Clinical trials: Myocardial Inflammation
Endothelial Dysfunction, Cardiovascular Risk Factor
Intracoronary Features in the Prognosis of Endothelial Dysfunction and MACES in Population With Acute Coronary Syndrome
Coronary Artery Disease (CAD) is common in Mexico, while morbidity and mortality is high. Drug therapy can relieve angina pain and stabilize plaque, but it is not able to re-flow a coronary artery.
- Conditions
- Endothelial Dysfunction, Cardiovascular Risk Factor, Coronary Syndrome, Acute
- Trial name
- iphoneSPACE (NCT03583047)
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Myocarditis, Myocarditis Acute
Outcome of Clinical Phenotypes of Pediatric Myocarditis at Assiut University Children Hospital
This study aims to investigate the clinical phenotypes, management approaches, and outcomes of myocarditis in children admitted to Assiut University Children's Hospital.
- Trial name
- PED-MYO (NCT07175948)
- Testing
- Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Assiut University
Myocardial Infarction, Inflammation
Inflammatory Cell Trafficking After Myocardial Infarction
Myocardial infarction (heart attack) is usually the consequence of rupture of a fatty 'plaque' in a heart artery. The presence of this fat and debris causes the propagation of a blood clot and blockage of the artery.
- Trial name
- NCT01127113
- Testing
- Infusion of investigational product, Cardiac magnetic resonance imaging
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Endothelial Dysfunction, Atherosclerosis
Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries
The investigators are hoping to discover the cause of chest pain in patients with a normal coronary arteriogram. For patients with chest pain coronary angiography is the standard method by which the blood vessels of the heart can…
- Conditions
- Endothelial Dysfunction, Atherosclerosis, Inflammation, Myocardial Ischemia
- Trial name
- ACOVA (NCT01162824)
- Testing
- Acetylcholine, Adenosine
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's Healthcare NHS Trust
COVID-19
Cardiac Injury in COVID-19: a Pathology Study
The primary goal of the study is to conduct the first systematic cardiac autopsy study in 60 patients dying from COVID-19 to understand the pathology and pathogenesis of cardiac injury in patients with COVID-19, with/without…
- Trial name
- NCT04367792
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Myopericarditis, Myocarditis
Myopericarditis After Messenger Ribonucleic Acid (mRNA) COVID-19 Vaccination in Children 5-11 Years Old
Myopericarditis is a rare complication to messenger ribonucleic acid (mRNA) COVID-19 vaccines, especially in male adolescents and young adults. The risk in children 5-11 years old is unknown.
- Conditions
- Myopericarditis, Myocarditis, Vaccination; Complications, COVID-19 Pandemic
- Trial name
- NCT05186571
- Testing
- Pfizer-BioNTech mRNA COVID-19 vaccination
- Where
- Denmark
- Volunteers
- 350,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Risk Factor, Cardiovascular Diseases
Umbrella Review of the DASH Dietary Pattern and Cardiometabolic Risk
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding the Dietary Approaches to Stop Hypertension (DASH) diet, a dietary pattern that emphasizes fruits and…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Coronary Heart Disease, Stroke
- Trial name
- NCT03542370
- Testing
- DASH dietary pattern
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Sepsis-related Myocarditis
Sepsis and Myocarditis
This prospective cohort study aims to investigate the cardiac manifestations of sepsis and their influence on disease outcomes among adult patients at Jimma University Medical Center, Ethiopia, from May 2025 to May 2026.
- Trial name
- NCT07079605
- Testing
- Standard treatment for sepsis of any focus, Treatment for the sepsis with standard management of cardiac failure
- Where
- Ethiopia
- Volunteers
- 226 people
- Sponsor
- Jimma University
Enterovirus Infections
Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection
Enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. Whether Enteroviruses can also affect the kidneys is not known yet.
- Trial name
- NCT00426699
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ischemic Heart Disease, Coronary Artery Disease
ITA Vs LAD; Evaluation of Inflammatory Burden in OP-CABG Patients
Introduction. Ischemic cardiomyopathy is one of the death leading causes in industrialized countries. Up-to-date ESC guidelines recommend a surgical approach (coronary by pass graft) in patients with multivessel coronaropathy…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Atherosclerosis, Inflammation
- Trial name
- NCT05574621
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Cardiochirurgia E.H.
End Stage Kidney Disease, Fibrosis Myocardial
Validating Novel, Non-contrast Cardiac MRI Imaging in Haemodialysis Patients
There are currently no good ways of measuring levels of scarring in the hearts of patients with advanced kidney disease and patients on dialysis, although recent research has shown a new cardiac MRI technique, called native T1…
- Trial name
- CONFIRM (NCT03586518)
- Testing
- Cardiac MRI scan, Echocardiogram, Cardiac explantation
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Leicester
Cardiogenic Shock Acute, Bypass, Cardiopulmonary
Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock
Mixed cardiogenic-vasoplegic shock (M-CS) represents a distinct and severe phenotype of cardiogenic shock characterized by concomitant myocardial dysfunction and inappropriate systemic vasodilation.
- Conditions
- Cardiogenic Shock Acute, Bypass, Cardiopulmonary, Septic Shock, Mechanical Circulatory Support
- Trial name
- PROMIX (NCT07354568)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Myocard Infarctus
New Predictors in Determining the Need for Invasive Treatment in Non-STEMI
Non-ST elevation acute coronary syndrome (NSTE-ACS) is a heterogeneous disease with a wide range of treatment options from the medical follow-up to early invasive treatment due to complete occlusion of the culprit artery.
- Trial name
- non-STEMI (NCT04763213)
- Testing
- Coronary Angiography
- Where
- Turkey (Türkiye)
- Volunteers
- 276 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Acute Coronary Syndromes (ACS)
Association Between SYNTAX Score and Leukoglycemic Index In Patients Wiht Acute Coronary Syndrome
This study looks at people who come to the hospital with acute coronary syndrome, a serious heart condition. When these patients first arrive, doctors take routine blood tests.
- Trial name
- NCT07276256
- Testing
- leukoglycemic index calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 552 people
- Sponsor
- Kırıkkale University
Myocardial Infarction
Ferumoxytol for Magnetic Resonance Imaging of Myocardial Infarction
The investigators wish to examine whether a novel 'nanoparticle' of iron oxide, administered intravenously allows an area of heart muscle damage after heart attack to be visualised using a magnetic resonance scanner.
- Trial name
- NCT01323296
- Testing
- Ferumoxytol
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Edinburgh
Acute Myocardial Infarction (AMI)
Radiolabeled TSPO Targeted Molecular Probe in AMI
Evaluate the clinical application value of the novel radiolabeled TSPO-targeted molecular probe Gallium [68Ga]-DOTA-HK-011 for inflammation imaging associated with acute myocardial infarction.
- Trial name
- NCT07105982
- Volunteers
- 8 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Sarcoidosis, Arrhythmogenic Right Ventricular Cardiomyopathy
PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare condition in which the heart muscle cells especially of the main pumping chamber (the 'ventricle') is replaced by fat and scar tissue.
- Trial name
- NCT02989480
- Testing
- PET CT, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen