Clinical trials: Myocardial Inflammation
Prevalence of Myocarditis in MINOCA Patients
Prevalence of Myocarditis in Patients Suspected Myocardial Infarction With Non-Obstructive Coronary Arteries
This study aims to determine the prevalence of myocarditis among patients suspected of having myocardial infarction with non-obstructive coronary arteries (MINOCA) and to analyze its clinical characteristics, diagnostic markers .
- Trial name
- NCT06966531
- Testing
- Coronary angiography
- Volunteers
- 148 people
- Sponsor
- Assiut University
Metabolic Preparation, Myocardial Inflammation
Impact of 100mL Lipid Emulsion for Intravenous for Suppression of Myocardial Glucose Metabolism in 18F-FDG PET/CT
There is increasing evidence that [18F]-2-fluoro-2-deoxy-D-glucose (18F-FDG) PET/CT is useful in the identification and treatment of disease processes that involve cardiac inflammation and infection.
- Trial name
- NCT04437927
- Where
- Monaco
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Princesse Grace
Myocarditis
International Myocarditis Registry
Myocarditis is an inflammatory heart disease primarily of viral origin that can lead to heart failure and death. Despite an unfavorable long-term outcome and mortality rate as high as 50%, classification, diagnosis, and treatment…
- Trial name
- mmr (NCT01307735)
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- Libin Cardiovascular Institute of Alberta
Myocardial Inflammation
COUREUR Study Myocardial Inflammation in Cyclist Part 1
The study will evaluate myocardial inflammation in cyclists after high intense and sustained exercise. Our hypothesis is that strenuous exercise in recreational cyclists may be associated with myocardial inflammation.
- Trial name
- NCT04940650
- Testing
- exercise testing, Echocardiography
- Where
- 2 sites in Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Jessa Hospital
Heart Transplantation, Dilated Cardiomyopathy (DCM)
Multimodal Analysis of Endomyocardial Biopsies
The goal of this observational study is to pursue a multimodal approach to identify the molecular signatures and immune signalling molecules of various myocardial diseases and thereby contribute to improving diagnosis and…
- Conditions
- Heart Transplantation, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Myocarditis, Pericarditis
- Trial name
- NCT07359690
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- University Hospital, Essen
Septic Cardiomyopathy, Septic Shock
The Preventive Effect of Shenfu Injection on Myocardial Dysfunction in Sepsis
This study focuses on improving heart function in patients with life-threatening blood infections (septic shock). When the body fights severe infections, the heart sometimes struggles to pump blood effectively, which can lead to…
- Trial name
- SHIELD Trail (NCT06898723)
- Testing
- Shenfu Injection
- Where
- China
- Volunteers
- 440 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Inflammatory Cardiomyopathy
CZECH-ICIT (CZECH Inflammatory Cardiomyopathy Immunosuppression Trial)
The aim of this study is to compare the effect of combined immunosuppressive therapy given on the top standard medical therapy of chronic heart failure according to current guidelines with standard medical therapy of chronic…
- Trial name
- NCT01877746
- Testing
- Combination of prednisone and azathioprine, No intervention
- Where
- 2 sites in Czechia
- Volunteers
- 234 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Ischemic Heart Disease, Myocardial Infarction
Rituximab in Patients With Acute ST-elevation Myocardial Infarction Study
RITA-MI aims to develop of a novel therapeutic concept to target the immune response in patients with acute myocardial infarction (MI) by depleting B-cells with a single injection of Rituximab which is approved for clinical use…
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Inflammation
- Trial name
- RITA-MI (NCT03072199)
- Testing
- RiTUXimab Injection
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Myocarditis
Acute Eosinophilic Myocarditis International Registry
Retrospective collection of clinical, histological, imaging data regarding patients with acute histologically-proven eosinophilic myocarditis.
- Trial name
- NCT06447935
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Myocarditis Acute, Ventricular Arrythmia
Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis
Myocarditis is an inflammatory disease of the heart muscle which is mostly caused by viruses, bacteria, parasites, toxic substances/drugs or by primary autoimmune mechanisms.
