Clinical trials: Myocardial Function
Coronary Artery Disease
Clopidogrel Proton-Pump Inhibitors Study
To find out the impact of two different proton-pump inhibitors (PPIs) (Omeprazole and Pantoprazole) on platelet function in patients with stable coronary artery disease (CAD) on clopidogrel therapy.
- Trial name
- NCT01016717
- Testing
- Omeprazole, Pantoprazole
- Where
- Israel
- Sponsor
- Sheba Medical Center
Coronary Artery Disease
Effect of Cocoa Flavanols on Vascular Function
Endothelial dysfunction is associated with a higher incidence of adverse cardiovascular events in patients with coronary artery disease (CAD).
- Trial name
- Cocoa (NCT00553774)
- Testing
- Cocoa Flavanols
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
Coronary Artery Disease, Depression
The Recovery of Cardiovascular Patients With Depression
Cardiovascular disease increases the risk of depression and vice versa. Many cardiovascular patients are subjected to percutaneous coronary intervention (PCI).
- Conditions
- Coronary Artery Disease, Depression, Cardiovascular Diseases
- Trial name
- NCT03841474
- Testing
- Psychiatric treatment with sertraline, Psychiatric treatment with escitalopram
- Where
- Croatia
- Volunteers
- 150 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Angina Pectoris, Kuanzhong Aerosol
Bidirectional Cohort Study on Improvement of Quality of Life in Patients After Coronary Intervention With Kuanxiong Aerosol
The goal of this observational study is to compare in patients with Angina Pectoris after PCI for Coronary Heart Disease. The main questions it aims to answer are: To evaluate the effect of Kuanxiong Aerosol on the quality of…
- Conditions
- Angina Pectoris, Kuanzhong Aerosol, Quality of Life, Cardiac Function
- Trial name
- NCT06480097
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Heart Disease, Ischemic Heart Disease
Stem Cell Injection to Treat Heart Damage During Open Heart Surgery
Background: Bone marrow stromal stem cells (also known as mesenchymal stem cells) have been isolated and are found to make large amounts of growth factors.
- Conditions
- Heart Disease, Ischemic Heart Disease, Coronary Artery Disease, Coronary Artery Disease (CAD)
- Trial name
- NCT01557543
- Testing
- Cell Therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Coronary Arterial Disease (CAD)
Virtual Reality-Supported Cardiac Rehabilitation: Psychological, Functional, and Physiological Perspectives
The study aims to evaluate the effectiveness of virtual reality-assisted cardiac rehabilitation compared to conventional cardiac rehabilitation in improving psychological outcomes-depression, stress, anxiety, and…
- Conditions
- Cardiovascular Diseases, Coronary Arterial Disease (CAD), Myocardial Disease, Heart Disease
- Trial name
- NCT06896318
- Testing
- Virtual Reality Therapy, Cardiac rehabilitation
- Where
- 2 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Coronary Heart Disease
Testosterone and Myocardial Perfusion in Coronary Heart Disease (CHD)
Testosterone has traditionally been regarded as a risk factor for heart disease due to the fact that males have a higher incidence of this disease than women, at least until the menopause.
- Trial name
- NCT00239590
- Testing
- Testosterone undecanoate
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Imperial College London
Type 2 Diabetes, Diabetic Cardiomyopathies
IMPROVE-DiCE: Study to Evaluate Effect of IMB-1018972 on Cardiac Energetics in T2DM & Obesity (Pt 1) With HFpEF (Pt 2)
The purpose of this study is to assess the activity of IMB-1018972 on cardiac energetic reserve at rest and during stress and to assess safety and tolerability
- Conditions
- Type 2 Diabetes, Diabetic Cardiomyopathies, HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT04826159
- Testing
- IMB-1018972
- Where
- United Kingdom
- Volunteers
- 49 people
- Sponsor
- Imbria Pharmaceuticals, Inc.
Coronary Artery Occlusion
Effects of N-acetylcysteine on Pulmonary Function in High-risk Patients Undergoing Off-pump Coronary Bypass Surgery
The purpose of this study is to study the effects of N-acetylcysteine on pulmonary function in high-risk patients undergoing off-pump coronary bypass surgery.
- Trial name
- NCT01021163
- Testing
- N-acetylcysteine, saline
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Left Ventricular Dysfunction
Insulin Cardioplegia for Poor Left Ventricular Function
The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor preoperative ventricular…
- Trial name
- NCT00188994
- Testing
- Insulin Cardioplegia
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University Health Network, Toronto
Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction
Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD
The aim of the study is to evaluate the influence of physical training and respiratory rehabilitation performed by patients at home on quality of life, symptoms, physical endurance, force of respiratory and skeletal muscles and…
- Conditions
- Pulmonary Hypertension, Heart Failure With Reduced Ejection Fraction, Ischemic Heart Disease
- Trial name
- NCT03780803
- Testing
- home cardiac rehabilitation and respiratory rehabilitation
- Where
- Poland
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Refractory Angina, Raised Lipoprotein(a)>50mg/dL or >500mg/L
Lipoprotein Apheresis in Refractory Angina Study
The goal of this study is to determine the impact of apheresis on clinical parameters and symptoms of patients with refractory angina and raised Lp(a).
- Trial name
- NCT01796912
- Testing
- Lipoprotein Apheresis
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Left Ventricular Function Systolic Dysfunction, Cardiotoxicity
Usefulness of Myocardial Deformation Imaging for Trastuzumab-induced Cardiotoxicity
Trastuzumab prolongs survival in patients with human epidermal growth factor receptor type 2-positive breast cancer. Sequential left ventricular (LV) ejection fraction (EF) assessment has been mandated to detect myocardial…
- Trial name
- NCT01665300
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Seoul National University Hospital
Ventricular Fibrillation
High Low Biphasic Energy Defibrillation (HiLoBED)
This inhospital study aims to compare the efficacy of high-versus low-energy biphasic shocks in order to determine the optimal level for defibrillation. Time is the essence when attending to a VF patient.
- Trial name
- NCT00429611
- Testing
- Cardiac defibrillation at high energy vs low energy levels
- Where
- 7 sites in Singapore
- Volunteers
- 600 people
- Sponsor
- Singapore General Hospital
Myocardial Infarction, Iron-deficiency
An Open Study on the Efficacy of Iron Therapy Using iv Iron Relative to Oral Iron for Increasing LV Systolic Function
The OPERA-MI trial evaluates the effect of i.v. ferric carboxymaltose compared to the effect of oral iron, on left ventricular systolic function.
- Trial name
- OPERA-MI (NCT05309499)
- Testing
- ferric carboxymaltose, ferrous sulphate
- Where
- Russia
- Volunteers
- 298 people
- Sponsor
- Kazan State Medical University
Left Bundle-Branch Block
Effects of Isolated LBBB on Maximal Functional Capacity
Left bundle branch block (LBBB) has been commonly associated with adverse cardiovascular (CV) events, but the effect of an isolated LBBB on maximal functional capacity is not well characterized.
- Trial name
- NCT05643404
- Testing
- Cardiopulmonary exercise testing, Echocardioghaphy
- Where
- Spain
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Acute Non-ST Elevation Myocardial Infarction
DLBS1033 for Acute NSTEMI Without Early Coronary Revascularization
This is a prospective, randomized, double-blind, double-dummy, and controlled study of DLBS1033 in the management of acute non-ST elevation myocardial infarction (NSTEMI) without early coronary revascularization.
- Trial name
- NCT02146664
- Testing
- DLBS1033
- Where
- 2 sites in Indonesia
- Sponsor
- Dexa Medica Group
Acute Coronary Syndrome
Class IV Laser Therapy on Ejection Fraction, Cardio Biomarkers and Functional Outcomes
A total of 60 Individuals with Acute coronary Syndrome who underwent angioplasty with or without stent will be recruited by purposive sampling method in a randomized double-blinded sham controlled trial.
- Trial name
- NCT05160519
- Testing
- Class IV Laser
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Asir John Samuel
Coronary Artery Disease
Functional Assessment by Virtual Online Reconstruction. The FAVOR III Europe Trial
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of coronary stenosis. QFR is estimated based on two angiographic projections.
- Trial name
- NCT03729739
- Testing
- QFR-based diagnostic strategy, FFR-based diagnostic strategy
- Where
- 35 sites in Denmark, France and 9 more
- Volunteers
- 2,001 people
- Sponsor
- Aarhus University Hospital Skejby
Unstable Angina, NSTEMI
Dual Antiplatelet Therapy Tailored on the Extent of Platelet Inhibition
The purpose of this study is to evaluate the efficacy (reduction of major ischemic events at 6 and 12 months of follow-up) of a tailored clopidogrel therapy in patients with UA/NSTEMI undergoing PCI with stent implantation and…
- Trial name
- DANTE (NCT00774475)
- Testing
- comparison of different dosage of clopidogrel, doubled therapy
- Where
- Italy
- Volunteers
- 442 people
- Sponsor
- University of Florence