Clinical trials: Myocardial Function
Obesity, Diabetes
Effect of GLP-1 Receptor (GLP-1R) Agonists on Cardiac Function and on Epicardial Adipose Tissue (EAT) Volume and on Myocardial TG Content in Obese Diabetics
Glucagon-like peptide-1 (GLP-1) receptor agonist are new treatment of type 2 diabetes, they lower blood glucose level (by enhancement of glucose-dependent insulin secretion and suppression of excess glucagon secretion) and reduce…
- Trial name
- NCT02042664
- Testing
- BYETTA treatment, Metformine
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pregnancy
Echo-Cardiographic Assessment of Cardiovascular Characteristics During Pregnancy and Postpartum Periods
The purpose of this echocardiographic study is to restudy the longitudinal changes in cardiac size and function during and after pregnancy in healthy women using relatively new parameters of systolic and diastolic function as…
- Trial name
- NCT00522977
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Acute Myocardial Infarction (AMI), PCI Patients
The Effect of Cardiac Rehabilitation on Left Ventricular Remodeling in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction
Cardiac rehabilitation has proven to improve the functional capacity of patients who had acute myocardial infarction. However, its effect on Left ventricular remodeling following an MI event treated with Primary PCI is not yet…
- Conditions
- Acute Myocardial Infarction (AMI), PCI Patients, Percutaneous Coronary Intervention (PCI), Primary Percutaneous Coronary Intervention
- Trial name
- NCT07155928
- Testing
- Cardiac Rehabilitation, Primary Percutaneous Coronary Intervention
- Volunteers
- 100 people
- Sponsor
- Assiut University
Coronary Artery Disease
Prompt Human Coronary Collateral Vasomotor Function Induced by Dynamic Physical Exercise
The purpose of this study in humans with stable coronary artery disease (CAD) treatable by PCI (percutaneous coronary intervention) is to evaluate if dynamic physical exercise leads to an instantaneous improvement of coronary…
- Trial name
- NCT00947050
- Testing
- dynamic physical exercise
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Failure, Ventricular Function, Left
Resistance Exercise With Blood Flow Restriction by Vascular Occlusion on Myocardial Function in Heart Failure With Reduced Ejection Fraction
Exercise is essential in cardiac rehabilitation for heart failure patients.Aerobic training and resistance training are both recommended.
- Trial name
- ERFOCARD (NCT07118410)
- Testing
- Application of a vascular restriction device during resistance training
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Coronary Artery Disease
Fear of Activity and Functional Capacity in Patients With Coronary Artery Disease
To identify whether coronary artery disease (CAD) patients have fear of activity, and to assess the relationship between fear of activity and exercise capacity in CAD patients.
- Trial name
- NCT04335760
- Testing
- Modified Bruce protocol on treadmill
- Where
- Turkey (Türkiye)
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Tuğba Atan
Liver Dysfunction, Liver Insufficiency
An Investigational Study of Experimental Medication BMS-986231 Given in Participants With Different Levels of Liver Function
This is an investigational study of experimental Medication BMS-986231 given to participants with weakened or damaged liver function.
- Conditions
- Liver Dysfunction, Liver Insufficiency, Hepatic Failure, Myocardial Failure
- Trial name
- NCT03515980
- Testing
- BMS-986231
- Where
- 4 sites in Hungary, Poland
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Diabetes Mellitus, Type 2
Effect of the Antidiabetic Drug Dapagliflozin on the Coronary Macrovascular and Microvascular Function in Type 2 Diabetic Patients
Cardiovascular events remain a major driver of morbidity and mortality in patients with type 2 diabetes mellitus. Diffuse coronary atherosclerosis, combined with impairment of the microcirculation are frequent even in…
- Trial name
- DAPAMICRO (NCT05392959)
- Testing
- Dapagliflozin 10 mg Tab
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Coronary Artery Disease, Coronary Arteriosclerosis
Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease
This study investigates whether chronic heart rate reduction with ivabradine (Procoralan®, Servier, France) affects aortic compliance and endothelial function in patients with chronic stable coronary artery disease.
- Trial name
- NCT01768585
- Testing
- Ivabradine
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital, Saarland
Acute Coronary Syndromes
PRAsugrel or clopIdogrel In Acute Coronary SyndromE With CYP2C19 GENEtic Variants
The investigators hypothesize that reduced loading dose of prasugrel followed by reduced maintenance dose of prasugrel in acute coronary syndrome patients with CYP2C19 polymorphism undergoing percutaneous coronary intervention…
- Trial name
- PRAISE-GENE (NCT01641510)
- Testing
- Prasugrel, Clopidogrel
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Dong-A University
Coronary Artery Disease, Coronary Stenosis
An Evaluation of a Physiology-guided PCI Optimisation Strategy
There has recently been renewed interest in the measurement of post percutaneous coronary intervention (PCI) Fractional Flow Reserve (FFR).