- Trial name
- AIM-ICD (NCT04264455)
- Testing
- Biomonitor, Life Vest, Implantable Cardioverter-Defibrillator (ICD)
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Wuerzburg University Hospital
Heart Failure With Preserved Ejection Fraction (HFPEF)
Hearts on Fire: Targeting Inflammation in Heart Failure With Preserved Ejection Fraction
Subjects undergo a gadolinium-based CMR followed by an iron infusion and then a repeat CMR in 72 hours
- Trial name
- NCT07634640
- Testing
- Ferumoxytol infusion
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Florida
Cardiovascular Diseases, Heart Diseases
Inflammation: Correlates and Prognosis in Framingham
To determine the relation between cardiovascular disease risk factors and systemic markers of vascular inflammation in the Framingham Study cohort.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Disease
- Trial name
- NCT00006403
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Peripheral Artery Disease
Synergistic Influence of Rivaroxaban on Inflammation and Coagulation Biomarkers in Patients With CAD and PAD on Aspirin Therapy
This is a phase IV, prospective biomarker study that will be conducted at Sinai Hospital of Baltimore. After screening for patients who were treated with aspirin, thirty patients will be treated with 81 mg enteric coated (EC)…
- Trial name
- NCT04059679
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet, Aspirin 81 mg
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- LifeBridge Health
Myocarditis
Prognostic Impact of Cardiac Imaging During Suspected Immune Checkpoint Inhibitor Myocarditis
It consists of evaluating the advantage of routine detection of phIGFBP-1 to reduce the total duration of hospitalization for patients with a risk of preterm labor before 32 weeks of gestation without increasing the number of…
- Trial name
- IMMUNOIMAGING (NCT05086146)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Myocarditis, Ventricular Arrythmia
GEAM Study Aims At Assessing the Role of Genetic Testing in Patients with Arrhythmic Myocarditis.
This study aims to answer multiple unsolved questions in the field of arrhythmic myocarditis. Improving the diagnostic work-up. While endomyocardial biopsy (EMB) and cardiac magnetic resonance (CMR) constitute the gold standard…
- Trial name
- GEAM (NCT06889662)
- Where
- Italy
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
Arrhythmia, Long QT Syndrome
AI-powered ECG Analysis for Deadly Arrhythmias and ICI Myocarditis
ELDORA is a non-interventional observational data-science study aiming to develop and validate clinical-grade artificial intelligence tools applied to electrocardiogram (ECG) data.
- Conditions
- Arrhythmia, Long QT Syndrome, Immune Checkpoint Inhibitor-Related Myocarditis
- Trial name
- ELDORA (NCT07644715)
- Where
- France
- Volunteers
- 127,000 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Myocarditis Acute, Myocardial Inflammation
CMR Evaluation of Myocardial Inflammation Persistence After Acute Myocarditis: Prognostic Relevance
Patients with acute myocarditis (AM) usually experience spontaneous healing, but a considerable percentage of them evolve towards chronic long-term cardiac impairment.
- Trial name
- MIAMI (NCT03525639)
- Testing
- Cardiac Magnetic Resonance
- Where
- 3 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Antonio Esposito
Coronary Artery Disease, Diabetes Mellitus, Type 2
PIPAF Platelets in the Pathogenesis of Ageing Associated Frailty
This is a prospective observational study aimed at testing the existence of an association between frailty, inflammatory status, and degree of platelet activation and reactivity in elderly subjects with type 2 diabetes or…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Alzheimer Disease
- Trial name
- PIPAF (NCT05798637)
- Testing
- Standard of care
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Acute Coronary Syndrome, Atherosclerosis
The Microbiome as a Target for Precision Medicine in Atherosclerosis
Cardiovascular diseases are the main cause of death in industrialized countries. Among them, atherosclerosis has the highest prevalence and constitutes a common pathological pathway responsible for the majority of cases of…
- Trial name
- MIGATER (NCT03434483)
- Testing
- Assessment of the atherosclerotic plaque in a moderate lession., Gene variants in atherosclerosis, Microbiota analysis
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Psoriasis
Effect of Chronic Inflammation on Myocardial Perfusion and Function
Background: Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF.
- Trial name
- NCT04870827
- Testing
- 13N Amonia
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)