Clinical trials: Myocardial Function
Myocardial Failure, Cardiac Failure
A Study of Experimental Medication BMS-986231 in Patients With Different Levels of Kidney Function
The purpose of this study is to investigate experimental medication BMS-986231 in patients with different levels of kidney function.
- Conditions
- Myocardial Failure, Cardiac Failure, Congestive Heart Failure, Kidney Failure
- Trial name
- NCT03332186
- Testing
- BMS-986231
- Where
- 3 sites in Czechia, Poland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Non ST Segment Elevation Acute Coronary Syndrome, Coronary Artery Disease
Non-IRA Functional Evaluation With AccuFFRangio in NSTE-ACS
This is a prospective, single-center clinical trial. AccuFFRangio (ArteryFlow Technology Co., Ltd., Hangzhou, China) is a novel method for evaluating the functional significance of coronary stenosis by computing the pressure in…
- Conditions
- Non ST Segment Elevation Acute Coronary Syndrome, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05202041
- Testing
- AccuFFRangio-guided strategy, Angiography-guided strategy
- Volunteers
- 500 people
- Sponsor
- Wuhan Asia Heart Hospital
Coronary Artery Disease
Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function
Older adults with coronary artery disease (CAD) have impaired vascular and inspiratory muscle function. The overarching goal of this double-blind, randomized, crossover, placebo-controlled pilot trial was to inform the…
- Trial name
- NCT04920799
- Testing
- Nitrate rich beetroot juice, Nitrate depleted beetroot juice
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Coronary Artery Disease
Effects of Almonds On Endothelial Function In Patients With Coronary Artery Disease
The vascular endothelium (inner lining of cells in blood vessels) normally prevents vasospasm and thrombosis by production of a variety of regulatory substances, including nitric oxide.
- Trial name
- NCT01038362
- Testing
- NCEP Step 1 diet plus Almonds, No Almonds
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Boston University
Hypertrophy, Left Ventricular, Aortic Stenosis
Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and overall hemodynamics were studied in patients undergoing elective aortic valve replacement with severe aortic stenosis and associated left…
- Conditions
- Hypertrophy, Left Ventricular, Aortic Stenosis, Myocardial Ischemia, Cardiopulmonary Bypass
- Trial name
- NCT01144039
- Testing
- LG-group, HG-group
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Medical University of Vienna
Acute Coronary Syndrome
Evolution of Cardiovascular Function and Quality of Life in Patients Included in the SCArabée Therapeutic Education Program
Coronary artery disease is defined as a disease of the arteries that vascularize the heart, resulting in myocardial ischemia, i.e. insufficient blood supply to the heart muscle.
- Trial name
- SCArabée (NCT03669211)
- Testing
- Cardiac stress test
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Groupe Hospitalier Mutualiste de Grenoble
Coronary Artery Disease, Coronary Microvascular Dysfunction
The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease
The objective of this study is to investigate, as a proof-of-principle, long-term (52 weeks) effects of tirzepatide once-weekly vs.
- Conditions
- Coronary Artery Disease, Coronary Microvascular Dysfunction, Overweight or Obesity, Stable Angina Pectoris
- Trial name
- IDEAL-COR (NCT06606821)
- Testing
- Tirzepatide
- Where
- 3 sites in Denmark
- Volunteers
- 124 people
- Sponsor
- Tina Vilsbøll
Coronary Artery Disease, Coronary Stenosis
QFR-Guided Virtual Stenting for Preprocedural Physiological Optimization of Percutaneous Coronary Intervention: A Randomized Controlled Trial
Coronary angiography-guided percutaneous coronary intervention (PCI) remains the standard treatment strategy for patients with coronary artery disease; however, suboptimal post-PCI physiological outcomes remain common and are…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Ischemic Heart Disease
- Trial name
- FAVOR-Virtual (NCT07635407)
- Testing
- Virtual Stenting-Guided PCI Optimization, Standard Angiography-Guided PCI
- Where
- China
- Volunteers
- 1,472 people
- Sponsor
- China National Center for Cardiovascular Diseases
Sickle Cell Disease
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart…
- Trial name
- NCT05583721
- Testing
- [13N]NH3, Lexiscan, Positron emission tomography
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Type 2 Diabetes Mellitus, Overweight
Effects of Low Versus High Carbohydrate Diet During Rehabilitation on Cardiovascular Function and Metabolism in Type 2 Diabetes
Compared to the traditional low fat diet for overweight patients with type 2 diabetes, recent evidence shows that low carbohydrate/high protein diets lower triglycerides and postprandial glucose levels more effectively.
- Trial name
- NCT01004757
- Testing
- LOGI diet, Low Fat diet
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Munich Municipal Hospital
Left Main Coronary Artery Disease
Functional Diagnostic Accuracy of Ultrasonic Flow Ratio in Assessment of Left Main Coronary Artery Stenosis
This is a prospective, observational, single-center study. The main purpose of this study is to evaluate the diagnostic accuracy of offline computational ultrasonic flow ratio (UFR) in predicting functionally significant left…
- Trial name
- FUNCTION II (NCT06053944)
- Testing
- fractional flow reserve (FFR); ultrasonic flow ratio (UFR); intravascular ultrasound (IVUS)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease
Pressure-wire Guided PTCA: Drug Eluting Stent Versus Drug Eluting Balloon (WinDEB Study)
The aim of the study is to show the safety and efficacy of the SeQuent® Please (Drug Eluting Balloon or DEB) vs. commonly used Drug Eluting Stents in the treatment of small vessel disease and side branches by pressure wire guided…
- Trial name
- NCT01399463
- Testing
- Angioplasty performed via Paclitaxel Eluting Balloon catheter, Angioplasty via DES
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Coronary Artery Disease
Coronary Physiology and Its Relationship to Anatomy in Patients With Diabetes Mellitus
Comprehensive assessment of coronary physiology (fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microcirculatory resistance (IMR)) in patients with diabetes mellitus and coronary artery disease (CAD).
- Trial name
- NCT02745821
- Testing
- Pressure Wire Certus, St. Jude Medical, USA
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Heart Disease
Levosimendan Pretreatment for Weaning Patients From Cardio-Pulmonary Bypass
The study evaluates the efficacy of intravenous levosimendan treatment started during a coronary artery bypass operation to wean patients from a heart lung machine.
- Trial name
- NCT00130871
- Testing
- levosimendan
- Where
- 2 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Orion Corporation, Orion Pharma
Coronary Heart Disease, Healthy Control
Periodization of Exercise Training in Patients With Coronary Heart Disease.
The research project includes two components that assess exercise physiology parameters, cerebrovascular reserve, cognitive functions and cardiac function in coronary heart disease patients at rest, during an acute exercise, and…
- Trial name
- PERIOD (NCT03443193)
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Myocardial Infarction, Unstable Angina Pectoris
Beta-cell Function in Glucose Abnormalities and Acute Myocardial Infarction
A three months, double-blind, randomised, parallel-group study evaluating the efficacy of sitagliptin (Januvia™) versus placebo on beta-cell function in patients with newly detected glucose abnormalities and acute myocardial…
- Conditions
- Myocardial Infarction, Unstable Angina Pectoris, Diabetes Mellitus, Impaired Glucose Tolerance
- Trial name
- BEGAMI (NCT00627744)
- Testing
- Sitagliptin
- Where
- 2 sites in Sweden
- Volunteers
- 85 people
- Sponsor
- Karolinska Institutet
Vitamin D Deficiency, Non-ST Elevation Myocardial Infarction (nSTEMI)
Vitamin D Deficiency Treatment Outcomes After Non-ST-Segment Elevation Myocardial Infarction
The leading cause of death in the world is due to cardiovascular events, which originate from coronary artery stenosis therefore it affects myocardial blood flow and finally may cause infarction.
- Conditions
- Vitamin D Deficiency, Non-ST Elevation Myocardial Infarction (nSTEMI), Inflammation, Coronary Artery Disease With Myocardial Infarction
- Trial name
- NAVID (NCT03405207)
- Testing
- Vitamin D3 50000 UNT Oral Capsule
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Isfahan University of Medical Sciences
Oxidative Stress, Coronary Artery Disease
Efficacy of Pioglitazone on Myocardial Function in Patients Undergoing Coronary Stent Implantation.
The purpose of this study is to determine the effects of pioglitazone, once daily (QD), on heart functioning before, during and after stent implantation.
- Conditions
- Oxidative Stress, Coronary Artery Disease, Type 2 Diabetes
- Trial name
- NCT00771004
- Testing
- Pioglitazone
- Where
- 7 sites in Germany
- Volunteers
- 63 people
- Sponsor
- Takeda
Cardiovascular Diseases, Ischemic Cardiomyopathy
Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study
The study will investigate whether a new high resolution heart Magnetic Resonance Imaging scan, combining assessment of ischemia and viability by perfusion and Late Gadolinium Enhancement -Cardiac Magnetic Resonance is superior…
- Conditions
- Cardiovascular Diseases, Ischemic Cardiomyopathy, Cardiac Ischemia
- Trial name
- NCT03798652
- Testing
- Research CMR scan, Research 3D transthoracic echocardiogram, 6-minute walk test
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- King's College London
Type2 Diabetes Mellitus
SGLT-2 Inhibitor and Myocardial Perfusion, Function and Metabolism in T2 DM Patients at High Cardiovascular Risk
Patients with type 2 diabetes (T2 DM) have a markedly increased risk of heart disease and it is estimated that, in the danish population, up 80% percent of patients with type 2 diabetes die from heart disease.
- Trial name
- SIMPLE (NCT03151343)
- Testing
- Empagliflozin
- Where
- Denmark
- Volunteers
- 92 people
- Sponsor
- Caroline M Kistorp