- Trial name
- Target-FFR (NCT03259815)
- Testing
- P.I.O.S., Pre and post-PCI coronary physiology measurements
- Where
- United Kingdom
- Volunteers
- 260 people
- Sponsor
- NHS National Waiting Times Centre Board
Myocardial Ischemia, Coronary Artery Disease
Peripheral Endothelial Function Assessment of Patients on Ticagrelor vs. Clopidogrel Who Have Undergone PCI
Usage of antiplatelet agents and cardiac procedures such as coronary angioplasty has dramatically improved the morbidity and mortality associated with coronary artery disease.
- Conditions
- Myocardial Ischemia, Coronary Artery Disease, Endothelial Dysfunction
- Trial name
- NCT02469740
- Testing
- Ticagrelor, Clopidogrel
- Where
- Ireland
- Volunteers
- 61 people
- Sponsor
- University Hospital of Limerick
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myocardial Infarction
Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction
This study is planned to investigate the impact of Empagliflozin on biomarkers of heart failure in patients with myocardial infarction with and without type 2 diabetes mellitus within 6 months after the event.
- Trial name
- EMMY (NCT03087773)
- Testing
- Empagliflozin 10 mg
- Where
- 11 sites in Austria
- Volunteers
- 476 people
- Sponsor
- Medical University of Graz
Covid19, Heart Failure
Complications and the Influence of COVID-19 on Myocardial Function and Exercise Capacity
The subject of the study is the impact of COVID-19 on the indicators of myocardial efficiency and exercise capacity. As a result of the observed dependencies, it will be possible to start an appropriate diagnostic procedure…
- Trial name
- NCT04828629
- Testing
- Diagnostic tests
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Perioperative Myocardial Infarction, Disability
Troponin Elevation After Major Noncardiac Surgery 2
Major adverse cardiac events (MACE) are a leading cause of mortality in patients undergoing noncardiac surgery. Patients with perioperative myocardial injury (PMI), defined as either myocardial infarction and lower elevations in…
- Conditions
- Perioperative Myocardial Infarction, Disability, Perioperative/Postoperative Complications
- Trial name
- TEAMS2 (NCT03408522)
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Coronary Artery Bypass Surgery, Coronary Heart Disease
An Efficacy and Safety Study for Nesiritide in Heart Failure Patients With Reduced Kidney Function Undergoing Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass (CPB Pump or Heart Lung Machine)
The purpose of this study is to assess whether nesiritide compared to placebo when given with standard of care therapies, helps preserve kidney function in heart failure (HF) patients undergoing heart bypass graft surgery that…
- Conditions
- Coronary Artery Bypass Surgery, Coronary Heart Disease, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
- Trial name
- NCT00530361
- Testing
- Nesiritide
- Sponsor
- Scios, Inc.
Coronary Artery Disease, Atherosclerosis
Assessment of Stent Strut Coverage and Endothelial Function After Drug-Eluting Stents
The purpose of this study is to compare coronary endothelium function in patients with a zotarolimus-eluting versus a sirolimus-eluting or a everolimus-eluting stents with optical coherence tomography, vasoconstriction in…
- Trial name
- ASSESS (NCT01073111)
- Testing
- zotarolimus-eluting stent (ENDEAVOR®), sirolimus-eluting stents (CYPHER SELECT® PLUS), everolimus-eluting stents (PROMUS®)
- Where
- Japan
- Sponsor
- Hyogo Medical University
Coronary Disease
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
The purpose of this study is to identify the role of endothelin 1 (a natural vasoconstrictor) in the adverse vascular effects demonstrated after exposure to air pollution
- Trial name
- NCT00745693
- Testing
- Endothelin-1, BQ-123 and BQ-788
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cardiovascular Diseases, Endothelial Dysfunction
Anti-Inflammatory Drug and Endothelial Function
In this randomized double-blinded clinical trial, 400mg of hydroxychloroquine will be given daily to people over the age of 65 years with moderate-severe obstructive sleep apnea for 8 weeks.
- Conditions
- Cardiovascular Diseases, Endothelial Dysfunction, Sleep Apnea, Atherosclerosis
- Trial name
- HOLD (NCT04161339)
- Testing
- Hydroxychloroquine
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul