Clinical trials: Myocardial Injury
Heart Injuries
Subclinical Hypothyroidism and Acute Anterior Myocardial Infarction: Is it Cardio-protective or Not?
The study plans to investigate whether recovery of the heart function after acute anterior myocardial infarction is dependent upon improvement in thyroid gland functioning.
- Trial name
- NCT03017157
- Testing
- Echo-cardiogram, Blood test
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Acute Myocardial Infarction, Acute Coronary Syndrome
MERITnI - Mindray-hs-cTnI Assay: Analytical and Clinical Evaluation for the Diagnosis and RIsk AssessmenT of Myocardial InfarctIon.
The Mindray High Sensitivity Troponin-I Measurement System is an in vitro diagnostic test for the quantitative determination of high sensitivity cardiac troponin I (hs-cTnI) in human serum or plasma.
- Trial name
- MERITnI (NCT05853042)
- Testing
- high-sensitivity cardiac troponin testing
- Where
- United States
- Volunteers
- 1,559 people
- Sponsor
- Fred Apple
Perioperative Care
Validation of B-type Natriuretic Peptide With N-terminal Pro B-type Natriuretic Peptide in Perioperative Risk Assessment
This is a single-centre, prospective study to determine the correlation and comparative thresholds between N-terminal pro-brain natriuretic peptide (NT ProBNP, Roche) and brain natriuretic peptide (BNP, Abbott) tests.
- Trial name
- NCT05352698
- Testing
- NT ProBNP (Roche)
- Where
- Canada
- Volunteers
- 466 people
- Sponsor
- Jordan Leitch
Ischemia Reperfusion Injury, Myocardial Injury
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
A Randomized, Double-blind, placebo-controlled Trial to Evaluate the Efficacy of Oral Nam for the Prevention of Acute Kidney Injury in Patients Undergoing On-Pump Cardiac Surgery
- Conditions
- Ischemia Reperfusion Injury, Myocardial Injury, Acute Kidney Injury
- Trial name
- NACAM (NCT04750616)
- Testing
- Niacinamide
- Where
- United States
- Volunteers
- 331 people
- Sponsor
- Kaiser Permanente
Myocardial Infarction
Relationship Between CMR-derived Parameters of Ischemia / Reperfusion Injury and Timing of CMR in STEMI
This a prospective observational study including patients with ST-segment elevation myocardial infarction undergoing cardiovascular magnetic resonance for clinical reason during the index hospitalization.
- Trial name
- NCT03522116
- Testing
- No intervention
- Volunteers
- 220 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute ST Elevation Myocardial Infarction
Nitrites in Acute Myocardial Infarction
The research question to be addressed is "Does a 2.5 - 5 minute systemic intravenous injection of sodium nitrite administered immediately before opening of the infarct related artery result in significant reduction of ischaemia…
- Trial name
- NIAMI (NCT01388504)
- Testing
- sodium nitrite
- Where
- 3 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Aberdeen
Acute Myocardial Infarction
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?
Rationale: A safety and dose defining study in which the investigators hypothesize that in patients with acute coronary syndrome without ST-elevation (NSTEMI) treatment with heme arginate results in better clinical outcome by…
- Trial name
- HAEM (NCT00483587)
- Testing
- Heme arginate
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- University Medical Center Groningen
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Ischemia, Myocardial
Quantitative Stress Echocardiography to Diagnose Myocardial Ischaemia
Patients with chest pain on exertion need a reliable non-invasive test to identify if they have inducible myocardial ischaemia. This would reduce the use of diagnostic coronary arteriography, avoid its risks and costs, and guide…
- Trial name
- DEVISE (NCT03659526)
- Testing
- Deformation imaging
- Where
- 4 sites in Belgium, Sweden and 1 more
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University Hospital of Wales
Neurological Injury, Stroke
Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.
The objective of this study is to investigate the value of employing the aortic no-touch off-pump coronary artery bypass technique and the practice of carbon dioxide surgical field flooding for the prevention of type 1 and 2…
- Conditions
- Neurological Injury, Stroke, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- CANON (NCT03074604)
- Testing
- aortic no-touch OPCABG, OPCABG with partial clamp applying carbon dioxide, OPCABG with partial clamp
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Myocardial Infarction, Myocardial Injury
Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study
Perioperative Myocardial Infarction (PMI) is a major contributor to perioperative mortality and morbidity with overall incidence of 5-16%.
- Conditions
- Myocardial Infarction, Myocardial Injury, Major Adverse Cardiac Events, Infectious Complications
- Trial name
- COPMAN (NCT04139655)
- Testing
- Colchicine 0.6 mg
- Where
- Canada
- Sponsor
- University of British Columbia
Ischemic Heart Disease, Cardiac Arrest
Registry of Multicenter Brain-Heart Comorbidity in China
This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program.
- Conditions
- Ischemic Heart Disease, Cardiac Arrest, Atrial Fibrillation, Heart Failure
- Trial name
- BHC-C (NCT05961748)
- Testing
- Multi-disciplinary assessment
- Where
- 14 sites in China
- Volunteers
- 100,000 people
- Sponsor
- Beijing Tiantan Hospital
Leukemia, Cardiac Toxicity
Early Detection of Anthracycline Cardiotoxicity by Echocardiographic Analysis of Myocardial Deformation in 2D Strain
It is now accepted that the anticancer properties of anthracyclines were allowed in many malignancies improve the prognosis of affected populations.
- Trial name
- CA2D (NCT01212926)
- Testing
- Echographic analysis of myocardial deformation in 2D strain
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Bordeaux
Covid19, Myocardial Injury
Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19
With the results of this study the investigators aim to identify an effective treatment that will reduce morbidity and mortality of patients with symptomatic COVID-19 infection, which would in turn reduce the burden on the…
- Trial name
- SEMPATICO (NCT04615871)
- Testing
- semaglutide
- Where
- 10 sites in Brazil, Canada and 2 more
- Volunteers
- 400 people
- Sponsor
- Vladimír Džavík
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
ST Elevation Myocardial Infarction, Inflammatory Response
Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction
The overall primary objective of the PULSE-MI trial is to test the hypothesis that administration of single-dose glucocorticoid pulse therapy in the pre-hospital setting reduces final infarct size in patients with ST-segment…
- Conditions
- ST Elevation Myocardial Infarction, Inflammatory Response, Myocardial Reperfusion Injury, Myocardial Injury
- Trial name
- PULSE-MI (NCT05462730)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- Denmark
- Volunteers
- 530 people
- Sponsor
- Thomas Engstrom
Acute Myocardial Injuries
Acute Coronary Syndrome CardioFlux TM Study (ACCMED)
Approximately 16.5 million people suffer from coronary artery disease (CAD) and about 10 million present each year to emergency departments with symptoms like chest pain and shortness of breath, commonly suggestive of acute…
- Trial name
- MAGNETO (NCT04739267)
- Testing
- CardioFlux
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- Genetesis Inc.
Kidney Failure, Acute, Oxidative Stress Induction
N-acetylcysteine to Prevent Renal Failure
The purpose of this study is to determine the possible effect nephroprotective of N-acetylcysteine in patients with chronic kidney disease undergoing elective coronary artery bypass grafting by serial evaluation of renal function…
- Trial name
- NCT01359722
- Testing
- N-acetylcysteine, Control
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto do Coracao
Percutaneous Coronary Intervention, Myocardial Ischemia
Analysis of Myocardial Layer Specific Systolic and Diastolic Function During and After PCI
Investigators will analyzed systolic and diastolic function during and after ischemia induced by percutaneous coronary intervention.Also will be analyzed a local work index during acute ischemia induced by percutaneous coronary…
- Conditions
- Percutaneous Coronary Intervention, Myocardial Ischemia, Anginal Pain
- Trial name
- PCI-Strain (NCT02004483)
- Testing
- Percutaneous Coronary Intervention
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- RWTH Aachen University
Myocardial Infarction, STEMI
Intramyocardial Haemorrhage in Patients With Primary STEMI
The purpose of the study is to assess the frequency and intensity of intramyocardial haemorrhage in patients with primary STEMI and different reperfusion strategies.
- Conditions
- Myocardial Infarction, STEMI, Myocardial Necrosis, Myocardial Injury
- Trial name
- HaemInCor (NCT03677466)
- Testing
- Pharmaco-invasive strategy, Primary PCI
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences