the high-risk patients who might have in-stent thrombosis after PCI with thromboelastography and to head-to-head compare two intensified antiplatelet therapeutic strategies of double-dosage Clopidogrel and triple…
- Trial name
- CREATIVE (NCT01779401)
- Testing
- Clopidogrel 75mg, Clopidogrel 150mg, Aspirin 100mg
- Where
- 2 sites in China
- Volunteers
- 1,078 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Coronary Disease, Heart Failure
Functional Electrical Stimulation in Cardiac Patients
The purpose of this study was to determine the effects of Functional Electrical Stimulation (FES) on physical performance and quality of life of patients in cardiac rehabilitation.
- Trial name
- NCT02088138
- Testing
- Functional Electrical Stimulation
- Where
- 3 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Prof. Dr. Antônio Marcos Vargas da Silva
Endothelial Dysfunction, FMD
Role of Oxygen for Vascular Dysfunction
Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function.
- Conditions
- Endothelial Dysfunction, FMD, IMT, Microcirculation
- Trial name
- NCT02127333
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Cardiomyopathy, Hypertrophic
The Impact of Exercise-Induced Cardiac Remodeling on Myocardial Efficiency
This research study is being conducted to find out how heart function and energy use differ among healthy endurance athletes, individuals who do not exercise regularly, and patients with hypertrophic cardiomyopathy.
- Trial name
- NCT04580693
- Testing
- PET Scan
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Massachusetts General Hospital
Fibromyalgia (FM), Subclinical Ventricular Dysfunction
Evaluation of Myocardial Function by Global Longitudinal Strain (GLS) Measurement in 2D Echocardiography of Patients With Fibromyalgia
Fibromyalgia (FM) is a chronic pain syndrome that affects multiple body systems and is often associated with fatigue, sleep disturbances, anxiety, and other comorbidities.
- Conditions
- Fibromyalgia (FM), Subclinical Ventricular Dysfunction, Myocardial Function
- Trial name
- GLS in FM (NCT07150455)
- Testing
- Echocardiographic Assessment (2D Speckle Tracking)
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Coronary Artery Disease, Stable Angina
Functional Assessment of Myocardial Ischemia by Intracoronary Electrocardiogram
In patients with chronic stable coronary artery disease (CAD), percutaneous coronary intervention (PCI) targets hemodynamically significant coronary lesions, i.e., those thought to cause inducible ischemia.
- Conditions
- Coronary Artery Disease, Stable Angina, Coronary Artery Stenosis, Ischemia
- Trial name
- FFRicECG (NCT03985241)
- Testing
- Functional Assessment of Myocardial Ischemia by icECG
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
Evaluation of Respiratory Parameters and Functional Capacity in Coronary Artery Patients
The purpose of this study is to evaluate respiratory parameters and functional capacity in coronary artery patients.
- Trial name
- NCT05549739
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Refractory Angina
Study Protocol of Intramyocardial Injection of Autologous Bone Marrow Stem Cells for Refractory Angina
Therapeutic neovascularization is an innovative strategy for cardiac tissue recovery due to chronic, intense ischemia. Thus stem cell therapy has become a promising procedure for the large number of patients with refractory…
- Trial name
- ReACT (NCT01966042)
- Testing
- Local sedation, Bone Marrow Aspiration, Minithoracotomy
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- CellPraxis Bioengenharia Ltda.
ACS (Acute Coronary Syndrome), HF - Heart Failure
A Clinical Study on the Effect of Cardiopulmonary Function and Quality of Life in Patients With Acute Coronary Syndrome Complicated by Heart Failure by "Lying-Sitting-Standing" Sequential Baduanjin
This study investigates the effects of a sequential "lying-sitting-standing" Baduanjin intervention on patients with acute coronary syndrome complicated by heart failure.
- Trial name
- NCT07486791
- Testing
- standard treatment and routine rehabilitation nursing guidance, "Lying-Sitting-Standing" Sequential Baduanjin
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xiling Qi
Acute Myocardial Infarction
Bone Marrow Derived Adult Stem Cells for Acute Anterior Myocardial Infarction
Study hypothesis : The purpose of this study is to determine whether Intracoronary infusion of autologous bone marrow derived progenitor cells to patients undergoing primary angioplasty for acute anterior myocardial infarction…
- Trial name
- REGEN-AMI (NCT00765453)
- Where
- 5 sites in Denmark, Switzerland and 1 more
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust
Coronary Heart Disease
Niacin/Laropiprant and Endothelial Function
Primary objective: To evaluate the impact of 12 weeks' administration of extended release niacin/laropiprant (ERN/LRPT) compared to placebo added to statin therapy on endothelial dependant dilatation of the arterial wall assessed…
- Trial name
- NCT01126073
- Testing
- Niacin/laropiprant
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana