Clinical trials: Myocardial Function
Acute Myocardial Infarction
Safety and Efficacy of Three Different Loading Doses of Clopidogrel, in Patients With Acute Myocardial Infarction
The aim of this study is to determine both safety and effectiveness of three different loading dose regimens of clopidogrel in patients with acute myocardial infarction undergoing primary angioplasty.
- Trial name
- Load & Go (NCT00882739)
- Testing
- Clopidogrel 300 mg, Clopidogrel 600 mg, Clopidogrel 900 mg
- Where
- Italy
- Volunteers
- 168 people
- Sponsor
- Ospedale San Donato
Porphyrias, Hepatic
Acute Intermittent Porphyria Related Abnormalities in Cardiovascular System
This study aims to assess the changes in the cardiovascular system in patients with acute intermittent porphyria (AIP).
- Trial name
- AIPRACUS (NCT05882136)
- Where
- 2 sites in Poland
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Coronary Artery Disease, Cardiac Rehabilitation
Comparison of Conventional and Tele-cardiac Rehabilitation
This study aimed to compare the effects of tele-cardiac rehabilitation (TCR) and hospital-based cardiac rehabilitation (HBCR) on functional capacity (maximum oxygen consumption), fear of activity and quality of life in patients…
- Conditions
- Coronary Artery Disease, Cardiac Rehabilitation, Telecardiac Rehabilitation, Aerobic Exercise
- Trial name
- NCT06614634
- Testing
- Remotely supervised exercise at home or outdoors, Hospital-based exercise program, Cardiovascular risk modification
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Acute Anterior Myocardial Infarction
Effects of Intensive Statin Treatment on Left Ventricular Function
First acute anterior myocardial infarction in patients with primary PCI preoperative and postoperative 30 days intensive dose atorvastatin statin therapy compared with conventional -dose therapy , patients can improve left…
- Trial name
- NCT01936103
- Testing
- standard group, intensive group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenyang Northern Hospital
Chronic Myocardial Ischemia
Intracoronary Infusion of Bone Marrow Mononuclear Cells in Patients With Previous Myocardial Infarction.
Phase II clinical trial which will include all patients diagnosed with chronic anterior myocardial infarction (more than 6 months from the acute phase and the complete revascularization in which it is assessed the evolution of…
- Trial name
- NCT01454323
- Testing
- Bone marrow mononuclear cells
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Tetralogy of Fallot
Analysis of RV-Dysfunction in Fallot Patients
In the presented study TDI will be used as a modern technique to characterize RV-function in Fallot patients at rest and during different exercise conditions.
- Trial name
- Fallot (NCT03835494)
- Testing
- Transthoracic echocardiography at rest, during PLR, HG and CPX (including blood gas analysis in both groups). Additionally Fallot patients will undergo routine blood testings.
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Myocardial Infarct, Bone Marrow Cells
Efficacy Study of Intramuscular or Intracoronary Injection of Autologous Bone Marrow Cells to Treat Scarred Myocardium
The purpose of this study is to determine whether the administration of patient's own bone marrow cells into scar areas of the heart, can improve the contractile function of these areas.
- Trial name
- NCT00560742
- Testing
- Control, Intramuscular administration of bone marrow cells, Intracoronary administration of bone marrow cells
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- University Hospitals, Leicester
Coronary Artery Spasm, Autonomic Dysfunction
The Effect of Autonomic Function on Coronary Vasomotion
Autonomic nerve function is involved in both blood pressure (BP) regulation and the pathogenesis of coronary artery spasm (CAS), but few studies have been published about the relationship between CAS and BP, with the exception of…
- Trial name
- NCT01877993
- Where
- 3 sites in South Korea
- Volunteers
- 2,169 people
- Sponsor
- Korea University
Coronary Artery Disease
Implementation of CYP2C19 Genotyping to Guide Antiplatelet Therapy
It is well established that clopidogrel-induced antiplatelet effects is suboptimal in many patients who are thus exposed to an increased risk of adverse cardiovascular events.
- Trial name
- NCT02724319
- Testing
- SpartanRX
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Florida
Coronary Artery Disease
Myocardial and Arterial Phenotype of Coronary Artery Disease
The CAD-MAP (Myocardial and Arterial Phenotype of Coronary Artery Disease) registry is initiated with the goal to describe the cardiac imaging map including epicardial coronary artery, coronary microcirculation and myocardium…
- Trial name
- CAD-MAP (NCT06202300)
- Testing
- Inflammation burden
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease
The Effect of Fish Oil Supplementation on Endothelial Function, Heart Rate Variability and Intimal Media Thickness of Patients With Coronary Artery Disease
The purpose of this study is to investigate whether there is a difference in endothelial function, heart rate variability and carotid intimal media thickness in patients with coronary artery disease who are receiving fish oil…
- Trial name
- NCT00454493
- Testing
- Omacor (omega-3-acid ethyl esters)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Obesity, Gastric Bypass
Effect of Gastric Bypass-induced Weight Loss on Myocardial Structure, Function and Metabolism
Obesity affects more than 43 million Americans and is associated with an increased incidence of heart failure, sudden death, and cardiovascular death.
- Trial name
- NCT00841009
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease
AI ANC Headphones in Rotational Atherectomy
Background: Rotational atherectomy (RA) generates high-intensity drilling noise concentrated around 3000 Hz, creating a distinctive auditory stressor that may exacerbate perioperative anxiety and autonomic dysregulation in…
- Trial name
- ANC-RA (NCT07707843)
- Testing
- AI-Powered Active Noise-Cancelling Headphones (Sony WH-1000XM6)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Qilu Hospital of Shandong University
Duchenne Muscular Dystrophy
2D Strain Evaluation: Children With Duchenne Muscular Dystrophy Versus Healthy Children
Compare systolic function of left ventricle (LV) and right ventricle (VD) by 2D strain evaluation in Duchenne muscular dystrophy children versus a control group.
- Trial name
- NCT02418338
- Testing
- speckle tracking (2D strain) echocardiography
- Where
- France
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Left Ventricular Function Systolic Dysfunction
Global Strain and Mechanical Dispersion May Predict Death and Ventricular Arrhythmias Better Than Ejection Fraction
The aim of the study is to investigate if global strain and mechanical dispersion may predict death and ventricular arrhythmias better than ejection fraction(EF) in patients with myocardial infarction and heart failure regardless…
- Trial name
- NCT02286908
- Where
- 8 sites in Czechia, Norway
- Volunteers
- 3,100 people
- Sponsor
- Oslo University Hospital
Acute Coronary Syndrome (ACS), Myocardial Infarction
TeleheartCR vs. Clinic-Based Cardiac Rehabilitation After Acute Coronary Syndrome
Cardiac rehabilitation (CR) is an effective evidence-based intervention that improves outcomes in patients with acute coronary syndrome (ACS), but many eligible patients do not complete the program.
- Trial name
- NCT07541014
- Testing
- Telehealth-enhanced Hybrid CR, Traditional Cardiac Rehabilitation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Columbia University
Coronary Microvascular Disease
Personalized Medicine Using Coronary Microvascular Function Measured in Patient With Percutaneous Coronary Intervention in Angina
The evidence demonstrating the importance of coronary microcirculation in the management of patients with coronary artery disease is growing.
- Trial name
- DECISIONING (NCT05178914)
- Testing
- Treatment adaptation
- Where
- France
- Volunteers
- 280 people
- Sponsor
- University Hospital, Grenoble
Heart Attack, Cardiovascular Diseases
Stress Management and Resiliency Training Following Acute Myocardial Infarction
The goal of this pilot study is to use total body PET/CT imaging to examine the relationships between stress, amygdala activation, and arterial wall inflammation in participants before and after participating in a multi-modal…
- Trial name
- NCT05415735
- Testing
- Stress Management and Resiliency Training Program
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Davis
Hemodialysis
Intradialytic Exercise and Remote Ischaemic Preconditioning: a Cardioprotective Role ?
The aim of this clinical trial is to evaluate whether intermittent exercise and remote ischaemic preconditioning (rIPC) during haemodialysis (HD) can provide cardioprotection in adult patients (aged 20-79 years) undergoing HD for…
- Trial name
- EXPI-DIAL (NCT06856512)
- Testing
- Remote ischaemic preconditioning, Exercise, standard dialysis
- Where
- 3 sites in France
- Volunteers
- 33 people
- Sponsor
- University of Avignon
Sodium-glucose Cotransporter 2, Inhibitors
Impact of Sodium Glucose Co-transporter 2-Inhibitors on Clinical Outcome and Left Ventricular Function in Patients Presented by Acute Myocardial Infarction
This study aimed to assess the effect of adding sodium glucose co-transporter two inhibitors on clinical outcome and left ventricular function in patients with acute myocardial Infarction.
- Conditions
- Sodium-glucose Cotransporter 2, Inhibitors, Clinical Outcome, Left Ventricule
- Trial name
- NCT06964607
- Testing
- Sodium-glucose cotransporter-2 Inhibitors, Conventional treatment
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University